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Quotient Sciences Expands UK Facilities to Support Delivery of Translational Pharmaceutics® Programs

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Company Expands Laboratory and Clinical Capabilities to Meet Demand for Fully Integrated Drug Development Capabilities

NOTTINGHAM, England, September 22, 2022 /PRNewswire/ — Quotient sciencea drug development and manufacturing accelerator, has made significant investments and expansions at its Nottingham, United Kingdom and Reading, UKfacilities to support the delivery of fully integrated drug development programs through the company’s flagship platform, Translational Pharmaceutics®.

The new clinical pharmacology space and expanded development labs increase the company’s ability to conduct integrated translational pharmacology programs for global pharmaceutical and biotechnology customers.

Translational Pharmaceutics integrates drug substance, drug product, and clinical trial activities under a single outsourcing vendor to accelerate development times and reduce costs.

Developed in consultation with the UK’s Medicines and Healthcare Products Regulatory Agency (MHRA) and the US Food and Drug Administration (FDA), the platform uses rapid ‘manufacture-to-test’ cycles, where drug products are manufactured, released and dosed in a clinical setting. study in days rather than months.

In Nottingham, United Kingdom, Quotient Sciences has opened a 17,000 square foot, MHRA-inspected clinical pharmacology facility that includes 40 beds with ancillary volunteer lounges, processing labs, a dispensary and controlled storage. The new facility is located adjacent to their existing formulation development, manufacturing and clinical operations facilities at the Company’s plant. Nottingham Campus.

Their Reading, UK site, the company completed a £1.5 million expansion of its early development and manufacturing facilities, which doubled its formulation development and analytical footprint on the facility, increasing the office space also part of the expansion.

“Quotient Sciences’ mission is to help bring new medicines to patients faster by breaking down traditional industry silos,” said Marc EgertonPh.D., CEO of Quotient Sciences.

“Our unique Translational Pharmaceutics platform was launched over 15 years ago and has accelerated the development of nearly 1,000 molecules for our clients. These expansions are consistent with our overall growth strategy and in direct response to customer feedback and growing demand for our services.”

About Quotient Science

Quotient science is a drug development and manufacturing accelerator that offers integrated programs and tailored services throughout the development journey. By breaking down silos across a range of drug development capabilities, we save valuable time and money getting drugs to patients. Everything we do for our customers is driven by the unwavering belief that ideas must become solutions and molecules must become cures, fast. Because humanity needs solutions, fast.

SOURCE Science Quotient Global News

People Who Make a Difference: Terry Hunt

This is a monthly feature about someone making a difference in the lives of others. To submit an application, email [email protected]

People also read…

As executive director of the often underrated Community Cancer Association, Terry Hunt experienced starvation. Now he tastes the feast.

After struggling during COVID-19 with fewer funds to help the cancer patients he serves, then dealing with a shrinking gas budget as fuel prices soared, relief came from a multitude of sources.

The biggest came from this year’s Silo District Marathon in the form of a check for $50,000.

“It couldn’t have come at a better time,” Terry said.

A major grant from the Bowen Foundation has arrived. The Northwest Optimist Club announced that its golf tournament this year and in the future will raise funds to fund the ACC’s gas budget. A United Way grant benefits the group’s drug/pharmacy program and supplies. HEB offers gift cards to help patients afford nutritional supplements such as Ensure.

The Waco Foundation told Terry it pays for the Resilia program, an online support for nonprofits that he says will be of great help. This year, the Thanksgiving Day Turkey Trot includes CCA as a beneficiary.

“This year has been a blessing,” he said.

The Community Cancer Association is one of the lesser-known nonprofit organizations, but it has a large footprint in McLennan County. This is a grassroots organization that has local donors and helps local cancer patients, from providing chemo care bags to helping pay for outpatient cancer drugs, prescription co-payments, medically necessary travel, wound care items (including ostomy and mastectomy supplies, prostheses, compression bandages and clothing), wigs and dietary supplements.

The American Cancer Society refers patients to the CCA for wigs.

“All we do is help cancer patients,” he said. “All of our suppliers are local. Our pharmacies are local.

“Being selected as a charity champion opened doors for us,” he said. “The notoriety of us has grown,” and he hopes this will help spur the growth of donations to help his patients.

The services of the CCA will be needed even more, he said. The Texas Cancer Registry, which tracks cancer diagnoses, typically sees about 1,170 new diagnoses in any given year for McLennan County, he said. Last year there were 1,240 new cases for the county and this year the registry predicts 1,290 new cancer diagnoses.

Of particular concern is the increase in breast cancer, he said. Lung cancer is No. 1 in the county, followed by breast cancer, he said. Usually, breast cancer accounts for about a quarter of patients helped by ACC, he said, but currently new diagnoses of breast cancer account for nearly half of cases, he said.

Terry has over 40 years of radio experience, but moved into non-profit work in 2016 with CCA. Being asked to take over as Executive Director of the Community Cancer Association in 2019 came with a big learning curve. But he now feels like he’s hitting his stride.

“Our volunteer board of directors is wonderful,” he said. “It really is a team effort. We have all been touched by cancer. But I feel like we are in the right place at the right time to receive these blessings.

His radio mic can be put away, but his voice can still be heard over the PA system at Baylor football, riding, and baseball events, as well as high school football playoff games held at McLane Stadium.

“Radio was my career, but it’s my calling,” Terry said of CCA. “I didn’t know that until I got here.”

Waco Today spotlights people whose good works might otherwise go relatively unnoticed. To submit an application, email [email protected]

Caring Pharmacy launches CariDoctor for online prescriptions, minor consultations

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KUALA LUMPUR: With the advancements in medical technology, easier methods are now available for patients to consult health experts. One such method is the CariDoctor-Electronic Prescription Service (CariDoctor), a one-stop solution launched yesterday by the Caring Pharmacy Group to meet public health needs.

Through the platform, a pharmacist contacts available physicians on behalf of patients who require consultation for minor illnesses such as headaches, rashes, and skin infections. This enables them to get unfailing professional advice and medical prescriptions from licensed doctors.

Caring Pharmacy’s chief pharmacist, Wong Hooi Fen, said CariDoctor supplements a physical consultation and is not meant to completely replace a doctor’s visit.

“Telemedicine has been on the rise since the start of Covid-19, when the industry developed hybrid consultation services. This will not replace the physical consultation but will complement it.

“A patient can reduce the time it takes to get medical prescriptions from doctors and to go to the pharmacy to buy them,” she said. the sun.

“With CariDoctor, which is available in all our pharmacies across the country, the public can access immediate medical consultation for minor illnesses.”

Caring Pharmacy Marketing Director Loo Jooi Leng said CariDoctor has been trialed at a number of Caring outlets since June and around 1,000 people have signed up on the platform.

“With the national launch of CariDoctor across all Caring pharmacies today, we expect more people to use the platform and with that there will be more doctors available to cater to the high number of (participants). Currently, we don’t ‘we don’t have a fixed number of partner doctors,’ he said.

Pharmacy practice manager Lee Yean Ling said it will take some time for the public to adapt to technological advancements, but over time they will get used to it.

“Go to the nearest Caring pharmacy and try it for free. Our pharmacists will guide you on how to use the platform and you will eventually get used to it”,
she says.

Caring Pharmacy Group General Manager Chong Yeow Siang said, “The CariDoctor platform will promote good healthcare practices. We are constantly innovating to provide superior services that can help large numbers of people in terms of medical advice, convenience, quality, cost and reliability.

CariDoctor was launched in conjunction with World Pharmacists Day, which falls on September 25. The service is available at all Caring Pharmacy locations and select Georgetown Pharmacy and Wellings Pharmacy stores nationwide.

To celebrate World Pharmacists Day, the Caring Pharmacy Group is promoting better health and lifestyles by offering health checks (blood pressure, blood sugar and cholesterol), a Jom Kurang Manis diabetes counseling service, a Eat Well Stay Fit weight management and asthma counseling service at all of its outlets nationwide.

Governor candidate Stefanowski releases $2 billion tax relief plan

Photo by Julia Bergman

NEW HAVEN — Bob Stefanowski on Tuesday chose a family drugstore a few blocks from his childhood home as the backdrop to unveil a $2 billion tax relief plan for Connecticut residents.
The Republican gubernatorial candidate introduced a wide range of tax cuts – most of them permanent – ​​which he said were a way to lessen the effects of record inflation and provide relief to residents over his 100 years. first days in office.
His plan to pay for the aid is to use part of the state budget surplus. He said his administration would also audit state departments to find efficiencies and said he would tackle waste and fraud in public spending, which he dubbed the corruption tax. .
“I know there is a lot of ego in politics. I know there is a lot of noise in politics. But I grew up two blocks from here. I’m doing this to help the people of Connecticut. I do it to help my old neighborhood,” Stefanowski said outside Visels Pharmacy on Dixwell Avenue, which has been owned by the same family since 1913.
The plan, called the Connecticut State Inflation and Tax Reduction Plan, or CT FIRST, would save the average family $2,000 a year, according to Stefanowski’s calculations.
The package includes many of the ideas that Stefanowski and other Republicans have been circulating for months, including removing the 1% surtax on prepared foods, extending the state’s gas tax exemption until ‘ in 2023, and also the temporary repeal of the state tax on diesel fuel until then, and permanently reduce the sales tax from 6.35% to 5.99%.
Stefanowksi said he would also allow landlords to deduct up to $10,000 of their local property taxes on their state tax returns, but would not offer relief to tenants by making adjustments to the Connecticut motor vehicle tax.
He also called for disbanding the Utilities Regulatory Authority and replacing it with a 10-member council, comprising regulators and business and consumer representatives focused on affordability and accountability.
Notably missing from his plan is the signature proposal of his 2018 gubernatorial bid: the repeal of the state income tax. He said that idea is not on the table right now, nor has he proposed lowering income tax rates.
Democrats called the plan fiscally irresponsible and stressed the importance of using the budget surplus to pay back deeply underfunded state pension funds, which they say will allow residents to save more money in the long run and to help Connecticut weather a future economic recession, which many predict is on the horizon.
Stefanowski said he would pay for the tax cuts — more than half of which are permanent — with a combination of state surpluses, spending cuts and pandemic relief money.
He was not specific on spending cuts, but said it could be as high as 4.4%. Republicans haven’t formally offered spending cuts in a budget since 2017. The state budget is two-thirds made up of items like pension payments and aid to cities and towns. .
By the time the governor’s next term begins the first week of January, the state is expected to have already deposited about $4.3 billion in additional payments from the most fiscal year surplus. recent. The bulk of that filing, around $3 billion, is expected to take place by the end of next week.
The fiscal year 2022 surplus was about $4.4 billion, plus several hundred million dollars in federal pandemic assistance that was in the budget but not needed and was taken out to future use. But all that extra cash isn’t likely to happen again in the years to come.
In the current fiscal year, a cushion of $299 million was built in and it grew to $445 million in the first two months of the fiscal year, but not due to excess tax recoveries beyond forecast. Nonpartisan state budget experts have projected deficits for fiscal years 2024 and 2025.
Stefanowski said his plan “leaves another $3 billion to manage during the recession we all know is coming.” He said the state should prioritize paying down pension debt, but said his plan would help spur economic activity and job growth and ultimately generate a lot of revenue for the state. He offered no details. “We only show you the cost. There will be a lot of revenue from this,” he said.
Stefanowski’s visit to this stretch of Dixwell Avenue, which he says has suffered under Democratic rule for decades, was also meant to illustrate a major rift between him and Gov. Ned Lamont.
“People say we have two wealthy gubernatorial candidates,” Stefanowski said. “I’ll admit, I did pretty well, but one of the two runners grew up in Greenwich, Connecticut and went to the polo field on the weekends. I grew up here.
Stefanowski said his parents got married in the church down the street and remembered coming to Visels for ice cream. Asked how the neighborhood has changed since living here, Stefnaowski, 60, who said his family moved when he was in second grade, said many homes and businesses were in poor condition . His former elementary school is now a methadone clinic.
Several residents of the neighborhood approached the tall stranger who was visiting him. They pointed to the violence and lack of investment in their community where 37% of residents live below the poverty line and the median household income is $29,066, according to census data. In 2018, when Lamont and Stefanowksi first faced off, the governor won New Haven by more than 20,000 votes.
A man standing on the corner of Dixwell Avenue and Bassett Street questioned Stefanowski about his stance on guns. He said he heard that Stefanowski wanted to arm the teachers.
“That was a misquote,” Stefnaowski said, adding that in some cases armed security guards should be posted in schools. “We should not arm teachers,” he said.
Politicians only come here every four years and then disappear, said Charles Murphy, a 39-year-old New Haven resident.
“A lot of people come, they talk, they say they’re going to do anything… we don’t see them for four years. Ned Lamont said he was going to do this and that for the people of Connecticut, but it only seems to help a few and not everyone,” Murphy said. “We all want to be part of Connecticut.”

To increase concentration and get a sharp mind, drink this thing daily by mixing it with milk.

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Delhi, lifestyle office. Benefits of water hyssop: Brahmi is considered a medicine in Ayurveda. It is used to prevent many types of diseases. Brahmi has been used in the form of medicine in India since ancient times. The medicine is called Brahmi in the name of Lord Brahma. Brahmi is also mentioned in Charaka Samhita. It is composed by Acharya Agnivesh. Brahmi is a vegetable. Its flowers are white. At the same time, the sheets are soft and padded. It is only found in India. Brahmi is known by many names across the country. Brahmi is nothing less than a boon to health. Its consumption relieves many diseases. Brahmi medicine is similar for women. It also has blood purifying properties. At the same time, its consumption increases concentration and sharpens the mind. Come on, let’s know all about it-

Journal of Pharmacognosy and Phytochemistry It has been revealed through research that by consuming Brahmi twice a day, the brain becomes sharpened. Memory power increases. For this, those involved in the research were advised to consume 300mg of Brahmi twice a day. The result of this research was very encouraging. In this research, it was found that daily consumption of Brahmi can boost memory power in just 2 months.

According to health experts, the natural compound Bacoside is found in Brahmi which sharpens the brain. Its consumption increases concentration. Apart from this, consumption of Brahmi also relieves stomach related disorders. Above all, Brahmi is like a medicine for people suffering from constipation. Its regular consumption helps to get rid of constipation. Its taste is cold. For this, it is also beneficial in stress.

how to consume

Brahmi leaves can be eaten for this. In parallel, take 150 mg of Brahmi powder mixed in a glass of milk every night before sleeping. With its regular consumption, the mind becomes sharp. Memory power also increases.

Disclaimer: Story tips and suggestions are provided for general information only. Do not consider them as advice from a doctor or healthcare professional. If symptoms of illness or infection occur, seek medical attention.

Edited by: Pravin Kumar

Honey has sweet potential for wound healing, say scientists

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2O2. Most of the antimicrobial activity of honey comes from H2O2, killing pathogens through DNA damage and multiple cellular targets. (B) Honey is acidic with an average pH of 3.91 (ranges between 3.4 and 6.1), which makes it potent against microbial strains with an optimum pH for growth around 7. The acidity comes from mainly gluconolactone/gluconic acid. (C) Bee Def-1 is an antibacterial peptide originating from the hypopharyngeal gland of the bee. It acts by interfering with bacterial adhesion to a surface, or in the early stage of biofilm by inhibiting the growth of attached cells; and by modifying the production of extracellular polymeric substances. (D) MGO is generated in honey during storage by the non-enzymatic conversion of dihydroxyacetone, a saccharide present in high concentrations in the nectar of Leptospermum flowers. The antimicrobial activity of MGO is attributed to alterations in bacterial fimbriae and flagella, which impair the adhesion and motility of the bacterium. (E) Honey is a supersaturated solution of sugars. The strong interaction between these sugars and water molecules prevents the abundance of free water molecules (low water activity) available for the growth of microbes. (F) The combination of different phenols acts as an enhancer of the antimicrobial efficacy of honey. Under alkaline conditions (pH 7.0 to 8.0), polyphenols can display pro-oxidant properties, inhibiting microbial growth by accelerating hydroxyl radical formation and oxidative DNA strand breakage. They could also support the production of considerable amounts of H2O2 via a non-enzymatic pathway. Credit : Pharmaceutical (2022). DOI: 10.3390/pharmaceutics14081663″ width=”800″ height=”354″/>

Main antimicrobial components of honey. (A) The sucrose in the flowers is broken down by the bee into glucose and fructose. The bee’s hypopharyngeal glands secrete GOx. Glucose is then oxidized by the oxidized form of GOx resulting in the production of gluconolactone/gluconic acid and H2O2. Most of the antimicrobial activity of honey comes from H2O2, killing pathogens through DNA damage and multiple cellular targets. (B) Honey is acidic with an average pH of 3.91 (ranges between 3.4 and 6.1), which makes it potent against microbial strains with an optimum pH for growth around 7. The acidity comes from mainly gluconolactone/gluconic acid. (C) Bee Def-1 is an antibacterial peptide originating from the hypopharyngeal gland of the bee. It acts by interfering with bacterial adhesion to a surface, or in the early stage of biofilm by inhibiting the growth of attached cells; and by modifying the production of extracellular polymeric substances. (D) MGO is generated in honey during storage by the non-enzymatic conversion of dihydroxyacetone, a saccharide present in high concentrations in the nectar of Leptospermum flowers. The antimicrobial activity of MGO is attributed to alterations in bacterial fimbriae and flagella, which impair the adhesion and motility of the bacterium. (E) Honey is a supersaturated solution of sugars. The strong interaction between these sugars and water molecules prevents the abundance of free water molecules (low water activity) available for the growth of microbes. (F) The combination of different phenols acts as an enhancer of the antimicrobial efficacy of honey. Under alkaline conditions (pH 7.0 to 8.0), polyphenols can display pro-oxidant properties, inhibiting microbial growth by accelerating hydroxyl radical formation and oxidative DNA strand breakage. They could also support the production of considerable amounts of H2O2 via a non-enzymatic pathway. Credit: Pharmacy (2022). DOI: 10.3390/pharmaceutics14081663

According to scientists from the University of Manchester, honey has exceptional antimicrobial and tissue regenerative properties that should be fully exploited to aid wound healing.

Their review of more than 250 papers over 85 years – with the oldest paper dating from 1937 – is published in the journal Pharmacy.

The sugary substance, the researchers say, offers an alternative to conventional antimicrobial drugs that are becoming increasingly ineffective in the face of growing resistance. However, more work, the researchers say, is needed to identify and quantify the compounds that give honey its antimicrobial and wound-healing properties in order to make it more reliable and standardized.

Honey has primarily been used topically on wounds for its antibacterial properties, resulting from its ability to generate hydrogen peroxide and the presence of other active compounds. Compounds include phenols, defensin-1, and methylglyoxal (found in manuka honey). Its acidity and low water availability also contribute to the healing properties of honey. Its stickiness also provides an effective moisture barrier between the wound site and the external environment.

According to researchers, various types of wounds have been treated with honey, such as burns, trauma, and chronic wounds. Mesitran, one of the first product lines to incorporate medical grade honey in the UK, was launched in 2005 in Manchester. Over the years, other companies followed suit. In recent years, research has focused on the use of honey in tissue engineering applications.

Things like electrospun nanofibers, hydrogels and cryogels, foams, films, powders, cements, and bio-inks have been used to make honey-based scaffolds. And some studies have shown how antibiotic-resistant bacteria can be more susceptible to antibiotics when used in tandem with honey.

In an article they cite, when methicillin-resistant Staphylococcus aureus (MRSA) was exposed to manuka honey in combination with oxacillin, they acted together to desensitize the MRSA to the antibiotic. The antimicrobial activity of honey also includes the ability to kill or slow the spread of fungi and viruses.

Honey, however, used in combination with traditional dressings has some limitations, such as being absorbed by the dressing, poor penetration into the wound site, and short-term antimicrobial action. However, manufacturers of impregnated dressings are trying to improve their delivery mechanism to improve the effectiveness of the substance.

Lead scientist Joel Yupanqui Mieles, a postgraduate researcher at the University of Manchester, says “honey has interesting antimicrobial properties and has been used in traditional medicine to treat wounds since ancient times.”

“The ancient Egyptians used it to heal wounds and there are direct references to the consumption of honey in the Bible and the Quran.”

“Compounds in honey offer a bank of potential antimicrobial and regenerative agents that can be used to combat antibiotic resistance and aid in tissue healing.”

“But while deposition of compounds in honey may have immense medical benefit, more research is needed to better understand how they work and how they can be effectively and safely delivered to wounds in a standardized way.”

He added that “knowing the type and composition of honey used in different types of wounds will also improve the quality of research. artificially reproduce them in honey – inspired biomaterials that can be exploited with current advances in tissue engineering technologies.This would minimize processing risks in terms of sterilization, storage, transportation and determination of authenticity and security.

“One thing is certain: the growing resistance to antibiotics around the world is driving the development of new therapies as alternatives to fight infections – and honey, we believe, has a role to play in this. People who are worried about an injury should not treat themselves with honey. without first talking to a medical body.”


Scientists in search of medicinal liquid gold


More information:
Joel Yupanqui Mieles et al, Honey: an advanced antimicrobial and healing biomaterial for tissue engineering applications, Pharmacy (2022). DOI: 10.3390/pharmaceutics14081663

Provided by the University of Manchester


Quote: Honey has sweet potential for wound healing, say scientists (2022, September 20) Retrieved September 21, 2022 from https://medicalxpress.com/news/2022-09-honey-sweet-potential-wound- scientists.html

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Online preview – September 2022

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The Pharmacy Fair: October 16 – 17, 2022

We will participate in the presentation of two sessions at this year’s pharmacy fair entitled “LGBT+ Inclusion in Pharmacy” and “Medicines in Ukraine”. Speakers for these sessions have now been announced.

LGBT+ inclusion in pharmacies

Taking place at the Théâtre des Affaires on Sunday October 16, 2022 from 4:25 p.m. to 4:55 p.m.

The PDA LGBT+ Network provides a structure through which members can work together to proactively fight and campaign around sexual orientation and transgender discrimination. This session will review the achievements of the network since its launch in April 2020; in particular, the campaign around greater inclusion of LGBT+ education in the MPharm curriculum.

Speakers confirmed for this session

  • Scott Rutherford, President of the PDA LGBT+ Network and Trainee Pharmacist
  • Soh Xi Ken, Honorary Secretary of the LGBT+ PDA Network and Trainee Pharmacist

Medicines in Ukraine

See you at the Théâtre des Affaires on Monday, October 17 from 11:55 a.m. to 12:25 p.m.

EPhEU is the umbrella union for many pharmacist unions across the European continent. We hold a leadership position in this organization, and Mark Koziol, President of the PDA, is currently the General Secretary of the EPhEU. We have worked with various continental pharmacists’ union partners and are responding to calls from Ukrainian hospitals for help and specialist medicines, launching a Medicines to Ukraine campaign.

Confirmed speaker for this session

  • Mark Koziol, President of the PDA

Other PDA speakers will participate in panels and other sessions at the show.

Ensysce Biosciences and Quotient Sciences announce a partnership

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Ensysce Biosciences and Quotient Sciences are partnering to develop and test Ensysce’s novel opioid designed to prevent abuse and overdose.

Ensysce Biosciences, a clinical-stage biotechnology company focused on improving prescription drug safety, and Quotient Sciences, a drug development and manufacturing accelerator, announced a partnership to support the development and clinical trials of the PF614-MPAR.

According to an August 31, 2022 press release, PF614-MPAR is Ensysce’s new combination opioid product for the potential treatment of chronic pain, designed to prevent both abuse and overdose. Quotient Sciences will use its Translational Pharmaceutics integrated platform to identify a PF614-MPAR formulation that allows conversion to oxycodone within the prescribed dose range, but reduces conversion to oxycodone at higher than prescribed dose levels in an overdose scenario. The formulation will balance dose and release rate and will be clinically tested in humans rather than preclinical species.

“The PF614-MPAR program is designed to address a high unmet need for effective pain relievers that reduce the risk of abuse and especially prescription drug overdose,” said Lynn Kirkpatrick, CEO of Ensysce Biosciences, in the press release. “This partnership serves as validation of our mission and ultimately our platforms. We continue to make great strides towards our clinical development of PF614 and are excited to partner with Quotient Sciences to develop PF614-MPAR as we believe we will bring important therapeutic options to market for people with severe pain. .

Source: Quotient science

Youngstown State University Honors College Backyard Archeology Course Gains Field Experience

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SPRINGFIELD, Ohio (WKBN) — Fifteen students from Youngstown State University put their “classroom” knowledge to work Sunday during a field study in Springfield.

The Honors College Backyard Archeology course teaches students the basic methods for discovering artifacts.

On Sunday, they got hands-on experience digging their own layout units.

“The units produce the artifacts. That’s where everything comes from and they learn how to arrange them correctly,” says archaeologist and professor Tom Delvaux.

Delvaux says that on a real site, layout units are numbered on a map and organized in a line.

“At the end of the day, you sit down and you look at everything that’s been found, and you look at the map and you can work out where people were doing things,” says Delvaux. “Where they cooked, where they made tools. where they lived.

Professor Matt O’Mansky leads the class. He describes archeology as a unique puzzle where it’s hard to tell how many pieces there are or what’s missing, let alone how they fit together.

“We bring the dead back to life. We give people a voice – mainly ordinary people who were the backbone of society but left no trace,” says O’Mansky. “Now we may not know their names, but now I can talk about the lives of Mayan children, Mayan women, Mayan elders, thanks to the work we do.”

Sunday’s field project gives students a taste of some of the basic digging skills they could bring to a foreign country.

“As we were working in a cornfield near Youngstown today, I told them several times that the methods they are learning, that we are doing, will take you to Guatemala where I work. You would do the same thing in Egypt or China – the same techniques all over the world,” says O’Mansky.

Aurora Fares is a second-year biology and pre-pharmacy student. She says there is a lot to learn through archaeology.

“We need to know what happened in the past to apply it in the future so that we don’t repeat those mistakes,” says Fares. “We can learn from the fall of other civilizations.”

Launch of business registration manual for start-ups

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The Ghana Bioenterprise Innovations Partnership (GBIP) and the Ghana-Britain Partnership for Innovation and Entrepreneurship (GB-PIE) of the Innovations for African Universities (IAU) have launched a manual to guide young start-ups through the process of regularizing their their businesses.

The manual, entitled: “A step-by-step guide to business registration for young start-ups”, aims to simplify the process which very often becomes an insurmountable obstacle for small businesses.

The development of the handbook was part of the action point of the two (2) projects which aimed to equip potential young entrepreneurs with the knowledge and skills to translate their ideas into viable businesses.

Speaking at the event, project leader Prof. Desmond Omane Acheampong said the handbook comes at a time when there are calls for graduates to start their own businesses as the demand for labor Work has not increased in all sectors of the economy.

He also said that most students and graduates find the business registration process tedious and therefore put their ideas aside.

“Therefore, this manual provides a step-by-step guide from business name selection to final inspection by a regulatory body,” he said.

The document was developed by Medory Naturals, a Ghanaian start-up that is involved in the development, manufacture and sale of natural health products from local plants.

This start-up received technical assistance from GBIP and GB-PIE to regularize their business, improve packaging and branding, and market their products as part of a translator acceleration program.

Launch of business registration manual for start-ups

Head of Medory Naturals, Dr. Ama Kyeraa Thomford, said the handbook was based on Medory’s practical experiences during the business registration stages, therefore it will be relevant for all young start-ups. -ups.

Launch of business registration manual for start-ups

The launch of the manual occurred with the introduction of Medory Naturals herbal teas to the university community. The two products presented at the event, Medory Blue Tea and Medory Flora Tea, are formulated from certain local medicinal plants.

The products are indicated to invigorate and reduce stress. They are aimed at people of all ages, especially those looking for healthy alternatives to the sugar and caffeine based drinks common in the Ghanaian market.

The event held at the University of Cape Coast’s Sam Jonah Library brought together team members from IAU project partners, faculty, students and teaching assistants from the university community. IAU projects have as partners the University of Cape Coast, the University of Health and Allied Sciences and the University of St Andrews, Scotland-UK.

Were present Professor Desmond Omane Acheampong – Dean SAHS, UCC, President; Dr Francis Ackah Armah – Lecturer, Department of Biomedical Sciences; Dr Ama Kyeraa Thomford – Senior Lecturer, Department of Biomedical Sciences; and Dr. Richael Odarkor Mills – Lecturer, Department of Biomedical Sciences.

The rest is; Dr George Ghartey-Kwansah – Lecturer, Department of Biomedical Sciences; Dr Kwame Kumi Asare – Researcher, University of Cape Coast; and Dr. Kwesi Prah Thomford – Lecturer, Department of Pharmacognosy and Herbal Medicine.

Are plants better chemists than humans? | The Guardian Nigeria News

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Plants have had an essential role in the folklore of ancient cultures. In addition to their use as food and spices, plants have also been used as medicine for over 5000 years. Traditional Chinese Medicine (TCM) and Ayurveda, Traditional Indian Medicine (TIM), have provided most of the current knowledge related to medicinal plants. In TCM and TIM folklore, herbal medicines were prepared as teas, tinctures, poultices, powders, and other types of formulations. The expertise to select the right plants, methods of preparing medicines and their specific use was first passed down orally from generation to generation until it was established.

It is estimated that 70-95% of the population in developing countries continues to use traditional medicines. Today, medicinal herbs are defined as plants that contain a valuable substance that has a therapeutic or beneficial effect in curing and preventing various ailments in humans and animals. Herbal products such as plant extracts, dry powders and parts of plants, fungi and algae have been used as complementary treatments to conventional medicines.

Many flowering plants in nature and cultivated gardens around the world are not only beautiful to be used only as ornamental plants, they also carry properties with the power to cure diseases and treat various ailments of humans and creatures. animals. For example, Feverfew (Tanacetum parthenium L. family Asteraceae) is a medicinal plant traditionally used for the treatment of fevers, migraines, rheumatoid arthritis, stomach aches, toothaches, bites of insects, infertility and problems with menstruation and labor during childbirth.

The low fever herb has a long history of use in traditional and folk medicine, especially among Greek and European herbalists. The first-century Greek physician Dioscorides used Fever few as an antipyretic. Feverfew was also known as medieval aspirin or 18th century aspirin.

Feverfew has also been used for psoriasis, allergies, asthma, tinnitus, dizziness, nausea, and vomiting. The plant contains a large number of natural products, but the active ingredients probably include one or more of the sesquiterpene latones known to be present, including partnenolide. Other potentially active constituents include flavoid glycosides and pinenes. It has multiple pharmacological properties, such as anticancer, anti-inflammatory, carchotonic, antispasmodic and emmenagogue, and as an enema for worms.

Feverfew, originally native to the Balkan Peninsula, is now widely cultivated in large areas of the world. It is now found in Australia, Europe, China, Japan, North Africa, the United States, Canada and almost all parts of the world and its importance as a medicinal plant is increasing dramatically with increasing reports and stronger in support of its multiple therapeutic uses. .

Another example
Researchers have developed an anticancer drug based on a decade of research into the commercial applications of jasmonate, a synthetic compound derived from the jasmine flower itself. Grandifloracin, a chemical found in the large tropical flora of Uvaria, could help treat deadly pancreatic cancer. Genius anticancer activities such as puella, tuberrosa, brittoniana (mexcan pertunia) are alternative treatment for cervical cancer cells, and the list goes on.

A new trend, which involved the isolation of active compounds from plants, began in the early 19th century. This trend led to the discovery of analgesic (analgesic) drugs, morphine and codeine, from opium (Papaver somniferum L.) cocaine obtained from erythroxylum coca, cardiac glycoside, digitoxin which has been isolated from Digitalis purpurea and Digitalis lanata which has been used for heart ailments and as an anticancer drug, and quinine from Cinchoma calisaya. Some of these molecules are still used. Such natural compounds provide enormous varieties, often with high biological activity and, therefore, play an important role in the development of therapeutic treatments.

The discovery of plant-derived substances has evolved over the past 200 years due to the variety of experience and expertise required to identify such a compound. First, a plant is identified by a botanist, ethonobotanist, ethnopharmacologist or phytoecologist. Next, plant extract followed by biological screening performed by a phytochemist to identify potential therapeutic activity, followed by isolation of the active compound. Finally, molecular biology studies are needed to reveal the mode of action and relevant molecular targets. The combination of these fields determines an interdisciplinary approach called pharmacognosy.

Today, it is estimated that around 25-28% of all modern medicines are directly or indirectly derived from higher plants, demonstrating the enormous medicinal potential of plants known for thousands of years in traditional medicine.

Over the past few decades, more and more new plant-derived materials have been licensed and subscribed as drugs. Important examples of herbal medicines are Artether (artmotil), a sesquiterpene lactone isolated from Artemisia annua and used for the treatment of malaria, and Galantamine, an Amaryllidaceae alkaloid from Galanthus woronowii used for the treatment of Alzheimer’s disease. due to its activity as a selective acetylcholinesterase inhibitor.

Apomorphine hydrochloride (apokyn), a dopamine receptor agonist produced in papaver somniferum L. is used to treat Parkinson’s disease; Tiotropium bromide isolated from atropa belladonma is used to treat COPD (chronic obstructive pulmonary disease; nitisinone (orfadine), a modified mesotrione from callistemon citrinus, inhibits the enzyme 4-hydroxyphenyl (pyrivate dioxygenas (HPPD) and prevents accumulation of fumaryl and maleyi acetoacetate in the liver and kidneys.
Interestingly, many isolated cancer-fighting substances are linked to interactions between plants and microbes. These interactions are related to rhizospheric or endophyte bacteria, yeasts and fungi.

These microorganisms enter and reside in plants without harming them or causing disease. In addition, these microbes serve as a barrier to colonization by pathogenic microorganisms and participate in plant growth and defense response through the production of a wide variety of secondary metabolites.

Since almost all plants coexist, at least one endophyte and many molecules have been isolated from these systems. Two recent studies revealed that extracts of Chaetomium globosum and 5-methylphenazine-1-carboxylic acid produced by Pseudomonas putida had cytotoxic effects against cancer cell lines. The similarity of secondary metabolites produced by endophyutes and their hosts implies gene transfer between them throughout co-evolution. Taking advantage of biotechnology, a new drug from endophytes can be made in faster and controlled processes

In addition to the drugs mentioned above, other plant-derived substances with anticancer activity such as paclitaxel (Taxol) and camptothecin have been isolated and approved for use.

Examples of plant-derived substances with anti-cancer activity
Cancer is one of the leading causes of morbidity and mortality worldwide. In 2012, 8.2 million cancer-related deaths and about 14 million new cases were counted. The number of new cases is expected to increase by about 70% over the next two decades. Among men, the five most frequently diagnosed cancer sites in 2012 were lung, prostate, colorectum, stomach and liver. In women, the five most frequently diagnosed sites were the breast, colon, lung, cervix and stomach. Cancer cases are expected to rise from 14 million in 2012 to 22 million over the next two decades

Today, solid tumors are surgically removed and patients receive adjuvant radiotherapy and chemotherapy which cause serious side effects and significantly reduce quality of life. In addition, the toxicity of some treatments limits their use and effectiveness. Some types of cancer, such as breast cancer, can be treated with biologic drugs (Herceptin).

However, the cost of these drugs is very high and their effectiveness is limited in most cases to certain types of tumors. In many cases, the tumor develops resistance to a particular drug and patients are switched to a different drug. Additionally, many patients are treated with a combination of several drugs. Thus, there is no doubt that there is a real need for new effective cancer drugs with reduced side effects, and plants are a promising source for such entities.

Paclitaxel (Taxol) is probably the best known plant-derived anti-cancer drug. The cytotoxic activity of this dipertene taxane is found in extracts of the bark of Taxus brevifolia nutt (western yew). Later, other Taxus species were found to produce this molecule. Interestingly, in 1993 it was also discovered that Taxol was produced at low levels by the endophytic fungus of Taxus, Tamomyces andreanae and later by endophytic fungi, allowing its possible production by future fermentation of microorganisms.

Other compounds of plant origin such as Vinca alkaloids, Taxol, disrupt the function of microtubules. However, unlike Vinca alkaloids which disrupt microtubule assembly by binding depolymerized microtubules, Taxol (essentially all taxanes) inhibits microtubule disassembly by binding polymerized microtubules.

Although discovered in the early 1970s of the 20th century, it took over 25 years to bring Taxol to market. It was not approved by the Food and Drug Administration (FDA) until 1992 for the treatment of metastatic ovarian cancer.

Clinical trials have also shown encouraging results for other types of cancer such as head, neck, lung and breast cancers.

This cancer drug which is now produced in a semi-synthetic process hit the top 20 list and sold above $1 billion a year in 1999 peaking at $1.6 billion. in 2000. Before generic drugs appeared in the In 2002, sales of Taxol and camptothecin, a DNA topoisomerase I inhibitor, were more than $2.75 billion, or about one-third of the cancer drug market. Docetaxel (Taxotere), the analogue of Taxol, achieved sales of $3 billion in 2009. Taxol’s success serves as an example and encouraging story for the discovery and marketing of plant-derived substances additional.

MPB.Health provides the ultimate alternatives to health insurance

MPB.Health offers a great alternative to health insurance that includes more benefits to meet all of your health care needs. It includes the components you need at an affordable price.

MPB.Health is a member-driven, charitable organization designed for people who want to take control of their healthcare costs. The company offers an alternative to health insurance that includes more benefits to meet all health care requirements. MPB.Health offers a variety of options that include the components you need at a reasonable price.

In response to a question about their services, a spokesperson for MPB.Health said, “We provide comprehensive healthcare solutions designed to help people live healthier, longer and happier lives. We are a community of health and freedom conscious individuals, providing an economical alternative that provides greater access to high quality healthcare services. » MPB.Health’s health solutions are successfully designed to provide a full range of services in a single low-cost plan without sacrificing quality of care, with shared medical costs, mental health counseling, virtual care 24/7, personalized membership support, and more.

MPB.Health provides Shared health care plans in the United States; they provide comprehensive care that meets the physical, emotional and mental health needs of members. The organization never loses sight of the human behind the need for better healthcare and empowers and promotes healthy living and healthy lifestyle choices. The alternatives offered by MPB.Health are not the same as insurance; in these plans, each member of the community contributes funding which is shared by members whenever significant medical needs arise. MPB.Health is the only low-cost, non-insurance-based solution available today, offering various health plan options that include a full suite of services.

MPB.Health also provides the best health insurance plans for small groups. Their innovative healthcare delivery model can equip your small business with a cost-effective solution that provides control, protection, and barrier-free access to high-quality healthcare. The company offers various customized solutions for companies of different sizes, unlike health insurance plans which offer a “one size fits all” option. MPB.health considers your budget, the diversity of your employee group and their unique needs. The options provided by MPB.Health can eliminate the burden of expensive premiums, giving your employees the flexibility to choose for themselves and their families.

MPB.Health’s medical cost sharing plans are an excellent solution to protect against unexpected high medical costs. This is a community-driven alternative where medical expenses incurred outside of the United States are also shareable within the community. Members will also have access to pharmacy benefit programs that will provide discounted medications.

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MPB.Health is a healthcare community that provides individuals with high quality healthcare solutions at reasonable prices. They offer a variety of plan options that cover all necessary health care needs. The organization is committed to providing cost-effective alternatives to health insurance.

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Media Contact
Company Name: MPB.Health
E-mail: Send an email
Call: +00 1(800) 519-2969
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Website: https://mpb.health/

AHF Press Conference: CVS Ordered to Compensate AHF $23 Million

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LOS ANGELES–(BUSINESS WIRE)–The United States District Court for the District of Arizona upheld an earlier $23 million arbitration award awarded to AIDS Healthcare Foundation (AHF) against Caremark LLC, a subsidiary of pharmaceutical giant CVS, for unfair refunds.

AHF will host a virtual press conference by Zoom on Monday, September 19 at 10 a.m. PDT / 1 p.m. EDT. Michael Weinstein, AHF President will comment on the outcome of the dispute and the attorneys representing AHF in Caremark LLC v AIDS Healthcare Foundation will be on hand to answer questions.

WHAT:

Virtual press conference.

AHF granted a $23 million judgment against a subsidiary of CVS.

WHEN:

Monday, September 19, 2022 at 10 a.m. PDT / 1 p.m. EDT

WHERE:

Participate via Zoom: https://ahf-org.zoom.us/j/81109693861

WHO:

  • Michael Weinstein, AHF President

  • Tom Myers, AHF General Counsel

  • Andrew Kim, attorney at Kim Riley Law, representing AHF

NEWS DESK NOTE & B-ROLL VISUALS

MEDIA CONTACTS:

Denys Nazarov, Senior Director of Media Relations, AHF

(323) 219-1091 | [email protected]

Ged Kenslea, Senior Director of Communications, AHF

(323) 791-5526 | [email protected]

Background: In November 2019, AHF filed a lawsuit with the American Arbitration Association against Caremark LLC, a pharmacy benefit manager (PBM), for breach of agreement and undertaking of good faith and fair use. The dispute arose out of Caremark’s unfair practice of charging back prescriptions filled by AHF pharmacies on behalf of prescription insurance plan sponsors, such as those covering Medicare Plan D beneficiaries.

Due to chargebacks by Caremark, for a number of years AHF was reimbursed less than what Part D plan sponsors were receiving in prescription reimbursement from public Part D funds. In November 2021, the arbitrator ruled in favor of AHF and ordered Caremark to reimburse AHF for nearly $23 million in damages and arbitration costs. Subsequently, in November 2021, Caremark filed a court motion to vacate or correct the arbitration award, but on September 15, 2022, the United States District Court for the District of Arizona affirmed the arbitration award. ‘AHF.

AIDS Health Foundation (AHF) is a global nonprofit organization that provides cutting-edge medicine and advocacy to more than 1.6 million people in 45 countries around the world in the United States, Africa, Latin America/Caribbean, Asia/Pacific region and Europe. We are currently the largest not-for-profit provider of HIV/AIDS medical care in the world. To learn more about AHF, please visit our website: www.aidshealth.org, find us on Facebook: www.facebook.com/aidshealth and follow us on Twitter: @aidshealthcare and Instagram: @aidshealthcare

FDA grants orphan drug status to SY-5609 for pancreatic cancer

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The FDA has granted orphan drug designation to the CDK7 inhibitor SY-5609 for use as a potential treatment option in patients with relapsed metastatic pancreatic cancer.

The FDA has granted orphan drug designation to CDK7 inhibitor SY-5609 for use as a potential treatment option in patients with relapsed metastatic pancreatic cancer, according to an announcement from Syros Pharmaceuticals, Inc.1

SY-5609 has been shown to inhibit cancer growth in pancreatic ductal adenocarcinoma (PDAC) xenograft models; in many cases, the agent was found to lead to regressions.2 The agent has also been shown to potentiate the activity of gemcitabine in PDAC cells in vitro as well as in xenografts in vivo. In preclinical PDAC models, SY-5609 has also been found to potentiate the activity of paclitaxel.

Currently, the agent is being explored in combination with chemotherapy in patients with pancreatic cancer who experienced disease progression after receiving FOLFIRINOX, in a phase 1 trial. in progress (NCT04247126).3

“The orphan drug designation underscores the urgency of our efforts to develop SY-5609 for patients with pancreatic cancer, one of the most devastating and difficult to treat malignancies,” said David A. Roth, MD, chief medical officer of Syros Pharmaceuticals, Inc., said in a press release.

The multicenter, open-label, dose-escalation study enrolled patients with advanced breast, colorectal, lung, ovarian, and pancreatic cancers, as well as patients with solid tumors with Rb pathway alterations, regardless of histology.4

In the dose escalation phase of the research, SY-5609 was given as monotherapy to patients with certain advanced solid tumors and in combination with fulvestrant (Faslodex) to those with receptor breast cancer. hormone positive and HER2 negative. Those who received treatment received continuous daily dosing and intermittent dosing regimens, which included a 7 day on/7 day off regimen, as well as a 5 day on/2 day off regimen.2

A total of 54 patients received treatment with SY-5609 monotherapy as of July 6, 2021. All of these patients were eligible for evaluation in the safety analysis and 45 were evaluable for efficacy. The median age of the patients was 65.5 years; they were rated as heavily pretreated, having received a median of 4 – but up to 8 – prior therapies.2

The data showed that 28.9% of evaluable patients achieved stable disease (SD). In 6 of these patients, tumor regressions of up to 20% were observed. Notably, the most clinical activity with the agent was derived from heavily pretreated patients with pancreatic cancer (n=13). Specifically, 38.5% of these patients had DS and 2 of them experienced tumor reductions.2

Of the 4 patients with pancreatic cancer who had CA 19-9 serial data, 3 had reductions in this marker, and these reductions ranged from 32% to 72%. A patient who had metastatic pancreatic cancer that had progressed on 2 previous lines of treatment and relapsed after a third line of treatment was found to have prolonged SD with SY-5609 for up to 12 months.2

For all doses and schedules examined, most toxicities were found to be mild and reversible. Nausea, diarrhea, thrombocytopenia, fatigue and anemia were the most common treatment-related adverse events (TEAEs). Notably, there was a low rate of treatment discontinuations due to AEs.2

The 7 days on/7 days off regimen was noted to result in optimal tolerability as those who received the agent according to this regimen had the lowest rate of TEAEs. These patients still had similar rates of SD compared to those who received regimens with higher dose intensity. As such, this timeline has been selected for further exploration.2

“Based on the early data we reported last year, which demonstrated single-agent activity in heavily pretreated patients, along with compelling preclinical data and strong mechanistic rationale, we believe that SY-5609 could provide significant benefits to people with pancreatic cancer, whose tumors have otherwise escaped therapeutic intervention,” Roth added in the press release.

In the dose expansion portion, the agent will be considered in patients with confirmed metastatic PDAC with at least 1 measurable lesion per RECIST v1.1 criteria and an ECOG performance status of 0 or 1. Patients with central nervous system metastases or who have previously received CDK7, CDK9 and pan-CDK inhibitors will be excluded.4

One group will consist of second- or third-line patients who experienced disease progression after FOLFIRINOX or modified (m) FOLFIRINOX. This group will receive SY-5609 at a starting dose of 4 mg on a 7 day on/7 day off schedule plus gemcitabine every other week at 1000 mg/m2. The other group will include second-line patients who progressed after FOLFIRINOX or mFOLFIRINOX. These patients will receive SY-5609 on a 7 day on/7 day off schedule plus gemcitabine every other week plus nab-paclitaxel.4

The primary endpoints of safety introductions are safety and tolerability, and primary secondary endpoints include disease control rate (DCR) and progression-free survival (PFS). For the expansion phases, which will include approximately 25 patients in each group, the primary endpoint is PFS, and the secondary endpoints are DCR, safety and tolerability.4

“We look forward to sharing initial data from the preliminary safety portion of our ongoing Phase 1 study later this year.” Data from the introductory part of the safety trial are expected in the second half of 2022.

References

  1. Syros receives orphan drug designation from the FDA for SY-5609 for the treatment of pancreatic cancer. Press release. Syros Pharmaceuticals, Inc. September 13, 2022. Accessed September 15, 2022. https://bit.ly/3S74aoc
  2. Sharma M, Bashir B, Juric D, et al. Ongoing trial: Phase I study of SY-5609, a potent selective CDK7 inhibitor, with initial expansion in adults with metastatic pancreatic cancer. J Clin Oncol. 2022;40(supplement 16):TPS4180. doi:10.1200/JCO.2022.40.16_suppl.TPS4180
  3. A study of SY 5609, a selective CDK7 inhibitor, in advanced solid tumors. ClinicalTrials.gov. Updated September 14, 2022. Accessed September 15, 2022. https://clinicaltrials.gov/ct2/show/NCT04247126
  4. Syros presents new data from the Phase 1 trial of SY-5609 and details a three-pronged combination strategy to advance SY-5609 in solid tumors and blood cancer. Press release. Syros Pharmaceuticals, Inc. September 20, 2021. Accessed September 15, 2022. https://bit.ly/3QO1SJB

Friday, September 16, 2022 | Kaiser Health News

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Indiana abortion ban is in effect after injunction denied

The first state abortion ban passed since the Supreme Court struck down Roe v. Wade went into effect Thursday in Indiana. A judge denied a request for a temporary injunction from health providers.

AP: Indiana judge denies request to block state abortion ban

An Indiana judge on Thursday denied a request to block enforcement of the state’s abortion ban just hours after it went into effect. The decision came amid a lawsuit brought by abortion clinic operators who argue that the state constitution protects access to the procedure. Special Judge Kelsey Hanlon offered no explanation for her decision with the order denying a temporary injunction sought by the American Civil Liberties Union of Indiana, which represents the clinics, but cited a court hearing scheduled for Monday on the court case. (Davies, 9/15)

CBS News: Near-total abortion ban goes into effect in Indiana: ‘My patients are being denied their human rights’

Most of the lights are now off at Women’s Med, an Indianapolis abortion provider. The clinic is among two providers in Indiana set to close, while the state’s five remaining clinics will offer limited health care. “I’m so angry,” said Dr Katie McHugh, who works at the clinic. “As a doctor, I get angry because insurance companies deny claims. I’m not normally angry because my patients are denied human rights.” (Diaz, 09/15)

In other abortion updates –

Bloomberg: ‘Need an abortion? California is ready to help: Newsom’s billboards in GOP states

The signs, which also appear in Indiana, Mississippi, Ohio, South Carolina and South Dakota, point to a website – abortion.ca.gov – which instructs users on how to access to an abortion in California, according to a statement released Thursday. An image shows a woman in handcuffs next to the phrase “Texas doesn’t own your body.” You do.” Another said, “Need an abortion? California is ready to help. (McGregor, 9/15)

AP: Judge continues to bar anti-abortion activists from clinic

A group of anti-abortion activists will continue to be barred from interfering with patients and providers at a reproductive health clinic outside of Nashville, a federal judge has ruled. In July, protesters attempted to enter the clinic run by the nonprofit carafem twice during a nationwide conference of Operation Save America – formerly Operation Rescue, according to court documents. (Kruesi, 09/15)

KHN: “What The Health?” From KHN: Graham’s Bill Refocuses Abortion Debate

Sen. Lindsey Graham (RS.C.) put abortion back on the Republican agenda this week with a legislative proposal calling for a nationwide ban on most abortions after 15 weeks of pregnancy. For many in his party, it was an unwelcome intrusion that could add to public unease over the party’s efforts to limit access to abortion as they face midterm elections. (9/15)

KHN: New abortion laws jeopardize cancer treatment for pregnant patients

As abortion bans take effect in a contiguous part of the South, cancer doctors are wondering how new state laws will influence their discussions with pregnant patients about the treatment options they can offer. Cancer occurs in approximately 1 in 1,000 pregnancies, most commonly breast cancer, melanoma, cervical cancer, lymphomas and leukemias. But drugs and other treatments can be toxic to the developing fetus or cause birth defects. In some cases, hormones boosted during pregnancy fuel cancer growth, putting the patient at increased risk. (Huff, 9/16)

Stat: Q&A: A doctor and an ethicist on tough abortion care decisions

As new abortion bans are enacted across the country, doctors working with pregnant patients face potential ethical and legal dilemmas. (Gaffney, 9/15)

In other reproductive health news –

Detroit Free Press: Michigan Tube Procedure: Permanent Birth Control Often Denied

Ashley Steffen went under the knife about a month after the U.S. Supreme Court overturned Roe v. Wade in June, nullifying the constitutional right to abortion. Steffen, 37, of Lansing, is among a growing number of women to seek a sterilization procedure known as tubal ligation in the months following the ruling in Dobbs v. Jackson Women’s Health Organization, leaving the abortion access to states to decide. (Jordan-Shamus, 09/15)

PBS NewsHour: Birth control options that target sperm have been in the works for decades. Are we closer?

Drug development for new contraceptives involves restricting a “target” or function in the body, in order to prevent pregnancy, explained Gunda Georg, regent professor of medicinal chemistry at the University of Minnesota College of Pharmacy. This can be a non-hormonal option, such as inhibiting a certain protein or disrupting the electrical currents that sperm need to be viable, or an option that interferes with hormone levels. The goal of most methods is to significantly suppress sperm development or interfere with their mobility to ensure they never encounter an egg. (Isaac-Thomas, 9/14)

Indiana abortion ban is in effect after injunction denied

0

The first state abortion ban passed since the Supreme Court struck down Roe v. Wade went into effect Thursday in Indiana. A judge denied a request for a temporary injunction from health providers.

AP: Indiana judge denies request to block state abortion ban

An Indiana judge on Thursday denied a request to block enforcement of the state’s abortion ban just hours after it went into effect. The decision came amid a lawsuit brought by abortion clinic operators who argue that the state constitution protects access to the procedure. Special Judge Kelsey Hanlon offered no explanation for her decision with the order denying a temporary injunction sought by the American Civil Liberties Union of Indiana, which represents the clinics, but cited a court hearing scheduled for Monday on the court case. (Davies, 9/15)

CBS News: Near-total abortion ban goes into effect in Indiana: ‘My patients are being denied their human rights’

Most of the lights are now off at Women’s Med, an Indianapolis abortion provider. The clinic is among two providers in Indiana set to close, while the state’s five remaining clinics will offer limited health care. “I’m so angry,” said Dr Katie McHugh, who works at the clinic. “As a doctor, I get angry because insurance companies deny claims. I’m not normally angry because my patients are denied human rights.” (Diaz, 09/15)

In other abortion updates –

Bloomberg: ‘Need an abortion? California is ready to help: Newsom’s billboards in GOP states

The signs, which also appear in Indiana, Mississippi, Ohio, South Carolina and South Dakota, point to a website – abortion.ca.gov – which instructs users on how to access to an abortion in California, according to a statement released Thursday. An image shows a woman in handcuffs next to the phrase “Texas doesn’t own your body.” You do.” Another said, “Need an abortion? California is ready to help. (McGregor, 9/15)

AP: Judge continues to bar anti-abortion activists from clinic

A group of anti-abortion activists will continue to be barred from interfering with patients and providers at a reproductive health clinic outside of Nashville, a federal judge has ruled. In July, protesters attempted to enter the clinic run by the nonprofit carafem twice during a nationwide conference of Operation Save America – formerly Operation Rescue, according to court documents. (Kruesi, 09/15)

KHN: “What The Health?” From KHN: Graham’s Bill Refocuses Abortion Debate

Sen. Lindsey Graham (RS.C.) put abortion back on the Republican agenda this week with a legislative proposal calling for a nationwide ban on most abortions after 15 weeks of pregnancy. For many in his party, it was an unwelcome intrusion that could add to public unease over the party’s efforts to limit access to abortion as they face midterm elections. (9/15)

KHN: New abortion laws jeopardize cancer treatment for pregnant patients

As abortion bans take effect in a contiguous part of the South, cancer doctors are wondering how new state laws will influence their discussions with pregnant patients about the treatment options they can offer. Cancer occurs in approximately 1 in 1,000 pregnancies, most commonly breast cancer, melanoma, cervical cancer, lymphomas and leukemias. But drugs and other treatments can be toxic to the developing fetus or cause birth defects. In some cases, hormones boosted during pregnancy fuel cancer growth, putting the patient at increased risk. (Huff, 9/16)

Stat: Q&A: A doctor and an ethicist on tough abortion care decisions

As new abortion bans are enacted across the country, doctors working with pregnant patients face potential ethical and legal dilemmas. (Gaffney, 9/15)

In other reproductive health news –

Detroit Free Press: Michigan Tube Procedure: Permanent Birth Control Often Denied

Ashley Steffen went under the knife about a month after the U.S. Supreme Court overturned Roe v. Wade in June, nullifying the constitutional right to abortion. Steffen, 37, of Lansing, is among a growing number of women to seek a sterilization procedure known as tubal ligation in the months following the ruling in Dobbs v. Jackson Women’s Health Organization, leaving the abortion access to states to decide. (Jordan-Shamus, 09/15)

PBS NewsHour: Birth control options that target sperm have been in the works for decades. Are we closer?

Drug development for new contraceptives involves restricting a “target” or function in the body, in order to prevent pregnancy, explained Gunda Georg, regent professor of medicinal chemistry at the University of Minnesota College of Pharmacy. This can be a non-hormonal option, such as inhibiting a certain protein or disrupting the electrical currents that sperm need to be viable, or an option that interferes with hormone levels. The goal of most methods is to significantly suppress sperm development or interfere with their mobility to ensure they never encounter an egg. (Isaac-Thomas, 9/14)

This is part of the KHN Morning Briefing, a summary of health policy coverage from major news outlets. Sign up for an email subscription.

Assistant professor of pharmacy dies after cardiac event

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Assistant Professor Suresh Bandari, a researcher at the School of Pharmacy, died on September 5 following a cardiac arrhythmia event. Bandari leaves behind his wife, Pavani Konagala, and two children, Anish and Srihan.

Bandari joined the university in 2017 and worked as a postdoctoral research associate and research scientist in the Department of Pharmacy and Medication Administration in the School of Pharmacy. In 2022, he was promoted to assistant research professor.

While at university, Bandari mentored and bonded with his many doctoral students. students, who remember his kindness and willingness to help others.

Suresh Bandari. Photo courtesy of Ole Miss School of Pharmacy.

“Even during the holidays, he was available for his students,” said UM’s doctor of pharmacy. said graduate student Dinesh Nayavanandi. “No matter what time it was, he was always there – and I think that’s the most important thing.”

Priyanka Srinivasan, a PhD student at UM, said she has had a close relationship with Bandari since she joined the university in 2017.

“I met him almost every day at his office for his advice and for the valuable suggestions he used to give me for my projects,” Srinivasan said. “It’s a very close bond. I am extremely happy to have worked with him and terribly upset that he is (gone).

Srinivasan says her mentor’s commitment and support for her students is what she admired most about Bandari.

“He is one of the sweetest, down to earth and humble people. He is a very capable man and he has always been there for his students,” Srinivasan said. “His commitment and his support of his students during his research and during their research has always been a great pillar of strength.”

Bandari was popular not only among UM students, but also among the many students and colleagues Bandari taught and trained in his native India.

Sagar Narala, who holds a Ph.D. from UM. Pharmacy and Drug Administration student, met Bandari in 2007 while pursuing his bachelor’s degree in India. After 15 years of friendship and mentorship, Narala says he wouldn’t be where he is today without Bandari’s help and guidance.

” He is everything for me. He is a friend, a brother, a teacher, a mentor, a guide. So it’s a huge loss for me. I didn’t expect that,” Narala said. “He was always by my side when I had to face difficult situations. He always supported me through everything.

During Bandari’s career, he established his name in pharmaceutical research with over 100 peer-reviewed publications in renowned journals with many additional contributions to his field. He was a member of the editorial advisory board of the renowned American Association of Pharmaceutical Sciences, and he co-authored a book chapter, a book and a patent according to the University of Mississippi School of Pharmacy News and Media Center.

The great appreciation felt for Bandari and his contributions can be seen through the multitude of donations made through a GoFundMe organized by his wife to support her husband’s heavy medical bills. Bandari spent more than a week in intensive care at Baptist Memorial Hospital in Memphis before his death, during which time more than 900 donations were made. As of September 14, over $78,500 has been raised.

Eman Ashour, an assistant professor in the Department of Pharmacy and Medication Administration, said the GoFundMe is a way to give back to Bandari all he has given his students.

“It’s all because of the students, because he loves his students,” Ashour said. “And I think it’s time for the students to pay back…as a sign of appreciation and great respect.”

VPL Travels to Orlando to Present at NASP 2022 Annual Meeting and Expo

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VPL present at the first specialty pharmacy event

“This event will really help us show the industry what we can do to help pharmacies simplify their prescription shipping workflows.”

This year’s National Association of Specialty Pharmacy (NASP) Annual Meeting and Expo celebrates the 10th anniversary of the premier specialty pharmacy event, and VPL, an industry leader in supply chain solutions solutions for healthcare customers, continues to support its expansion into the pharmacy market by exhibiting their cloud-based pharmacy solutions at the event. NASP 2022 will take place in Orlando, Florida at the Gaylord Palms Resort & Convention Center from September 19-22.

Last March, VPL announced the launch of its specialty pharmacy software solutions, VPL TrajectRx™, prescription fulfillment, tracking and fulfillment software designed for pharmacists, by pharmacists, to ensure that specialty medications are delivered cost-effectively and securely.

“We are excited to showcase our pharmaceutical solutions for the first time ever at this year’s NASP Annual Meeting and Expo,” said Eric McGlade, CEO and Co-Founder of VPL. “Amanda Awe, our Pharmaceuticals Specialist, spent over 10 years as a clinical pharmacist before joining VPL to help other pharmacists solve familiar problems with technological solutions. His unique perspective helps us continuously innovate VPL TrajectRx, making it as useful as possible to our customers. »

VPL is proud to lead two presentations for the Technology Day Workshop on Monday, September 19 in the Suwannee 1 Mezzanine Coastal Breakout Room.

The first session, entitled “Innovation Lab #5 – VPL & St. Luke’s”, will take place from 12:00 p.m. to 12:30 p.m. and will be presented by Marc Choquette (St. Luke’s), Derrek Seif (VPL) and Amanda Awe, PharmD, RPh (VPL ). In this presentation, VPL will present a case study with a pharmacy customer that will demonstrate the actual results of VPL TrajectRx.

The second session, titled “The Role of Technology in Solving Last Mile Logistics,” will run from 4:30-5:30 p.m. and will be presented by Sheila Arquette, RPh (NASP), Amanda Awe, PharmD (VPL), Tim Ramsey (US Pack Logistics), Kirk Nilson (Parcel Shield). This panel will describe how specialty pharmacies are using technology to provide personalized, convenient, and customer-centric solutions to meet patient needs, improve customer satisfaction, manage costs, and preserve drug quality.

“This event will really help us show the industry what we can do to help pharmacies simplify their prescription shipping workflows.” said McGlade. “I think those who attend his presentations will really enjoy them because they will get the perspective on pharmacy software from a real pharmacist who played a big part in developing it all.”

Attendees can stop by the VPL TrajectRx booth (#606) to chat with their team about the specialty pharmacies that can make the prescription dispatch workflow more seamless than ever, learn about the offered prices available, and see what tricks their magician du stand has rolled up its sleeves.

About VPL

By making procurement-to-execution processes smarter and more profitable, VPL creates a new supplier dynamic through which customers benefit from lower costs, better insights, and increased transparency and efficiency. . The industry’s only intelligent supply chain platform automates inbound and outbound shipments, unlocks visibility into the status of critical shipments, and identifies cost reduction opportunities for all healthcare, including IDNs, critical access, outpatients and pharmacy. With over 700 hospital pharmacies and outpatient surgery centers, over 6,000 vendors and a 97% customer retention rate, it’s clear that VPL is the company the healthcare industry trusts to deliver savings, information and peace of mind. To learn more or to schedule a demo, visit the company’s website at http://www.getvpl.com.

About NASP

NASP is a 501(c)(6) non-profit business organization and is the only national association representing all stakeholders of the specialty pharmacy industry. The mission of the National Association of Specialty Pharmacy (NASP) is to elevate the practice of specialty pharmacy by developing, providing, and promoting continuing professional education and specialty certification while advocating for public policies that ensure patients have access suitable for specialty drugs in tandem with critical benefits. NASP supports a free market health care system in which all specialty pharmacies compete on the same level playing field, because it is in the best interests of the patients we collectively serve. NASP is committed to working with all stakeholders and policymakers to ensure that all patients have access to the life-saving medicines they need and the care and support services they deserve in their home pharmacy. choice. To learn more, visit http://www.naspnet.org.

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Hudson and older NYers call for more age protections in place for seniors

The data shows that seniors are the “fastest growing demographic” in New York City. Councilwoman Crystal Hudson, the American Association of Retired Persons (AARP) and other elected officials have joined forces to introduce bills that will help elderly tenants age in place on Sept. 7.

At least 23 of the 55 census-defined neighborhoods citywide have a predominantly elderly immigrant population, Hudson said. She added that older New Yorkers over the age of 50 generally want to age in their homes and neighborhoods rather than in an institutional setting.

“This desire to age in place, combined with rising rates of poverty, social isolation, limited high-speed internet access and limited English proficiency, leaves many older people disconnected from health services. city,” Hudson said during a committee hearing on aging. “This is especially true for immigrant communities and older people of color who make up a steadily growing proportion of the city’s older population.”

AARP polls also indicate that seniors make up the largest block of volunteers and votes in the city.

Hudson’s legislative package consists of three bills aimed at enabling seniors to age comfortably in the city and raising awareness of city programs for them, such as meal-on-wheels programs or seniors’ clubs. day for the elderly. Some of the “gaps” in services for seniors relate to scheduling, transportation and population growth, said Department of Aging (DFTA) Commissioner Lorraine Cortés-Vázquez.

The first bill requires DFTA to create a “Know Your Rights” education campaign for seniors to inform them of agencies and community organizations with relevant services for seniors. The second bill expands language and cultural programs in centers for the elderly. And the final bill expands current tenant housing laws to include any resident over 60 who faces eviction in housing court to get full legal representation at no cost.

Kevin Jones, deputy state director of advocacy for AARP New York, testified at last week’s hearing. He said AARP introduced its full draft of seniors legislation in January and began working with Hudson after the city’s budget passed in June.

Jones said many older people have built these New York neighborhoods, raising children, opening small businesses and buying homes. They believe the city is the best place to grow old due to its walkability and proximity to services. “You can walk to your doctor’s office, to your pharmacy. You can walk to cultural events. There’s a real sense of community when things aren’t far apart,” Jones said.

AARP New York State Director Beth Finkel noted that the bills incorporate core AARP principles, such as housing availability and affordability, ensuring that older adults know the services available and the fight against life-threatening social isolation.

“Our seniors helped build this great city and deserve to age with dignity and have their rights protected,” Finkel said in a statement. “Council member Crystal Hudson’s legislative package is an important step in fighting ageism and creating a more age-friendly city. These bills would help protect the dignity and quality of life of New York City’s large, diverse, and rapidly growing senior population.

Ariama C. Long is a member of the Report for America corps and writes about New York culture and politics for The Amsterdam News. Your donation to match our RFA grant helps him keep writing stories like this; please consider making a tax deductible donation of any amount today visiting : https://tinyurl.com/fcszwj8w

Is it safe to take a turmeric supplement during pregnancy?

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Although no research has been conducted regarding the effects of curcumin on pregnant women, a 2007 study published in Food and Chemical Toxicology found that female rats given curcumin gave birth to lower weight pups. at birth. Another 2010 study published in Advances in Molecular Toxicology found that female mice given high levels of curcumin had a lower implantation rate, as well as puppies with a lower birth weight.

Although pregnant subjects have been excluded from human studies, research has suggested that curcumin may also have an influence on the human reproductive system. A 2013 study published in the Iranian Journal of Reproductive Medicine reported that curcumin inhibited the growth of endometrial cells (in cases of endometriosis) by lowering estrogen levels.

Although there is no evidence deeming curcumin dangerous for pregnant women, most experts agree that pregnant women should avoid medicinal doses of curcumin or turmeric – like the dose you might find in capsules of turmeric (per Medical News Today). It is suspected that changes in estrogen levels that occur when taking large amounts of curcumin may induce uterine contractions and bleeding. This increases the risk of pregnancy loss and early labor. However, fresh or dried turmeric in small doses – like you would get in your favorite Indian dish – is probably safe for pregnant women.

Dr. Simone Badal makes massive breakthroughs in the fight against prostate cancer

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Science and Technology Minister Daryl Vaz presents a plaque to S&T XXtrordineers winner Dr Simone Badal at the launch of the recognition program on July 14.

While black men are two and a half times more likely to die from prostate cancer and Jamaican men have one of the highest incidences of cancer in the world, pioneering Jamaican scientist Dr. dedicated his life to research aimed at developing better treatments, including drugs to fight cancer in black people.

His research is also relevant to the fact that black women are more likely to develop triple-negative breast cancer, the most aggressive form, and have the highest mortality rate. Badal’s work takes on even more meaning when you consider that more than 90% of Jamaica’s population is black.

Badal is fearless in the task at hand, she dares to make a difference. The more difficult the task, the more determined she is to succeed. This fixity of purpose has led to his groundbreaking work in cancer research that will benefit black people in Jamaica and the wider Caribbean. His findings mean that treatments can now be tailored to this specific group.

Badal’s track record is impressive. The graduate of Meadowbrook High School in St Andrew, where she fell in love with science, is a lecturer in the Department of Biochemistry at UWI. She is also a member of the editorial board of the Journal of Cancer Science and Clinical Research and the American International Journal of Biology. She taught at the University of Technology where she led the delivery of the pharmacognosy course to second-year pharmacy students.

Her greatest achievement to date has come from her tireless work at the Anti-Cancer Research Jamaica Foundation (ACRJ) which she founded in 2014 with the determination to develop a cell line for prostate cancer in black men.

After several years of diligent work at the ACRJ Cell Culture Laboratory, located on the Mona Campus of the University of the West Indies, Badal developed the first Caribbean prostate cancer cell line dubbed ACRJ-PC28. The development was revolutionary.

Cell lines are taken from the body and can be manipulated outside the body. Scientists can grow them for long periods of time while observing what happens in cancer cells and normal cells. This is crucial for developing more effective drugs.

Prior to Badal’s breakthrough, only white cell lines for white males were available.

“During my research into the effectiveness of some promising Jamaican compounds in a possible cancer treatment, I realized that there were a lot of disparities in cancer research. For example, the cell lines that I I used in my research to test these compounds all came from Caucasian individuals,” Badal explained.

She was determined to change that.

“That led me to where I am today, developing Caribbean black cancer cell lines so we can have better representation,” she added.

Badal noted that when drugs are being developed, having these black Caribbean cell lines “will help us develop more effective drugs against cancers in black people.”

Badal is preparing to publish his first book, “No Cell Left Behind” with BambuSparks.

The pioneering Jamaican scientist’s impact was evident when in 2020 she received an NIH Emerging Global Leader Award of over US$500,000. This funding, she said, helps advance prostate cancer cell line development and expand facilities in the lab.

In 2014, she was one of five winners of the Elsevier Foundation Awards for Early Career Women Scientists in Developing Countries. The awards were presented at the AAAS annual meeting in Chicago.

Photodynamic therapy shows promise for cancer treatment

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Human colorectal cancer cells. Credit: National Cancer Institute/Unsplash

Although chemotherapy drugs can save lives, they do not work for all patients or for all cancers. But a team of UTM researchers is investigating new ways to use special types of light to target cancer cells that are resistant to current drug therapy, in an approach that may be easier for some patients than traditional chemotherapy.

Photodynamic therapy – the use of precisely targeted light, usually from a laser, that activates or “ignites” a drug to kill cells – has been used primarily to treat skin cancers because it is easier to diffuse the light outside the body. But light does not travel very far through the tissues of the body. So how do you safely illuminate deeper cancers, like those of the pancreas or breast? And how do you know which cancers will respond to cell-killing drugs and which will be resistant? The challenge is to get the traffic light as close to the red light as possible. Of all the colors in the visible light spectrum, red has the longest wavelength, which allows it to penetrate tissue, but also the lowest energy, which minimizes damage to healthy cells.

Karishma Kailass, Ph.D. candidate in the Department of Chemical and Physical Sciences, discovered that using an approach called two-photon light, where two tiny particles of light strike at exactly the same time, achieved this result. It doubled the wavelength, halved the energy and, with a special cancer-fighting molecule that is only activated by light, succeeded in destroying cancer cells that would otherwise have been resistant to conventional chemotherapy.

Kailass says that in creating cancer therapies, most research focuses on certain proteins that are overexpressed in cancer cells; more of the molecule or drug you make will bind to that overexpressed target. “What’s new about what we’ve done,” she explains, “is that we’ve taken an approach that targets something that’s underexpressed in cancer.” The drug-resistant pancreatic and breast cancer samples the team examined showed low levels of a protein called carboxylesterase 2. As this is the protein targeted by the most common chemotherapy drugs, the low-level cancers would be resistant.

Levels of this protein vary from individual to individual, but the use of two-photon light causes the molecule to show different colors of fluorescence depending on the level: when there are high levels of protein present , it emits a red fluorescence; at low levels it fluoresces yellow. “That way you can tell if the patient will respond or resist chemotherapy,” says Kailass. “And then if they’re resistant, you can use the molecule itself to actually treat them.”

Therapy can be extremely precise. For cells that are red – showing high levels of protein – conventional chemotherapy would work but the molecule wouldn’t, because the protein would break it down. For cells that are yellow and resistant to regular chemotherapy, the molecule would retain its shape and the two-photon light would activate it to kill the cancer cells. This approach should be easier for patients, take less time and be performed on an outpatient basis, using an intravenous route to deliver the photosensitizer molecule to settle in the tumor site, and fiber technology optics to deliver light. So far, the research has only been done in the lab, but Kailass says the next steps are animal studies and then, hopefully, human clinical trials.

Kailass’ discoveries came about by happy accident, when she used the wrong light in the middle of an experiment examining the molecule’s photosensitivity. “I took the purple light to shine on the yellow when I was supposed to take the green light to shine on the red,” she laughs. She observed with surprise that the molecule produced an increase in anti-cancer properties. “Hmm, I’ve never seen this before!” she thought. Realizing her mistake, she continued to replicate the study, the results of which were published in June in the Journal of Medicinal Chemistry.

Kailass works in the lab of chemistry professor Andrew Beharry, who calls her “exceptionally talented”. Looking to the future, he adds, “We envision our molecule to help clinicians make drug decisions, as well as provide them with a new therapeutic that kills cancers differently from conventional chemotherapeutic drugs.


Drug acts like Trojan horse to kill cancer cells


More information:
Karishma Kailass et al, Two-photon photodynamic therapy targeting cancers with low carboxylesterase 2 activity guided by ratiometric fluorescence, Journal of Medicinal Chemistry (2022). DOI: 10.1021/acs.jmedchem.1c01965

Provided by University of Toronto Mississauga


Quote: Photodynamic Therapy Offers Promise for Cancer Treatment (September 14, 2022) Retrieved September 14, 2022 from https://medicalxpress.com/news/2022-09-photodynamic-therapy-cancer-treatment.html

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Tinnitus Pipeline Assessment – FDA, EMA, and PMDA Approvals, Emerging Drugs, Clinical Trials, Therapeutic Analysis, Growth Prospects, and Key Companies by DelveInsight

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Tinnitus pipeline includes over 8 key companies continuously working to develop over 8 tinnitus treatment therapies, DelveInsight analysis

Tinnitus is usually caused by an underlying condition, such as age-related hearing loss, ear injury, or circulatory system problem. For many people, tinnitus improves with treatment of the underlying cause or with other treatments that reduce or mask the noise, making the tinnitus less noticeable.

“Tinnitus Pipeline Overview, 2022” The DelveInsight report presents complete information regarding the current clinical development scenario and growth prospects in the Tinnitus market.

The Tinnitus Pipeline report includes an in-depth commercial and clinical evaluation of the products in the pipeline from the preclinical development phase to the commercialization phase. The report also covers a detailed description of the drug, including the mechanism of action of the drug, clinical studies, NDA approvals (if any) and product development activities including technology, collaborations, mergers, l acquisition, financing, designations and other product details.

To learn more about the Tinnitus Pipeline report, click here: Tinnitus Pipeline Overview

Tinnitus report from DelveInsight covers about 8+ products under different phases of clinical development like

• Late-stage products (Phase III)

• Mid-term products (Phase II)

• Produced at an early stage (Phase I)

• Candidates in the preclinical and discovery phase

• Abandoned and inactive candidates

• Route of administration

Emerging tinnitus drugs in different phases of clinical development include:

• AM-101: Auris Medical

• OTO-313: Otonomy

And many more.

Further details about Tinnitus products are provided in the report. Download the Tinnitus Pipeline Report to learn more about emerging tinnitus therapies at: Tinnitus therapies and companies

Tinnitus Pipeline Analysis

The report provides information on:

  • The report provides detailed information about companies which are developing therapies for tinnitus treatment with overall therapies developed by each company for the same.

  • It accesses the various therapeutic candidates segmented into early, intermediate and advanced stages of development for the treatment of tinnitus.

  • Key tinnitus companies involved in the development of targeted therapies with respective active and inactive (dormant or discontinued) projects.

  • Tinnitus Drugs under development based on stage of development, route of administration, target receptor, monotherapy or combination therapy, different mechanism of action and molecular type.

  • Detailed analysis of collaborations (company-company collaborations and company-university collaborations), license agreement, and funding details for future advancement of the Tinnitus market.

The report is constructed using data and information from the researcher’s proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, Featured investor presentations and press releases from company/academic websites and industry-specific third-party sources. etc

Request Sample PDF Report for Tinnitus Pipeline Assessment, click here – Therapeutic assessment of tinnitus

Leading Companies in the Tinnitus Therapeutics Market:

Some of the tinnitus companies working in the market are Otonomy, Auris Medical, Gateway Biotechnology, Cognosetta, Knopp Biosciences, Otologic Pharmaceuticals, Decibel therapys, AudioCure Pharma and others.

Request for a Sample PDF Report to know more about recent developments in the Tinnitus Treatment Market – Advances in Tinnitus Clinical Trials

Table of Contents (TOC)

1. Presentation of the report

2. Executive Summary

3. Current tinnitus treatment models

4. Tinnitus – Analytical Perspective from DelveInsight

5. Therapeutic assessment of tinnitus

6. Late Stage (Phase III) Tinnitus Products

7. Mid-Stage Products for Tinnitus (Phase II)

8. Early Stage Tinnitus Products (Phase I)

9. Preclinical products for tinnitus and products in the discovery phase

10. Inactive Tinnitus Products

11. Sleeping Tinnitus Products

12. Discontinued Tinnitus Products

13. Tinnitus Product Profiles

14. Key Companies in Tinnitus Market

15. Key Products of Tinnitus Therapeutics Segment

16. Dormant and Discontinued Products

17. Tinnitus Unmet Needs

18. Tinnitus Future Outlook

19. Tinnitus Analyst Review

20. Appendix

21. Report Methodology

*The table of contents (TOC) is not exhaustive; final content may vary. Refer to the sample report for the complete table of contents.

Download sample PDF report to learn more about tinnitus therapies and medications – Tinnitus treatment and medications

About DelveInsight

DelveInsight is a leading business consultant and market research company focused exclusively on life sciences. It supports pharmaceutical companies by providing complete end-to-end solutions to improve their performance.

Media Contact
Company Name: DelveInsight Business Research LLP
Contact person: Ankit Nigam
E-mail: Send an email
Call: +19193216187
Address:304 S. Jones Boulevard #2432
Town: Albany
State: New York
Country: United States
Website: https://www.delveinsight.com/report-store/tinnitus-pipeline-insight

Here’s how $135 million in federal funding will be used in Southwest Virginia

WASHINGTON –American senses Mark Warner and Tim Kaine secured about $135 million in federal funding for Virginia in fiscal year 2023 budget bills.

The legislation now awaits tagging and advancement by the Senate Appropriations Committee.

“I’m proud to have worked to secure these investments for communities across Virginia,” Warner said. “By propelling impactful local projects, these dedicated federal dollars will further build on the progress we have made through the bipartisan Infrastructure Act and the many rounds of COVID-19 relief funding authorized by Congress. I look forward to seeing these diverse projects generate jobs, support Virginia’s tourism economy, make neighborhoods safer, and bring communities together.

“The annual budget is always an important opportunity to fight for Virginia’s priorities and America’s leadership in the world, and I’m thrilled with how this effort prepares for the upcoming fiscal year,” said Kaine. “I will continue to fight to keep the many essential elements of these bills intact as we bring this budget to the finish line – protecting Virginia communities from gun violence, COVID and future health crises. ; to address food insecurity and the root causes of migration.

A d

If the pending bills pass, this budget includes money for areas in southwestern Virginia, including:

  • $2,500,000 for Virginia Department of Transportation (VDOT) efforts to replace the Wiley Drive Bridge in Roanoke

  • $2,000,000 to the City of South Boston in Halifax County to complete repairs and replace storm sewer lines in the area

  • $2,000,000 to help the Virginia Passenger Rail Authority with its plans to move rail forward in the New River Valley

  • $1,201,000 to support TriArea Community Health in the renovation of the Laurel Fork Clinic and Pharmacy

  • $1,000,000 for the New River/Mount Rogers Workforce Development Board in its efforts to increase industry partnerships

Copyright 2022 by WSLS 10 – All rights reserved.

Is drug price negotiation a concept whose time has come?

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Howard S. Hochster, MD, considers drug price negotiation in this month’s letter to the reader.

As of this writing, the US Congress has just approved the Cut Inflation Act of 2022, which includes a provision allowing Medicare to negotiate drug prices with pharmaceutical companies. The first steps will not happen until 2026, when 10 of the most popular drugs will be subject to drug price negotiation. Additional provisions in the bill will make key changes to reimbursement for patients enrolled in Medicare Part D.

Why is this important? Currently, by US regulations and law, Medicare must pay for any FDA-approved drug. Prices are set by pharmaceutical companies. That’s it. We pay the price set by the pharmaceutical companies, which is primarily tied to the price set for the last drug approved for the indication or disease, plus an additional cost. There is no link to drug complexity, manufacturing cost or development costs. Incremental costs have doubled the cost of some drugs in a few years. And surprisingly, for those who have studied the economy, even with more competition (eg, all the anti-PD-1 drugs now available), the prices don’t come down.

This pricing structure contrasts with almost every other country where drug prices are negotiated with regulatory bodies. In England, for example, a second process of evaluating agent cost-effectiveness is required by the National Institute for Health and Care Excellence committee for reimbursement by the National Health Service. One way to improve profitability is to reduce costs. And that explains why brand name drugs are generally cheaper in all other countries. It also explains why many patients order “grey market” drugs from Canada, Mexico, or Europe, which can be even cheaper than their share in the United States. For example, a new colon cancer drug for refractory disease, Lonsurf (trifluridine/tipiracil), can cost $20,000 a month for 70 mg twice a day. A patient I saw recently couldn’t afford the $3,000 monthly copay and had too much income to qualify for patient assistance. He was stuck and had to take out a second mortgage on his house to get the necessary funds. And who hasn’t experienced major heartbreak and dismay, like when a patient tells you she didn’t take her pain medication this month because the choice was either to pay for the medication or to feed his family? These are examples of the economic toxicity we see in our daily practice.

With the new legislation, price negotiation will not begin for a few years and only for the top 10 prescription drugs, which are unlikely to include chemotherapy agents. This is a small step towards leveling the playing field, as patients in the United States are paying more than their fair share.

Additionally, Medicare only paid for drugs administered in the doctor’s office before Medicare “Part D” came into effect in 2006 (following compromises with industry lobbyists). The system is far from perfect. Patients end up with a “doughnut hole,” or coverage gap, after paying a base amount, in which case they have a 25% co-payment. In 2022, Medicare part D (outpatient drug benefits) covers an initial cost of approximately $4330 then has a donut hole up to $6550 for which the patient co-pay is 25%. Patients falling into this coverage gap will have significant expenses. The new legislation eliminates this coverage gap and the 5% copayment after $7,000.

Many commentators have opined that this will lead to a serious decrease in innovation and new drugs. This is unlikely to be the case. There is too much at stake for these companies to stop developing new drugs. Additionally, much of the discovery of new drugs is done by licensing new technologies to universities. These discoveries and their intellectual property may be licensed by biotechnology companies, and sometimes these biotechnology companies are acquired by large pharmaceutical companies. You, the taxpayers of the United States, pay for much of this basic academic research leading to new drugs, but you don’t see much benefit from it.

Here are some ways to save money: end direct-to-consumer advertising; remove pharmacy benefit managers to reduce purchasing costs; making biosimilars interchangeable (just like interchangeable generic small molecule drugs, as permitted by the Hatch-Waxman Act) and ending branded biosimilars; and ending the prior authorization process, which costs the health care system more than it saves.

Other countries pay less for their drugs, and we in the United States end up paying more than our fair share. Negotiations by Medicare and the VA system should help rebalance our costs against what everyone pays.

Scorpion Therapeutics Appoints Michael Streit, MD as Chief Medical Officer

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BOSTON-(BUSINESS WIRE)–Scorpion Therapeutics, Inc.a pioneering oncology company redefining the boundaries of precision medicine, today announced the appointment of Michael Streit, MD, MBA as the company’s first medical director.

“We are delighted to welcome Michael to Scorpion at this exciting time in the company’s evolution, as we develop our first clinical development plans and prepare to submit Investigational New Drug Applications (INDs). ) for our two development candidates, STX-478 and STX-721, in 2023,” said Axel Hoos, MD, Ph.D., CEO of Scorpion Therapeutics. “Michael is an industry veteran with extensive experience in ‘bench to bedside’ oncology drug development. He has also helped advance the field of personalized medicine by developing new targeted therapies combined with companion diagnostic tests. Over his career, Michael has led clinical studies for innovative drugs comprising both first-in-class and first-in-class molecules, and he will play a critical role in advancing our extensive discovery pipeline to clinical studies. efficient and well designed. tests.”

Dr. Streit brings more than 20 years of oncology and clinical development expertise to Scorpion Therapeutics. Prior to joining the Company, he served as Vice President, Senior Global Project Manager at Sanofi, where he was responsible for leading the development of SAR444245 (THOR-707), the precisely pegylated, non-alpha interleukin-2 candidate from Sanofi. Previously, Dr. Streit held positions of increasing responsibility at GlaxoSmithKline, including Vice President of Development, where he led the development of several oncology drugs. Previously, he was a Senior Director at Janssen, where he worked as Head of Early Development for the company’s prostate cancer and hematology portfolios and supported the Phase 1 development of several early development assets. . Dr. Streit earned his MD from Free University of Berlin and his MBA in International Business from Golden Gate University in San Francisco. He completed a postdoctoral fellowship at the Cutaneous Biology Research Center of Massachusetts General Hospital.

“I am thrilled to join the talented team at Scorpion Therapeutics and look forward to advancing the company’s next-generation cancer drug portfolio into the clinic, beginning with its PI3Kα and EGFR Exon 20 programs,” said Dr Streit. “In preclinical studies, these compounds demonstrated superior selectivity against well-validated oncogenic drivers, which may allow them to overcome toxicity issues that limit currently available therapies and provide superior safety, tolerability and efficacy. I look forward to advancing STX-478 and STX-721, as well as more than 15 additional Company programs, through discovery and clinical development, and fulfilling Scorpion’s mission to deliver optimized and transformational therapies to cancer patients.

About Scorpion Therapeutics
Scorpion is a pioneering oncology company redefining the frontier of precision medicine to deliver optimized, transformational therapies to larger cancer patient populations, a strategy Scorpion calls Precision Oncology 2.0. Scorpion has built a proprietary, fully integrated platform of the most advanced technologies in cancer biology, medicinal chemistry and data science to consistently and rapidly create small molecule compounds. extremely selective against an unprecedented array of targets. Scorpion aims to leverage its platform to advance a broad portfolio of fully owned and optimized compounds in three target categories: best-in-class molecules targeting validated oncogenic targets; first-class molecules for hitherto impossible-to-treat targets; and first-in-class molecules for new anti-cancer targets. For more information, visit www.scorpiontx.com.

Book chronicles mercy and madness in the life of Spokane’s first female doctor

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Dr. Mary Archard Latham, Spokane’s first female doctor, quickly gained respect in the pioneering city after opening a practice in 1888.

Latham was a sought-after specialist, especially for childbirth and care for women with difficult pregnancies. She helped found the city’s first library and the Spokane Humane Society. She did philanthropy, wrote letters to the editor, advocated for others, and found homes for babies to adopt.

His influence is marked by a bust and tribute – “Physician, Essayist, Library Advocate” – among other sculptures of early Spokane leaders along Monroe Street in the former press building of The Spokesman-Review.

But Latham’s accolades seem to collide with later downfalls – property and legal entanglements, a nervous breakdown after the accidental death of a son, an arson conviction, and then an escape to rugged Idaho before his capture. She spent over a year at Walla Walla Penitentiary.

Now more about Latham’s life is covered in a new book, “Mercy and Madness: Dr. Mary Archard Latham’s Tragic Fall from Female Physician to Felon.” Beverly Lionberger Hodgins, author and Spokane resident, is interested in more than the story. She has family ties to Latham.

“Mary’s grandfather is my fourth great-grandfather on my family tree,” Hodgins, 72, said. Latham’s grandfather was John Archard, sometimes spelled Archerd. His first wife died, but they had a son who was Latham’s father. John Archard and a second wife had Hodgins’ third great-grandfather.

“Mary’s father and my third great-grandfather are half-brothers. Mary and I are distant cousins, but I can claim her.

Six years ago, Hodgins began uncovering historical records with Latham’s abundance of written words. Hodgins leads each chapter with something written by Latham. A clearer picture of the doctor emerged, she said, from the early years in Ohio to the tragedy later in life. Near the book’s submission, Hodgins landed a treasure.

“Perhaps a few months before the final manuscript was due, I finally received the complete file of everything related to Mary from the penitentiary.” This included Latham’s photo, entry card and letters at the time.

“A letter I particularly like is when she was on parole; she is very polite, writing to essentially ask permission to practice medicine again.

A different script tops the stationery, apparently from the director, “Tell her she can do it with pleasure.”

“He underlined ‘with pleasure,'” the author said. “I thought it revealed what he must think of Mary, even though she was a convicted felon in prison.”

And Latham’s photo became the book’s cover photo.

“When I opened the photo it filled my whole computer screen and I found myself saying ‘Hi Mary’ because of her eyes. Two old portraits are in the book, but this one, for a some reason, was beautiful. It felt like I was really seeing her for the first time.

Hodgins said Latham’s perseverance always showed, despite the tragedy, as did her expertise in health care, especially for women and children and especially the poor.

“Mary had several firsts as a woman during this time, and I think she had a lot of courage,” Hodgins said.

“I think Mary had an incredible brain. It’s apparent from her letters to the editor and her essays that she’s very educated, very insightful. She’s not afraid to speak her mind.

One of Latham’s sisters, Eliza Archard Conner, wrote for the Saturday Evening Post and was a suffragist. Their mother, Jane, mainly ran the farm and raised five daughters, “so they knew what a strong woman was”.

Latham’s story is definitive book material, said Jim Kershner, a journalist who wrote about the doctor for HistoryLink.org in 2015.

“This is one of the most compelling and tragic stories in Spokane history,” Kershner said. “It’s just a remarkable story because she was so respected. In the beginning, she was so pioneering and so critical of women’s health care at a time when there weren’t many female doctors, if any. .

“She was truly seen as a tremendous asset to the community, which makes her downfall particularly tragic. It happened in a very short time. »

Latham’s story is almost like a Greek tragedy, he said. “If you know the first half of the story, and that’s all you knew, you would think she would be a saint in Spokane history. But that second half of the story, you wouldn’t have never could predict that this is how the story would unfold.

In 1886, at age 42, Latham earned an medical degree from the Cincinnati College of Medicine and Surgery, a few years after her husband Edward had graduated from medical school. They had raised three sons and briefly practiced together in Ohio. But her “severe asthma” sent her west to Spokane with their sons. Edward stayed to close business.

He arrived in Spokane in 1889, shortly before the “great fire” destroyed most of downtown and Latham’s home, Hodgins said. Less than two years later, Edward went to the Colville reservation to become their doctor. They divorced about four years later.

Mary Latham maintained her medical practice, drawing on her skills whether patients lived in cabins by the river or in mansions in Browne’s Addition, Hodgins said.

“I learned how much Mary loved babies — delivering babies and finding homes for babies who needed them,” Hodgins said. “She ran the Spokane Home Finding Society almost from the time she arrived until she retired, and even then I don’t think she stopped.”

Hodgins also learned that Latham apparently performed abortions, then called “illegal operations”. Latham was cited as an advocate for doctors in a newspaper article.

“Mary stands up for other doctors, including obviously herself I think, brought into situations where a woman’s life is in danger because of a botched abortion, say, so they have to come in and save her life. of women,” Hodgins said.

“There was also a family rumor that Mary and her stepdaughter Emma Latham performed abortions together.”

Latham was charged in 1911 with performing abortions. She had had this felony charge before, shortly after prison, but she had been dropped. This time it was a 17-year-old delinquent girl who told police, Kershner wrote. His research revealed that the latter charges were dismissed when Latham agreed to “retire from active life”, i.e. medical practice. Authorities noted his poor health and “altered” mental state.

But Latham still helped others. In 1917, she agreed to take care of a 12-day-old child suffering from pneumonia. She contracted pneumonia and died on January 20, 1917, aged 72.

More than half of the book covers Latham’s milestones and contributions, said Hodgins, a member of Women Writing the West who has written short stories, poems and screenplays. The author moved with her husband from Oregon to Washington in 2006, then to Spokane in 2012.

“I wanted to understand Mary’s life. I wanted to know if she had really done what she had been condemned for.

For the arson charge, Latham was suspected of burning down a Mead store and pharmacy to keep it safe from another woman, apparently her son James’ former fiancé, who claimed the property was hers and won in court. It’s clear that in 1903, after her son James was killed in a train accident at work, Latham became unhinged, Hodgins said, but she’s still unconvinced of what she called condemnation. circumstantial.

“I’m not sure, because she was under the influence of people who apparently were trying to profit from their association with her,” Hodgins said. “You kind of have to read the trial chapter to understand.”

Hodgins learned that Latham had suffered a stroke shortly after her son’s death and that she wanted to kill herself.

The same Dr. Latham probably never returned after 1903, Kershner said. Her bad decisions and bizarre actions weren’t those of the same woman who, 10 years prior, was “a very strong, brilliant woman who had it all.”

Hodgins also saw this change, but mercy ultimately won out when it came to Latham’s legacy.

“Mary gave mercy and received mercy in the end,” Hodgins said. “She had moments of what some would say were insane, after the traumas she went through, but she persevered until the end. She never gave up.”

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Nothing is strange about cesarean delivery

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This week I had to stop the project to start a new series just to share something that has bothered me for so long. Although what I’m about to say is a clear departure from what you’re used to, I don’t think it’s a bad idea if I use this platform to project what will benefit us all. Before I hit the nail on the head, let me share a few stories with you.

In 2018, a woman who lived near my mother’s store died because she refused to have her babies (a twin pregnancy) by caesarean section. Every time his photo comes to mind, I get goosebumps. There is a second woman, she was advised not to give birth in the hospital and where she went she had a difficult delivery. She not only lost the child, she also lost her womb and she never got pregnant again.

Besides the fact that a woman may be afraid of losing her life during cesarean delivery, the main reason why women run away is due to religious beliefs and it is from this angle that I want to approach this discussion. I am sorry. I’m going to sound a little religious to drive the point home. The usual scenario when a woman is told to prepare for a caesarean birth (also known as cesarean section) is that you will start to hear things like, “I will give birth like a Hebrew woman, God did not not entered into a caesarean birth covenant with me. The next thing you see is that she stops going to her antenatal clinics and when she goes into labor she won’t go to the hospital. Some are lucky but most are unlucky because they lose their babies, some have serious complications and some even die during labour. Our clerics always support women in times like this. They always support them on the “no to cesarean” position. Older women, especially the mother of the woman in labor, are not left out, especially if she’s had all her children vaginally, which is when you hear things like “a kii fi obe gba ebi ewure” meaning “a goat will not give birth by caesarean section.

Aren’t we twisting our faith? Alright, let’s go on a trip to clear things up. At creation, God put Adam to sleep and removed a rib from him to make Eve. Isn’t that how doctors put women to sleep before a caesarean and have their babies removed from their wombs? So, God himself is an anesthetist and surgeon! And as the Yoruba will say, eni bi ni la n jo“, which means the apple never falls far from the tree. What doctors do is they just pick up where God left off!

Don’t get me wrong, there’s nothing wrong with having faith, but what I’m trying to say is that people should add wisdom to their faith. Having a cesarean does not mean that God has become powerless and cannot save you. Let’s just say he chose another way to save you. Jesus told Bartimaeus to get his sight back and another man Jesus had to resort to the fundamental principle on which man was formed – from dust by spitting on the ground and making clay out of saliva. He then anointed the blind man’s eyes with clay and told him to go wash himself in a pool before his sight was restored. A C-section may be scheduled by your doctor before your due date or it may become necessary during labor due to an emergency.

Other reasons such as prolonged labor, breech baby, fetal distress, birth defects, repeated C-sections, chronic health conditions, cord prolapse, or carrying multiples can be the causes of a cesarean delivery. Whatever the cause, always listen to your doctors.

Pregnancy comes with many challenges, the joy of it all is being alive with your baby after the nine month journey. So if going through a CS is the only option you have left, go for it. Women who have given birth by caesarean section are stigmatized, they are considered weak. I keep hearing people who have had their babies vaginally say, “It’s a normal birth. Which is abnormal? If you had your baby by caesarean section, you are a strong woman. Don’t let anyone think less of you. Either way, you are still a “Hebrew woman.” Maybe campaigns can be done in religious places to make them see things from the perspective that God also operated on man because that’s where the strongest opposition to caesarean births comes from. We cannot continue to lose women. All these deaths must stop.

On a lighter note, the video of a woman eating plantation peels has gone viral recently and many have emailed me the video. They wanted my opinion on that. Yes, keep eating the peels! While on Medicines in the Unlikely Plant Parts series, I discussed plantain peels and the fact that they are edible. I recall that during my discussion with the Head of Herbarium and Medicinal Plant Gardens, Department of Pharmacognosy, Faculty of Pharmacy, Obafemi Awolowo University, Ile-Ife, Osun State, Mr. Ife Ogunlowo , he said that ripe plantain peels are one of the constituents his wife uses to make an herbal soap that his family uses because it removes wrinkles and can moderately lighten or tone the skin without side effects. He said the unripe peels can be soaked or mixed and taken to manage high blood pressure and diabetes. If you can’t eat it raw, you can cut it into small pieces, cook it and add it to all your recipes. You can also boil and drink the water.

I like that the wife said this (eating plantain peels) was passed down from her grandfather. This recalls the importance of indigenous or traditional knowledge about plants.

I won’t forget my weight loss tips. If you choose walking as your form of exercise, you can get people to join you. It makes it more interesting. After every walk, the first thing I do when I get home is have a cup of warm water with lime squeezed into it. I usually take it with a straw. A new series starts next week. It’s going to be interesting.

Scientists are developing a better type of chemotherapy

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Researchers have found two compounds that are more potent and less toxic than existing leukemia treatments, which often cause unpleasant side effects in patients.

Researchers are discovering a new class of drugs that offer leukemia patients a safer, more targeted form of treatment.

Chemotherapy is no fun. It’s no secret that the drugs used in treatments often have harmful side effects on the patient and their cancer. Since tumors grow so quickly, the theory is that chemotherapy will eradicate the disease before its adverse effects take the life of the patient. For this reason, researchers and medical professionals are always looking for more effective treatments.

Researchers from the University of California, Santa Barbara, along with colleagues from the University of California, San Francisco and Baylor College of Medicine, have discovered two compounds that are both more potent and less toxic than current therapies for cancer. leukemia. The molecules work in a way that differs from conventional cancer treatments and may form the basis of an entirely new class of drugs.

Additionally, the compounds are already approved for the treatment of other diseases, greatly reducing the amount of paperwork required to modify them for the treatment of leukemia or even to administer them off-label. The results were recently published in the Journal of Medicinal Chemistry.

“Our work on an enzyme that is mutated in leukemia patients has led to the discovery of an entirely new way to regulate this enzyme, as well as new molecules that are more efficient and less toxic to human cells,” said the professor emeritus at UC Santa Barbara. Norbert Reich, the corresponding author of the study.

DNMT3A enzymes

A pair of DNMT3A enzymes joins two helper proteins (green) to form a four-part complex that moves along DNA adding chemical tags that tell a cell which genes to express. Credit: Jonathan Sandoval et al.

The epigenome

Although every cell in your body has the same DNA, or genome, depending on what type of cell it is, each uses a different part of this blueprint. This allows different cells to perform their specific tasks while using the same instruction manual; in reality, they just use different sections of it. The epigenome tells cells how to follow these instructions. Chemical markers, for example, control which sections are read and therefore dictate the actual fate of a cell.

A cell’s epigenome is copied and preserved by an enzyme (a type of protein) called DNMT1. This enzyme ensures, for example, that a dividing liver cell becomes two liver cells and not one brain cell.

However, even in adults, some cells have to differentiate into different cell types than they did before. For example, bone marrow stem cells are able to form all different types of blood cells, which do not reproduce on their own. This is controlled by another enzyme, DNMT3A.

All is well until something goes wrong with DNMT3A causing the bone marrow to turn into abnormal blood cells. It is a primary event leading to various forms of leukemia, as well as other cancers.

Toxic treatments

Most cancer drugs are designed to selectively kill cancer cells while leaving healthy cells alone. But it is extremely difficult, which is why so many of them are extremely poisonous. Current leukemia treatments, such as decitabine, bind to DNMT3A in a way that deactivates it, thereby slowing disease progression. They do this by obstructing the active site of the enzyme (essentially, its business activity) to prevent it from performing its function.

Unfortunately, the active site of DNMT3A is virtually identical to that of DNMT1, so the drug shuts down epigenetic regulation in all 30-40 trillion cells in the patient. This leads to one of the biggest bottlenecks in the pharmaceutical industry: off-target toxicity.

Obstructing the active site of a protein is an easy way to knock it offline. That’s why the active site is often the first place drug designers look when designing new drugs, Reich explained. However, about eight years ago he decided to investigate compounds that could bind to other sites to avoid off-target effects.

Work together

As the group investigated DNMT3A, they noticed something peculiar. While most of these epigenetic-related enzymes function alone, DNMT3A has always formed complexes, either with itself or with partner proteins. These complexes can involve more than 60 different partners and, interestingly, they act as guidance devices to direct DNMT3A to control particular genes.

Early work in the Reich lab, led by former graduate student Celeste Holz-Schietinger, showed that disrupting the complex with mutations did not interfere with its ability to add chemical markers to DNA. However, DNMT3A behaved differently when singly or in a single pair; it was not about staying on the DNA and marking one site after another, which is essential for its normal cellular function.

Around the same time, the New England Journal of Medicine conducted an extensive analysis of the mutations present in leukemia patients. The authors of this study found that the most common mutations in patients with acute myeloid leukemia are in the DNMT3A gene. Surprisingly, Holz-Schietinger had studied the exact same mutations. The team now had a direct link between DNMT3A and epigenetic changes leading to acute myeloid leukemia.

Discover a new treatment

Reich and his group were interested in identifying drugs that could interfere with the formation of DNMT3A complexes that occur in cancer cells. They obtained a chemical library containing 1,500 previously studied drugs and identified two that disrupt DNMT3A’s interactions with partner proteins (protein-protein inhibitors or PPIs).

Furthermore, these two drugs do not bind to the active site of the protein, so they do not affect DNMT1 at work in all other cells in the body. “This selectivity is exactly what I hoped to discover with the students on this project,” Reich said.

These drugs are more than just a potential breakthrough in the treatment of leukemia. These are a whole new class of drugs: protein-protein inhibitors that target a part of the enzyme away from its active site. “An allosteric PPI has never been done before, at least not for an epigenetic drug target,” Reich said. “It really made me smile when we got the result.”

This achievement is no small feat. “Developing small molecules that disrupt protein-protein interactions has proven challenging,” noted lead author Jonathan Sandoval of UC San Francisco, a former doctoral student in Reich’s lab. “These are the first reported inhibitors of DNMT3A that disrupt protein-protein interactions.”

The two compounds identified by the team have already been used clinically for other diseases. This eliminates a lot of the cost, testing, and bureaucracy involved in developing them into leukemia therapies. In fact, oncologists could prescribe these drugs to off-label patients now.

Building on success

There’s still more to understand about this new approach, however. The team wants to learn more about how protein-protein inhibitors affect DNMT3A complexes in healthy bone marrow cells. Reich is collaborating with UC Santa Barbara chemistry professor Tom Pettus and one of their doctoral students, Ivan Hernandez. “We are making changes to the drugs to see if we can further improve selectivity and potency,” Reich said.

There is also more to learn about the long-term effects of medications. Since the compounds act directly on enzymes, they might not alter the underlying cancer-causing mutations. This warning affects how doctors can use these drugs. “One approach is for a patient to continue on low doses,” Reich said. “Alternatively, our approach could be used with other treatments, perhaps to reduce tumor burden to a point where stopping treatment is an option.”

Reich also admits that the team has yet to learn what effect PPIs have on long-term bone marrow differentiation. They are curious whether drugs can elicit some type of cellular memory that could alleviate problems at the epigenetic or genetic level.

That said, Reich is excited about their discovery. “By not targeting the active site of DNMT3A, we are already miles beyond the currently used drug, decitabine, which is definitely cytotoxic,” he said, adding that this type of approach could also be suitable for other cancers.

Reference: “First-class allosteric inhibitors of DNMT3A disrupt protein-protein interactions and induce cellular differentiation in acute myeloid leukemia” by Jonathan E. Sandoval, Raghav Ramabadran, Nathaniel Stillson, Letitia Sarah, Danica Galonić Fujimori, Margaret A. Goodell and Norbert Reich, July 22, 2022, Journal of Medicinal Chemistry.
DOI: 10.1021/acs.jmedchem.2c00725

The importance of keeping up to date with stock market news

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The stock market is a tough nut to crack for everyone. Even some of the best investors who have made millions, and in the case of Warren Buffett and others, billions, don’t have the perfect formula for success. Of course, there are many guides and manuals one could read for market strategies and indicators, but they wouldn’t tell the reader what stocks to invest in. At best, they impart knowledge on how to identify and make the best trade possible.

However, one thing that is quite common in all stock market textbooks is the need to keep up to date with the latest stock market news. There are many stock market news publications in the market, and like this Seeking Alpha review watch, it is important that traders choose a service that fits their personal needs well.

Much of the market fluctuation is due to speculation. The sentiment of how a stock is perceived by the market is the most crucial factor in determining the price of that individual stock. The importance of being aware of global financial news is something that cannot be underestimated, and this applies to both a retailer and brokers. Here are some types of news you should pay attention to.

Financial reports and analyzes

Take the case of any listed company. They are required by law to declare their financial income to their shareholders as well as to the general public. Now, the company’s performance over the financial quarter will determine whether more investors would be interested in buying their shares or whether they would prefer to dump their holdings in the expectation of lower prices.

Now, that’s one way news about a company’s performance over the past quarter or multiple quarters impacts its stock price. But it is also possible for the stock price to drop even with a positive financial report. This is due to the company performing below market expectations. Naturally, therefore, it is crucial to be aware of stock analysis and market expectations regarding company earnings.

Good news/Bad news

A company’s financial performance is not the only parameter that determines whether its share price rises or falls. It’s just one of many. The general mood of the market is also crucial for the rise/fall of stock prices. Negative market performance, weak corporate governance, deteriorating financial condition, etc., will induce investors to sell their holdings and cut their losses. The same goes for political and geopolitical news. Turbulence in the political situation and geopolitical disputes are also clouding the mood of the market.

On the other hand, if the news is positive (on all fronts), it would encourage investors to buy more stocks, both for long-term and short-term investments. Good earnings reports, new product launch, expansion into new markets, business acquisition, and positive indicators in finance and geopolitics will generate buying pressure, leading to a steady increase of the stock price.

Not all bad news is bad for stock prices.

Now, it shouldn’t feel like all bad news would have a negative impact on stock prices. Take the case of COVID-19, a horrific time in human history. Not only is the death toll in the millions, but businesses and individuals have had to suffer financial hardship and uncertainty. However, one sector saw a record rise in stock prices and earnings: pharmaceuticals and healthcare. The unparalleled demand for PPE kits, disinfectants, medicines and healthcare products has made it a profitable trade for investors. Pharmaceutical companies like Pfizer are still seeing the rewards to this day, with their stock prices and the company’s market valuation higher than ever.

All this indicates the importance of being aware of the latest stock market news, especially if one does not want to be left behind. Stock market trends change rapidly, with an investor having a small window to maximize their profits. Therefore, one should do everything they can to be informed of the latest happenings in and around the stock market.

This article does not necessarily reflect the views of the editors or management of EconoTimes

The real effects of Aloe Vera on your body

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Aloe vera is famous for being the go-to natural product for burns, scrapes, scrapes and cuts, according to the Iranian Journal of Medical Sciences. Its therapeutic use for skin lesions and diseases dates back to 1500 BC. AD, and since then it has remained popular in countries like Greece, Mexico, and China.

The ancient plant has been shown to cure skin conditions such as psoriasis, ulcers, herpes, and bedsores. It can soothe a nasty burn after it has occurred, reducing the chances of getting a blister. It is also commonly used for rashes caused by sunburn. The application of aloe gel can be used as a complementary treatment for all kinds of skin wounds. Aloe vera is packed with immune-boosting nutrients like polysaccharides, amino acids, and zinc, which keep your skin hydrated and intact.

Aloe works its magic by reducing inflammation, according to an article published in Surgical Science. In turn, it can relieve pain, itching, burning, and redness. It promotes the synthesis of cytokines, which speed up the healing process and help your body fight infections. Additionally, by stimulating collagen production and shedding dead tissue, aloe vera encourages the skin to repair itself.

Belarusian products displayed at the exhibition in Tajikistan in October

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MINSK, Sept. 8 (BelTA) — The Belarusian exhibition will be represented at an exhibition in Tajikistan, BelTA learned from the BelInterExpo company of the Belarusian Chamber of Commerce and Industry.

Important business events involving representatives of the Belarusian private sector will take place in Dushanbe on October 11-12 – a Made in Belarus exhibition as well as a Belarus-Tajikistan business forum. A Belarusian delegation will travel to Tajikistan: representatives of government agencies and state organizations, business leaders, experts concerned.

The food industry, agriculture, mechanical industry, civil engineering, woodworking, healthcare, pharmaceutical, petrochemical industry, science and education will be represented at the exhibition.

The Belarusian Chamber of Commerce and Industry is the organizer of the business forum on the Belarusian side. The exhibition of Belarusian companies Made in Belarus in Dushanbe will be organized by the BelInterExpo exhibition company of the Belarusian Chamber of Commerce and Industry.

Companies interested in participating are invited to submit their applications before September 10. More information is available on the BelInterExpo website.

Top Stock Market Gainers: List of Nasdaq Stocks with Maximum Returns

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Contrary to the reputation that September has on stock returns, US stocks rebounded stronger on Wednesday. US stocks closed higher with the Dow 30 up 435.98 points and the S&P 500 gaining 1.83% while the Nasdaq recorded 2.14% on Wednesday. The small cap Russell 2000 also showed strength and was up 2.21% from the previous day’s close.

About 95% of S&P 500 companies rose in value, with all sectors except energy ending the day in the green. Only four of the Nasdaq 100 components fell as the tech-heavy index rose more than 2%. The list of Nasdaq stocks with peak returns on Wednesday were DexCom Inc. (7.73%), Match Group (6.85%), Ross Stores (6.25%), Netflix (4.84%) among other actions.

On the Nasdaq Composite Index, Imara (71.79%), Shuttle Pharmaceuticals Holdings (26.55%), Spero Therapeutics (26.55%), Pingtan Marine Enterprise (21.92%), Nutex Health (21.92 %), Molecular Templates (21.83%), NLS Pharmaceuticals (21.56%), Reata Pharmaceuticals (21.06%), Datasea (20.16%) were among the top winners.

The reason U.S. equities found buyers could be the pause in the global bond market selloff as Treasury yields halted a surge to multi-year highs. The only key factor the market is betting on is the expectation of lower inflation and therefore the upcoming US CPI numbers on September 13 will be a highly watched event.

Also Read: Will Apple’s Market Cap Hit $3 Trillion Again With Launch of New iPhone Model?

The best performing industries on Wednesday were Airlines, Retail, Automotive, Chemicals, Travel/Leisure, Credit Cards and Software. The drop in oil has put pressure on the energy sector. Transportation, logistics, international mining and tobacco stocks underperformed.

Since the June lows, markets have already seen a bearish rally. More such rallies could be seen until a solid base is formed and macro factors change for the better. Many strategists believe that the heightened inflationary pressures that will force the Fed to keep interest rates high for an extended period have not been sufficiently offset by declines in US equities.

US inflation data, which will be released on September 13, 2022, and the Fed’s FOMC meeting, which will take place on September 20-21, are the last two major events of September. Most analysts predict that the Fed will raise rates by 75 basis points in September in order to manage inflation. If approved, a 75 basis point rate hike would be the third in a row and demonstrate the Fed’s unwavering commitment to containing inflation at all costs.

According to history, September is the worst month ever because it has never been good for stock market investors.

Also Read: US Stock Investors Are Eyeing These 2 Major Events in September

It is uncertain whether the stock market will close in September 2022 with lower prices as in the past. In the coming months, new data streams may reveal the Fed Pivot option that was rejected in the aftermath of Jackson Hole. Ahead of next quarter’s earnings release and as macro conditions change in 2023, market participants are anticipating Fed activity to provide guidance.

Breakthrough of Saudi students in the fight against deadly livestock diseases * – Trademark

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Two Saudi undergraduate students, Fahad Shaya Al-Mutib and Abdullah Fahad Al-Dosari of Prince Sattam Bin Abdulaziz University have obtained a patent for a chemical component isolated from the plant Peganum harmala, also known as wild rue or African rue, which appears to be a promising weapon against the highly contagious foot-and-mouth disease known to destroy herds and bankrupt farmers. This discovery will be a source of immunization for livestock to keep them vaccinated and protected against viral diseases.

It was the idea of ​​Maged Saad Abdel-Kader, professor of pharmacognosy at Prince Sattam Bin Abdulaziz University, to encourage these students to use herbal components, especially since Peganum harmala was once commonly used. by the farmers, to treat his cattle for the said death. The research was initiated by the students, under the guidance of their mentor in 2019.

According to traditional practice, this disease was treated by farmers, by soaking a large quantity of Peganum harmala in water for at least a day, allowing the plant’s chemicals to dissolve in the water, and then fed to livestock. to drink.

The research involved various steps, such as collecting the plant, then extracting the components, and finally sending it to the virology laboratory of the Armed Forces Veterinary Medicine Hospital in Cairo.

The researchers faced a number of hassles throughout the procedure, such as finding a laboratory capable of conducting experiments on the target virus, the time-consuming process, and the complexity of the procedures, among others.

* https://www.arabnews.com/node/2123456/saudi-arabia

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Pharmacy signs MoU with Jordan University of Science and Technology

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The Department of Pharmacy of the University recently signed a Memorandum of Understanding (MoU) to promote collaboration with the Jordan University of Science and Technology (JUST) and the Eastern Mediterranean Public Health Network (EMPHNET)

Pictured above is Prof. Sayer Al-Azzam, Dean of the Faculty of Pharmacy at the Jordan University of Science and Technology (JUST), the university’s Dr. Mamoon Aldeyab, Senior Lecturer in Clinical Pharmacy and Director of ICPRU, Professor Suhad Al-Jundi, Vice President of JUST and Professor Yousef Khader, on behalf of EMPHNET.

A Memorandum of Understanding (MoU) has been signed between the University of Huddersfield, Jordan University of Science and Technology (JUST) and the Eastern Mediterranean Public Health Network (EMPHNET) to promote academic collaboration between the three parts.

The collaboration will be implemented through the International Clinical Practice Research Unit (ICPRU), a joint academic unit between the University and JUST and is part of the Pharmacy and Administration Research Center of University drugs.

Founded in 2009, the Eastern Mediterranean Public Health Network (EMPHNET) has a regional network headquarters in Jordan and focuses on strengthening public health systems, building local capacity, promoting collaboration, strengthening program planning and implementation, supporting evidence-based decision-making, and promoting health and well-being in the Eastern Mediterranean Region (EMR).

EMPHNET has extended its support to more than 15 countries and works in partnership with Ministries of Health, nongovernmental organizations, international agencies, the private sector and other public health institutions in the region and globally to promote public health and applied epidemiology.

25th annual conference of professors of pharmacy held

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Mysore/Mysore: The 25th Annual Three Day Convention of Association of Pharmaceutical Teachers of India (APTI), Mysuru, (APTICON-2022) hosted by JSS College of Pharmacywas inaugurated on Friday at the Sri Rajendra Auditorium at the JSS Medical College campus.

Sudarshan Jain, Secretary General of the Indian Pharmaceutical Alliance (IPA) opened the convention and presented awards to the professors of pharmacy.

Speaking on the occasion, Jain said the convention is themed “Empowering Academia to Advance Pharmacy Education.” Emphasizing that conventions like this will motivate and help pharmacy educators and students update their knowledge and skills with current trends, he said it will also help bring knowledge from the pharmaceutical industry to the students, researchers and teachers.

Dr. Milind Janrao Umekar, President, APTI (Central), India, in his presidential address, noted that the healthcare profession comprising of industry and practice sectors is undergoing rapid change. In recent years, the Indian pharmaceutical industry has made tremendous progress. Ever-expanding areas of practice need clinically and technologically trained pharmacy professionals who can meet global challenges and compete with multinational corporations (MNEs), he added.

Earlier, the Director of JSS College of Pharmacy, Dr. TM Pramod Kumar, who gave the welcome speech, hoped that the convention would take the industry-institution interaction to a new level leading to joint scientific study projects, recruitment, joint R&D projects and other industry benefits. academic staff and institutions.

JSS Mahavidyapeetha Executive Secretary Dr CG Betsurmath, Secretary SP Manjunath, JSS AHER Vice Chancellor Dr Surinder Singh, Pro-Chancellor Dr B. Suresh, Pharmacy Council of India Chairman Dr Montu Patel, APTICON-2022 Organizing Secretary Dr V Balamuralidhara, APTI (Centre ), Indian Secretary Dr. Raman Dang and others were present.

About two thousand pharmacy professionals, students, industrialists and others took part in this three-day event.

Miami Cancer Institute Named Winner of ACCC Innovation Award

The Association of Community Cancer Centers (ACCC) recently announced that Baptist Health’s Miami Cancer Institute is the recipient of a 2022 ACCC Innovation Award. The award recognizes Miami Cancer Institute’s use of technology to improve patient compliance with oral oncolytic consent.

It is common for cancer control programs and practices to struggle with timely treatment education, consent collection, and compliance monitoring, particularly when an oral oncolytic is prescribed. These challenges are due in part to older solutions that no longer benefit all patients equally. Problems like this have persisted in oncology despite rapid healthcare innovations and there is no single solution.

To meet the needs of the cancer care team and their patients, Miami Cancer Institute leadership knew a same-day solution was needed, and technology was the answer.

The team looked to solutions based on technology that was already in use by Baptist Health South Florida as a whole, technology already familiar to nurses and patients who had been patients with the system before.

For example, Access Passport and DocuSign have been implemented across the oncology service line to complement patient consent – ​​the former for in-person appointments and the latter for the virtual setting. As a result, Miami Cancer Institute staff provide high-quality cancer care without having to strain more of its operating budget.

“We are committed to continuing to serve our community and those who visit our facility with the highest level of quality cancer care. The pandemic has allowed us to rethink our innovative approach to care and we are deeply honored to be recognized by the ACCC,” said Dr. Mark Davis, Chief Operating Officer of Miami Cancer Institute at Baptist Health.

“There was always the danger that the patient would take that paper prescription, go fill it at their specialty pharmacy, get that medication delivered, and start taking it ahead of time,” said Morgan Nestigen, director of admissions and of navigation at the Miami Cancer Institute. “For us, the opportunity was to do all these steps in real time without any additional support.”

Nestigen will speak at the ACCC’s 39th National Oncology Conference about the successes and challenges she and her team have encountered in identifying and implementing technology to address treatment education, collection consent and compliance monitoring in their oral oncolytic workflow, including how optimizing these tasks has led to improved patient experience and employee satisfaction. Learn more about this innovation on the ACCCBuzz blog and CANCER BUZZ podcast, then subscribe at https://streaklinks.com/BLNL3KKExGlCXKyZngK3FnVG/https%3A%2F%2Fwww.accc-cancer.org%2Fhome%2Fattend% 2Fnational-oncology-conference %2Register to attend the ACCC National Oncology Conference, October 12-14, in West Palm Beach.

The Miami Cancer Institute is part of Baptist Health South Florida, the region’s largest healthcare organization, with 12 hospitals, more than 24,000 employees, 4,000 physicians and 100 ambulatory care centers, nursing homes emergency and medical offices covering Miami-Dade, Monroe, Broward and Palm Beach counties.

To see more #Miaminews from #Aventura to #Coralgables to #SouthMiami, #Pinecrest, #Palmetto Bay and #Cutler Bay and throughout #Miamidadecounty, go to:
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Lab Solutions will be the first UK distributor of Eraly & Associates Envirotech Online Halogen Analyzers

Led by a team of specialists with over two decades of experience, Lab Solutions leads the market in automated chemical analysis with a working knowledge of the specific methodologies required to meet ASTM, EPA and ISO standards. As the first UK distributor for Eraly & Associates, Laboratory solutions will supply the full General Elemental line for environmental and petrochemical laboratories that analyze sulphur, nitrogen and chlorine. Above all, Lab Solutions will be able to offer Eraly & Associates’ unique pyro-oxidizer furnace. A pyro-combustion instrument for the extraction of tritium and carbon 14 from a wide variety of samples (including: soils, sediments, solvents, water, algae, leaves, fish, plastics, food) in the nuclear sector.

Keith Thomas, Managing Partner at Lab Solutions, said, “We are delighted to announce our full-service storage and distribution partnership with Eraly & Associates. This will provide Lab Solutions customers with a wider selection of elementary instruments and we look forward to offering them a new range of high quality, multifunctional instruments, in a variety of rental and purchase options.

Learn more, visit Laboratory solutions at WWEM 2022.

Commissioners must consider preliminary spending of $68.5 million from hospital sales funds and opioid settlement money

New Hanover County commissioners will vote next week on how to plan a strategy for mental and behavioral health services with money from hospital sales and opioid settlements. (Port City Daily/File)

NEW HANOVER COUNTY — A community stakeholder group with a mission to improve mental and behavioral services in New Hanover County will present key findings to the Board of Commissioners on Tuesday.

Members were tasked with developing a framework on how to spend its share of $18.5 million in funds from a national opioid settlement, as well as $50 million in proceeds from the sale of the county-owned hospital toward wellness initiatives.

READ MORE: County and city committee to draft spending plan for $19.5 million opioid settlement fund

The committee includes: Delta Behavioral, RHS Services, Coastal Horizons, Novant Health, City of Wilmington, Trillium Health Resources, Resiliency Task Force, NHC Schools, LINC, NAMI, Cape Fear COG – Continuum of Care, Community Care of the Lower Cape Fear , Office of the Public Defender, Wilmington Police Department, New Hanover County Sheriff’s Office, NHC Fire Services, NHC Office of Diversity and Equity, NHC Health and Human Services, NHC Community Justice, NHC Department of Social Services – Child Protective Services and Commissioners Jonathan Barfield and Rob Zapple.

It has met eight times over the past five months to draft a draft strategy focusing on three areas: education and awareness, access to services and treatment, and sustainable recovery and well-being. Within each are strategic goals, desired outcomes, and a plan to measure success.

The group began thinking by reviewing data, understanding trends, and listening to community members who have had experience with mental health and addictions services in the county. Members also met with the North Carolina Department of Health and Human Services and the Association of North Carolina County Commissioners.

For education and awareness, the county hopes to provide additional information on how to spot early signs of mental health and addiction disorders, raise awareness of programs, and support and remove stigma and barriers. preventing people from seeking treatment.

Based on a draft of the strategy obtained by Port City Daily, initiatives being considered for funding include drug treatment for prison and EMS services, a mental health court, an expansion of the Mobile Crisis Team, a youth crisis center, money for The Harbour, a non-hospital adult drug rehabilitation center, and funds for the New Hanover County Sheriff’s Office and the Wilmington Police Department for the additional NARCAN.

READ MORE: The county asked to contribute $3.4 million to the potential new location of The Harbour, a collaboration with LINC

Access to services and treatment aims to provide “immediate crisis stabilization” for people and their families, reduce the number of people going to the emergency room, and connect people in need of treatment more quickly and efficiently with care.

In 2020, there were 93 overdose deaths in New Hanover County and 44 in Brunswick County, with 430 emergency room visits between the two.

According to the draft plan, initiatives that could fall into this category include Coastal Horizons’ post-overdose response team; create scholarship opportunities to increase the number of minorities in the mental health profession; housing support for people in mental health treatment and recovery; outpatient services for the uninsured; and developing UNCW’s nurse practitioner program.

The third component surrounding sustainable recovery and well-being will develop a pipeline of mental health care providers to reduce hospital readmission rates to 15% or less and increase the ratio of health care partners to current population.

The draft plan includes 5% in a cash reserve for sustainable funding.

Other examples being considered for funding include the DARE program, training a crisis response team, lock boxes, and drug prescription drop boxes. Additionally, educational opportunities for trauma-informed training, safe opioid prescribing education, and public service announcements on destigmatizing mental health are also being considered.

The allocation of funds will be decided during the county’s annual budget process.

On Tuesday, commissioners vote to adopt the plan as presented, allowing the stakeholder group to move forward with finding the most needed initiatives and how much funding to spend on each.

There will be a separate vote on the exact initiatives at a later date, according to a county spokesperson.

New Hanover County received its first payment of $716,866 on May 31 and a second round of $1.5 million is expected to arrive in the coming weeks from the $26 billion nationwide settlement against major pharmaceutical manufacturers. Cardinal, McKesson and AmerisourceBergen for their role in creating and fueling the opioid crisis, used for treatment during the opioid epidemic. More than 3,000 lawsuits from nearly every state were combined into multidistrict litigation, which concluded in July 2021.

The funds are distributed to all 50 states and North Carolina will receive nearly $750 million. New Hanover County — one of the most populous — received the sixth-largest settlement amount among the 100 counties and 47 municipalities awarded.

He will receive $18.7 million over 18 years, including $8.5 million in the first five years. Another $1.2 million is planned for 2023 and $1.5 million will be awarded in 2024 and 2025.

The remaining funds will be distributed to New Hanover each year in increments of approximately $800,000 to $1.1 million until 2038.

Attorney General Josh Stein, who led the nationwide lawsuit charge, told county and city officials during a visit to Coastal Horizons in May that the structure deliberately charged the funds over the first five years to launch initiatives. The rest will be spread out to make sure the money doesn’t dry up to maintain the programs.

County Executive Chris Coudriet served as a member of the North Carolina Association of County Commissioners’ Opioid Regulation Task Force. Members helped form the settlement fund distribution model to ensure that local governments received the bulk of the share.

Stein said his goal is to put the majority of spending decisions in the hands of local communities. He said they could determine the needs of their residents in the most appropriate way.

The City of Wilmington will receive $769,823, Brunswick County will receive $13.6 million, and Pender County’s share is $2.4 million.


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Pharmacists praise Buhari for signing PCN law

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The Community Pharmacists Association of Nigeria has applauded President Muhammadu Buhari’s recent signing of the Pharmacy Council of Nigeria (PCN) Act 2022.

The organization believes that this long-awaited bill will improve the board’s regulatory framework and allow for better oversight of pharmacy operations and practices across the country.

However, the organization continues to advocate for the correct use of Nigeria’s national drug distribution guidelines to improve the security of the country’s drug supply.

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The recent signing of the Pharmacy Board of Nigeria Amended Act, 2022 has been received with approval in many quarters.

The act now extends the powers and duties of the Board to inspect, approve, license and regulate the registration and practice of pharmacy across the country.

The national chairman of the community pharmacists association, Adewale Oladigbolu, said he believed the development would contribute to Nigeria’s drive to regulate all players involved in the pharmaceutical supply chain.

One of the major challenges facing the pharmaceutical sector and healthcare delivery system in Nigeria is the uncoordinated drug distribution system which is not in line with the proper management of drug supply stipulated by the drug policy national.

Nigeria is still grappling with drug abuse and abuse, with over six thousand five hundred registered members of the ACPN alongside several other drug regulatory and control agencies,

This indicates that this threat is far from over.

The task now is to ensure the proper implementation of the national drug distribution guidelines, which should improve the order of the drug distribution system to provide the necessary checks and balances in the country chain and reduce the threat current drug.

The Pharmacists Council of Nigeria was established in 1992.

President Buhari has recently signed eight bills into law including the Pharmacy Board of Nigeria, Council Practitioners Council of Nigeria, 2022, Civil Aviation Act and Meteorological Agency (Establishment) Act, 2022, among others.

Check salary, essential qualifications and other details here

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HPPSC Recruitment 2022: Check Salary, Essential Qualifications and Other Details Here

HPPSC Recruitment 2022: The Himachal Pradesh Public Service Commission (HPPSC) has invited online applications from willing and eligible candidates for the recruitment of 03 pending positions of former non-reserved servicemen of HP of Drug Inspector, Class-II (Gazetted ) on contract basis in salary range of Rs. 10300 -34800 + 4200 GP

Wishing/eligible candidates should apply online through the official website of the Commission http://www.hppsc.hp.gov.in/hppsc. Applications received by any other mode will not be accepted and will be immediately rejected. The closing date for applications and fees is 09/29/2022, 11:59 p.m.

Check the details of the HPPSC recruitment 2022 below:

Job Name: Medication Inspector

Number of vacancies: 03

Department name: Health safety and regulations

Number of posts per category: Unqualified (HP Veterans)3 (Backlog)

Essential Qualification for HPPSC Recruitment 2022

Bachelor’s degree in Pharmacy or Pharmaceutical Chemistry or Post-Graduate Diploma in Chemistry with Pharmacy as a core subject from a legally established university in India or its equivalent qualification recognized and notified by the Central Government for this purpose or the Associate of Institution of Chemists (India) obtained by passing the exam with “Analysis of Drugs and Pharmaceuticals” as one of the subjects. Or Bachelor of Science or Graduate Diploma in Medicine from a university recognized for this purpose by the appointing authority and having completed postgraduate training of at least one year in a laboratory under

(i) a government analyst appointed under the Act, or

(ii) an examining chemist, or

(iii) the head of an institution specifically approved for this purpose by the appointing authority; Provided that only such inspectors:

(iv) who have at least 18 months of experience in the manufacture of at least one of the substances specified in Annex C;

WHERE

(v) who have at least 18 months of experience in the analysis of at least one of the substances specified in Annex C in a laboratory approved for this purpose by the Licensing Authority;

WHERE

(vi) who have acquired at least three years’ experience in inspecting a company manufacturing any of the substances specified in Schedule C annexed to these rules during the period of their service as inspectors of drugs will be allowed to inspect the manufacture of the substances listed in Annex – C.

Desired degree:

Knowledge of the customs, manners and dialects of Himachal Pradesh and ability to be appointed under the particular conditions prevailing in Pradesh

Salary for HPPSC Recruitment 2022

Rs.10300 – 34800+ (GP 4200)

Age Limit for HPPSC Recruitment 2022

The age limit for this position is between 18 and 45 years old. The age of a candidate is counted at 01.01.2022.

How to Apply for HPPSC Recruitment 2022

Wishing/eligible candidates should apply online through the official website of the Commission http://www.hppsc.hp.gov.in/hppsc. Applications received by any other mode will not be accepted and will be immediately rejected.

Applicants should exercise caution when entering their mobile phone numbers and email ids into Online Recruitment Applications (ORAs) for immediate notification regarding their application.

For detailed information about this position, applicants should go to the official notification.

The closing date for applications and fees is 09/29/2022, 11:59 p.m.

To read the official notification, click here

Disclaimer: The recruitment information provided above is for informational purposes only. We do not provide any recruitment guarantees. Recruitment should be conducted in accordance with the official recruitment process of the company or organization that advertised the recruitment position. We do not charge any fees for providing this employment information. Neither the author nor Studycafe and its affiliates accept any responsibility for any loss or damage of any kind arising from any information contained in this article or for any actions taken based on it.

Two-day Defense Seminar at Himachal Pradesh University : The Tribune India

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A two-day national seminar titled “India’s National Security: Military Challenges, Management and Response” was inaugurated on Friday at the Department of Defense and Strategic Studies, University of Himachal Pradesh (HPU). The keynote speaker at the ICSSR-sponsored seminar was SS Lieutenant General Mahal, who is the Chief GOC of India’s Military Training Command in Shimla. He referred to the superior organization of defense and the general decision-making body of the armed forces. The inaugural session was graced by Dr. Nagesh Thakur, Member of the Executive Council of the National Assessment and Accreditation Council. More than 120 participants, including academic researchers from different universities and colleges across the country, attended the seminar.

Quiz competition from September 2

The sixth phase of “Janbhagidari Se Sushashan-Himachal Ka Mahaquiz” was inaugurated by the Minister of Forests, Youth Services and Sports, Rakesh Pathania on Friday. It will continue until September 15. The Mahaquiz was launched by Chief Minister Jai Ram Thakur on National Technology Day on May 11. To participate in the competition, aspirants can register on the MyGov Himachal portal.

Discussion on the new education policy

A ‘Student Dialogue’ on National Education Policy was held at Rajiv Gandhi Government College, Chaura Maidan, Shimla. About 800 students participated in the event. The Minister of Urban Development, Suresh Bhardwaj, was the guest of honor on this occasion. Bhardwaj said the national education policy was prepared after extensive and in-depth discussions with scholars, educators, researchers and teachers. Professor DD Sharma, Vice Chancellor of Sardar Patel University, Mandi, said the policy was aimed at meeting the aspirations of young people for employment.

HPPSC will organize personality tests

The Himachal Pradesh Public Service Commission (HPPSC) has decided to organize a personality test for various positions in different departments/corporations in the state on September 22-23. The test for Assistant Professor (Commercial Arts), Assistant Professor (JMC) and Assistant Officer (Legal Executive Trainee) will take place on September 22. The examinations for assistant professor (pharmacognosy) and assistant professor (pharmacy) will take place on September 22 and 23. The letter of appeal to all admitted candidates will be uploaded on the commission’s website.

Experimental drug shows promise for autism-related syndromes | Spectrum

Frequency reduction: Children with severe forms of epilepsy who took an oral solution containing soticlestat showed a reduction of around 30% in the frequency of seizures.
rudi_suardi / iStock

An experimental drug called soticlestat decreases seizures in children with rare and severe forms of epilepsy linked to autism, a new study find.

Dravet syndrome accounts for 3-8% of all children who experience seizures in the first year of life, and Lennox-Gastaut syndrome is responsible for approximately 4% of all children. epilepsy. Both syndromes are resistant to treatment with conventional antiepileptic drugs, so scientists have explored drugs that use new mechanisms of action, such as Epidiolexwhich is based on a compound in marijuana.

Soticlestat inhibits an enzyme called cholesterol 24-hydroxylase (also called CH24H or CYP46A1), which metabolizes cholesterol in the brain.

The brain contains almost a quarter of the body’s total cholesterol, which is essential for many brain cell functions, such as the electrical behavior of cells and the release of neurotransmitters. Preclinical tests in a strain of mice prone to seizure-related death suggest that the drug lowers levels of glutamate, an excitatory neurotransmitter, decreases neuron excitability, and reduces premature death – all of which are linked to seizures.

“To our knowledge, there is no anti-epileptic drug, marketed or tested in epilepsy, with a similar mechanism of action,” says study investigator Mahnaz Asgharnejad, vice president and program manager. worldwide at Takeda Pharmaceutical Company in Cambridge, Massachusetts. , which is developing soticlestat as a potential treatment for Dravet and Lennox-Gastaut syndromes.

Still, the results “should be considered preliminary” and the data are too limited to determine how soticlestat compares to other drugs, says Emilio Perucca, clinical professor of medicine at Austin Health at the University of Melbourne in Australia, who did not take part in this study. “Larger clinical trials are needed to better understand the efficacy and safety of soticlestat.”

Still, its apparent efficacy and the way it was tolerated “are attractive features,” says Perucca. “This is important because in these patients, new treatments often impose a heavy burden of adverse effects that can worsen quality of life despite a reduction in seizure frequency.”

JThe new trial, called ELEKTRA, involved 126 children with Dravet syndrome or Lennox-Gastaut syndrome, aged 2 to 17, at 35 sites in Australia, Canada, China, Israel, Poland, Portugal, Spain and the United States. The researchers gave soticlestat by mouth twice a day for 20 weeks to 24 Dravet children and 42 Lennox-Gastaut children, and a placebo to 22 Dravet children and 38 Lennox-Gastaut children. All the children were taking at least one other anti-epileptic drug, 69% taking at least three.

During the first eight weeks of the trial, the researchers optimized the dose for each child, while during the last 12 weeks they maintained the optimized dose level. The children and their parents or guardians noted the number and type of seizures the children had each day.

Overall, children who took soticlestat showed about a 30% decrease in seizure frequency over the 12-week maintenance period compared to those who took the placebo. Children with Dravet syndrome saw a 50% drop, while those with Lennox-Gastaut saw a drop of around 17%. The findings were published in Epilepsy in July.

Only two children receiving soticlestat experienced serious adverse events deemed drug-related — one had slurred speech and seizures, and the other had septic shock — ruler Asgharnejad at say Takeda is “optimistic” about the safety profile. “We also believe that soticlestat, due to its novel mechanism of action, may complement the effectiveness of other anti-epileptic drugs,” she says.

Based on these results, Takeda launched two Phase 3 studies, one for each syndrome, Asgharnejad says. The company aims to submit its data to the U.S. Food and Drug Administration in fiscal year 2024, it says.

Soticlestat blocks the conversion of cholesterol into a compound known as 24S-hydroxycholesterol. As a result, scientists found a decrease in 24S-hydroxycholesterol levels in all children who received the drug, whether or not it lowered their seizure rate. Future studies should explore why some children might not benefit from soticlestat even though it appears to be doing what it should, Perucca says.

Given that Dravet and Lennox-Gastaut syndromes arise from different causes, with Dravet syndrome resulting from variants of the SCN1A gene, and Lennox-Gastaut syndrome resulting from many factors, “I’m a little surprised that this drug seems to be effective in both conditions, regardless of the underlying disease mechanisms,” explains Yang-Yangassistant professor of medicinal chemistry and molecular pharmacology at Purdue University in West Lafayette, Indiana, who was not involved in this study.

Further research could reveal genetic differences between those who responded and those who did not respond to the drug, Yang says. This could shed light on which children are most likely to benefit from the drug, he says.

Future research should also “explore how drugs used concurrently might impact the effects of soticlestat, and vice versa,” Perucca says. For example, children taking the antiepileptic drug perampanel “were excluded from the soticlestat study because researchers were concerned about a potential interaction between these drugs on glutamatergic pathways. I would be interested to know more about this.

Cite this article: https://doi.org/10.53053/AUQQ1739

HPPSC Assistant Professor Interview Call Letter 2022 To Release Soon @hppsc.hp.gov.in, Check Schedule

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Himachal Pradesh PSC will soon publish Personality Test Admission Card for Assistant Professor position on its official website – hppsc.hp.gov.in. Download the PDF here.

HPPSC Assistant Professor Interview Call Letter 2022

HPPSC Assistant Professor Interview Call Letter 2022

HPPSC Assistant Professor Interview Call Letter/Schedule 2022 Update: The Himachal Pradesh Public Service Commission (HPPSC) will soon publish the Admission Card for the Personality Test for the post of Assistant Professor on its official website. The Commission is to conduct the interview for the assistant professor from September 22.

Qualified candidates for the personality test interview series for assistant professor positions in the various departments/corporations can download the HPPSC assistant professor interview call letter/2022 schedule update from the website official-hppsc.hp.gov.in.

You can download the HPPSC Assistant Professor Interview Call Letter / 2022 Schedule Update directly from the link below.

Direct link to download: Call Letter for Assistant Professor HPPSC Interview / 2022 Schedule Update

In accordance with the brief notice published, HPPSC will conduct the personality test for the position of Assistant Professor (Commercial Arts) and Adjunct Professor (JMC) under the Department of Higher Education on September 22, 2022.

The interview for Assistant Officer (Executive Trainee-Law) within the framework of the HPPCL department will also take place on September 22, 2022. The interview for Assistant Professor (Pharmacognosy) within the framework of the Technical Education department will take place on September 22 and 23, 2022 Interview for Assistant Professor (Pharmaceutical) under the Department of Technical Education will be held on September 22 and 23, 2022.

Qualified candidates for the round of interviews for the above positions should note that the Commission will shortly post the interview call letter along with the “Instructions for Personality Test Candidates” on its official website.

You can download the HPPSC Assistant Professor Interview Call Letter 2022 Update from the official website after following the steps below.

How to download: HPPSC Assistant Professor Interview Call Letter / 2022 Schedule Update

  1. Visit the official website of HPPSC-hppsc.hp.gov.in.
  2. Access the WHAT’S NEW section available on the home page.
  3. Click on the link – Press Note – Regarding the Personality Testing Schedule of various posts on the homepage.
  4. A new window will open where you will get the PDF of the HPPSC Interview Admission Card / 2022 Schedule Update.
  5. Download and save it for your future reference.

Karnataka D Pharmacy Result 2022 Out; Direct link here

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Karnataka D Pharmacy result 2022 released

Image credit: Shutterstock

Karnataka D Pharmacy Result 2022: The Drug Control Department Board has released the Karnataka D Pharmacy Result 2022 today, September 1st. Applicants can now check and download their freshman results in online mode through the official website – beadpharmacy.org. Applicants will be required to enter their registration number to download the Karnataka D Pharmacy Result 2022 dashboard.

Karnataka D Pharmacy Result 2022 Direct Link





Karnataka D Pharmacy Result 2022: Steps to Check Result

  • Visit the official website – beadpharmacy.org.
  • Click on the results link on the home page.
  • Now enter login credentials such as registration number.
  • Pharmacy Karnataka D 2022 result will be displayed on the screen.
  • Download the scorecard and print it for future reference.

The Board of Examining Authority (BEA) arranges admission for the two-year Pharmacy D course in Karnataka. Pharmacy D course subjects include Pharmacy, Pharmaceutical Chemistry, Pharmacognosy, Biochemistry and Clinical Pathology, Human Anatomy and Physiology, Health Education and Community Pharmacy, Pharmacology and Toxicology, pharmaceutical jurisprudence, pharmacy and business management, and hospital and clinical pharmacy.

Candidates who have passed their upper secondary examination in the science stream and scored a minimum of 45% marks are eligible for the Pharmacy Course Karnataka D.

Pharmacists can prepare to play a growing role in holistic health and wellness efforts

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In an interview with Pharmacy hours At the National Association of Chain Drug Stores (NACDS) 2022 Total Store Expo, Rina Shah, PharmD, Group Vice President of Future Pharmacy and Healthcare Segment Strategy at Walgreen Co., discussed the growing role of pharmacists in promoting holistic health and wellness for patients.

Q: Health equity has become a major priority for healthcare in recent years. What role does pharmacy play in improving health equity?

Rina Shah, Doctor of Pharmacy: Yes, I think it’s something that even before health equity was the word everywhere, pharmacy has had a role in health equity since the dawn of time. Pharmacies, and specifically Walgreens, are within 80% of the 5 miles of patients who live across the country. And when you look at all pharmacies, pharmacies are located within 5 miles for 90% of the US population. So when we think about access to care, many of the communities we serve within the pharmacy are truly the first point of contact for patients looking not only for their pharmacy needs, but even just to find out where they want go for help. ? Should I see the doctor, take an OTC recommendation?

So it’s something we’ve been doing since the beginning, but over the last two years it’s definitely skyrocketed. You know, we’ve been able to expand vaccination services and testing services in areas that we know require increased access to care in a different capacity than we had in the past.

Q: How does pharmacists’ position as the most accessible healthcare providers enable them to help patients make lifestyle changes, such as improving their diet or improving their fitness levels?

Rina Shah, Doctor of Pharmacy: Yes, you know, at least at Walgreens we look at things around 3 specific pillars. The first is prevention, and so around prevention, we educate our patients about vaccinations, vitamins, making sure everyone stays healthy and gets screened, making sure they understand how they have access to these types of services and why it is important. And it’s not just on the prevention side, it’s also on the treatment side. So if something happens, make sure we understand, and that our patients and customers know what they can do about the treatment. It can be over-the-counter products or things that are behind the counter. And then there is the management. So, a key thing is in someone with diabetes, it is important that they get an A1c test every two months just to make sure they are managing their diabetes. We spend a lot of time training our pharmacists and technicians so that they can talk to their customers about the tools and resources available to them. And it’s not just on the testing side, but it’s nutrition and making sure there are healthy choices and what they can do, just, you know, take action and s ensure they lead the health care lives we need, so they can stay healthy. So that was great to see. we have about 15-20 stores in Chicago, where we are testing different ideas to help increase access, especially in underserved communities. And so we call them our incubator sites. And so we test different pilots and ideas and see what sticks and based on what sticks we go ahead and launch it nationally.

Q: What potential policies are being discussed or have been adopted to improve health and well-being?

Rina Shah, Doctor of Pharmacy: You know, it’s really critical. We learned during the pandemic that when you expand the scope of practice to allow pharmacists to use their full license and you also have a method of reimbursement so that our pharmacists and pharmacy technicians can be paid for that, the sky is the limit. We’ve seen vaccination rates and testing, access to testing services specifically in underserved communities increase and we’ve been able to see an impact because of that. So from a policy perspective, we’re really taking what we’ve learned from the pandemic and expanding it. And so there’s a bill at the federal level that we’ve submitted – HR 7213, for those who may not be as familiar with it – but in fact it’s meant to broaden the scope so that our pharmacists can continue on this path to increasing access to care, especially in underserved communities. And then working at the state level so that at the state level we can also enable different capabilities – maybe flu testing and treatment, exposure to PrEP and PEP against the HIV, working with providers in the community, so we can scale up what our providers and nurses are doing, and then leverage our pharmacists to help supplement what’s happening.

Q: How do health and wellness needs and goals vary from community to community?

Rina Shah, Doctor of Pharmacy: Ultimately, health care is local. So, you know, it’s important that we have broad goals, but really what’s needed in Chicago is very different from what might be needed in a Texas suburb or Atlanta. And that’s where it’s really important that we leverage data and actionable data in the right way. And so, we’ve partnered with the CDC and other entities to take localized information to customize our programs to meet community needs. And so, we have targets, again, overall we know we want specific vaccination rates, we want to make sure patients are adherent 90% of the time, but how we can get there really depends on what is needed in that local community.

Q: How can policies and efforts be shaped to meet these different needs?

Rina Shah, Doctor of Pharmacy: You know, the infrastructure is what really needs to be tweaked. And so if we’re able to expand access to care by expanding the scope and making sure there are reimbursable services that our teams can provide, then there’s flexibility in the system so that meets the needs of local health care, or the needs of the communities we serve. And so really, at the federal and state level, if we can keep it as broad as possible, it just allows for a lot more autonomy and what’s needed locally at the end of the day.

Q: Where do you see the role of pharmacists in the future when it comes to health and wellness efforts?

Rina Shah, Doctor of Pharmacy: Yes, I’m very excited about what the future of pharmacy can look like, especially the impact we’ve had in underserved communities. What this has shown is that there is a need, that there are health care deserts all over the country, that there are patients who do not have access to care. And our pharmacists, our pharmacies, are well placed to be able to serve that. But there are many things that have to happen. We’re transforming the model right now. You know, it’s important that we mitigate and take a lot of the work that’s done in the pharmacy right now and automate that, digitize it, being able to leverage technology. And so, at Walgreens, we’re spending a lot and investing so that we can really make it a lot more efficient for our teams, so that our pharmacists and our team members can then pivot and focus on those additional care services. And so, I’m excited over the next 18 months, a lot of things are going to change. You know, we’re looking to radically change that model so that we can deliver services and help our patients in a different way than we did before.

Q: This all seems to be part of a larger trend towards holistic health for the individual patient. How does this expanded focus change the roles of pharmacists?

Rina Shah, Doctor of Pharmacy: Yes, you know, we already play a vital role in ensuring that patients adhere to therapy. But we know that, for example, if someone is diabetic, or someone has just been diagnosed with HIV, it’s much more comprehensive in what we have to provide. So for diabetes, nutrition, health, being able to connect with the provider, offering testing services, identifying gaps in care, you know, making sure patients know they need to be screened for eyesight and a foot exam. These are aspects that we are working on, so that our pharmacists can play this navigational role, where they themselves may not be the expert, but they can direct patients to the appropriate resource. Hence our investment and partnerships with Village Medical and to ensure we have primary care in our locations we have an app called Find Care so that if our pharmacists identify a gap they are able to guide the patient to through online resources that can help them manage their conditions, right down to the point of that individual prescription, really looking at it holistically so that we’re helping that patient end to end.

Q: Is there anything you would like to add?

Rina Shah, Doctor of Pharmacy: You know, I just think our pharmacists, and all pharmacists in general, are just amazing public servants, and what’s been accomplished during the pandemic has been absolutely amazing. And so just a big thank you to all of our pharmacy teams for what they do every day to serve their communities. And I’m really looking forward to seeing what the sequel will look like so that we can continue to improve the experience not just for our team members, but ultimately for our patients.

Top 10 Pharmacy Schools in Andhra Pradesh (NIRF Ranking 2022)

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High 10 Pharmacy Schools in Andhra Pradesh in 2022 by the National Institutional Ranking Framework (NIRF) have been listed in the following article. Most of the times, applicants have no idea about colleges. They just get admitted to a random college and then lament the things that become too late to change. Hence, all aspiring students are advised to do their research on the top 10 colleges of pharmacy in Andhra Pradesh. Thereafter, it becomes easier for the students to continue their studies due to the quality of the college in which they study.

The NIRF publishes an annual ranking of all pharmacy colleges on its official website. In this article, we provide a table of Top 10 Pharmacy Schools in Andhra Pradesh based on the ranking provided by the NIRF in 2022. This will make it much easier for applicants to analyze the records of top colleges.

Top 10 Pharmacy Schools in Andhra Pradesh

College name Location of the College AIR Score
Gandhi institute of technology and management Visakhapatnam, Andhra Pradesh 49 46.66
Acharya Nagarjuna University College of Pharmaceutical Sciences Guntur, Andhra Pradesh 51 46.04
Shri Vishnu College of Pharmacy Bhimavaram, Andhra Pradesh 54 44.8
Sri Padmavathi Mahila Visvavidyalayam Tirupathi, Andhra Pradesh 66 43.05
Sri Venkateshwara College of Pharmacy Chittor, Andhra Pradesh 68 42.73
Raghavendra Institute of Pharmaceutical Education and Research Anantapur, Andhra Pradesh 71 41.86
Chalapathi Institute of Pharmaceutical Sciences Guntur, Andhra Pradesh 77 40.27
Sri Venkateswara University Tirupati, Andhra Pradesh 89 38.66
Nirmala College of Pharmacy Mangalagiri, Andhra Pradesh 100 37.69
Seven Hills College of Pharmacy Tirupati, Andhra Pradesh Not mentioned Not mentioned

* AIR – All India Ranking

List of Pharmacy Entrance Exams 2022

Top 10 Pharmacy Schools In Andhra Pradesh: Brief Information

To begin with, this section will provide basic information about the top 10 pharmacy schools in Andhra Pradesh ranked according to NIRF ranking list 2022.

1. Gandhi Institute of Technology and Management

Gandhi Institute of Technology and Management was established in 2008. In a short time, this college got a very good ranking. The college is also known as GITAM which is very popular among the students attending there. GITAM college is ranked the highest college of pharmacy in Andhra Pradesh according to the ranking list declared by the governing body of NIRF ranking in 2022.

The All India ranking given to the college is 49 with a score of 46.66 by NIRF in 2022. The courses offered by the colleges are listed below:

  • Bachelor of Pharmacy
  • Master in Pharmaceutical Pharmacy
  • Master of Pharmacy in Pharmaceutical Analysis
  • Master of Pharmacy in Pharmacology
  • Master of Pharmacy in Pharmaceutical Chemistry
  • Master of Pharmacy in Pharmaceutical Quality Assurance

2. Acharya Nagarjuna University College of Pharmaceutical Sciences

According to expert opinions, Acharya Nagarjuna University College of Pharmaceutical Sciences is one of the best platforms to study the field of Pharmacy in Andhra Pradesh. It was ranked best after GITAM college for pharmacy. According to NIRF Ranking in Colleges of Pharmacy, it has been awarded All India Rank of 51 and is the second best in Andhra State. Moreover, his score is 46.04 which is considered good. The program offered by the pharmacy is as follows:

  • Bachelor of Pharmacy (B.Pharm)
  • Master of Pharmacy in Pharmacology
  • Master of Pharmacy in Pharmaceutical Management as well as Regulatory Affairs
  • Mr Pharma. in industrial pharmacy
  • M.Pharm. in pharmaceutical analysis
  • M.Pharm. in pharmaceutical chemistry
  • M.Pharm. in pharmaceutical chemistry

3. Shri Vishnu College of Pharmacy

Shri Vishnu College was founded in 1997. It is also one of the good colleges to study pharmacy in Andhra Pradesh. The All India ranking provided by the NIRF in 2022 is also worth noting. The AIR of this college is 54 and has a score of 44.8. The courses offered are:

  • Master of Pharmacy (M.Pharm)
  • Doctor of Pharmacy (Pharm-D)
  • Bachelor of Pharmacy (B.Pharm) Programs in Pharmaceutical Chemistry
  • Pharmaceutical analysis
  • Pharmacology Pharmaceutical Quality Assurance.

4. Sri Padmavathi Mahila Visvavidyalayam

This university is also known as Sri Padmavati University. It was set up in 1983 in Tirupati, AP for female aspirants only. Funds are received by the UGC as well as the state government. This college is ranked 4th in Andhra Pradesh for Pharmacy. Also, the AIR of this college is 66 and a score of 43.05 was provided by the NIRF in 2022. The list below shows the pharmacy courses offered by the college:

  • B.Pharmacy in the field of pharmaceutical chemistry, pharmacology, pharmacy, pharmaceutical analysis, pharmacognosy.
  • Master in Pharmacy in the fields of Pharmaceutical Chemistry or Pharmacology.

5. Sri Venkateswara College of Pharmacy

Sri Venkateswara College of Pharmacy is an independent body and specifically the B.Pharmacy stream was started in 2007. This college is ranked 5th in the state of Andhra Pradesh for Pharmacy. According to the NIRF Rankings 2022, the All India ranking of this college is 68 with a score of 42.73. It offers the following courses:

  • M. PHARM (PHARMACEUTICAL ANALYSIS AND QA)
  • DOCTOR OF PHARMACY (PHARM.D)
  • PHARM.D programs (POST BACCALAUREATE).

6. Raghavendra Institute of Pharmaceutical Education and Research

Raghavendra Institute of Pharmaceutical Education and Research is abbreviated as RIPER college. It is an autonomous body established by a group of pharmacy colleges in 2002. The state rank of this college is 6th. According to the 2022 NIRF rankings, the college’s AIR is 71 with a score of 41.86. The courses offered are:

  • Diploma in Pharmacy (D.Pharm.)
  • Bachelor of Pharmacy (B.Pharm.)
  • Doctor of Pharmacy (Pharm. D.) & Post Baccalaureate (Pharm. D – PB)
  • Master of Pharmacy (M.Pharm.)
  • Doctor of Philosophy (Ph.D.)

7. Chalapathi Institute of Pharmaceutical Sciences

Chalapathi Institute of Pharmaceutical Science, an autonomous body, is also one of the colleges sought after by pharmacy students. In Andhra Pradesh, it is ranked 7th but the AIR rank is 77 with a score of 40.27 by NIRF in 2022. The courses offered are:

  • B. Pharma
  • M.Pharma in Pharmacy, Pharmaceutical Analysis, Pharmacology, Regulatory Affairs
  • D.Pharma

8. Sri Venkateswara University

Sri Venkateswara University was established in 1954. This university is ranked 8th in Andhra Pradesh for pharmacy courses. According to the NIRF ranking, it is ranked 89 with a score of 38.66. The courses offered by the university are:

9. Nirmala College of Pharmacy

Nirmala College of Pharmacy is also one of the most sought after pharmacy colleges in AP. It was established in 2004. The NIRF ranking of this college is 100 with a score of 37.69 in 2022. The following courses are offered by the institution:

  • B. Pharma
  • Pharm.D
  • M.Pharm
  • Pharm.D (PB)
  • PhD
  • D.Pharma in the stream of pharmacy.

10. Seven Hills College of Pharmacy

Seven Hills College of Pharmacy was founded in 2007. Although NIRF did not provide any rankings to this college, but according to experts, this college is said to be one of the top 10 colleges in Andhra Pradesh for pharmacy. The courses offered by this college are:

  • Master of Pharmacy (M.Pharm) Pharmaceuticals
  • Master of Pharmacy (M.Pharm) Pharmacology
  • Master of Pharmacy (M.Pharm) Pharmaceutical Analysis
  • Pharm.D (Post Baccalaureate)
  • Doctor of Philosophy (PhD.) Pharmaceutical Sciences
  • Doctor of Pharmacy (Pharm-D)
  • Bachelor of Pharmacy (B.Pharm).

Top 10 Pharmacy Schools In Andhra Pradesh – Important Links

About NIRF:

The NIRF was established in 2014-2015 by a 16-member committee appointed by the Ministry of Education. This committee is the sole government authority responsible for ranking colleges and universities nationwide. Therefore, as a government agency, it can be trusted completely.

Rating Settings

There are five parameters for classification by NIRF. They are the following:

NIRF classification parameters

Overall, the NIRF is a reliable constitutional body. The government collects and verifies the data. However, the task is very horrible many times.

Do NIRF releases rank every year?

Yes, NIRF publishes a ranking every year with the aim of improving the quality of education as well as internships provided by colleges.

Is the B.Pharma course easy to follow?

No, the B.Pharma course is not easy to follow. Students should have their concepts clear in previous classes.

Is the career in B.Pharma brilliant?

Yes, a career in B.Pharma is good enough. It also offers a lucrative career. The pharmaceutical industry is also believed to be in its growth years.

Brookings Registry | SDSU to Lead $1.5M BREATHE-SD Project

BROOKINGS – South Dakota State University is partnering with hospitals in Brookings, Huron and Madison to expand the public health and respiratory therapy workforce.

The Community Practice Innovation Center at SDSU’s College of Pharmacy and Allied Health Professions received a three-year federal grant of $1.545 million from the Health Resources and Services Administration.

The project aims to increase workforce awareness and provide educational opportunities through the recruitment, training and placement of respiratory therapists in rural South Dakota communities. Sharrel Pinto, an SDSU faculty member, is the director of BREATHE-SD – “Bringing Resources, Education, Outreach, Training, Holistic Care, and Empowerment to South Dakota.”

Pinto said the BREATHE-SD team plans to implement clinical rotations for SDSU respiratory students in Huron, Madison and Brookings, increase capacity for students in the SDSU respiratory program, hire additional staff for SDSU’s Respiratory Care program, set up scholarships for students seeking respiratory care. and public health, and launch an awareness campaign.

The state answers the call for the training program

When Huron Regional Medical Center program director Brooke Sydow approached SDSU about a potential partnership to deliver a respiratory training apprenticeship program to three independent rural hospitals, Pinto and her team at the Community Practice Innovation Center were immediately intrigued.

Pinto, who is also the department head of SDSU’s Department of Allied Health and Population, saw the potential for the department’s resources to use the grant to meet several additional needs.

The department is home to three divisions: Respiratory Care, Medical Laboratory Sciences, and Population Health, in addition to the Center for Community Practice Innovation.

“The fact that we have multiple programs and faculty from various health care disciplines makes it easier for us to work together,” Pinto said. “We have a very collaborative department, so when a funding opportunity like this arose, we brought our experts together around the table to put together a project that we are all extremely proud of.”

Lacy Patnoe, director of the respiratory care program at SDSU, said, “Hospitals in South Dakota are experiencing labor shortages among caregivers. Respiratory therapists are in high demand. This demand has been exacerbated by the COVID-19 pandemic, which has highlighted the need to increase the public health and respiratory therapy workforce.

Rural areas are particularly affected by labor shortages in these important areas of health, forcing many patients to travel long distances to receive the care they need. Patnoe said, “Currently, there are barriers to providing our rural partners with the opportunities needed to address the respiratory therapy workforce shortage.”

Hospitals belonging to Northern Plains Network

In rural communities like Huron, Brookings and Madison, health professionals are already working together to meet these needs.

Huron Regional Medical Center, Brookings Health System, and Madison Regional Health System are all members of the Northern Plains Health Network, which formed to provide greater opportunities for rural communities. The work done through BREATHE-SD will continue the work started by the network. Erick Larson, President and CEO of Huron Regional Medical Center, said, “We know quality health care brings tremendous value to our rural communities and we have partnered to help ensure that for years to come. come.

Through BREATHE-SD, the SDSU Respiratory Care Program will allow students to complete clinical rotations in Huron, Brookings, and Madison. Currently, the SDSU Respiratory Care program only offers its students the opportunity to complete clinical rotations at partner sites in Sioux Falls and Rapid City, but through this project, students will gain valuable experience in these rural communities, a said Pinto.

Sydow said, “Through this project, we will be able to provide students with not only the education and training needed for their program, but also an incredibly diverse experience across the spectrum of respiratory care, including emergency, in intensive care and in a traditional respiratory care facility. In turn, residents of these areas will also have access to the program.

Pinto added that another goal of the project is to recruit people from rural and underserved areas. “By expanding our respiratory care clinical sites into the rural parts of our state, we hope to recruit students from these communities and train them, so that after graduation they can return to serve these rural communities or d others across our state or country. ”

Project to increase accommodation capacity

Also thanks to BREATHE-SD, SDSU’s respiratory care program will increase its capacity by two thirds: from 24 students to 40.

To facilitate this, the program will also hire additional faculty to ensure that all students receive a quality education. Experienced faculty and hands-on training opportunities are just two of the factors that contribute to the program’s 100% placement rate for graduates, Patnoe said.

At the same time, the BREATHE-SD project will have a positive impact on public health across the state. “As with respiratory care, public health continues to face labor shortages,” Pinto said. “We have seen a need to train and educate advanced practice providers and other allied health professionals in public health, especially to meet the needs of those in rural and border states.”

SDSU’s Public Health program strives to meet this need, and Pinto is excited about how this grant can make students in public health and respiratory care programs feel less financially burdened.

“As a department head, two things keep me awake at night,” Pinto explained. “First, the ability to minimize the financial burden on our students, and second, improving access to education for students from rural communities. BREATHE-SD meets both of these elements.

Pinto explained that this project will offer students who are interested in both public health and respiratory care the opportunity to receive significant tuition assistance scholarships through this grant.

Awareness campaign also planned

Another major goal of the project is to increase awareness of respiratory therapy and other health professions so that future generations can view them as viable and important professions as they head to college. This awareness campaign will also focus on the prevention and management of COVID-19 and its long-term impacts.

“The BREATHE-SD project gives us a remarkable opportunity to demonstrate the value and impact of working in a rural setting,” Sydow said. Pinto, Sydow, Patnoe and the rest of the BREATHE-SD team are excited about what this means for the state of respiratory care, public health and other allied health professions in South Dakota, especially at the following the COVID-19 pandemic.

The first-ever pharmacy graduation exam will take place in November

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SHUBHANGI SHIFA

Ranchi, Aug 30: The Pharmacy Council of India is set to hold the first-ever National Eligibility Test (Diploma in Pharmacy Exit Examination) for state Pharmacy Council registration and sales license in the drug retail in November. The Pharmacy Council of India has notified the state government to take necessary action in this regard.

Speaking in this regard, Sachin Chaturvedi of Jharkhand State Pharmacy Council (JSPC) said, “The Pharmacy Council of India has made this examination compulsory by implementing the regulations in February this year. After passing this eligibility test, graduate students can become pharmacists.

“Only after passing this eligibility test will students be able to obtain registration with the Board of Pharmacy and a license to sell drugs at retail. At present, this is only after Upon graduation, students are registered with the board as pharmacists, and pharmacists are licensed to retail drugs.

When further asked whether current medical shop owners will also have to take the exam for certificate renewal, he said, “It is mandatory to have a pharmacist in every medical shop. If the traders themselves are pharmacists, then that’s fine. However, if they are not pharmacists themselves, they must hire one, if they do not already have one.

In particular, the eligibility test will be carried out twice a year. There will be no restriction on the number of attempts to take the exam. The exam will consist of three papers in which multiple-choice questions will be asked on pharmaceuticals, pharmacology, pharmacognosy, pharmaceutical chemistry, biochemistry, hospital and clinical pharmacy, pharmaceutical jurisprudence and pharmacy management.

The exam will be conducted in English. The exam for each of the tests will last three hours and a candidate will only be declared successful in this exam if he obtains a minimum of 50% of points in each test. The candidate will have to pass the examination of the three tests at the same time.

Pharmacists will then be issued a certificate of eligibility for registration and practice upon passing the eligibility test (Pharmacy Diploma Exit Examination). It will be mandatory to present this certificate of eligibility for registration with the Council of State. Also, this certificate must be presented for practices and pharmacies.

3-member panel to probe GNDU lab explosion : The Tribune India


Tribune press service

Amritsar, August 29

A departmental committee has been formed by the authorities of Guru Nanak Dev University (GNDU) to investigate the recent incident of an explosion that occurred in a chemical laboratory of the university. A student was seriously injured in the incident.

The three-member committee will consist of the head of the chemistry department, Dr. Sukhpreet Singh; senior chemistry teacher, Professor Kamaljeet Singh and a retired teacher, Manoj Kumar.

The HoD said: ‘The terms of reference include finding the cause of the incident and giving specific reasons behind the accident; to design a standard operating procedure for such experiments so that such cases can be avoided in the future and to make suggestions for greater student safety. The investigation report will be delivered within two or three days.

He said that contrary to previous reports, the lab was a medicinal chemistry research lab. “The raw material was used for research in medicinal chemistry and during the preparations the experiment became aggressive and an explosion was caused. The damage to the laboratory is minimal and we will assess the damage further during the investigation”, did he declare.

He also provided an update on the treatment and recovery of the student, who suffered serious eye injuries due to the blast. “Her left eye surgery has been done and the right eye surgery will be done. She is recovering,” he said.

Lukashenko discusses harvest campaign, agricultural groups and vaccines with Governor of Vitebsk Oblast

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MINSK, Aug. 29 (BelTA) — Belarusian President Alexander Lukashenko met with Chairman of the Executive Committee of Vitebsk Oblast Aleksandr Subbotin and discussed the progress of the harvest campaign, the work of integrated enterprises in agriculture and the the production of Belarusian vaccines, BelTA learned.

The progress of agricultural work in the region was on the agenda: the harvest campaign, the conservation of fodder and the sowing of winter rapeseed. Alexander Lukashenko said: “It turns out that you have to be the first to reap and the first to sow, even if you are the last to sow in the spring. That’s why you have to sow quickly: Vitebsk Oblast is after all a land of risky agriculture. With this in mind, it is necessary to quickly clear the fields after harvest and prepare them for sowing. How are you doing in this regard? »

Alexandre Subbotin

The work of integrated agribusiness structures was another important item on the agenda. The president still keeps an eye on it. “You and I rocked the one in Vitebsk back in the day after all. It seems that people realized that the inhabitants of Vitebsk Oblast did well. It is enough to inspire people to work without offending them,” he stressed.

Alexander Lukashenko went on to say: “Pharmacy, biotechnology and nanotechnology are another matter. Turns out we’ve set out to make our own vaccines. What is the development of our flagship company, BelVitunipharm?

According to the governor, the harvest continues vigorously in Vitebsk Oblast, many agricultural enterprises have already completed the harvest campaign and local end-of-harvest parties have been held in some places. Aleksandr Subbotin said, “We are now redeploying the machines to help the lagging agricultural businesses. This was decided at the oblast level and we are now actively monitoring it.

Aleksandr Subbotin did not come empty-handed to the Independence Palace: the governor brought a round loaf to the president in honor of harvesting 1 million tons of grain. Just over 89% of the cultivated area was harvested in Vitebsk Oblast. According to Aleksandr Subbotin, the region only harvested so much in 1976 and 2014. It was kind of a heroic act for the region.

The second victory of Vitebsk, about which the governor gladly informed the president and later informed the media, was the performance of the local team at the Salei Ice Hockey Cup. On August 28, the team from Vitebsk beat the team from Gomel and won the cup for the first time on record.

Speaking about the performance of agricultural industrial groups, Aleksandr Subbotin noted that they can feel the results of their work but the performance indicators could have been higher. “They are slightly behind on the goals they have set. Earnings are up and there are profits. Profit margins are increasing, but we are still underperforming a bit. That’s why the conversation has revolved around how these structures are supposed to evolve. If it is necessary to separate the dairy industry and the meat industry. The conversation was quite deep,” said the governor, referring to the details of the meeting with the head of state.

According to Aleksandr Subbotin, Vitebsk Oblast can become a kind of scientific and manufacturing hub for the production of various vaccines. For example, local universities have already enabled the creation of a pool of professors and lecturers, who are familiar with the particularities of these subjects. The BelVitunipharm company is already building a new factory to manufacture a vaccine against COVID-19. It will be a universal factory. In other words, he will also be able to manufacture any other vaccine.

The hub of our oncology program

By Dr Ajai Chari

It is with great pleasure that I write a nomination letter on behalf of Lisa Taylor for the 2022 Extraordinary Healer® Award. It has truly been a privilege to work closely with Lisa for over two years in the Multiple Myeloma Program at Mount Sinai, where Lisa is my clinic’s office nurse.

Lisa’s excellent knowledge, experience in oncology, exceptional judgment and interest in learning make her a truly exceptional clinician. Every time she sees a patient, she brings all of these skills to the bedside and I always know the patient is in good hands.

Its documentation and clinical evaluation (in myeloma, a complex interplay of symptoms, laboratory findings, imaging, and pathology) are exemplary. In the midst of a busy schedule, she is able to quickly identify an ill patient who requires further assessment and management. All of this is only possible because she is a seasoned clinician.

For example, recently one of our elderly patients called to complain about leaking stool. Lisa was the RN who took this call and she felt the story was concerning for the obstruction, so she discussed with me the possibility of getting x-rays to rule out an obstruction. I agreed with his concern and we found that his intestines were very distended with airborne fluid levels.

We had to send him to the emergency room. It should be noted that even the son of this patient, who is a doctor, did not think that the obstruction was part of the differential diagnosis. I think Lisa really saved this patient’s life with her history and sound judgment. Lisa’s interpersonal skills are equally exemplary. Her empathy, warmth, sense of humor, diligence, efficiency and dedication to patient care won over the entire program.

Our patients love it. I’ve lost count of the number of patients who say, “Lisa is amazing. She is always responsive and responds to me. Our administrative staff are always relieved when they know Lisa is available to answer their calls or patient questions, and countless patients call the program saying they only want to speak to her.

I recently had the privilege of participating in an oncology training effort with a mixed group of doctors and nurses. As we discussed the role of the RN in oncology, I realized that Lisa is truly the RN hub at the center of our practice, integrating patient care with caregivers, the infusion center, social work, nutrition, palliative care, mental health, consulting medicine and pharmacy. I can say without a doubt that Lisa is among the best AIs I have had the privilege of working with.

She is one of the brightest, most industrious and most compassionate people I have had the pleasure of knowing. She truly embodies an extraordinary healer.

For more information on cancer updates, research and education, be sure to sign up for CURE® newsletters here.

Minnesota man, 20, describes recovery from addiction – as experts warn of deadly effects of fentanyl

Twenty-year-old Isaac—we don’t use his last name—runs to save his life.

The Stillwater native uses physical training as part of his recovery from a three-year battle with Fentanyl.

“My first try with Fentanyl was when I was about eighteen,” Isaac recalls. “At the height of my addiction, I was spending about $250 a week on fentanyl pills. I remember taking at least five to six pills a day.

He says he’s been off fentanyl for five months now, after a friend connected him with Minnesota Adult and Teen Challenge, a faith-based recovery program.

” I had enough. At this point, I was already working my way through my fentanyl addiction,” says Isaac. “Somehow I just stopped using it, because I knew it was going to kill me.”

Isaac, 20, says he is grateful to be alive.

But others weren’t so lucky.

The latest figures from the Minnesota Department of Health show that in 2021, 834 people across the state died after using synthetic opioids, including fentanyl.

This is an increase of nearly 50% over the previous year.

“It kills people,” says Tom Truszinski, CEO of Minnesota Adult and Teen Challenge. “What is very evident is that the war on drugs is alive and very, very well.”

Truszinski – now drug-free – says that for 18 years he abused heroin, alcohol, PCP and other drugs.

He says he’s particularly worried about Fentanyl.

Truszinski says half of his 940 clients are recovering from the synthetic opioid.

“The truth is, a lot of these people are taking Fentanyl without even knowing it,” he says. “It comes counterfeit, thinking it’s Xanax or OxyContin, and it’s not, it’s actually pure Fentanyl.”

Law enforcement is also expressing concern.

Earlier this month, Minneapolis police said neighborhoods with the highest number of shooting calls also had the highest number of fentanyl pills recovered by officers.

“That tells me this is a very potent drug, and that’s something we need to be careful about,” says David Ferguson, a professor of medicinal chemistry at the University of Minnesota. “It’s a driving force and I think it creates crime, and something that we as citizens need to take very seriously.”

Ferguson says fentanyl causes a quick, euphoric high that wears off in just an hour or two, triggering withdrawal symptoms.

Even small amounts, he says, can be deadly.

“A sesame seed of Fentanyl could easily produce an overdose,” Ferguson notes.

He says there’s no way to know exactly what’s in these little pills – and they’re hugely addictive.

“Looking at Fentanyl, it’s about a hundred times stronger than morphine,” Ferguson says. “Tolerance develops and it develops quite rapidly in some individuals. So to get that same feeling, that same euphoria, or that same pain relief, you have to take a higher dose, and it just keeps getting worse.

Isaac remembers that feeling well when he was plagued by his addiction.

He thinks he overdosed at least once – passed out and woke up in hospital.

But the lure of the drug was strong.

“I remember committing crimes just to get it,” he says. “When I was in my Fentanyl addiction, you name it, I would. There’s not much I wouldn’t do for Fentanyl, honestly.

Minnesota Adult and Teen Challenge will not discuss details of Isaac’s recovery.

The program offers individual and group counseling and uses medication to help clients combat withdrawal symptoms and drug cravings.

Truszinski says Isaac’s story of staying drug-free should be an inspiration to others.

“For anyone using right now, it shows that there is hope, that there is an opportunity for people to recover,” he says. “That you can go from a hopeless drug addict to a hopeless drug addict.”

Isaac has seven months to complete the program.

When he’s finished, he thinks he might consider mentoring other young people and that he might pursue seminary studies.

Isaac also aims to become a graphic designer.

So far, he says, he has already found a powerful cure for his addiction.

“I would say there is hope,” says Isaac. “If you come off the streets, if that’s your situation, there are so many opportunities. I just encourage everyone to get help because there is a new way to live.

If you need help, it’s over there.

You can call the National Addiction and Mental Health Services Administration Helpline.

It is available 24 hours a day at 1-800-662-HELP.

More information is available here.

Diamondhead adds new businesses as development project continues

DIAMONDHEAD, Miss. (WLOX) – Diamondhead is only 10 years old, but it’s starting to act like a grown-up town in its own right. Business development is beginning to move in the direction envisioned by Mayor Nancy Depreo. “Our priority this year is to work on business development, to bring business ventures to Diamondhead,” she said.

And improving East Aloha Drive is one way to do that. The first phase is coming to an end with the paving of the new road which now has parallel parking. The second phase will include concrete sidewalks, decorative street lighting and crosswalks.

“Right now our budget is mostly based on rooftops — our landlords and property taxes,” Depreo said. “We are working very hard to increase sales tax revenue.”

Effort alone is already yielding results. A permit has been approved for a Taco Bell to be located. The Memorial Hospital Medical Clinic is now open and Petsense opened on Tuesday. Store manager Lacy Jarrell liked the idea of ​​moving here. “I thought it was going to be a fantastic idea because there’s nothing like it in this general area,” she said.

And the city’s development plans will help keep the commercial frenzy going. “We have great mom and pop type restaurants, and I really feel like a road would be more convenient to be able to get to those businesses.”

That’s enough to revive a business that started a few years ago. Love’s Pharmacy is planning its grand opening by September 1. “For this road here to be used so well, I think it’s going to be very good things for us,” said co-owner Amy Catherine Baggett.

But, for her, Diamondhead is more than a road. “We wanted to be able to give back to the community that has meant so much to us and poured out to us throughout our lives,” Baggett said. “And that’s where we wanted to make our home.”

The Aloha District is just one part of the city’s master plan which includes a downtown development and the Gateway project.

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With Indiana abortion ban soon to take effect, some Hoosiers push for better access to birth control – 89.3 WFPL News Louisville

Some Indiana lawmakers and health professionals continue to call for better access to birth control, less than a month before the state’s near-total ban on abortion takes effect.

After days of debate and testimony, state lawmakers passed Senate Bill 1 during the extraordinary session which ended earlier this month. This prohibits abortions in most caseswith exceptions only to save the life of the pregnant patient, if there are fatal fetal abnormalities, or in cases of rape or incest up to 10 weeks.

Democratic state Rep. Rita Fleming said increased access to birth control can help reduce the number of people seeking abortions. Since taking office in 2018, she has pushed for measures that would allow pharmacists to prescribe certain types of contraceptives, without prior approval from a healthcare provider.

“I think it’s very pro-life legislation,” said Fleming, a retired OB-GYN from Jeffersonville. “If you believe in trying to reduce abortions, this is a… very effective way to do it.”

More recently, Fleming has proposed an amendment to an expenditure bill during the special session. He won bipartisan support, but failed in the House by one vote, 48-49.

Current Indiana law prohibits pharmacists from prescribing contraceptives. Instead, Hoosiers must first obtain a prescription from their provider.

Fleming’s amendment would have reduced this step by allowing people to access birth control directly from a pharmacy.

It would have allowed pharmacists to prescribe hormonal birth control pills and patches to people 18 and older. Pharmacists would complete a training program, screen patients for medication safety, and refer them to a healthcare provider for a follow-up visit.

“Pharmacists are very well trained in this area and they have extensive knowledge of medications, side effects and contraindications,” Fleming said.

Nearly half of US states have already passed similar laws, according to the association Power to Decide.

But in Indiana’s Republican-controlled legislature, attempts to increase access through pharmacies gained little traction, with bills often failing to make it past committee stage.

Fleming is not the only lawmaker to have proposed the measure.

Republican Senator Sue Glick of LaGrange proposed a similar bill in the regular session earlier this year and an amendment to the abortion bill, which she authored, in the special session. Neither was heard.

Fleming said limited access to providers can make it difficult for people to get birth control under the current protocol, especially in rural parts of the state. She said a low-barrier pharmacy option might also be better for people with substance use disorders.

Power to Decide, which aims to reduce unintended pregnancies, reports that more than 428,000 low-income Indiana women live in counties with limited access to a health center that offers the full range of control options. births.

“It would be ideal if we had enough doctors and doctors’ offices were open evenings, weekends and holidays, because most women of childbearing age in this state work. And most of them have day jobs,” Fleming said.

Several lawmakers spoke out against Fleming’s latest amendment. They argued that while worth considering, the issue is complex and requires further discussion.

Republican State Rep. Brad Barrett of Richmond was among those who voted no.

“It’s a hot topic,” Barret told a hearing. “But I also think it involves a lot more than it first appears. I mean, there are scope of practice issues, there are accountability issues. When we scratched the surface about this before, it only revealed deeper issues.

Senator Glick said in a message to WFPL News that she expects legislation to increase access to birth control to be introduced again in the next session, which begins in January. She said she hoped it would pass, when there was more time for discussion.

Anti-abortion group Indiana Right To Life lobbied against allowing pharmacists to prescribe contraceptives in recent correspondence with lawmakers.

WFPL News obtained a statement the group sent to select Indiana Republicans ahead of the special session that outlined 11 positions, including opposition to over-the-counter birth control. The group wrote that birth control should only be dispensed after a patient has seen “a medical professional for individual counseling and an assessment of the risks and benefits of all forms of contraception.”

“The risks associated with birth control may be significant for some patients, depending on a variety of factors,” the statement read in part. “It’s important that a woman taking medication sees a doctor who knows the risks associated with it and who also has access to a patient’s medical records.”

The Indiana Right To Life statement also included concerns that President Joe Biden’s administration will “creatively redefine abortion drugs, clearly intended to induce abortions, as birth control.”

Indiana Right to Life did not respond to a WFPL News request for comment.

Veronica Vernon, an assistant professor of pharmacy practice at Butler University, said pharmacists are qualified to prescribe contraceptives. She said they are already responsible for keeping patients safe with other drugs.

“Your pharmacist makes sure that this prescription doesn’t interact with any other medications or even herbal supplements you’re taking,” she said. “We ask about over-the-counter medications you use, we ask about chronic conditions you may have.”

Vernon said that now that more states are restricting abortion, lawmakers need to step up their efforts to make sure people have other options, including birth control.

Indiana lawmakers have passed nothing to increase direct access to birth control. But they approved a measure at the special session to allow local health departments and other providers to receive grants to help people looking for contraceptives.

If people can’t access abortions, Vernon said they should have ways to reduce the need for them.

“Improving access to contraception has been shown to be effective in reducing abortion rates,” she said. “There are several other things we need to put in place…related to supporting women across the full spectrum of reproductive health care.

Vernon said the legislation “is just one piece of the puzzle, so to speak, but an incredibly important piece.”

Fermanagh School pupils delighted to collect A-Levels

Last Thursday (August 18), students across the district received their A-Level results, marking the start of the next chapter in their lives as they continue their studies in college, higher education, on the road. or at work.

Education Minister Michelle McIlveen congratulated A and AS level students who received their results following the first public exams since 2019 and the start of the pandemic.

The Minister acknowledged the significant challenges these young people have faced over the past three academic years, which she says makes their achievements all the more remarkable.

St. Joseph’s College

St. Joseph’s College A-level cohort celebrated an excellent set of A-level results, with a 95% pass rate and 86% of students earning three A*-C grades.

Principal Ms Palmer said: “We have seen some really positive results this year which I think reflects the resilience of our young men in the way they have come through the past two years.

“We are always grateful to their teachers, parents and guardians for keeping them motivated. The results they are achieving today are fantastic, and I am so proud of all of them!

“We wish our young men all the best as they enter the next chapter of their educational lives.”

Sainte-Fanchea College

Staff at St. Fanchea’s College are delighted with the results achieved by their post-16 students.

Principal Maurice Collins said: “Due to the Covid-19 pandemic over the past few years, students have gone through a very anxious and difficult time.

“The past school year has seen a return to some normality in education, following the reintroduction of the first public examinations since 2019.

“Despite the many challenges, we are confident that our students have reached their full potential through a range of A-Level courses and further BTEC Level 3 courses at AS and A2 levels.

“We wish all of our post-16 students continued success in their future courses or employment paths.”

Fivemiletown College

The Fivemiletown College Board and Staff have warmly congratulated all of their students in Years 13 and 14 for “another excellent set of AS and A2 level results”.

Principal Janice Allen said: “These results reflect the positive work ethic of students, the support of parents and the dedication of teaching and non-teaching staff.

“Our students have shown remarkable resilience in overcoming the challenges of the past two years, and we are delighted that all of our leavers have now secured their place beyond school, whether at university, college or the job market.

“We wish all of our leavers much success as they now embark on the next leg of their journey.”

Devenish College

Devenish College principal Simon Mowbray said the school was “once again delighted” to record a “very satisfying” set of results.

Mr. Mowbray noted: “Our students have worked extremely hard over the past two years and should be very proud of their dedication to their studies and their subsequent achievements.

“These results reflect the exceptional dedication, expertise and commitment of our staff as well as the strong support of their parents.

“These results are all the more significant, given the enormous difficulties that students have faced due to Covid-19.”

The college is also delighted with AS’s results which will ensure continued improvement next year.

St. Kevin’s College

Saying that after two years of hard work, St. Kevin’s students have “outdone themselves,” Principal Gary Kelly said, “A big shout out to all of the Grade 14 students; the hard work that students and teachers have put in to counter the effects of Covid -19 has paid off today.

“Level A results are as good or better than they were in previous years before Covid.”

Some 70% of students at Lisnaskea School achieved three A-level results, from A* to C, and 100% achieved two A-levels, from A* to E.

“St. Kevin’s College is proud of all of its students who have made outstanding efforts in their studies, as evidenced by these results,” Kelly said.

Mount Lourdes

Principal Sinead Cullen has praised Year 14 students at Mount Lourdes Grammar School for an “outstanding and impressive” set of A-level results.

She said: “The board, management team and staff are delighted and very proud of the success of our students.

“The students achieved outstanding results in all subjects, and I congratulate each student on their individual achievement.

“The results of our students are particularly commendable given the context of these exams, which are the first formal exams students have taken since the start of the Covid-19 pandemic.

“We wish all of our students continued success in their future studies and in the career path they have chosen.”

Southwestern College

South West College Acting Chief Executive Leo Murphy said the level of student achievement speaks to the high standard of teaching and learning that takes place at the college.

He continued: “All the students are to be congratulated as they have all worked extremely hard throughout the year, and I am delighted that all their hard work has paid off. We wish them every success in their studies and careers. future.

“More and more students are opting for the Extended Diploma courses, which are a three-level A-equivalent qualification that broadens and deepens knowledge in specialist professional areas such as business, construction, engineering, arts and sports, to name a few.”

Enniskillen Royal High School

Enniskillen Royal Grammar School principal Elizabeth Armstrong has praised her students for their A-level results, noting how they have shown “resilience and perseverance” throughout the pandemic.

She said: “We are absolutely delighted with the A-level results of the Class of 2022 who, with the support of their teachers and parents, have shown great resilience and perseverance throughout Covid-19 to produce a set of truly sparkling results.

“Overall, 54% of all A2 grades were A* or A and a third of all students had at least an A* in their portfolio – 28 students had three A grades or better.

“These excellent results now see our students taking courses as diverse as Actuarial Science and Medicinal Chemistry at QUB, International Relations at Royal Holloway, London and Environmental Geoscience at Glasgow.”

St. Michael’s College

The school community at St. Michael’s College was “absolutely delighted” with the results achieved by the A-Level students.

Manager Mark Henry said: “The post-16 boys have worked incredibly hard under very difficult circumstances over the past two years and these results are a testament to their resilience as well as their academic abilities.

“I am delighted that the vast majority of boys have been placed in their chosen course at university, with many securing places at some of the most prestigious universities in the UK and Ireland.

“We wish them all success in their studies.”

Erne Integrated College

There were smiles and celebrations as post-16 students at Erne Integrated College received their results last Thursday morning.

School Principal Jimmy Jackson-Ware said: “We are extremely proud of the achievement of all of our post-16 students.

“They have shown resilience and determination to succeed in the most difficult circumstances of the pandemic.

“A real strength of Erne Integrated College is the positive and respectful relationship between our students and our staff.

“They have worked together to reap this award. We wish the students happiness and fulfillment as they now take the next step in their educational journey.”

Castlederg High School

Headmistress Mrs Susan Wilson expressed her delight at the school’s excellent results at A level.

She said: ”We are absolutely delighted for our students. They’ve come a long way in the past three years and they’ve outdone themselves.

“I am immensely proud of their outstanding accomplishments and thrilled to see them on their way to their chosen career.

“I would also like to thank our highly dedicated staff, teaching and non-teaching, who have been instrumental in these great accomplishments.

“Their dedication over the past few years to supporting our students in every way possible has been inspirational.

“Immense credit also goes to the parents and guardians of all our students. We are indebted to them for their continued support of our school. It is indeed a great day for everyone involved.”

3D printing of starch for the development of personalized medicine

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3D printing makes it possible to produce personalized medicines adapted to each patient. Credit: UPV/EHU

Traditional methods produce drugs with specific parameters, but in many cases do not meet the individual needs of patients. In fact, conventional medications tend to be based on adult doses, so pediatric and elderly patients need age-appropriate doses. Additionally, some patient groups also require specific dosage form alternatives to facilitate oral drug delivery. In this regard, fast disintegrating tablets appear to be a good option because they dissolve the moment they are placed on the tongue. Another challenge that pharmaceutical companies face is the controlled release of the drug over time, especially when the drug is of the hydrophobic type (ie when dissolving in water causes problems).

In this context, “3D printing technology is an advanced technique for personalized medicine and the development of on-demand drug release tablets”, said Kizkitza González from the Materials + Technologies (GMT) group at UPV/ EHU. “The primary goal of this work was to produce 3D-printed starch-based tablets for the tailored delivery of hydrophobic drugs,” said the author of the paper published in the International Journal of Pharmacy.

3D printing is a technology that involves printing products layer by layer, in which materials are deposited according to the digital model designed by computer design software. By following a simple and fast methodology and thanks to 3D printing, “we were able to prepare tablets based on three types of starch – two types of corn starch (normal and waxy) and one type of potato – of different geometries and loaded with a non-soluble drug,” said Kizkitza González.

Corn and potato starch

“The material produced must be inserted into a syringe before printing. However, before that, it must be ensured that the material is going to be printable and that once printed, it will keep its shape. To do this, a rheological analysis detail has to be made”, explains the UPV/EHU researcher. All three types of starch showed suitable rheological properties, although in the case of potato starch the printing process proved to be more laborious in because of its properties.

Moreover, “we observed the importance of the botanical origin of starch in practically all properties, such as the porous microstructure, the formation of a stable network or the release of the drug. In the case of normal corn starch, the release of the drug is instantaneous and the drug is completely released in 10 minutes; in the case of waxy corn starch and potato starch, the release is more continuous and can take up to 6 hours for complete release. We were also able to demonstrate the importance of tablet geometry in drug release,” said Kizkitza González.

Finally, “tablets combining different types of starch have also been printed. In this case, the release takes place in two stages. For example, in the event of an infection, in a first step using normal cornstarch, a drug could be released immediately to relieve pain, and in a later step, with either of the other two types of starch, an antibiotic could be released more continuously,” said the UPV/EHU researcher.

Kizkitza González is aware that this work is only the first step in a long process, but she maintains that “the starch-based 3D-printed tablets they produced showed promising properties for future applications in ‘personalized drug delivery’.


Researchers create ingredients to produce food by 3D printing


More information:
Kizkitza González et al, 3D printing of personalized all-starch tablets with combined release kinetics, International Journal of Pharmacy (2022). DOI: 10.1016/j.ijpharm.2022.121872

Provided by University of the Basque Country


Quote: 3D Printing Starch for Personalized Medicine Development (2022, Aug 25) Retrieved Aug 25, 2022 from https://phys.org/news/2022-08-3d-starch-personalized-medicine.html

This document is subject to copyright. Except for fair use for purposes of private study or research, no part may be reproduced without written permission. The content is provided for information only.

Medivolve Announces Launch of Investor Outreach Campaign and Filing of Second Quarter 2022 Financial Statements

Medivolve Inc.

TORONTO, Aug. 24, 2022 (GLOBE NEWSWIRE) — Medivolve Inc. (“Medivolve“or the”Company” (NEO: MEDV; OTC: COPRF; FRA: 4NC) is pleased to announce the launch of an investor marketing campaign to raise awareness of the Company within the investment community. The Company also announces that it has amended and refiled its interim condensed consolidated financial statements (the “Finances Q2 2022”) and the corresponding management report (the “Q2 2022 MDA”) for the six-month period ended June 30, 2022.

Wallstreet Investors Club

Medivolve has entered into a services agreement with Lion Capital Investment Limited (“Lion“), under which Lion will provide marketing services under the trade name Wallstreet Investor Club for a period of six months for an amount of US$250,000. Lion is a marketing consultant based in the Cayman Islands. Lion has an exclusive partnership with Zemanta for content distribution and advertising platforms, which provides Lion with access to a multitude of other sites.Neither Lion nor any of its officers currently owns any securities, directly or indirectly, of the Company or n intend to acquire such securities.

Reclassified Q2 2022 financial statements and Q2 2022 management report

The Company has revised and refiled its Q2 2022 financial statements and its Q2 2022 MD&A. August 15, 2022, have been revised to correct: the date of the cash flow statements, which erroneously referred to the current and comparative periods presented as “December 31, 2022 and 2021” instead of “June 30, 2022 and 2021 » ; and the financial information presented in the statements of cash flows for the comparative period ended June 30, 2021, all of which were incorrect except for the net (loss) for the period. The Q2 2022 MD&A has been revised to correct comments related to the statements of cash flows, reflecting changes to the financial information for the comparative period of 2021 presented in the revised Q2 2022 financial statements, and an erroneous reference to “three months ended March 31, 2022”, which should refer to the “six months ended June 30, 2022”. The corrective disclosure was made at the request of the Ontario Securities Commission as part of a continuous disclosure review.

About Medivolve

Medivolve (NEO: MEDV; OTC: COPRF; FRA: 4NC) is a health technology company that seeks to reinvent America’s healthcare system by leveraging a bespoke telehealth platform, clinical diagnostic network and a data-driven AI framework to improve patient care. .

The Company was born out of the health crisis; to rethink, relearn, and ultimately reimagine a better way to make the healthcare system work. Our network of retail collection sites plays an important role in recovery by giving Americans access to fast, accurate, and inexpensive clinical services when and where they need them. These centers will also play a central role in diagnostic testing, vaccinations and other point-of-care services. We develop disruptive technologies to facilitate and accelerate the identification, treatment and prevention of medical problems. In doing so, we strive to give patients a holistic and empowered view of their personal health.

Our long-term mission is to solve the systemic problems of the country’s fragmented, overly complex and costly healthcare system. The next phase of growth for Medivolve is to pivot the model and put the pieces together to build a profitable health technology company. We are developing a unique and streamlined technology network to provide data-driven medical consultations, clinical diagnostics and prescription services. Our team is united by a powerful and singular purpose: to harness the transformative power of technology to create healthier lives.

Backed by a bespoke AI-powered platform, we’re building a system that constantly gets smarter, takes the guesswork out of diagnoses, and flags critical health issues to help doctors, delivering a high level of personalization for every patient. .

For any investment request, please contact: David Preiner, [email protected], 702-990-3737.

Caution Regarding Forward-Looking Information

This press release contains “forward-looking information” within the meaning of applicable Canadian securities laws. Forward-looking information includes, but is not limited to, statements regarding Lion’s commitment to investor relations services, the deployment and functionality of the company’s telehealth platform, and the company’s ability to integrate the Marbella Pharmacy into its business and expand its testing services beyond COVID-19. Generally, forward-looking information can be identified by the use of forward-looking terminology such as “plans”, “expects” or “does not expect”, “is planned”, “budget”, “expects”, “estimates”, “plans”, “intends”, “anticipates” or “does not anticipate”, or “believes”, or variations of these words and expressions or states that certain actions, events or results “may”, “could”, “would”, “could” or “will be taken”, “will occur” or “will be carried out”. Forward-looking information is subject to known and unknown risks, uncertainties and other factors that may cause the actual results, level of activity, performance or achievements of the Company, as applicable, are materially different from those expressed or implied. by such forward-looking information, including, but not limited to: uncertainties related to demand for a telehealth platform and pharmaceutical services; cash flow from operations may be insufficient to fund expected growth; risks inherent in the technology industry, including the emergence of disruptive technologies that may affect demand for the Company’s products and services; receipt of necessary approvals; general business, economic, competitive, political and social uncertainties; accidents, labor disputes and shortages and other health and medical related risks, as well as other risk factors discussed in the Company’s most recent Annual Information Form and MD&A, available at SEDAR at www.sedar.com. Although the Company has attempted to identify important factors that could cause actual results to differ materially from those contained in the forward-looking information, there may be other factors that cause results not to be those anticipated, estimated or expected. There can be no assurance that such information will prove to be accurate, as actual results and future events could differ materially from those anticipated in such statements. Accordingly, readers should not place undue reliance on forward-looking information. The Company does not undertake to update any forward-looking information except in accordance with applicable securities laws.

SOA’s new MoU with ICAR-CIFA is far-reaching. Here are the details – Edexlive

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Siksha ‘O’ Anusandhan (SOA) Deemed University on Wednesday August 24, signed a Memorandum of Understanding (MoU) with the Bhubaneswar-based ICAR-Central Institute of Freshwater Aquaculture (ICAR-CIFA) with the aim of facilitating the pursue academic study and research in a range of subjects.

Topics would include plant-based biomedicine, nanotechnology, marine and freshwater ecosystems, antimicrobial resistance, immunology, and translational medicine research.

The MoU was signed by Prof. Bibhuti Bhushan Pradhan, Pro-Vice Chancellor and Registrar of SOA, and Dr. Saroj Kumar Swain, Director, ICAR-CIFA at SOA.

Speaking on the occasion, SOA Registrar Prof. Pradhan said he believed the MoU would inspire a lot of teamwork and create synergies in the areas discussed.

Prof Bijay Kumar Sahoo, Dean, Institute of Agricultural Sciences; Prof Manas Kumar Mallick, Director, Institute of Technical Education and Research; Prof Sudam Chandra Si, Dean, School of Pharmaceutical Sciences; Prof. Goutam Rath, Department of Pharmacy; Pr Goutam Ghosh, Department of Pharmacognosy; Prof. Durga Madhav Kar, Department of Pharmacology; Dr. Biswakanth Kar, Department of Pharmacology; Dr. Vineet Kumar Rai, Department of Pharmacy; Prof. Santosh Kumar Swain and Dr. Debasmita Dubey from the Institute of Medical Sciences and SUM Hospital were present at the ceremony.
Dr Paramananda Das, Chief, Division of Fish Genetics and Biotechnology; Dr. Mrinal Samanta, Principal Scientist and other members of the management represented ICAR-CIFA.

ICAR-CIFA officials also appealed to SOA’s founding president, Professor (Dr) Manojranjan Nayak.

Marburg epidemic in Ghana forces African countries to remain vigilant

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Africa must strengthen its surveillance and detection infrastructure in light of an outbreak of the deadly Marburg virus in Ghana, public health officials have warned.

Last month, Ghana recorded its first-ever outbreak of Marburg after tests confirmed two men had died of the disease.

Ghana Health Service (GHS) Director General Patrick Kuma-Aboagye said the tests were carried out at the Noguchi Memorial Institute for Medical Research in Accra and corroborated by the Institut Pasteur in Dakar, Senegal.

On August 2, a World Health Organization (WHO) official said a child who contracted the disease also died, while a fourth case was also identified.

Kuma-Aboagye says community-based surveillance volunteers were deployed to help detect and report cases of the Marburg virus disease which had killed three people in the Ashanti region of Ghana.

GHS director of public health Franklin Asiedu-Bekoe told reporters that 98 people had been placed under strict surveillance and 39 had been released.

“Our approach is about containment. So what we do is we make sure we identify all the contacts by involving the members of the community who have better knowledge so that if the case were to occur, we detect and were managing,” he told a news conference in July.

This is the second time the zoonosis has been detected in West Africa. Guinea confirmed a single case in an outbreak declared over on September 16, 2021, five weeks after the initial case was detected.

Before Guinea, the disease had appeared in central and eastern Africa.

According to the WHO, Marburg is transmitted to humans by fruit bats and is spread among humans through direct contact with bodily fluids from infected people, surfaces and materials. It is a highly contagious viral hemorrhagic fever from the same family as the better known Ebola virus disease.

An outbreak of the disease in the Democratic Republic of Congo from 1998 to 2000 had a mortality rate of over 83%.

Emily Lebughe Nzimo, a doctor at the General Hospital in Kinshasa, Democratic Republic of Congo, witnessed Marburg’s death, especially in an underfunded environment. She says SciDev.Net that disease control measures must be implemented at borders.

Faced with the lack of approved treatment and vaccine, we must develop public health mechanisms. We need to strengthen passenger screening at the border.”


Emily Lebughe Nzimo, Doctor, Kinshasa General Hospital, DR Congo

Nzimo tells SciDev.Net that managing the outbreak in Congo was difficult, particularly because medicines and protective equipment for healthcare workers were limited.

“Congo was never prepared to deal with a generalized epidemic throughout the country,” she said. “So it’s really not a wish for an outbreak to get to the magnitude that we’ve had.”

Nzimo said the current outbreak in Marburg should be treated as a public health issue.

“Of the 154 cases of contamination (in DR Congo), there were 128 deaths. So even if it is a rare disease, Marburg must be considered a public health problem given its seriousness,” he said. she declared.

Nzimo says countries in sub-Saharan Africa need to collaborate and pool resources to fight the disease. She says lessons can be learned from DR Congo’s handling of the virus.

“Africa, Ghana and the DRC must collaborate on prevention. In countries where there is an epidemic, this is the best approach,” she said.

“The fact that DR Congo has a history with the disease can become an asset. Now that we know how the disease presents and what we have done to manage the disease, we can train other health workers in the area.

Ebola’s “big brother”

Titus Beyuo, Secretary General of the Ghana Medical Association (GMA), said SciDev.Net that the Ghana Health Services had acted appropriately to contain the situation.

“However, we must be aware that this is a disease that some have described as the older brother of Ebola,” he said. “It’s a disease that has a high mortality rate.”

Public health authorities in other countries have also sounded the alarm.

On August 14, news of a Marburg outbreak spread across Nigeria following a leaked memo from Abuja Teaching Hospital, titled Marburg disease: Nigeria prepares for possible outbreak. However, the university denies that the country has seen an outbreak of the disease.

The hospital’s public relations manager, Sani Suleiman, says SciDev.Net that there was no outbreak of Marburg virus disease in the hospital.

Suleiman said the memo was meant to be an internal memo sent to staff to remind them to take proactive measures in the event of an outbreak in Abuja or elsewhere in Nigeria.

“Unfortunately, one of our staff decided to send it to the general public, without attaching the precautionary measures we posted on our platform. The message was for proactive measures in the event of an epidemic in Nigeria, because Ghana has recently recorded cases of the disease.”

The communications officer at the Nigeria Center for Disease Control, Yahya Disu tells SciDev.Net that Nigeria has no cases of Marburg virus disease.
He said the country had stepped up
surveillance at the point of entry, in order to reduce the risk of importation from Ghana.

Disu says Nigeria can test for the virus.

“The National Reference Laboratory in Abuja and the Human and Zoonotic Virology Laboratory Center at Lagos University Teaching Hospital have the necessary equipment to test and identify the virus. We have the human, technical and laboratory capacity to identify and manage the disease, in case it finds its way to the country,” Disu explained.

Call to action

Solomon Woldetsadik, head of emergency response at the WHO Regional Office for Africa, said SciDev.Net that while the Ghanaian authorities reacted quickly, surveillance and detection systems need to be strengthened.

“Most countries are trying to strengthen surveillance, especially after Ebola,” he said. “There are efforts to identify and detect diseases like Marburg, but we’re not there yet.”

Woldetsadik said WHO will continue to work with countries in the region to help identify and contain diseases.

WHO Regional Director for Africa Matshidiso Moeti said: “Health authorities reacted quickly, getting a head start in preparing for a possible outbreak.
This is good because, without immediate and decisive action, Marburg can easily spiral out of control.”

Doctor and project manager for Amref Health Africa, a non-profit organization based in Kenya, said Kabinet Kourouma SciDev.Net that Ghana’s neighbors should implement border security measures, including screening at entry and exit points, tracking passengers to see if they develop symptoms, maintaining physical distancing and compliance with cough and sneeze etiquette.

“It is necessary to reinforce the measures at the different borders by controlling the temperature, by controlling the symptoms,” Kourouma said. “On the other hand, African countries in general and those in West Africa all have porous borders, we do not have full control of all our borders. Official ones or not. This is also a challenge .”

Constantin Bashengezi, pharmacognosy researcher and CEO of Creppat Laboratories in Kinshasa, DR Congo, tells SciDev.Net that since treatment and vaccines do not yet exist, existing drugs could be adopted into Marburg’s management.

He cited locally known antivirals: the Ebanga treatment approved in December 2020 to fight the Zaire Ebola virus and the Doubase C. antiviral developed by Creppat laboratories.

“We should extend the use of existing antiviral drugs to other types of viruses such as Marburg or Ebola,” he said.

Midwestern man pleads with Hobby Lobby Facebook group to ban his wife

Oh, it’s that time of year. The moment we start decorating our home for the next vacation in a row. Halloween, Thanksgiving and Christmas decorations abound.

For me and many others, Hobby Lobby is where it’s at. I like this store so much that I joined a Facebook group with others Hobby Lobby Fanatics. Everyone in the group shares great tips, tricks and tips for getting the most out of what I like to call, decorating season.

From time to time, someone will post fun stuff, related to Hobby Lobby decoration, in the fanatics group. A status posted last week cracked me up. Sounds like something my husband would do. He would try to beg the group admin to ban me so that I don’t send money to Hobby Lobby trying to bring FB decoration tips to life in our house.

Ohio man begs hilariously Fanatical Hobby Lobby Facebook group to ban his wife

Here’s what Curt Bolin had to say,

Dear admin, please block my wife from this group. Too many ideas leads to spending money, which leads to redecorating, which leads to me having to paint, which leads to an afternoon of choosing a color, which leads to spending more money in the hardware store/the lumber yard, which prevents me from being able to watch Football. Thank you for your help in this matter. Sincerely, all husbands everywhere.

The comments about her status were equally funny.

WATCH: Here are 25 ways to start saving money today

Whether it’s finding discounts or simple changes to your daily habits, these money-saving tips can come in handy whether you have a specific savings goal, want to save money, money for retirement or just want to earn a few pennies. It’s never too late to be more financially savvy. Read on to learn more about how you can start saving now. [From: 25 ways you could be saving money today]

WATCH: These are the 50 largest retailers in America

Why Windtree Therapeutics is trading higher by more than 60%, here are 61 stocks moving in Tuesday’s midday session

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Pamplin Media Group – Family and Emergency Medicine Practice Opens in Prineville

Bend practice expands to Prineville and will see patients from October 3

Prineville will soon have an independent emergency and family care practice.

Mountain Medical Family and Urgent Care will offer family medicine and urgent care and will be open to patients on October 3. They will be located at 198 NE Combs Flat Road. The facility will relocate to the former direct care clinic between Central Oregon Eyecare and Clinic Pharmacy.

Their firm has been discussing the possibility of opening an office in Prineville for some years. When Direct Care, located next to Clinic Pharmacy, closed and moved, they decided to take advantage of the opportunity.

“We saw the need for a community that didn’t have urgent care,” explained Tonya Busack, manager of the Mountain Medical Clinic. “We thought it would be a good place to try to open up and serve the locals there.”

She added that Mountain Medical is the last independent urgent care facility in central Oregon.

The clinic has another location in Bend, and they began practice there in 1986.

Busack is also a clinic partner and started working at Mountain Medical when he was 17 years old. She started at the front desk and worked her way up to become a certified X-ray technician and physician assistant. She also manages invoicing, human resources and electronic records.

“She is the lifeblood of our practice. It’s a remarkable story that she started answering the phone at the front desk as a young woman,” added Dr. Christopher DiGuilio, MD, Prineville Clinic’s senior physician. He is also a co-firm partner with Busack. “Now she owns the firm. It’s an American story of hard work, dedication and the good things that happen when you hang on.”

Although DiGuilio is the primary physician working in the Prineville office, they have five providers who will rotate through the practice weekly. They will have female and male providers. The clinic will initially be open three days a week on Mondays, Tuesdays and Thursdays. Once they have built up a clientele, they will add another day.

“Ultimately our goal is to be open five days a week, and if we’re busy enough we’ll eventually add a half day on Saturdays,” Busack said.

DiGuilio added that volume and community support will determine the number of days open.

DeGuilio has 25 years of medical board certification experience and has been board certified since 2001. He started as a partner in a family medicine practice, then opened and managed an occupational medical clinic. He later became Chief of Medicine for the Oregon Department of Corrections.

“We see patients from birth until death. A family physician is trained, licensed, and able to see geriatric newborns,” DeGuilio noted.

Mountain Medical manages patients’ chronic illnesses and provides preventive care and health maintenance care.

“Newborns check on children’s health, make sure children get the right shots, make sure they’re reaching their developmental milestones, and make sure they’re growing properly,” DeGuilio said. “We discuss safety issues such as bicycle helmets and seat belts – across the arc of life taking care of teens and discussing these important preventative health measures.”

He added that as people age, they also take care of chronic diseases as they develop in this age group, such as high cholesterol, high blood pressure, heart attacks and accidents. cerebrovascular and thyroid disorders. They also discuss preventative strategies for maintaining health and managing their chronic conditions.

“Family practitioners kind of do a lot and do everything. We don’t specialize in anything, but we get involved in almost everything.”

He concluded that his intention was to obtain courtesy privileges for patients visiting St. Charles Hospital.

“They can read records, they can discuss care with other doctors, but they’re not actively caring for the individual in the hospital,” DeGuilio noted.

Hospitalists are people in the hospital who specialize in inpatient care, and St. Charles has those types of doctors and specialists who do, DeGuilio pointed out.

Mountain Medical will be entirely outpatient-based, but Diguilio said his goal is to have courtesy privileges that will allow him to monitor and visit inpatients.

“Our main goal in Prineville is to open a family practice. We hope that as time goes on and the community continues to grow to provide emergency care, and we hope that will grow over time. Our main goal is to establish a family practice, primarily in Prineville, as well as emergency services.”

He added that they will be able to accept urgent visits from day one, but their main goal is to create a family practice.

Emergency Care also provides workplace health care, including pre-employment drug screenings, physical exams, and wellness and screening tools for employees from an assortment of employers. If patients need more extensive occupational health services, they can always go to Bend. The Prineville clinic also offers post-injury drug testing, services for injured workers, including fitness-to-work exams and return-to-work exams for companies.

In addition to Occupational Health, they service CDL drivers with an annual or bi-annual medical examination (DOT physical).

“We will provide this service in town. A lot of people have to leave Prineville to take these exams,” DeGuilio said. He added that they are available without an appointment and all of their providers are certified to do the exams.

Mountain Medical also has the vaccines needed for travel, such as the yellow fever vaccine. It is the only clinic in central Oregon that is certified to administer the yellow fever vaccine.

For patients who have already seen Lindsey McKay at Direct Care, they can come to Mountain Medical in Prineville and their patient data can be transferred to their clinic. Their clinic has contracts with most major medical insurance companies.

Lateral bar

Mountain medical family and emergency care

Address: 198 NE Combs Flat Road, STE 110

Telephone: 541-388-7799

Hours: Mondays, Tuesdays and Thursdays from 7 a.m. to 7 p.m.

Primary Family Physician: Dr. Christopher DeGuilio, MD

Office Manager: Tonya Busack


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DoubleRainbow Biosciences and Kelai Pharmaceuticals to Collaborate on New Natural Compound… | Your money

Lexington, MA, Aug. 22, 2022 (GLOBE NEWSWIRE) — DoubleRainbow Biosciences (“Double Rainbow”), a sustainable biotech company that leverages bioengineering to improve the quality of human health, today announced a new collaboration research with Kelai Pharmaceuticals (“Kelai”) to explore the potential of kavalactone-based biosynthetic therapies. Kelai will include one of Double Rainbow’s molecules in its ongoing cellular transcriptome study. In addition, the two organizations will combine Kelai’s patented advanced drug delivery systems with Double Rainbow’s leading plant natural product biosynthesis capabilities to explore new opportunities for sustainable therapies.

Today, as many as one billion people around the world live with mental and substance use disorders.i Kelai Pharmaceutical specializes in the development of advanced drug delivery (ADD) technologies that use natural compounds such as those found in kava (Piper methysticum) to develop innovative therapies for people living with addictions, mental health disorders and related conditions. Using Double Rainbow’s proprietary HARMONYTM platform, the companies will leverage synthetic biology to help Kelai unlock the potential of these natural compounds through sustainable biosynthetic production.

“Synthetic biology offers a solution that supports Kelai’s intentions. As a company, our mission is to do no harm in the name of doing good,” remarks Dr Jacqueline Jacques, Managing Director of Kelai Pharmaceutical. “The supply chain of a natural molecule could run out with the creation of a single new drug. It is an honor to engage with Double Rainbow on some of our early scientific discoveries. We feel very aligned with their team and their vision, and hope that this discovery process will lead to greater developments in the future.

Kava (Piper methysticum) belongs to the pepper plant family and is native to parts of the South Pacific. Kava has been used for centuries in traditional South Pacific cultures. The plant’s reported relaxing effect, with no associated cognitive impairment, makes it an ideal candidate for further research. Several recent studies have explored the potential of kava in generalized anxiety disorder, showing observed clinical effectsii, but further work is needed to understand the full therapeutic potential of kava-based therapies.

“It is an honor to collaborate with partners like Kelai who are working to use powerful herbal medicines to significantly improve the quality of life for hundreds of millions of people living with mental or drug use disorders. of substances,” said Jing-Ke Weng, co-founder of DoubleRainbow Biosciences. “At Double Rainbow, our goal is to leverage our technologies to pioneer the future of natural product bioengineering and create new opportunities to deliver safer and more effective therapies to patients around the world. »

HARMONYTM is a molecular biosynthesis platform that decodes the biosynthetic pathways of powerful bioactive compounds and recreates them sustainably through synthetic biology. Double Rainbow leverages HARMONYTM to explore molecules in all walks of life and revolutionize their global supply to create opportunities for sustainable use in pharmaceutical, nutraceutical and commercial applications.

Nature is a wonderful source of bioactive compounds that provide a wide range of medicinal benefits. These compounds have been explored and used in traditional medicine for centuries and underlie many modern therapies; however, any research seeking to leverage these powerful natural products for large-scale distribution must recognize the growing threats to the global supply of herbal medicines. In Europe alone, more than 31% of medicinal plants are in decline or on the verge of decline, according to the European Red List, with overexploitation being a major driver.iii Collaborations between organizations like Double Rainbow and Kelai to create new, sustainable sources for these critical plant compounds are essential to protect the long-term health and well-being of people and the planet.

About DoubleRainbow Biosciences

Double Rainbow is a sustainable biotechnology company that harnesses the power of natural evolution through bioengineering to improve the quality of human health and ensure the sustainability of our planet. By leveraging advances in genomics, metabolomics and synthetic biology, we are accessing the richness and power of natural chemistry like never before, to bring therapeutics to the world at scale without harm. to the environment. Learn more about www.doublerainbowbio.com

About Kelai Pharmaceutical

Kelai Pharmaceutical is a US-based pharmaceutical company that combines powerful natural molecules with patented Advanced Drug Delivery technology to create new, safe and effective treatments for addiction and mental health disorders. As a strategic joint venture created by Thorne HealthTech and Therapeutic Mycrodosis, Kelai leverages the resources, intellectual property and human capital of both companies to focus on the development and innovation of low-fat medicines for conditions with unmet or underserved needs. Learn more about www.KelaiPharma.com

i Rehm J, Shield KD. Global burden of disease and impact of mental and addictive disorders. Curr Psychiatry Rep. 2019 Feb 7;21(2):10. doi: 10.1007/s11920-019-0997-0. PMID: 30729322.

ii Sarris, J., Kavanagh, DJ, Byrne, G., Bone, KM, Adams, J. & Deed, G. (2009). The Kava Anxiety Depression Spectrum Study (KADSS): a randomized, placebo-controlled crossover trial using an aqueous extract of Piper methysticum. Psychopharmacology, 205(3), 399-407.

iii Summary of main results. European Red List — Environment — European Commission. (nd). Retrieved June 2, 2022 from https://ec.europa.eu/environment/nature/conservation/species/redlist/med—plants/summary.htm

Grant Smith DoubleRainbow Biosciences 3175189807 [email protected]

Copyright 2022 GlobeNewswire, Inc.

New Electronics – An Introduction to Quantum

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The word “quantum” is used as an umbrella term for the emerging field of technologies that harness quantum mechanics to develop fundamentally new capabilities in established fields such as computing, communications, sensing, pharmaceuticals, chemistry and materials research.

In its literal sense, the word “quantum” refers to the smallest unit or entity of a physical system that we describe using quantum mechanics. The reason we physicists have a separate formulation of mechanics for the quantum world is because at the scale of very, very small particles the rules of classical physics don’t necessarily apply , and we observe a strange and new behavior that we cannot explain with classical particles. physics. These phenomena include quantum interference and entanglement which allow particles that may be very far apart to become bound together.

What is the promise of quantum? Why is this important?

The promise of quantum is to push the limits of classical physics by exploiting these quantum mechanical properties of matter. Depending on the context, this can offer whole new ways of processing information that has the potential to be faster and more resource-efficient, allowing us, for example, to compute things that we have never been able to. calculate before, such as the formation of proteins or predict the complex behavior of financial systems.

Where is the disruptive potential of the quantum?

There are many areas where quantum can potentially be disruptive. To name a few, consider:

  • Optimization: Quantum computers might be able to solve difficult optimization problems much faster and even allow us to solve problems that are completely out of reach today (in terms of classical computing resources required).
  • Pharmaceutical/Chemical Research and Modeling: Quantum simulation can help us understand how molecules and proteins form and lead to breakthroughs in chemistry and biology, drug discovery, and healthcare.
  • Cybersecurity: A powerful quantum computer could potentially break existing encryption protocols that rely on factoring large numbers, such as RSA-based encryption protocols. Currently, no conventional computer or algorithm can do this in a reasonable time – and therefore we have the opportunity to develop completely new types of encryption to ensure information security.

What are the benefits of quantum computing? What are the risks associated with this technology?

Quantum computing promises the efficiency of processing power. The ability to process information faster opens up the possibility of pushing areas such as basic research, optimization, information technology and pharmacy beyond what we imagined possible when we only had conventional computers.

There are anticipated security risks. It is theoretically known that a large-scale quantum computer can crack NSA encryption. A big outstanding challenge right now is to create secure security protocols for both classical and quantum computers.

The unforeseen risks are that there are many applications still unimaginable for a significantly more powerful computer. The strength of a quantum computer is processing Big Data, which can have privacy implications.

For example, approximately 1% of energy consumption in the United States is devoted to the production of fertilizers. This process is inefficient in part due to the complexity of simulating the chemical reaction at a quantum mechanical level. A quantum computer could be used to simulate biological/chemical processes such as nitrogen fixation in nitrogenase, thereby increasing production efficiency and leading to a greener approach.

What technical advances are needed to take quantum computing from a niche existence to the mainstream?

At present, we are fundamentally limited by the stability of quantum systems over time and our ability to control them precisely. The unique sensitivity of quantum systems to their environment is what makes them so powerful for computation, but it’s also what makes them difficult to control with great precision. For this reason, current quantum computers are very small (consisting of only tens of quantum bits or qubits – classical computers have hundreds of millions of bits), and the calculations we can perform with these small systems are often imprecise.

To move quantum computing from its niche existence into the mainstream, we must learn to better isolate quantum systems from their surroundings and at the same time control them with a much greater degree of precision. We need to reduce the errors we see in quantum calculations and then expand the system to hundreds of millions of qubits.

How can we overcome these challenges?

We need to overcome the error problem in quantum calculations through innovations in quantum computing hardware and software. Further research is needed to understand the error processes that occur in quantum systems and how to build hardware that is more resilient to these errors. At the same time, advancements in software and how we implement certain algorithms are needed as we reach the physical limits of chip-making capabilities.

How will quantum computing affect the human-technology relationship? What impact will this have on people’s daily lives?

People are unlikely to have quantum computers in their homes that replace their classical computers. Instead, think of quantum computers as a research tool that can be used by both researchers and industries. The way it will affect people’s daily lives is through innovations in the aforementioned sectors.

What trends are emerging with quantum computing? What new developments are on the horizon?

In addition to advanced quantum computing technologies, there are several proposals for new types of quantum computing hardware such as photonic quantum computers or neutral atom-based quantum computers that are highly anticipated. Moreover, researchers from all fields are working hard to develop algorithms capable of improving the performance of noisy, intermediate-scale quantum computers to achieve breakthroughs in quantum computing faster.

What does quantum communications look like?

In practice, most quantum communications look quite similar to their classical counterparts for fiber optic communications. In general, quantum communications have more stringent performance requirements and are more sensitive to environmental effects. Therefore, a major challenge is to create secure quantum repeaters to overcome the challenges of implementing a quantum network in our daily life.

What is the advantage of quantum in communications?

The advantage is communications security as well as the ability to distribute entanglement. Entanglement is a quantum mechanical effect that contributes to the ability to improve computations and detection. A quantum network would be able to distribute entanglement so that we could create quantum sensor networks or quantum computer networks. Just as there are CPU clusters for distributed computing, we could create a distributed QPU cluster for quantum computing.

Could 7G be quantum?

Unlikely. Quantum is generally never faster but rather more efficient. For example, a classical computer can divide two numbers much faster than a quantum computer. Only by using quantum efficient subroutines does quantum gain an advantage. Expecting an increase in speed by going quantum is unrealistic.

What does the quantum computing timeline look like?

This is a very difficult question to answer because the problems we face today are not certain to have a definitive solution. If our research and development efforts continue to be successful, we could consider a time scale of ten years, but if we encounter new challenges or do not find adequate ways to overcome the problem of error in the quantum computing, we may actually never get there. , and instead refocus our efforts on more achievable goals such as building quantum simulators that solve more focused problems (as opposed to building general-purpose quantum computers).

Which regions of the world does Keysight consider to be the most active in the field of quantum computing?

We are excited to see quantum computing start-ups as well as industry giants such as IBM and Google developing significant quantum computing efforts around the world. While major industry players have their base in North America, growing engagement can be seen in Europe, Asia, and Oceania. It’s amazing to see that quantum computing has become a global activity and we’re excited to be a part of it.

While many companies are still looking to generate expected revenue from disruptive technologies such as 5G, AI/ML, cloud, etc., when will be the best time to implement quantum computing?

The revenue potential of quantum computing is complementary to other disruptive technologies and offers potential advancements in a wide variety of industry and research areas. I believe that as soon as the technology becomes viable, it will be successfully implemented and generate vast revenues for any industry that has a stake in it.

Author contact details: General Manager of Quantum Engineering Solutions Elizabeth Ruetsch, at Keysight Technologies

The Post-Zombie Apocalypse In The Flesh Series Was Buried Too Soon

Zombies aren’t the first thing you’d associate with the quintessentially British genre of kitchen sink drama, but “In the Flesh” works perfectly guessing that Brits would probably treat the post-zombie apocalypse the same way we do. let’s all deal with other uncomfortable topics: by not talking about it.

Even though he’s plagued by visions of killing people and eating brains while in his pre-medicated state, the doctor’s prescribed treatment for Kieren’s trauma is to disassociate himself from it completely. After stating bluntly “I am a zombie and I have killed people”, he is corrected and forced to recite the mantra: “I have partial death syndrome, and what I have done in my condition untreated was not my fault.”

In group therapy, he stumbles over approved phrasing while trying to express the enormity of the horror and guilt he feels. Among his fellow SPD sufferers, there seem to be only two acceptable views: either they are entirely innocent and not responsible for anything they did while enraged, or they were justified in kill because there was a war between the living and the dead, and they were in “survival mode”. There is no room for Kieren’s guilt among either group. Prior to his release from the treatment center, he was given make-up and colored contact lenses so he could appear “normal” in public. The great machine of British culture and politics is keen to cover up the whole question of zombies. Keep Calm and carry on.

When Kieren returns home, things get even more absurd as his parents create a desperate veneer of normalcy. Kieren is gay and committed suicide after her boyfriend was killed in Afghanistan. Along with these facts, his undead state becomes just another taboo subject he’s supposed to keep quiet about. Instead of telling Kieren that he can’t leave the house because his neighbors might kill him, his father happily tells him about all the board games and DVDs they’ve bought to entertain him. When Kieren tells his mother that he can’t eat any more food, she asks him to “pretend”, and he is forced to mime by cutting the food and eating it. His parents bring him cups of coffee that he can’t drink. And when potential buyers come to see the house, Kieren’s father literally pushes him into the closet.

Of course, not everyone is ready to play the game, especially in Roarton. Apart from the politically correct pamphlets distributed to PDS sufferers and their families, the walking dead are ridiculed as “rotten” by people still reeling from the horrors of the uprising. Instead of a frank discussion, there is extremism, hatred and fear. The recent collapse of society has prepared Britain for further unrest and full-fledged fascism. Kieren watches as his undead neighbor, an elderly woman, is dragged from her home and executed in the street in front of her sobbing husband. When he tries to bring up the subject of the “crazy night” to his parents the next morning, his father agrees that it was a crazy night…of weather, and turns the topic of conversation to the rush and the drainage.

Mathematical model of animal growth shows life is defined by biology and more

Metabolic theory posits that physical constraints on energy absorption and allocation drive biological processes. This theory predicts broad ecological patterns such as the observed allometric scaling relationship between animals’ metabolic rate and body size.

Monash University scientists have challenged the conventional wisdom that physical constraints explain biological patterns. They created a new mathematical model of animal growth that describes how animals devote energy to growth and reproduction as they age and grow.

Lead author of the study, Professor Craig White of Monash University The School of Biological Sciences and the Center for Geometric Biology said: “Despite the fact that living organisms cannot break the laws of physics, evolution has shown itself to be extraordinarily adept at finding fault lines.”

“An unexplained problem in biology concerns the non-proportional (allometric) relationship between energy metabolism and size.”

“Finding that an animal’s metabolism can be explained without invoking physical constraints means we’ve been looking in the wrong places for answers about why this widespread pattern occurs.”

“We believe that physical constraints do not drive biology as much as we observe as previously assumed, and that evolution has a wider range of options than previously thought.”

During growth or evolution, a gain in size is often followed by a less than proportional increase in energy requirements, so that more giant creatures consume less food and expend less energy than smaller ones. .

For example, small mammals such as shrews may need to consume up to three times their body weight in food each day, while the most giant baleen whales eat only 5-30% of their body weight in krill. each day.

Professor White said, “Our study flies in the face of conventional wisdom that biological patterns such as allometric scaling occur due to physical constraints.”

“We have designed a mathematical model of animal growth that describes how animals shift their energy allocation from growth to reproduction as they grow in age and size, and show that lifetime reproduction is maximized when the metabolism changes disproportionately with size.”

“Many models presented since the beginning of the 19th century have used physical or geometric constraints to explain this pattern, but not ours. Simply put, classical theories held that animals have the metabolism they have because they have to; we find that they have the metabolism they have because it is the best.

“The study showed that allometric scaling does not have to result from physical or geometric limitations. Instead, natural selection, not physics, favors allometric scaling.

Journal reference:

  1. Craig R. White et al., Metabolic scaling is the product of life cycle optimization, Science (2022). DOI: 10.1126/science.abm7649

Mathematical model of animal growth shows that life is defined by biology

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Foliforce Reviews – Negative Side Effects or Real Results for Customers?

Foliforce is a hair regrowth supplement that targets dormant hair follicles that have stopped producing hair due to scalp corrosion. Users can get up to six jars in a single purchase, and no doctor’s approval or supervision is required to get the benefits.

What is Foliforce?

Everyone goes through changes in their life that can make them feel different from themselves. While it’s easy to cover up weight gain or blemishes, it’s almost impossible to hide thinning or baldness. The appearance of a slowly receding head is embarrassing for many people, especially when a large part of their daily appearance includes the way they style their hair. Both women and men are prone to hair loss as they age, but changes in hormones and body chemistry can also be the cause.

The creator behind Foliforce, Robert Sinega, suggested that the real cause of hair loss has to do with a habit that causes the scalp to corrode, preventing hair follicles from growing new hair. According to Robert, this remedy restored 97% of his lost hair, restoring his confidence and hairline. The medical community has apparently been silent about this solution, but that silence may not last when the industry starts losing money from its less effective methods.

Other hair products are not suitable for consumers who want their hair back. Some more intense remedies come with side effects, such as skin sensitivity or excessive hair growth on the rest of the body. Although invasive methods (like hair transplants) seem practical, the cost is high and not everyone has this type of cash flow. Topical remedies can help to some extent, but changes in hair often only last for the duration of this treatment. Using Foliforce changes the problem from withinand all it takes is a quick mix of the powder daily.

The Foliforce remedy was designed with the idea that the real cause of hair loss has nothing to do with stress, age or hormones. It doesn’t even have to do with a chronic illness. Instead, Robert says the problem is related to a scalp condition caused by water quality issues when washing their hair. He learned about all the harmful compounds found in water from Dr. Purvis, who also said male pattern baldness is nothing more than a hoax. To solve this cycle of problems, Robert moved quickly to develop the remedy consumers now know as Foliforce.

What does Foliforce contain?

This whole formula revolves around 12 ingredients which have their benefits individually but bringing them together is the perfect recipe for hair. The ingredients the creator primarily focuses on include:

  • Bamboo
  • Horsetail extract
  • collagen
  • Protein
  • Vitamin C
  • Vitamin B6
  • acerola cherry
  • Hyaluronic acid

So far, this concoction has been tried by over 156,000 people and regrowth begins within weeks. Bamboo and Horsetail Extract are crucial for the onset of changes, helping hair follicles get the protection they need from water-based chemicals. They work together to keep hair follicles clean, clearing the way for new growth.

The cleaning process takes time so consumers don’t see the new growth right away. However, according to a study published by the Journal of Medicinal Medicine and the National Center of Biotechnology Information (cited on the official website), bamboo is an excellent source of antioxidants. These antioxidants naturally eliminate free radicals from the body, such as contaminants found in water. It is also a rich source of phenolic acids and flavonoids that help fight heavy metals that users encounter with every shower.

As a result, bamboo aids blood circulation to soothe the scalp and improve hair growth by up to 140%, primarily because it naturally contains silica. However, it offers much more than support for the hair. Studies in the International Journal of Scientific Development and Research link bamboo to healing skin problems and helping wounds, psoriasis and eczema.

Horsetail extract is added for the same reasons this remedy includes bamboo. Research shows that horsetail extract contains many antioxidants and other compounds that eliminate harmful substances at the root of the hair follicle. It also improves hair regeneration as it reduces dandruff, improves collagen production and promotes better hair quality for hair that has not been shed.

While this formula naturally enhances collagen production, it also adds collagen to the hair. According to a study in the scientific journal Science, collagen reduces thinning. It is a necessary protein for hair, skin and nails, but age and other factors can lead to a decrease in natural production. By supplementing with collagen, the body creates more strength in the hair follicles while clearing the inhibitions caused by toxic water.

At this point, consumers will notice new hair growth as the follicles are finally freed from the damage they have endured for so long. Protein is a crucial element in the structure of hair and follicles. Harvard University states that protein is essential for elasticity, luminosity, and production because it triggers keratin production. Keratin is one of the main proteins found in hair.

Along with vitamin C, users get another helpful antioxidant, reducing dryness and protecting the scalp from new infections. It is also a powerful ingredient against inflammation and for the immune system. Vitamin B6 is involved in helping follicle development, according to Dermatology and Therapy. It also helps in protein metabolism and other ingredients in this remedy.

The addition of acerola cherry and hyaluronic acid was a no-brainer, helping to rejuvenate hair follicles and enhance healthy hair growth. They also protect the scalp and hair roots from diseases that could impact growth.

To date, no consumer has reported any side effects; they only need one serving a day for it to work.

Buy a bottle of Foliforce

While many hair supplements can be found in stores, consumers can only get the support offered by Foliforce through the official website. With no other authorized retailers selling it, consumers who see the product elsewhere may not get what they think it is.

The company offers three packages to ensure customers get exactly what they need. Users get a bigger discount when ordering multiple bottles at once, though each pack is discounted from the typical price of $99. Choose from:

  • One bottle for $69
  • Three bottles for $177 (or $59 each)
  • Six bottles for $294 (or $49 each)

Users will have to pay a small shipping fee when ordering a standalone bottle. However, to show customers how much they value loyalty, the creator is offering free shipping on either multi-bottle order.

If the user finds that Foliforce does not meet their needs, they can request a refund from customer service according to the 60-day money-back guarantee. The customer service team can be contacted by emailing [email protected]

Foliforce Final Thoughts

Foliforce offers consumers a solution for hair loss they experienced as adults. The remedy is rich in supportive ingredients backed by medical research and clinical studies. While they provide personal benefits, they also create the right environment for a healthy scalp and new growth. Users should see a change in their hair by the end of the month, although the only reason for the delay is the natural growth process.

UW lawmakers and officials attend WF West STEM camp and leave impressed with student learning

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By Matthew Zylstra / [email protected]

The three legislators from the 20th Legislative District – Representatives Ed Orcutt and Peter Abbarno and Senator John Braun – were at WF West High School on Wednesday afternoon to observe student activities at the science, technology, engineering and math camp ( STEM) of the school. The camp, which is held annually with assistance from the University of Washington (UW) and the Chehalis Foundation, involves a variety of STEM-based activities. It was open to students from all over the area for $25. This year’s STEM camp was organized with the support of the Institute for Stem Cells and Regenerative Medicine (ISCRM) and the College of Engineering at the University of Washington.

The lawmakers were joined by a group that included administrators from the University of Washington and the Chehalis School District as well as representatives from the Chehalis Foundation. They were taken to the school’s STEM wing where they heard UW representatives speak before they had a chance to participate in student activities.

“We have a certain champion in the Senate,” ISCRM director Chuck Murry said, alluding to Braun.

Murry told the group that the UW views community outreach, including its work at WF West’s STEM camp, as a crucial part of its role as a public university.

“We’re a state university and we love getting out into the community,” Murry said. “Part of what we hope to do is promote life science industries in the community. I wish our state was not only known for its aerospace and computer industries, but also for its regenerative medicine.

While it may seem unusual for Washington’s flagship university to have such a large presence in a rural community, UW views the camp as part of its community outreach mission, a mission that exists, in part, thanks to May -being Chehalis’ most notable export. , Orin Smith, the former CEO of Starbucks who donated a large sum of money to the community before his death.

“Orin was regent at UW. I worked with Orin and it was his alma mater here, as was the UW and he wanted to bring the university to the community,” Randy Hodgins, vice president of external relations at UW, told About Smith, who grew up in Chehalis.

“We don’t have a huge presence in Southwest Washington and we thought it would go really well with the focus on STEM here at WF West. We bring undergraduate and graduate programs here and the kids just eat… We’re happy to be back, we’re happy to be here again and hope to make this a long-lasting (event). We work with the district (so that) whatever works is what we want to do. Lewis County is just as much a part of the state as anywhere else.

For students, the activities UW brings to STEM camp present exciting new experiences.

“I think it’s a really cool new experience because it’s unlike anything I’ve done before and I’m learning more career paths and opportunities for the future,” Bryce Kuykendall said. , a 16-year-old student at WF West.

“The experience gave me a broader idea of ​​biology and careers, which are very broad,” added Shivtaj Dhudwal, a 15-year-old student at WF West.

During the camp, students and legislators who came to observe had the chance to participate in various activities. Activities included inflating pig lungs with a pump to see what breathing looks like, holding a human brain, touching the lungs of someone who died of COVID-19, and using a device that when wires are attached to the arms of two people, allowed one person to move another person’s arm with their own by sensing nerve activity.

“It’s fascinating,” Abbarno said. “It didn’t hurt, but you could definitely feel it.”

The excitement about the learning opportunities that STEM camp offers hasn’t just been felt by the students.

“It’s been amazing, the medical side of things. Lots of little mini-lessons that last about 45 minutes or an hour and get kids excited about medical topics,” said WF West math teacher Chris White.

Bob Walters, director of WF West, said the school’s STEM camp has evolved over the years, and since partnering with UW several years ago, the camp has grown.

“We connected with UW and I think they were also aware of our new STEM wing. They also have an awareness program. The medical program and the engineering school were able to work with us and they grew from there,” Walters told The Chronicle.

But students and staff weren’t the only ones impressed with what they saw at camp. Researchers who traveled from Seattle to teach at the camp were also impressed, particularly with the technology high school students have access to at WF West.

“Do you have a scanning electron microscope?” It’s incredible ! Nate Sniadecki, professor of mechanical engineering and associate director of ISCRM, told The Chronicle.

“It’s really cool that you have one right there in the other room!” Kendan Jones-Isaac, a UW Ph.D. student studying pharmacy, told a group of students while teaching them about an experiment he had been involved in finding kidney stones in astronauts.

For state lawmakers watching the activities, the camp was an example of the kinds of learning experiences that can benefit children and open their eyes to the opportunities available to them.

“This STEM camp is a great opportunity for student learning – and if that was all it did, it would bring huge benefits to students,” Orcutt said. “But it also gives students an introduction and insight into potential career opportunities and builds excitement into the possibilities of following one of these career paths. The courses we have seen today will not only benefit students in choosing their studies and career paths, but when they choose one of these career paths, it can also lead to the advancement of healthcare and increased availability of healthcare professionals – a benefit for everyone.

For Abbarno, the camp was the type of experience he hopes to offer statewide to inspire more students to learn.

“STEM Camp is an incredible educational experience for our local students and is a product of partnership. The program ignites our students’ passion for science, technology, engineering, and math, which helps cultivate a life of learning and exploration. This is exactly the type of program we want to support and replicate across the state,” Abbarno said.

Braun saw the camp as an opportunity to help students recover from learning loss suffered during the COVID-19 pandemic while getting them excited about potential new career paths.

“I was happy to visit the STEM camp organized through a partnership between the University of Washington and the Chehalis School District. I was impressed,” he said. “Students were clearly involved in the content. Distance learning and other COVID restrictions have taken their toll on our children and resulted in learning loss that has left our graduates unprepared for higher education. Partnerships that enrich the curriculum and excite children about what comes after high school could be an important tool in offsetting this loss. This camp, which emphasizes engineering and the medical field, is taught, in part, by university students. Peer education is effective, especially with teenagers. And exposure to industry leaders goes beyond what students get in the standard public school curriculum. I hope to see more of these programs implemented statewide by UW and other universities. It’s a bridge our children need right now to get back on track.

Four Native Americans win New Jersey’s Healthcare Heroes Awards

The awards recognize individuals and organizations that have a significant impact on the quality of health care in New Jersey

Four Indian American healthcare professionals – Dr. Nisha Kotecha, Dr. Amit Borah, Dr. Tushar Patel and Ritesh Shah – have been recognized as NJBIZ Healthcare Heroes.

They were among individuals and organizations across 12 categories celebrated as 2022 Health Heroes at an event at the Palace in Somerset Park on August 19.

Read: Dr. Ponisseril Somasundaran elected Chairman of the Hoover Board of Award (August 3, 2022)

The HealthCare Heroes program was created to recognize excellence, promote innovation and honor the efforts of individuals and organizations that have a significant impact on the quality of health care in New Jersey, according to a press release.

Dr. Nisha Kotecha, Chief of Critical Care at Overlook Medical Center received the award in the Doctor of the Year category. Kotecha is a pulmonologist in Summit, New Jersey and is affiliated with several area hospitals. She received her medical degree from Topiwala National Medical College and has been practicing for 20 years.

Read: Johns Hopkins gives top honor to Indian vaccine maker (May 25, 2022)

Dr. Amit Borah, Atlanticare Regional Medical Center was honored in the Innovation – Individual category. Borah is a medical pioneer – an interventional pulmonologist, one of internal medicine’s newest subspecialties. It uses sophisticated technology to diagnose and treat lung and airway problems.

Borah is board certified in Internal Medicine, Pulmonary Medicine and Critical Care Medicine. He is a member of the American Thoracic Society and the American Association of Bronchology and Interventional Pulmonology, among others.

Dr. Tushar Patel, Indian Health Camp of New Jersey and Ritesh Shah, Pharmacist/Founder of Ritesh Shah Charitable Pharmacy – NJ’s 1st Charitable Pharmacy were honored in the Public Health category.

Read: NJBIZ honors 2022 New Jersey healthcare heroes (August 13, 2022)

Patel and Shah have worked together for the past two decades. Under Patel’s leadership, Indian Health Camp provided free services to more than 12,000 patients. Shah has run a charity pharmacy with Indian Health Camp in New Jersey for two decades.

Since RSCP’s inception, it has provided over $100,000 worth of medicine to people in need in New Jersey communities to start making a difference in improving access to medicine.

Dennis Douroumis: “We focus on new and innovative research”

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The most important attribute of a newspaper editor is enthusiasm and experience in his subject, and Dennis Douroumis has both of these qualities in spades.

Douroumis has just been appointed editor-in-chief of a new pharmacy journal, RPS Pharmacy and Pharmacology Reportswhich is the first open access journal published by the Royal Pharmaceutical Society.

This is an exciting development which should broaden the evidence base for pharmacology and pharmacy in the UK and overseas, and Douroumis is particularly keen to provide young researchers with the opportunity to publish their work.

“There are young researchers who may have difficulty, for different reasons, in having their work accepted and we will apply a fair system for these people in the evaluation process,” he explains.

Douroumis himself started with a BSc in Chemistry, followed by a PhD in Pharmaceutical Technology at the Department of Pharmacy, University of Patras, Greece in 2000, specializing in pharmaceutical nanotechnology.

He then joined the Greek army for two years of military service, before continuing his postdoctoral career in Germany on a project funded by Novartis. Here he worked for two years trying to make “nano dispersions” for anti-epileptic drugs.

More recently, Douroumis has worked in industry and academia in the UK. Since 2007, he has been based at the University of Greenwich and studies, among other things, 3D printing of pharmaceutical products.

“We have made a lot of progress, and if all goes well, in December 2022 we will have a clinical trial with some hospitals,” he explains. “People have different needs: for example, children often don’t adhere to medication, and for this reason we have developed whimsical designs that resemble Haribo.”

It is this experience that Douroumis brings to his new role; to learn more about his projects, The Pharmaceutical Journal interviewed him on Zoom.

RPS Pharmacy and Pharmacology Reports is a new newspaper: can you tell me a bit about it? How is this journal different?

It is a multidisciplinary journal and it is not very easy to find this type of journal. We cover pharmacology and pharmacy. Pharmacy is a very broad field, it covers drug delivery systems, clinical pharmacology, pharmacognosy, analytical technologies, analytical pharmacy: so there is a wide range of fields. Academics now tend to publish journals online because it is easier to disseminate their research and they also attract citations. So it’s a good approach for academics.

We only focus on research that is new and innovative, and has substantial evidence. If people provide good proof of their original work, we are happy to publish. There is a sister newspaper, Journal of Pharmacy and Pharmacology (JPP), but the idea was to have an open access system. The JPP does at some point, but we wanted a pure open access journal.

What is the difference between the two journals?

We will overlap in some areas, but JPP now focuses a bit more on clinical applications. We won’t look much at clinical applications; we will look for a proof of concept. If anyone has clinical data, that’s fine – we’d be very happy to, but it won’t be a prerequisite for submitting it to the journal.

Who should consider submitting their research to this journal?

As a new journal, we don’t have an impact factor yet, but I would say people around the world are welcome to apply. There are young researchers who may have difficulty, for different reasons, in having their work accepted and we will apply a fair system for these people in the evaluation process.

You won’t have to wait long to see your work published

We’ve also sped up the publishing time, so you don’t have to wait ages to see your work published: because that’s what happens quite often, even if your work is on top. Everyone is invited to apply, but especially young researchers who want to communicate quickly about their work.

Could you tell us about the fees involved?

There is a handling charge of around £2,000 for developed countries, but we also have a system in place where underdeveloped countries get free posting and there are deep discounts for some other countries, where they are not fully developed. We have measures in place to try to make things fair.

We have a few other ideas: for example, if someone wants to organize a special issue, they can get, for ten articles, two free articles.

Some of our editorial board members are well known in the research field, but we also have young people — or “rising stars”, as I call them.

How did you select the editorial board?

We wanted it to be diverse, with a balance between men and women, because women are underrepresented not only on the boards of other journals, but also in universities. We have also reviewed different universities around the world and have editorial board members from China, USA, Australia and Europe.

We also have a mix of backgrounds on the board: some are experienced and well known in research, but we also have young people — or “rising stars”, as I call them — who were well known, but there is still a way for them to leave. I think in September 2022 we will start expanding the editorial board again.

When will the first issue be released?

We have already started the commissioning and we have invited colleagues from very different backgrounds to submit. Recently, we’ve had submissions that have come in out of the blue, so it looks like the review is getting noticed, which is really good. We expect the first issue to come out at the end of August 2022, with around 10-16 articles, which is a very good number.

In a year, we expect to get about 30 articles in total in each issue, before we start going to Scopus and PubMed and the other databases.

Is there anything else you would like people to know?

We promise scholars that the editorial board and I will work hard to make it a success. There is a good team behind the newspaper; that he will make it flourish and make itself known. It is our personal commitment.

Moncton man charged over drugs and weapons seizure

A 39-year-old man has been charged with drug trafficking and other offenses following an investigation in Moncton.

Traffic stop near Hal Betts SportsPlex leads to arrest of drug trafficking suspect

On Friday August 12 at approximately 3:30 p.m., members of the Codiac RCMP Crime Reduction Unit intercepted a vehicle at the intersection of Assomption Boulevard and Vaughan Harvey Boulevard in Moncton, according to Sgt. Marco Leger of the Codiac Regional RCMP. As part of the drug trafficking investigation, 39-year-old Ryan Michael Shanks of Moncton was arrested at the scene without incident.

Later that afternoon, at approximately 4:00 p.m., police executed a search warrant at a residence on Savoie Drive in Moncton. During the search, officers reportedly seized what were believed to be amounts of crystal meth, crack and fentanyl, as well as a loaded unsecured handgun and an unsecured rifle.

Police said they also seized items believed to have been stolen, as well as drug paraphernalia and cash.

Codiac Regional RCMP

Codiac Regional RCMP

Moncton man appears in court on drug and weapons charges

Ryan Shanks appeared in Moncton Provincial Court on Saturday August 13 and again on Tuesday August 16. He is currently charged with: Two counts of unsafe storage of a firearm, Two counts of possession of property obtained by crime, Unauthorized possession of a restricted firearm, Possession for the purpose of trafficking methamphetamine , Possession for the purpose of trafficking fentanyl.

He was released on conditions set by the judge and is due back in court on September 6 at 9:30 a.m.

Codiac RCMP say the investigation is ongoing. We will update this post as new information becomes available.

WATCH: Things from the year you were born that no longer exist

Iconic (and sometimes silly) toys, tech, and electronics have been usurped since their grand entrance, either through technological advancements or common-sense breakthroughs. See how many things on this list trigger childhood memories – and which ones were there and gone so fast you completely missed them.

WATCH: Baby names that are illegal around the world

Stacker scoured hundreds of baby name databases and press releases to compile a list of illegal baby names somewhere in the world, along with explanations of why they are banned.

Landmark bill to reduce prescription drug prices is signed into law


“Our fight is not over,” Jenkins said. “AARP will continue to work to ensure the law is implemented, and we will continue to advocate for additional measures to bring down the price of prescription drugs.

Here are the main elements of the parts of the new health care law.

Changes to Part D

For the first time, out-of-pocket costs for Medicare Part D prescription drugs will be capped. Starting in 2025, beneficiaries will not have to pay more than $2,000 per year for their share of Part D drug prices.

Starting in January, most vaccines will be free in Medicare.

Part D premiums cannot increase by more than 6% per year until at least 2029. The income threshold for recipients to qualify for a grant to help with Part D costs is increased by 135% of the federal poverty level ($18,347). for an individual in 2022) to 150% ($20,385 for an individual in 2022).

Negotiate drug prices

The law authorizes the Secretary of Health and Human Services to begin negotiating prices for 10 expensive prescription drugs in 2023, and negotiated prices will take effect in 2026 for Part D drugs and 2028 for covered drugs by Medicare Part B. The number of drugs whose prices will be negotiated on behalf of Medicare will increase in the following years, and by 2029, a total of 60 drugs will be subject to negotiated prices.

Inflation reimbursement

Starting in October, if the price of a Part D prescription drug is increased by more than the general inflation rate, the drugmaker will have to reimburse Medicare for the amount of the increase above the rate. of inflation. Rebates for price increases above inflation for drugs covered by Medicare Part B (typically office-based infusions, such as for cancer drugs) will begin in January 2023.

Extended Health Care Subsidies

For people who buy their health insurance through ACA Marketplaces, the bill extends the expanded federal premium subsidy and other financial improvements made under the U.S. bailout to 2025. For people aged 50 to 64, these subsidies save an average of more than $950 a year, and all consumers will continue to pay no more than 8.5% of their income for health insurance premiums. TO THAT.

Editor’s Note: This story has been updated with new information.


“All We Had Was An Idea”: Driving Entrepreneurship in Nova Scotia

SYDNEY, NS — Matthias Bierenstiel admits he knew next to nothing about business when he started his entrepreneurial journey in 2020.

Now, just two years later, the university researcher turned businessman is the co-founder of Maskwiomin, a Cape Breton-based start-up that has married traditional Mi’kmaq medicine with modern chemistry to create a product innovation that is already on the market. market.

The learning curve was steep and fast for Bierenstiel and his business partner Tuma Young, another faculty member at Cape Breton University. He admits that the extent of his knowledge was limited when it comes to business.

“You have to remember I’m a professor of chemistry – I didn’t know anything about business,” exclaimed Bierenstiel, a southern German native who holds a PhD from the University of Guelph and a professor at CBU. since 2006.

“I didn’t know anything about business. I knew nothing about distribution channels or business structuring or business plans or marketing. And that’s just the tip of the iceberg. There was so much to learn.

It was then that the duo became involved with Spark Nova Scotia.

Maskwiomin co-founders Matthias Bierenstiel, left, and Tuma Young are making their mark as entrepreneurs after winning a Spark Nova Scotia competition two years ago.  CONTRIBUTED
Maskwiomin co-founders Matthias Bierenstiel, left, and Tuma Young are making their mark as entrepreneurs after winning a Spark Nova Scotia competition two years ago. CONTRIBUTED

Light the fire

Spark is both a competition and a mentorship program for tech start-ups in the province. It is funded by the Atlantic Canada Opportunities Agency (ACOA) and presented through the Nova Scotia Association of Community Business Development Corp.

The Spark competition is held annually in three districts — Nova Scotia Southwest, Nova Scotia North and Cape Breton Island — to promote budding entrepreneurs who are typically located outside of the Halifax area.

In 2020, Bierenstiel and Young competed in the Cape Breton competition. Maskwiomin was one of the winners and received a $40,000 prize.

“When we applied to Spark, we only had one idea – we really didn’t have any type of product at that time,” Bierenstiel said.

“Hands down, I think Spark has been the most effective support, both financially and mentorship-wise, that we’ve had at the start of our business. It was exactly what we needed at that time. It gave us some funding to build our commercial type extractor and it got us started.

He also stated that the company is a Cape Breton-only company.

“You can’t do that in China – the trees have to come from Cape Breton because we need a particular species. We are proud of it. We want to be here at Unima’ki. We have incorporated this into our business plan and into the corporate philosophy.

ancient medicine

The products now made and sold by Maskwiomin (“maskwi” is the Mi’kmaq term for birch bark, while “omin” means oil or extract) are unique in themselves.

It all started years ago when Young, a Mi’kmaq from Cape Breton and longtime resident of Membertou First Nation, discovered that some medical knowledge was in danger of being lost. Through research, he was able to replicate the methods of his ancestors to transform the oil extracted from the bark of a birch tree into a kind of healing balm used to treat conditions such as eczema.

Young then met the chemistry teacher. Together, they crafted Maskwiomin’s go-to-market plan, but in a conscious way to ensure the business remained culturally ethical. It was a brilliant collaboration that resulted in the duo receiving over $1 million in two grants from Health Canada for research purposes.

“Receiving the Spark award was kind of a sign of approval then that we were for real, that we weren’t just a one-day wonder,” Bierenstiel recalled.

“Spark facilitated that.”

Permjot Valia, Entrepreneur in Residence, Navigate Startup House:
Permjot Valia, Entrepreneur in Residence, Navigate Startup House: “It shows our bright and ambitious people that there are great things they can do in Cape Breton. CONTRIBUTED

Mentorship and progress

In particular, Bierenstiel praised his Spark-appointed mentors and the efforts of Permjot Valia, a well-known London-trained startup expert who is also an entrepreneur-in-residence at Cape Breton’s Navigate Startup House.

“Permjot really helped us identify the type of business we wanted to be,” he said.

“It worked. We made sure to participate in ethical marketing. We are working with the community and are still in negotiations with Membertou First Nation to become a partner in our business. We last met a few weeks ago. So, it’s all very positive.

For her part, Valia said Maskwiomin is one of several successful Cape Breton-based Spark winners. And he added that collective progress both keeps smart, ambitious people home and attracts other bright minds to the region.

“I think what Spark does, what the start-up business does, is show our bright, ambitious people that there are great things they can do in Cape Breton,” Valia said. .

“They no longer need to leave to go to Halifax, Toronto, New York or Vancouver to pursue a career in technology entrepreneurship. So right now, with the world as it is, you can have an excellent quality of life and the happiness of being close to your family without sacrificing your career goals or professional ambitions. It can be done.”

New contest

Spark Nova Scotia 2022 has now launched its final competition with training registration opening on August 9, followed by weekly workshops that will run until September 12.

Companies applying for the competition face the official application deadline of September 19, with finalists being notified the following week.

After a week of individual pitch training, the competing companies will present their pitches in front of a jury and the winners will be announced on October 24.

For more information, visit sparknovascotia.com.

David Jala is a business reporter at the Cape Breton Post.

Eating popular snack can ‘reduce dementia risk and add FIVE years to your life’

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WE are often encouraged to eat at least five servings of fruits and vegetables a day if we want to keep the doctor away.

However, experts have discovered one particular fruit that may help lower your risk of developing dementia later in life.

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Grapes contain antioxidants that reduce inflammation, which may help reduce the risk of heart disease and cancerCredit: Getty

The series of studies, published in the journal Foods, all found that eating grapes can have a positive impact on your health, especially for those consuming high-fat Western diets.

Grapes are known to be high in chemicals that boost gut bacteria and lower cholesterol.

They also contain high levels of antioxidants which can reduce the risk of many diseases and cancers.

Antioxidants work by protecting your body from free radicals in the body, such as inflammation, or outside the body, such as pollution, UV exposure, and cigarette smoke.

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Researchers have found that the antioxidants in grapes protect the brain against the development of dementia by improving the function of neurons or nerve cells.

Several studies have already shown that inflammation in the brain is linked to several forms of dementia.

Dementia is one of the biggest killers in Britain, with one in ten male deaths caused by the disease and one in eight females.

Another study found that eating grapes can also reduce the risk of fatty liver disease and can add an extra five years to your life.

Fatty liver disease is a common condition caused by the storage of extra fat in the liver.

It is currently a growing problem across the world, due to unhealthy eating habits.

Although it is rarely fatal, if left untreated it can lead to liver failure or liver cancer.

Grapes may also burn calories by helping to boost your metabolism, the third study found.

Researchers at Western New England University conducted all three studies in mice.

All of the mice in the studies were fed high-fat diets commonly eaten in Western countries, and only half of the mice were given grape supplements.

The researchers then compared the brain, liver and metabolic health of mice that received grape supplements with mice that did not.

“This adds a whole new dimension to the old adage ‘you are what you eat,'” study co-author Dr. John Pezzuto said in a statement.

Grapes actually modify the expression of genes, explains the professor of pharmacy, author of more than 600 scientific studies. “It’s really remarkable,” he adds.

Scientists are learning how we turn genes on and off so we can control how the body develops throughout life.

Exercise, stress, diet, sleep, and meditation are thought to impact the expression of our genes.

Many people take antioxidant supplements, however, Dr. John said it is not possible to consume “enough” of the antioxidant to make a “big difference” to your health.

“But if you change the level of expression of antioxidant genes, as we observed with grapes added to the diet, the result is a catalytic response that can make a real difference,” he explained.

The research was partially funded by the California Table Grape Commission, which provided the grapes used in the experiments.

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Previous research has shown that strawberries may protect the brain from dementia by reducing inflammation.

Some warning signs of dementia include: slow thinking, planning difficulties, language problems, attention and concentration problems, mood or behavior changes.

Inslee rescinds more than a dozen COVID proclamations as CDC updates guidelines for schools

OLYMPIA, Washington, August 14, 2022 – Governor Jay Inslee rescinds 13 COVID-19 proclamations under his emergency authority according to proclamations issued Aug. 5 and signed July 29. All reviews take effect at 12:01 a.m. on October 27, 2022.

The reviews relate to long-term care facility guidelines and the reinstatement of various policies and laws, including elective medical procedures, licensing requirements, eligibility for Medicaid admission, eligibility for the family emergency assistance program, and much more.

The justification for rescinding the executive orders according to the amended proclamations are “recent advances in medicine”, including COVID-19 reminders and antivirals. It also states that “health experts and epidemiological modeling experts believe that as a state, we have made adequate progress against COVID-19 in rescinding and/or modifying amending proclamations related to health issues. specific health”.

Violators of the recension which takes effect at the end of October may be subject to criminal penalties in accordance with RCW 43.06.220(5).

On Thursday, August 11, the Centers for Disease Control and Prevention (CDC) updated its K-12 guidelines for schools to support safe in-person learning. Below are the latest updates:

  • Removed Cohort Recommendation: Keeping groups of students together throughout the day to minimize contact with others.
  • The CDC no longer recommends routine drug testing in K-12 schools. Schools may consider screening tests to focus on high-risk activities during a high community level of COVID-19 or in response to an outbreak.
  • Removed quarantine recommendation except in high-risk gathering environments.
  • Schools no longer need to implement “test to stay” policies. Students who have been exposed to the virus are now subject to the same advice as adults, regardless of their vaccination status.
  • Added detailed information on when to wear a mask, case and exposure management, and outbreak response

To view the Department of Health’s updated COVID-19 guidelines for K-12 schools and daycares, click here.

20-74.4: Association for Behavioral Health, Children’s Long-Term Hospital Program and Residential Treatment Facilities – Operations and Visits

Per the latest sequence, 20-74.4, Proclamation 20-74 is terminated and void effective 12:01 a.m. October 27, 2022.

The review terminates the requirements of the guidelines issued by the BHA for the following facilities of the Behavioral Health Administration:

  • State-run adult psychiatric facilities including Western State Hospital, Eastern State Hospital and the Child and Study Treatment Center – RCW 72.23.020, RCW 72.23.010(9).
  • The Special Engagement Center on McNeil Island – RCW 71.09.020(19)
  • King County Secure Community Transitional Facility – RCW 71.09.020 (15)
  • Pierce County Safe Community Transitional Facility on McNeil Island – RCW 71.09.020 (15)
  • Fort Steilacoom Skills Restoration Program Residential Treatment Facility – RCW 10.77
  • Maple Lane Skills Recovery Program Residential Treatment Facility – RCW 10.77 4
  • Yakima Skills Restoration Program Residential Treatment Facility – RCW 10.77 20-66.6 Long Term Care – Operations and Visits

Operations at Child Long-Term Inpatient Programs (CLIP) facilities will no longer be required to comply with guidance documents issued by the HCA and guidance documents issued by the DOH for residential treatment facilities ( RTF) will also no longer be required for operations from October 27. , 2022.

20-66.6 Long-term care – Operations and visits

Per the latest sequence, 20-66.6, Proclamation 20-66 is terminated and void effective 12:01 a.m. on October 27, 2022. The original order was due August 12, 2020.

The proclamation restricting visits to long-term care facilities, according to the executive order, was implemented in an effort to save the lives of the elderly in “congregate settings”.

“The risk of serious illness and death from COVID-19 appears to be higher among members of our population aged 60 and over and those with chronic health conditions; and …residents, staff, vendors, and visitors to the facility may bring COVID-19 into the facility and start an outbreak or spread an existing outbreak to a new population,” the initial proclamation said.

The following facilities listed below are no longer required to comply with guidance documents for (a) Certified Community Residential Services and Supports, (b) Family Homes for Adults, Assisted Living and Service Facilities improved, and (c) nursing homes and intermediate care. developmental facilities, as of October 27, 2022:

  • Intermediate Care Facilities – 42 CFR 483 Subpart I and WAC 388-835, WAC 388-837
  • State Operated Living Alternatives – RCW 71A.12
  • Nursing facilities – RCW 18.51 and RCW 74.42
  • Residences with assistance – RCW 18.20
  • Family homes for adults – RCW 70.128
  • Improved service facilities – RCW 70.97

20-65.6 Long-term care – Workers, facilities and resources

Per the latest sequence, 20-65.6, Proclamation 20-65 is terminated and void effective 12:01 a.m. October 27, 2022.

The initial proclamation addressed various laws relating to nursing homes and assisted living facilities, such as educational requirements, staffing requirements, eligibility for Medicaid admission for individuals, and more. – see initial proclamation 20-65 for details.

20-59.9 Department of Health – Temporary practice permits

According to the latest sequence, 20-59.9, Proclamation 20-59 is terminated and void effective 12:01 a.m. on October 27, 2022.

The initial proclamation permitted the issuance of a “temporary license to practice” allowing healthcare workers “to practice the profession pending the completion of documentation showing that the applicant meets the requirements for a license and nor is it subject to the refusal of a license or the issuance of a permit”. a conditional license.

The purpose of the original proclamation was “to avert a shortage of licensed health care providers by modifying the eligibility for temporary licensure for recent graduates of professional programs in dentistry, pharmacy and dental hygiene.”

Proclamation 20-59 Details Waived and Suspended Portions of the Licensing and Administrative Bylaws and Rules Relating to the Issuance of Temporary Practice Permits (TPPs) for Recently Graduated Healthcare Workers professional health care programs.

Healthcare workers with a TPP in dentistry, pharmacy and dental hygiene must meet the legal requirements of their profession to practice as of October 27, 2022.

20-52.11 Statewide COVID proclamations regarding long-term care

According to the last sequence, 20-52.11, proclamations 20-06, 20-10, 20-16, 20-17, 20-18 and 20-52 are terminated and canceled effective 12:01 a.m. on October 27, 2022.

The COVID Proclamations policies and programs listed below are impacted as follows:

  • The Family Emergency Assistance Program will no longer be expanded to include individuals and families without children
  • Removal of restrictions and visitation bans in long-term care facilities – see 20-16 and 20-17 for details
  • Discusses various laws relating to nursing homes and assisted living facilities, such as training requirements, staffing requirements and Eligibility for admission to Medicaid for individuals – see 20-10 for details
  • Removal of resident visitation and isolation restrictions and visitation records may be destroyed after 30 days for care homes and assisted living facilities – see 20-06 for details.

20-36.11 Ministry of Health – Health Care Facilities and Hand Sanitizer

According to the latest sequence, 20-36.11, Proclamation 20-36 is terminated and canceled effective 12:01 a.m. on October 27, 2022.

The policies and companies listed below are impacted as follows:

  • Any person exercising a pharmacy or establishing or operating a pharmacy must again be authorized
  • Merchants will no longer be considered licensed pharmacists
  • Drugmakers will again have to pay licensing fees
  • Medical institutions will again be required to notify the Ministry of Health of adverse health events and medical errors within 48 hours and submit a report within 45 days of the event.
  • Reinstate licensing requirements to operate a hospital in Washington State

20-32.12 Ministry of Health – Health workers

According to the last sequence, 20-32.12, proclamation 20.32 is terminated and cancelled. As of 12:01 a.m. on October 27, 2022, the reinstatement of all licensing requirements for healthcare workers will come into effect.

20-24.4 Restrictions on Non-Emergency Medical Procedures

According to the last sequence, 20-24.4, proclamation 20-24 is terminated and cancelled. Effective 12:01 a.m. on October 27, 2022, health care services, procedures and surgeries for all elective medical procedures are restored to all hospitals, outpatient surgical facilities, dental, orthodontic and of Endodontics from Washington State.

Limerick researchers develop guide to creating medicinal foods

RESEARCHERS at the University of Limerick (UL) have developed a new step-by-step guide to designing foods that not only provide nutrition, but can act as medicine.

The study led by Daniel Granato, a professor of food science and health at the college, showed how a group of so-called “functional” foods can help reduce heart disease.

He said: “The ability of our food to do more than provide us with nutrition is enormous and relatively unexplored. Cardiovascular disease is a leading cause of death, but it can be avoided. By bringing together food scientists, medical scientists and pharmaceutical companies, we can use the same methods used to produce drugs and produce foods that can alleviate health problems.

The study involves research staff from UL’s Bernal Institute, Federal University of Alfenas in Brazil, and the South American nation’s university college, Universidade Federal de Minas Gerais.

It has also been published in a world renowned food research journal titled Trends in Food Science and Technology.

Professor Granato, who leads a food chemistry research team at UL, said: “Food science, heart disease therapy and computational modeling should be linked to produce functional foods to mitigate atherosclerosis. . This is essential to achieve the United Nations Sustainable Development Goals for good health and well-being, as well as to ensure healthy lives and promote well-being for all at all ages, by maximizing the discovery of sources of bioactive compounds and reducing time to market for new functional foods. .”

The guide will form the basis of another research project aimed at identifying functional foods that reduce the risk of diseases such as Alzheimer’s disease.

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Changing pharmacist and technician roles due to the pandemic

Ed Cohen, PharmD, FAPhA: Over the past 2 years we have seen and received many emergency use privileges. The technicians were able to get vaccinated against the flu and COVID-19. We see the PREP [The Public Readiness and Emergency Preparedness] Emergency law and decrees by individual states. Now things are looking up a bit. We don’t feel that urgency like we did in the beginning. There are rumors that the PREP law could expire. We are already seeing some activity in states where they are reversing some of these emergency orders. With this sunset comes the potential loss of privileges for some of the things pharmacists may have been doing, which will surely impact technicians. Without some proactive movement within pharmacy boards or the legislative process, technicians may lose the opportunity to get vaccinated. It’s an area that I’m passionate about because I really believe that pharmacy has grown, and all of a sudden there’s talk of bringing pharmacy back to where we started, where we were at the start of the pandemic.

Traci Poole, PharmD, BCACP, BCGP: Without the technicians stepping in and taking on some of these additional roles, the season would have been much longer for us. We were criticized and the technicians able to administer vaccines and tests helped enormously. If many states haven’t addressed this issue in their policies and regulations, and haven’t legislated for techs to administer, I’m afraid my community pharmacy brethren are going to have a very long flu year and COVID-19 simultaneously, depending on what happens with the boosters.

I’m also concerned about pediatric capacity, because those poor pediatric practices are probably going to be completely overwhelmed with new approvals for children. This relieves some of the burden on these offices to be able to offer other vaccines, even up to your recommended childhood vaccine schedule. I am a bit worried. I’m not clear, and you may know it. In Tennessee, we fixed that problem. In many other states, they also take care of it when it comes to the administration of technicians. But I don’t know to what extent the country has done that. It would be unfortunate if they dropped this deadline and did not make it a standard of pharmacy practice.

Ed Cohen, PharmD, FAPhA: With any immunization experience in building programs, you all know what you see in 1 state is just 1 state. There are 50 states and 50 individual vaccination programs across the country. There are no 2 alike. It was a great opportunity for the pharmacy profession to have a federal executive order that said things could be the same in all states. It has been very refreshing over the past 2 years. The loss of this authority at the federal level is enormous. I don’t think individual states take the ball and move forward with it. Many of them pick it up and back off. Do any of you have any information on what’s going on in your state?

Wesley Nuffer, PharmD, BCPS, CDCES: We are very similar to Traci in that our state advocacy group acted relatively quickly and got the technicians authorized by state law to do so. It’s not a new idea. There were a few states doing this before the COVID-19 pandemic. When I first heard about it, I was totally against it because I felt it was going to take away an essential role from the pharmacist. But then I spoke to pharmacists in those states and found that it freed them up to have the conversations we need to have. These are the pieces of education and information that pharmacists can provide. The actual task is what the technician helps alleviate. To pick up on Tracy’s point, we need it, and we need it badly in community practice today. I totally agree that this is an area where we now have students in pharmacy school who have done hundreds of vaccines already, and it’s a great thing that they can bring to the table. It’s something the techs have shown they can do well, and it would be a tragedy to see that backtracked.

Ed Cohen, PharmD, FAPhA: We’ve heard so much talk about making the technician role a career path and not just a job. By giving them these advanced privileges and opportunities, if you take them away, it destroys the idea of ​​career paths and reinforces that we don’t value techies. As pharmacists, if you’ve ever worked behind the counter, you know how valuable the technician is. If only those in decision-making positions could experience this and see firsthand how valuable it is to have good technicians and this career path for them. It would change all their minds.

Transcript edited for clarity.

2 cups of grapes a day could help you live longer, study finds

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  • Recently published studies suggest that grape consumption can have a positive impact on health and lifespan.
  • Adding more grapes to a high-fat Western diet could reduce the risk of fatty liver disease and increase longevity.
  • Despite positive results, experts say eating grapes is not a panacea for poor eating habits and does not offset the overall effects of consuming a high-fat Western diet long term.
  • A healthy, balanced diet made up of nutrient-dense whole foods is recommended by most experts for optimal health and well-being.

A growing body of evidence supports the positive effects of a diet derived from whole food sources, including fruits, vegetables, and other unprocessed foods.

A series of new studiespublished in the journal foodsuggest that grape consumption can have a significant impact on health and mortality, especially when added to a high-fat Western diet.

The research, which was partially funded by the California Grape Commission, suggests that adding about 2 cups of grapes a day to a high-fat Western diet resulted in less fatty liver disease and longer lifespans. in mice.

Fatty liver disease can lead to cirrhosis of the liver and possibly liver cancer. According to the results of the study, table grapes may have an important role to play in reducing the incidence of fatty liver disease and its fatal sequelae.

Main author John PezzutoPhD, dean and professor of pharmacy at Western New England University College of Pharmacy and Health Sciences, said his research demonstrates how eating grapes could help offset some of the effects of a high-fat Western diet.

“First, lifespan is increased, which indicates an overall whole-body response,” Pezzuto told Healthline. “Then the body’s antioxidant defense system is strengthened. In addition, fatty liver disease, which is believed to affect 25% of the population and lead to poor health outcomes, is prevented or at least delayed. »

According to Pezzuto, the study results also indicate that anyone could potentially benefit from eating more grapes, regardless of what type of diet or eating pattern a person might adhere to.

“The mechanisms we have shown to be mediated by grapes can be generalized to promote good health regardless of diet,” Pezzuto said.

A healthy gut microbiome is important for overall health and well-being and influences the functioning of vital organs, including the brain.

Study co-author Jeffrey IdlePhD, Director and Endowed Professor of Arthur G. Zupko Systems Pharmacology and Pharmacogenomics at Long Island University, explained that it was evident in the research that adding grapes had a profound effect on the microbiota in the mouse model.

But more research is still needed to determine if the health effects of grapes can be replicated in humans, particularly if eating grapes can reduce or reverse fatty liver disease.

In general, experts don’t recommend a high-fat Western diet, although adding more grapes to the mix could potentially offset some — but not all — of the negative effects.

“Grapes are known to contain resveratrol, a phytonutrient [and] antioxidant which is anti-inflammatory and may benefit health,” said Dana Ellis HunnesPhD, MPH, RD, senior clinical dietitian UCLA Medical Center, assistant professor UCLA Fielding School of Public Health and author of “Recipe for survival.”

“That said, a high fat content [or] The high animal protein Western diet cannot be completely reversed with just the addition of 2 cups of grapes [per] day, just as we have seen that adding fish oil supplements to an unhealthy diet is also not a panacea for what ails us.

Hunnes noted that it is often difficult to observe sufficient changes in health outcomes in nutritional studies conducted over short periods of time, especially in studies with non-human animals (Pezzuto’s mouse study has lasted just over 18 weeks).

Research from 2020 attributes the high-fat Western diet to the prevalence of fatty liver disease in developed countries like the United States, with up to a quarter of all Americans affected.

To reduce the effects of Western dietary habits, most health experts recommend eating a healthy, balanced diet rich in nutrient-dense whole foods.

For example, a Mediterranean diet, which emphasizes fish and plant-based foods, is rich in nutrients, including healthy fats (monounsaturated fats and polyunsaturated fats), which are known for their health benefits. and their ability to help prevent chronic disease.

Additionally, a whole plant-based diet, when balanced, is known to reduce the risk of chronic diseases, including heart disease, stroke, diabetes, obesity, and fatty liver disease.

In other words, simply adding a few cups of grapes to an otherwise unhealthy diet is less effective for overall health than eating a healthy, balanced diet for life. According to new research, grapes may be a valuable addition to current dietary recommendations.

“As diet influences disease, a healthy, balanced diet offers the best overall disease prevention,” Idle said.

“A daily consumption of 5 servings per day of fruits and vegetables has been recommended, with no stipulation as to specific fruits, for example. Our research in collaboration with Dr. Pezzuto strongly suggests that table grapes should be a major constituent of these 5 servings a day.

A next step to study could be the palliative effect of grapes on the development of fatty liver disease.

“This could be extremely important because so many people are affected by fatty liver disease. We need to look at this in more detail,” Pezzuto said.

“We are particularly fascinated by the effect of grapes on gene expression. We have reported this effect in brain and liver, both with good results, but we know from unpublished work that gene expression is also altered in other tissues, such as the kidney, for example,” said Pezzuto. “We will explore this in more detail.”

Additionally, Pezzuto’s grape study was conducted with females, and his team is currently conducting studies to investigate the effect of grapes on males.

“Some colleagues have suggested that the effects could be even greater [in] males,” Pezzuto said. “This is a long-term study, but we are excited to have the opportunity to continue this work.”

The growing body of research on the health benefits of grapes attests to the positive health effects of consuming a nutrient-dense whole food.

“Overall, I think this work will be considered a tour de force in the field of nutrigenomics,” Pezzuto said. “Not only [are] ‘you are what you eat’, but ‘you become what you eat” by altering gene expression, even in the brain. You have to wonder if eating habits, behavior and personality are more intertwined than ever imagined.

Despite the positive results, however, experts note that adding healthy foods like grapes to an otherwise unhealthy diet is unlikely to have a significant impact on human health and long-term lifespan.

More studies in humans are still needed to determine if eating grapes can reduce the risk of chronic diseases like fatty liver disease and increase lifespan. For now, experts continue to recommend a healthy, balanced diet rich in nutrient-dense whole foods to promote overall health and well-being.