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Volodymyr Zelensky: across the country we are rolling out a new project “Points of invincibility” to support people


We have much-needed financial news today. Firstly, there is another tranche of macro-financial assistance from the European Union worth EUR 2.5 billion. It is very important. We are also awaiting the approval of the macro-financial assistance program for next year amounting to 18 billion euros.

Second, the United States of America has announced that it will soon provide $4.5 billion in additional funding to directly support our budget.

I am grateful to the partners for these important steps of solidarity. Thanks to such decisions of our friends, we maintain social stability and, despite all the Russian strikes, fulfill our social obligations. And these are obligations to millions of people.

Since the beginning of the full-scale war, we have made stable payments to pensioners, which is almost 11 million elderly Ukrainians. The indexation of pensions has been carried out, in accordance with the law. 6 million citizens benefit from some form of social support.

This month alone, social payments totaled almost 14 billion UAH. It is about helping people with many children, the poor, single mothers and people with disabilities. In addition, more than 2 million internally displaced persons receive state assistance. Plus the salaries of budget sector employees. We do everything to ensure the payments of all our defenders.

The financial front line for Ukraine is now as important as the front line on the battlefield.

And I thank everyone who helps our state to accumulate the necessary funds. Both to our friends around the world and to the companies that, despite everything, continue to work and pay taxes.

As for the energy front. Energy and utility workers in many regions are continuing to restore the grid. We are also preparing responses to possible new terrorist attacks against our energy system.

As of tonight, only stabilizing quit programs are used in 16 regions and Kyiv. But it must be understood that in the event of consumption peaks, emergency stops are also possible.

We are also rolling out our new ‘Points of Invincibility’ project to support people across the country. To date, more than 4,000 points of this type have already been prepared. Others are planned.

If massive Russian strikes happen again and it is understood that the electricity supply cannot be restored within a few hours, the work of “points of invincibility” will be activated – all basic services will be there, including electricity, mobile and internet communications, heat, water and a first aid kit. Absolutely free and 24/7.

The points will necessarily work in all regional and district administrations, as well as in schools, state emergency service buildings, etc.

A special website, nezlamnist.gov.ua, with a map of such points throughout the country is already available. It is constantly updated.

It’s important to see now where these points are in your city, in your community, and keep an eye on the map for updates in the coming weeks as new points are added.

On the website and in all “Invincibility Points” you will be able to find out where the nearest gas station, bank, pharmacy and grocery store operate.

We all need to be prepared for any scenario considering what the terrorists are fighting against our people and what they are trying to do.

Local authorities are responsible for informing populations about the existence of “points of invincibility”. It should be very simple: in government buildings, in pharmacies, grocery stores, in post offices, there should be information about where a person can find help in the event of a power failure long term.

And it is very important that conscientious companies already join our initiative. Thank you to all the entrepreneurs who have decided to support the company now and make their business facilities “points of invincibility” – with generators, Starlinks, water and other things.

And please note that on our website nezlamnist.gov.ua there is a special form for representatives of companies who want to join and become a “point of invincibility” for Ukrainians. I’m sure: by helping each other, we can all get through this winter together.

The situation on the front line has not changed over the past day. In all areas of the front, the same dynamic as the previous days is maintained.

Donetsk region – fierce attacks, constant shelling. I thank all our heroes, who bravely resisted despite everything!

Lugansk region – with battles but little by little we are strengthening our position and advancing step by step.

Kherson region and other southern territories – we are doing everything to reduce the combat potential of the occupiers and eliminate their ability to bombard our cities.

Step by step we will bring the Russian army to new defeats, and no bombardment of Kherson or any of our cities will help the occupiers.

The sea… On our fundraising platform United24, we are actively fundraising for naval drones. The unit, as always, gives an excellent result. Ordinary people. More than 50 Ukrainian companies. International companies. Plus our Lithuanian friends. Plus the IT community. In total, people from 93 countries have joined this initiative of ours! We are gradually building the Ukrainian fleet of naval drones!

I thank everyone who supports us!

Thank you to everyone who fights and works for Ukraine!

Thank you to everyone who is helping their loved ones through this difficult time!

Glory to Ukraine!


Girijananda Chowdhury University Recruitment 2022

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Applications are invited for various pedagogical, technical and administrative positions in Girijananda Chowdhury University Assam.

Girijananda Chowdhury Assam University is inviting applications from eligible candidates for the positions of Professors, Associate Professors, Assistant Professors, Deans, Registrar, Officer, Executives and Assistants.

Job name: Professor

Subjects: English, Assamese, Political Science, Sociology, History, Economics, Social Work, Education, Teacher Training, Physics, Chemistry, Zoology, Botany, Computer Science, Commerce, Management, Law, Pharmacy, Pharmacology, Pharmacognosy, Nursing, Commerce , Management, Law

Eligibility criteria: According to UGC / AICTE standards

Missions & Responsibilities: Teaching, Research, Popularization and participation in the life of the company

Position name: Associate Professor

Subjects: English, Assamese, Political Science, Sociology, History, Economics, Social Work, Psychology, Education, Teacher Training, Mass Communication, Anthropology, Physics, Chemistry, Zoology, Botany, Mathematics, Computer Science, Business, Management, Law, Pharmacy, Pharmacology, Pharmacy Practice, Library Science, Medical Laboratory Technology, Physiotherapy, Nursing

Eligibility criteria: According to UGC / AICTE standards

Missions & Responsibilities: Teaching, Research, Popularization and participation in the life of the company

Read also : Assam Career: IIT Guwahati Recruitment 2022

Job name: Lecturer / Lecturer

Subjects: English, Assamese, Bodo, Linguistics, Political Science, Sociology, History, Economics, Social Work, Rural Development, Psychology, Education, Teacher Training, Mass Communication, Anthropology, Physics, Chemistry, Zoology, Botany, Mathematics, Computer Science , Business, Management, Law, Pharmacy Practice, Pharmacy, Pharmacology, Pharmacognosy, Library Science, Foreign Languages ​​(Mandarin, Japanese, German, French), Medical Laboratory Technology, Physiotherapy, Fire and Safety Management, Nursing, civil engineering

Eligibility criteria: According to UGC / AICTE standards

Missions & Responsibilities: Teaching, Research, Popularization and participation in the life of the company

Job Name: Clerk

Eligibility Criteria: A graduate degree with at least 10 years of experience at the Assistant Professor/Associate Professor/Deputy Registrar/Deputy Registrar level or similar administrative/research experience at a teaching/research institution .

Job name: Chief Financial and Accounting Officer

Eligibility Criteria: A graduate degree in Business/Economics with a minimum of 10 years experience at the Assistant Professor/Associate Professor/Deputy Registrar/Deputy Registrar level or similar accounting and finance experience in a any educational/research institute or business sector.

Read also : Assam Career: Apply for Visiting Professor Vacancy at Tezpur University

Job Name: Exam Controller

Eligibility Criteria: A graduate degree with at least 10 years of experience at the level of Assistant Professor/Associate Professor/Deputy Registrar/Deputy Registrar or similar experience in examinations at any educational institute

Position name: Dean of Schools

Eligibility criteria: UGC/AICTE eligibility for the Professor

Job Name: Dean (Academic)

Eligibility Criteria: Graduate degree with at least 10 years of experience at the level of Assistant Professor/Associate Professor/Deputy Registrar/Deputy Registrar or similar administrative/research experience in a teaching/research institution.

Position name: Dean (Research & Development)

Eligibility criteria: UGC/AICTE eligibility for the Professor

Position name: Director (Marketing & Promotion)

Eligibility Criteria: Graduate/post graduate with good knowledge of computer applications and excellent communication skills and at least 5 years of similar experience in an academic/corporate organization at a senior level.

Job Name: Secretary to the Chancellor

Eligibility Criteria: Graduate/post graduate with good knowledge of computer applications and excellent communication skills and at least 5 years of similar experience in an academic/corporate organization at a senior level.

Job Name: Secretary to the Vice-Chancellor

Eligibility criteria: Graduate/post-graduate with a good knowledge of computer applications and excellent communication skills and a minimum of 5 years of experience in an academic/corporate organization in a similar position at a senior level.

Read also : Assam Career: Apply for an assistant professor position at Handique Girls’ College

Job Name: PS to Registrar

Eligibility criteria: Graduate/post-graduate with good knowledge of computer applications and good communication skills and at least 3 years of similar experience in setting up an academic/corporate organization.

Job Name: System Administrator

Eligibility criteria: MCA/MSc-IT with knowledge of software development and ICT

Job Name: MIS Executive

Eligibility criteria: Graduate/post-graduate with good knowledge of computer applications and communication skills having similar experience in academic/corporate setting. New candidates willing to learn and work in a highly professional setting can also apply.

Job Name: Promotions and Marketing Manager

Eligibility criteria: Graduate/post-graduate with good knowledge of computer applications and communication skills having similar experience in academic/corporate setting. New candidates willing to learn and work in a highly professional setting can also apply.

Read also : Assam Career: Bodoland University Recruitment 2022

Job Name: Admissions Officer

Eligibility criteria: Graduate/post-graduate with good knowledge of computer applications and communication skills having similar experience in academic/corporate setting. New candidates willing to learn and work in a highly professional setting can also apply.

Job Name: Front Office & Information Executive

Eligibility criteria: Graduate/post-graduate with good knowledge of computer applications and communication skills having similar experience in academic/corporate setting. New candidates willing to learn and work in a highly professional setting can also apply.

Job Name: Administrative Officer

Eligibility criteria: Graduate/post-graduate with good knowledge of computer applications and communication skills having similar experience in academic/corporate setting. New candidates willing to learn and work in a highly professional setting can also apply.

Job name: Multi-Task Executive

Eligibility criteria: Graduate/post-graduate with good knowledge of computer applications and communication skills having similar experience in academic/corporate setting. New candidates willing to learn and work in a highly professional setting can also apply.

Read also : Assam Career: Apply online for 14 vacancies in the Office of Deputy Commissioner Hojai

How to register : Applicants can send their application along with certified copies of relevant documents to [email protected]

Detailed announcement : Click here

University of Alabama CCHS Expands Health Care Across Alabama for 50 Years

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The University of Alabama’s College of Community Health Sciences celebrates 50 years of responding to the state’s acute need for more doctors for small towns and rural communities that have suffered from a severe lack of care health.

Founded in 1972 by Dr. William R. Willard, who served as the college’s first dean, CCHS focused on the specialty of family medicine.

Dr. Richard Friend is Dean of the College of Community Health Sciences at the University of Alabama and a family physician. (contributed)

“In many ways it was the hardest job I’ve had…because we were trying to train a new kind of doctor, a family doctor,” Willard said in a 1979 interview for “Point in Question”, a UA TV production. “But at the same time, I think it’s perhaps one of the most rewarding because I think we have the opportunity to have a significant impact on an important social issue, which is people’s health care. small towns and rural areas. ”

Since opening its doors five decades ago, CCHS has done just that. The college has educated thousands of medical students and resident physicians, created programs to recruit and mentor high school and rural Alabama students interested in medicine and wanting to practice in their hometown or similar communities, and added graduate programs in population health, and community and rural health.

The Tuscaloosa Family Medicine Residency Program has graduated 527 family physicians. More than half of the graduates have remained in Alabama to practice, and about half of them practice in rural communities across the state. In fact, one in seven family physicians practicing in Alabama graduates from residency. CCHS has also developed fellowships through residency to provide additional training for family physicians in behavioral health, emergency medicine, geriatrics, hospital medicine, obstetrics, pediatrics, and sports medicine – the highest number of scholarship offers from any institution in the country.

A key CCHS initiative during the 1990s was the creation of a sequence of programs, the Rural Health Leaders Pipeline, to recruit and train high school and college students in rural Alabama who wanted to return home, or in similar communities, to practice medicine. To date, hundreds of students have participated in these programs, and many are now practicing as doctors and other health care providers in rural Alabama communities. The college has also made a commitment to rural health and awareness by establishing the Rural Health Research Institute in 2001.

RELATED: New University of Alabama program prepares pre-med students for rural health care

The college built a community medical practice, University Medical Center, which is now the largest in western Alabama with locations in Tuscaloosa, Northport, Demopolis, Fayette, Carrollton, and Livingston. The college recently formed Capstone Hospitalist Group, whose physicians treat inpatients at DCH Regional Medical Center in Tuscaloosa and Northport Medical Center.

Along with its Capstone Hospitalist Group and as operator of UA’s student health center and pharmacy, the college’s medical practice saw nearly 250,000 patient visits last year.

“It is exciting to see the College prosper and expand in the areas of medical education, patient care and research,” said Dr. Richard Friend, Dean of CCHS and physician at family. “Going forward, we are committed to further elevating the distinction of our medical students’ training and residency, the care of our patients, and the translation of research and discovery to improve the health of Alabama. and South East.

This story originally appeared on the University of Alabama website.

Auburn Pharmacy’s Amin is developing Alzheimer’s drug with NIH support

Body of the article

Thanks to a new approach to treating Alzheimer’s disease, the Harrison College of Pharmacy Raj Amin is partnering with biopharmaceutical company Oleolive to advance the drug candidate into phase 2 studies.

The study will be supported by a $2.58 million grant through the National Institutes of Health, or NIH, Small Business Technology Transfer Program. The compound was designed and developed by Amin, an associate professor at Department of Drug Discovery and Development, and collaborators including Tracey Ward, professor of medicinal chemistry and medicinal biochemistry at Ferris State University, and Orlando Acevedo, professor of chemistry at the University of Miami. To help commercialize the compound, Auburn’s technology transfer office, known as The IP Exchange, applied for and was granted a US patent.

The compound, called AU9, is an intellectual property manufactured and designed at Auburn and Harrison College of Pharmacy.

“I am very excited about the capabilities the NIH is giving us to advance our studies and enable us to proceed with a potential Investigational New Drug Application with the Food and Drug Administration,” Amin said. “Our capabilities to design and develop novel therapies at Auburn in the Drug Discovery and Development department will allow us to advance the field of drug discovery related to Alzheimer’s disease.”

AU9 is a new drug that activates the peroxisomal proliferating nuclear receptor, activating the delta and partially gamma receptor, also known as PPAR delta and gamma.

The in silico design and development of AU9, i.e. it was designed and developed by computer simulation, induces the expression of neurotrophins that act to enhance synaptic plasticity and memory while separately reducing inflammation associated with disease progression.

“Our drug candidate is unique because it was engineered in silico to activate the PPAR nuclear receptor,” Amin said. “This is a very exciting and promising area with many challenges and opportunities to explore, including extensive testing needed to assess the safety, efficacy and bioavailability of this substance.”

Early research was supported by an NIH R15 grant awarded to Amin and Vishnu Suppiramaniam, Gilliland Professor at Harrison College of Pharmacy, focused on understanding how AU9 ameliorates behavioral deficits and neuronal function in animal models of the disease. of Alzheimer’s.

After the success of this study, Amin partnered with Oleolive to continue work on the drug. To enable AU9’s commercial development and strengthen continued small business financing, The IP Exchange licensed Auburn’s commercial rights to Oleolive. Together, Amin and Oleolive received an NIH Small Business Innovation Fellowship for Phase 1 work where they learned more about the drug’s bioavailability in the brain, as well as the impact on pathologies. , especially beta-amyloid.

The Small Business Technology Transfer Program, also known as STTR, is an NIH program that supports translational research between small businesses and nonprofit research institutions. Rusty Arnold, a professor at Harrison College of Pharmacy, is a co-principal investigator on the Phase 2 grant.

“The Phase 2 project is considerably more financially intensive and studies in different animal models the biosafety for liver and heart after prolonged treatment periods,” Amin said. “These studies focus on Good Manufacturing Practice facilities. Additionally, Phase 2 grants have a significant commercial component that focuses on evaluating large industrial-type biopharmaceutical companies with scientists in the field of neuroscience drug discovery.

The study’s small business partner, Oleolive, is a biopharmaceutical company based in Shreveport, Louisiana. Oleolive has experience in developing and commercializing potential therapies for various diseases.

“Oleolive is focused on building the business component of the app,” Amin said. “It helps to understand the value of the drug candidate as it progresses towards an investigational new drug application with the FDA. In addition, they also collect all the information necessary for application requirements, including safety and bioavailability.

With all the work required to bring AU9 to this point in the process, Amin is grateful for the support and opportunities from Auburn and Harrison College of Pharmacy to design and develop such a novel drug.

“We are fortunate in the Department of Drug Discovery and Development to have personnel and equipment available for the discovery, design and development of new drugs for various diseases,” Amin said. “I sincerely appreciate the tremendous support from the department, college, dean’s office, and Auburn University that allows us to be competitive at the highest level in the field of drug discovery.”

Fentanyl vaccine a potential ‘game changer’ for the opioid crisis

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Texas researchers have developed a vaccine that blocks the euphoric effects of fentanyla potent synthetic opioid that is increasingly implicated in opioid overdose deaths in the United States.

In studies with male and female mice, the vaccine generated significant and long-lasting levels of anti-fentanyl antibodies that were highly effective in reducing the antinociceptive, behavioral and physiological effects of the drug.

The vaccine prevents fentanyl from entering the brain. “Thus, the individual won’t experience the euphoric effects and can ‘get back on the train’ to sobriety,” said lead researcher Colin Haile, MD, PhD, of the University of Houston in Texas and a founding member of the UH Drug Discovery Institute. in a Press release. The study was published online October 26 in the newspaper Pharmacy.

“Anti-fentanyl antibodies were specific for fentanyl and a fentanyl derivative and did not cross-react with other opioids, such as morphine. This means that a vaccinated person could still be treated for pain relief with other opioids,” Haile said.

The vaccine caused no adverse effects in immunized mice. The research team plans to begin manufacturing a clinical-grade vaccine in the coming months with human clinical trials expected soon.

If proven safe and effective in clinical trials, the vaccine could have major implications for the country’s opioid epidemic by becoming a relapse prevention agent for people trying to stop using opioids. , note the researchers.

Like before reported by Medscape Medical Newsthe United States recorded more than 107,000 drug overdose deaths in 2021 — a record, according to federal health officials — and fentanyl was implicated in most of those deaths.

Lead author Therese Kosten, PhD, director of UH’s Developmental, Cognitive, and Behavioral Neurosciences Program, calls the new fentanyl vaccine a potential “game changer.”

“The use and overdose of fentanyl poses a particular therapeutic challenge that is not adequately addressed with current drugs due to its pharmacodynamics, and the management of acute overdose with short-acting therapy naloxone [Narcan] is not effective enough because multiple doses of naloxone are often needed to reverse the deadly effects of fentanyl,” Kosten said.

Funding for the study was provided by the Department of Defense through the Alcohol and substance abuse Disorders Program run by RTI International’s Pharmacotherapies for Alcohol and Substance Use Disorders Alliance, which funded Haile’s lab for several years to develop the fentanyl vaccine. The authors have no relevant conflicts of interest. A provisional patent has been filed by the University of Houston on behalf of four of the investigators containing technology related to the fentanyl vaccine.

Pharmacy. Published online October 26, 2022. Summary

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Announcing an Emergency Review of Community Pharmacy Services

The Department of Health is setting up an emergency review of community pharmacy services in Northern Ireland in light of the continued pressures the sector is facing.

The review will aim to define the services that can be reliably delivered this winter and bring certainty to the public and the health and social care system.

Community pharmacy representatives continue to raise serious concerns about the rising costs faced by their members.

There has been a constructive approach to the partnership between the Department and Community Pharmacy NI over the past three years. Significant additional investments in the sector have been made between 2019/20 and 2021/22, to ensure that community pharmacies are able to provide essential frontline support during the COVID-19 emergency.

This constructive approach has also led to agreement on a three-year go-live plan for 2022-2025, with a dedicated work program offering community pharmacies the opportunity to deliver new HSC services worth £7 million , such as a “Pharmacy First” service for common conditions. , as well as an additional £3.5m for immunization services and consideration of additional funding for medication adherence services.

This year the Department has drawn up a new financial package worth over £5.3 million. This package is currently being implemented.

However, industry representatives have indicated that the package will not be enough.

The Ministry is very aware of the challenges faced by community pharmacies. Likewise, the Department itself and all parts of the HSC system are under severe pressure – the Department still has no confirmed budget for 2022/23 with a significant overspending expected for the year. Financial constraints are expected to continue and potentially worsen further in the years to come.

An emergency review of all community pharmacy services had already been carried out at the start of the pandemic, in light of the pressures at that time.

Department of Health Permanent Secretary Peter May has offered to meet with Community Pharmacy NI next week to discuss the situation facing the sector.

Notes to Editors:

  1. For media inquiries, please contact the DoH Press Office by email [email protected]
  2. Follow us on twitter @healthdpt
  3. The Executive Information Service offers an after-hours service for media inquiries only between 6:00 p.m. and 8:00 a.m. Monday through Friday and weekends and holidays. The duty press officer can be contacted on 028 9037 8110.

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Company buys 51st pharmacy in Scotland

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A PERTHSHIRE-based pharmacy business has welcomed the purchase of its 51st premises in Scotland.

Specialist commercial property adviser Christie & Co managed the sale of St Mary’s Pharmacy in Dundee, a community pharmacy, which is mainly run by locum pharmacists and dispenses an average of 4,500 NHS items a month.

The company occupies a site in a residential area in the Downfield area of ​​the city.

It has been owned by John Ross (Chemists) Ltd since 2010 and has recently come onto the market due to a shortage of pharmacists in the area.

Following a confidential sale process with Christie & Co, St Mary’s Pharmacy was acquired by Blairgowrie-based group Davidsons Chemists, which now owns more than 50 pharmacies in Scotland.

Allan Gordon, Managing Director of Davidsons Chemists, said: “I am delighted to acquire this pharmacy for Davidsons Chemists, bringing the group to 51 across Scotland.

“Our plans are to continue to develop the chain and to have a medium-term objective of 60 pharmacies.”

Karl Clezy, Medical Director at Christie & Co, who handled the sale, said: “Despite staffing issues, particularly in this part of Scotland, we still attracted three offers for this business. This purchase for Davidsons Chemist made sense as they also operate several other pharmacies in the Dundee area.

St Mary’s Pharmacy was sold at an undisclosed price.

THE UK is ‘now in recession’, Jeremy Hunt told the Commons as he outlined a series of tax hikes and spending cuts in a bid to plug a £55billion fiscal black hole.

The Chancellor revealed that the Independent Office for Budget Responsibility (OBR) forecast the UK’s inflation rate to reach 9.1% this year and 7.4% next year.

LIDL said around 770,000 more people shop with it every week than at the same time last year, as consumers flock to the discounter amid the cost of living crisis.

The German grocer reported this morning that shoppers had shifted £58m of spending to Lidl from traditional supermarkets as households sought savings as finances came under pressure from soaring inflation and of rising interest rates.

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Vetster launches mobile app for virtual practice vets

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Vetster Mobile App for Veterinarians

“For veterinarians who want to practice virtually, the Vetster platform provides a seamless user experience, with a user-friendly interface, high-quality video, and the ability to capture medical records within the app” Dr. Jo Myers, DVM practitioner on Vester.

Vetster, the world’s fastest growing veterinary telehealth and pet care marketplace, today announced the launch of the Vetster for Veterinarians mobile app for Android and iOS. The app complements the company’s top-rated web app, giving veterinary professionals another tool to connect with pet parents in their virtual practice. The app is now available to practicing veterinarians on Vetster through the App Store and Google Play Store.

“Vetster develops the solutions veterinarians need to practice virtually – on their terms,” ​​said Mark Bordo, CEO and co-founder of Vetster.com. “Our new mobile app is another way to provide veterinary professionals with a flexible platform to connect with pet parents between appointments, on the go between clients, or from the comfort of home. With just a few clicks on their mobile phone, veterinarians connect with pet owners with excellent video quality and easy-to-use scheduling and tracking features.

A massive increase in pet adoption combined with a shortage of veterinary labor expected to continue through at least 2040 has caused many veterinarians to look for other ways to meet demand, while improving their work-life balance. Vetster is stepping forward to fill a much needed gap in the market. The Vetster platform gives veterinarians the freedom to determine where, when and how they practice. Vetster veterinarians use the platform to provide teletriage, treat non-emergency cases, provide follow-up appointments, as well as proactive and preventative health care plans for pet owners. Many use Vester to supplement their income and alleviate student debt.

“Vetster helps overcome both the barrier to access and the overwhelming demand for veterinary care,” said Dr. Jo Myers, DVM practitioner on Vetster. “For veterinarians who want to practice virtually, the Vetster platform offers a seamless user experience, with a user-friendly interface, high-quality video, and the ability to capture medical records within the app.”

Designed for veterinarians

  • High-Quality Video Calls – Connect with pet parents via secure, high-quality video calls from an iOS or Android device.
  • Improved Appointment Management – Set your own hours and pause availability to accommodate unexpected schedule changes.
  • Direct Messaging – The direct messaging feature allows veterinarians to correspond with pet parents after appointments to provide additional assistance.
  • Electronic Medical Records – Patient medical records are captured and stored within the app for convenient reference by veterinarians and pet owners.
  • VetsterRx – In the United States, veterinarians can use VetsterRx powered by PetMeds to prescribe prescription and over-the-counter medications that can be delivered directly to the client. In Canada and the UK, vets can use the built-in prescription pad to provide an Rx or OTC recommendation that customers can fill at their local pharmacy.

Veterinarians can join Vetster by visiting Vetster.com. Once registered and authorized to practice on the Vetster platform, they can download and use the Vetster for Veterinarians mobile app.

About Vetster Vetster is an online veterinary telehealth marketplace that connects veterinary professionals with pet parents via video chat, text or audio. From the comfort of their own home, pet owners can access quality virtual care in minutes, and veterinary professionals can set their own price and schedule themselves based on their personal preferences. Create a free account today at vetster.com.

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Researchers from the University of Cordoba dig deeper into the genetic regulation of strawberry ripening

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“Spain is the leading strawberry producer in the EU, and the province of Huelva is the most important strawberry production area in the country, accounting for almost 95% of national production.

“However, between 5 and 25% of the production is lost (depending on the variety) due to the softening that the fruit undergoes throughout its maturation, infection by different pathogens and other factors that affect its quality. “said Francisco Javier. Molina Hidalgo, researcher in the BIO278 “Biotechnology and Plant Pharmacognosy” group at the University of Córdoba (UCO).

“This is why strawberry is a particularly interesting crop for the application and development of plant biotechnology,” he added. In this sense, this research group, led by Juan Muñoz Blanco, has developed two studies in which they have managed to advance and deepen the knowledge of the molecular control of the strawberry ripening process, said the UCO.

More specifically, the BIO278 group studied how DNA methylation, which is a mechanism that regulates gene expression, is involved in the strawberry ripening process. To check this, the research team injected a chemical compound called 5-azacytidine into the strawberries. The function of this compound is to remove methylation marks from DNA. This made it possible to compare treated samples, which lost methylation, with untreated samples, which retained them.

The areas of the fruit treated with 5-azacytidine remained white, while the rest, which was not treated, ripened normally. This means that the lack of methylation stops the ripening of strawberries. Subsequent studies showed that 5-azacytidine treatment altered the hormonal balance governing fruit ripening and the expression of genes involved in the biosynthesis and degradation of these hormones.

Additionally, the researchers described the function of the FanCXE1 (carboxylesterase) gene, which plays an important role in the production of strawberry volatiles. These compounds appear during the ripening process and constitute the aromas of the fruit. Therefore, they greatly influence its quality.

Since carboxyl esterase is fundamental in the regulation of volatile compounds, “we propose this gene as a marker for selection programs or as a target for genetic improvement with more up-to-date techniques”, specifies Molina Hidalgo.

The two studies, published in the journals BMC Plant Biology and Horticulture Research, provide new knowledge and tools that can help the strawberry industry and other fruit industries, as genetic improvement techniques can improve the characteristics most appealing and healthy foods.

Source: uco.es

Five Ayurvedic Herbs That Could Boost Your Hair Growth

Ayurveda offers a bunch of whole herbs that stimulate hair growth and solve various problems. Gone are the days of bad hair and the anxiety associated with baldness. It’s time to embrace the natural benefits of ancient Indian herbs and say goodbye to hair loss and premature graying problems.

By Vaishnavi Parashar: On average, our scalp has 1,00,000 hairs going through the cycle of growing, resting, shedding and regenerating. According to the American Academy of Dermatology, it is common to lose 50 to 100 strands of hair per day. However, people of all ages and genders can experience increased hair loss and fear baldness. With pollution, stress, seasonal fluctuations and lifestyle changes, hair loss has become a common concern for Indians.

India Today spoke with Dr. Sanchit Sharma, Director of Ayoutveda of AIMIL, who holds a Pharmacy degree in Chemistry and Pharmacognosy of Natural Products.

“According to Ayurveda, hair loss is caused by a ‘Tridosha’ imbalance (imbalance of the three main energies) in our body. Nutritional deficiencies, hormonal imbalances, dandruff, and chemical treatments can trigger excessive hair loss and stop the growth of new follicles,” says Dr. Sanchit Sharma.

He also says that Ayurveda has secrets to control hair loss and restore hair growth. This age-old natural medicine system blends herbal extracts and provides your crowning glory with forever shine and luster.

List of 5 Ayurvedic Herbs Best for Hair Growth:

AMLA

Indian gooseberry, or Emblica Officinalis, is a “rejuvenating fruit” with exceptional health benefits. It is rich in vitamins, minerals, amino acids and active phytonutrients, nourishing the scalp and strengthening hair strands. The essential fatty acids and antioxidants in amla help fight dandruff and remove oil and dirt from the scalp.

Massage oil rich in amla extract onto your scalp to increase blood circulation and stimulate hair follicles to promote growth. It also prevents premature loss of pigment from your hair strands and is a natural remedy for graying.

BHRINGRAJ

Bhringraj (Ecliptaelba), commonly known as ‘false daisy’, grows in humid areas and is packed with vitamins, calcium, magnesium and iron. It is recognized as the “king of hair” due to the immense benefits of herbal extracts for hair nutrition.

The herb contains flavonoids, phytosterols, and abundant hair growth-stimulating elements that help reduce hair loss and stimulate hair growth. It increases blood circulation to the scalp and hair roots and activates the follicles to induce natural hair growth. Additionally, the antimicrobial, antifungal, and anti-inflammatory properties of Bhringraj extracts help prevent infections and control dandruff.

FENUGREEK OR METHI SEEDS

Fenugreek or TrigonellaFoenum-Graecum is an annual herb whose seeds and leaves are common culinary ingredients in Indian cuisines.

Methi seeds are widely used throughout the country as a spice and have great medicinal value. Fenugreek seeds are soaked overnight and ground into a fine paste to be applied to the scalp. They are a rich source of iron, protein and essential nutrients that nourish hair and promote growth. The nicotinic acid contained in methi is very effective against dandruff and hair loss and solves various hair problems.

Fenugreek also contains vitamins A, C and K, folic acid, flavonoids and saponins with anti-inflammatory and antifungal properties. They treat scalp issues like dry hair, baldness, and thinning hair while nourishing your follicles for healthy growth.

ALOE VERA

Aloe vera is named “GhritKumari” in Ayurveda. The highly nutritious gel is widely used to treat various hair issues. A recent study found that the fatty acid components of aloe vera gel have anti-inflammatory properties that help resolve scalp inflammation and dandruff. Vitamins A, C and E in aloe contribute to cell renewal, promoting the repair and rejuvenation of follicles.

Vitamin B12 and folic acid can prevent hair loss and alleviate scalp issues like itching, seborrheic dermatitis, and excessive oil secretion. Aloe vera gel also has a cooling and soothing effect that moisturizes and hydrates the scalp, promoting healthy hair growth.

BRAHMI

Brahmi or Bacopamonnieri is considered a brain tonic in Ayurveda but has a wonderful effect on hair growth and thickening. For traditional hair wellness, Brahmi leaves are boiled in coconut oil and then the prepared oil rich in Brahmi extracts is used to massage the scalp.

It cleanses Kapha-dominated oily scalps, removing dandruff and excess oil while hydrating dry scalps for healthy hair growth.

Houston researchers test experimental fentanyl-blocking vaccine

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November 15 (UPI) — A lab-tested vaccine can prevent the dangerous opioid, fentanyl, from entering the brain and leading to abuse, University of Houston researchers said this week.

A study published in the peer-reviewed journal Pharmaceutics details how the experimental vaccine was able to generate antibodies that would bind to fentanyl, sending it to the kidneys which would turn it into waste.

This, in turn, would block it from entering the brain and eliminate the high associated with fentanyl.

“We believe these findings could have a significant impact on a very serious problem that has plagued society for years – opioid abuse,” said Colin Haile, a research associate at the University of Houston and lead author of the study.

Fentanyl is a dangerous opioid that many people may not realize they are taking because it is often added to so-called street drugs like cocaine and methamphetamine.

The US Department of Justice announced in September that it had seized 10 million fentanyl-containing pills and 82 pounds of fentanyl powder during a five-month nationwide investigation.

“Across the country, fentanyl is devastating families and communities, and we know violent and criminal drug cartels are responsible for this crisis,” the attorney general said. Merrick Garland said.

Depending on a person’s size, a Houston researcher said just 2 milligrams of fentanyl – about the size of two grains of rice – can prove fatal in humans. The vaccine has so far only been tested in rats, but Haile’s team has so far seen few adverse side effects and it hasn’t interfered with other opioids, such as morphine. .

“That means a vaccinated person could still be treated for pain relief with other opioids,” he said.

The researchers add that opioid abuse is treatable, but nearly 80% of people who try to quit usually suffer a relapse. Opioids in general, meanwhile, are ubiquitous.

A federal judge in Ohio in August ordered Walmart, Walgreens and CVS to pay two counties near Cleveland $650 million for their role in distributing abuse-prone opioid painkillers.

Human clinical trials of the vaccine are expected to begin soon, Houston researchers said.

Did they “quietly quit” or are they saving their sanity? : Risk & Insurance

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Michelle Kerr is the editor of workers’ compensation and chair of the National Conference on Risk and Insurance. She can be reached at [email protected]

By now, most of us have heard the term quitting smoking quietly. Is it a negative or a positive thing?

There is confusion over what it is or what it means. Some think it means the period of disengagement an employee can go through before quitting.

Is it really?

It depends on the lens through which you view it. I read an article from a recruiting firm that listed some of the “key signs” of a quiet shutdown:

  • People go out exactly at 5:00 p.m.
  • Employees are no longer willing to work overtime
  • Employees are unwilling to perform tasks or take on responsibilities that are not in their job descriptions
  • People who only perform tasks specifically described in their contracts
  • People are no longer willing to hustle, fend for themselves, or go beyond

Is this a disengagement, or has this person simply engaged in very deliberate boundaries to protect their work/life balance?

When you view these behaviors as setting healthy boundaries, perhaps quitting quietly is simply rejecting a culture where working to the point of mental/physical overload is celebrated and encouraged.

But how does this rejection reflect on our working cultures?

That’s a good question to ask. The pandemic brought the very real topic of burnout to the forefront, but the phenomenon was not new. Millennials and Gen Z have watched colleagues, friends and family fall prey to burnout for years, since the days of the unspoken rule that we all keep it to ourselves. Why wouldn’t they reject it for themselves and their families?

COVID-19 has also caused many people to rethink their life choices, including their goals, priorities and values. It’s no surprise that the daily, weekly and monthly toll of lives lost during the pandemic is causing a shift in values ​​in many people.

If you remove the negative implication of ‘quit quietly’ and call it ‘putting well-being first’, shouldn’t we be supporting that? Shouldn’t we also reject cultures where working to mental/physical overload is celebrated?

For everyone who just said “we don’t do that”, how many meetings have you been to where someone was praised for something they did, even though they were on their honeymoon at that time, even though he hadn’t slept for three days to do it, even though they had gone into labor, even though they had just been discharged from the hospital?

We applaud and say: “Bravo! and set that public bar high to praise the wrong priorities.

Mental health, wellbeing, stress/burnout, work/life balance — these are all part of the biopsychosocial elements that we now understand impact the overall picture of demands. workers’ compensation.

Silent abandon is a trending hashtag that we probably won’t even remember next year. But it sparked conversations that should continue. Employers and the workers’ compensation community should reflect on this and consider what it means for the future of our workplaces and our employees. &

Narcan-resistant ‘grey death’ street drug discovered in Minnesota for the first time

Claims made this week by Bloomington Police Chief Booker Hodges about a cocktail of synthetic opioids called “grey death” are coming under intense scrutiny.

Speaking at a press conference on Thursday, Hodges announced the seizure of the drugs – so called for their gray appearance – following a recent search warrant in the city, and expressed extreme concern over the discovery, claiming the drugs are resistant to the opioid antidote Narcan, also known as Nalaxone.

However, this claim was immediately rebuffed by drug experts, with medical toxicologist Ryan Marino say FOX 9 that Hodges’ comment was “pretty dangerous” and factually incorrect, and that no opioid is confirmed to be Narcan-resistant.

There have been many claims in recent years that new super potent synthetic opioids such as fentanyl and carfentanil are “nalaxone resistant”.

But the Center for Health Policy and Law says that is not the case. He notes that strong synthetic opioids still respond to Narcan, but because of their potency, Narcan must be administered much sooner after an overdose and in larger amounts.

Dr. Elizabeth Ambrose, associate professor of medicinal chemistry at the University of Minnesota Masonic Cancer Center, said bring me the news that is essentially correct.

However, she notes that a “very potent and lethal combination of opioids” such as Gray Death has the potential to cause instant death.

“Technically, this combination is not ‘resistant’ to Narcan, but reversing ‘grey death’ may require doses of Narcan far greater than those needed to counter typical ‘street’ opioids, and yes, prompt administration is essential,” she said.

In 2017 notes the National Heroin Coordinating Group that claims that potent synthetic analogs render Narcan ineffective are “incorrect and misleading”, acknowledging that additional doses of Narcan may be required in such cases to fully resuscitate a patient.

“If given quickly and in sufficient doses, naloxone and other opioid antagonists are effective against all opioids, regardless of potency,” the statement said.

According to Bloomington Police, “Grey Death” and “black tar” heroin-style fentanyl were found during a search of a home in the 10300 block of Devonshire Circle on Tuesday. Authorities also seized more than 755 “m-box” fentanyl pills.

Two suspects were arrested.

“Black tar” heroin-type fentanyl. Courtesy of the Bloomington Police Department.

At a news conference Thursday, Hodges said the department is working to raise awareness about the drug, which might be unrecognizable to most people, including police.

“Grey death” substances look like sludge, he said, and “black tar” substances could be mistaken for the tar left behind by marijuana smoke from a pipe.

“It looks like dirt to me,” he said, pointing to a sample of “gray death.” “If I saw that, I would think it was dirt.”

There have been several reports over the years identifying a style of “grey death” drug cocktail, although there does not appear to be consensus on its constitution, although carfentanil, an elephant tranquilizer, and fentanyl, another synthetic opioid, are usually mentioned .

Bloomington is currently having a record year for overdoses, with 15 deaths so far this year. There were six recorded overdose deaths in the city last year.

Penetration Study of p-Methoxycinnamic Acid (PMCA) in Nanostructured Lipid Carrier, Solid Lipid Nanoparticles and Simple Cream in Rat Skin

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Particle size

The results of particle size examination (Table 1) showed that all formulas were included in the nanoparticle size range, which was 10-500 nm18 and obtained the granulometry of the cream NLC PMCA

Table 1 Particle size and polydispersity index (PI) of PMCA cream, PMCA_SLN, NLC base and PMCA_NLC.

The PI values ​​showed that the NLC base was the most homogeneous compared to the others, while PMCA_NLC was more homogeneous than PMCA_SLN. This could be due to the addition of liquid lipids in the PMCA_NLC which dissolve the PMCA.

pH formula measurement

The pH of APMS, SLN APMS and NLC APMS cream formulas in Table 2 in accordance with the pH range of the skin from 4 to 619.

Table 2 pH of PMCA cream, PMCA_SLN, NLC base and PMCA_NLC.

Trapping efficiency (EE)

Previously, a homogeneity test was performed to determine the homogeneity of the levels performed for each replication performed. Based on the results of the recovery test, it was known that the recovery of each repeatability formula was good because the recovery value of each formula met the requirements i.e. 85-115%20. In addition, this method was considered to have good repeatability due to the low %CV.

From the results of the determination of EE, data were obtained which can be seen in Fig. 1. NLC PMCA formula had higher entrapment efficiency. The addition of liquid lipids in the formula affected the imperfections of the crystal lattice so that upon solidification of the lipid phase many drugs were trapped in the system21. Besides, it can also leave enough space for drug placement and trapping16.

Figure 1

Trapping efficiency of PMCA_SLN and PMCA_NLC.

The data was statistically analyzed with the sampling method of T test, they obtained the value of α sig. Bilateral accounts (0.028)

Occlusivity

The results of the occlusivity test of each formula are provided as a histogram of the average occlusivity for one week from the different formulas which can be seen in Fig. 2. PMCA_NLC had greater occlusivity than PMCA_SLN and PMCA_Cream. Indeed, PMCA_NLC had the smallest particle size and the most homogeneous particle size. Small particle size could make the structure between particles tighter, causing increased occlusivity, and small particle size resulted in increased surface area of ​​particles in contact with the skin22. The presence of occlusivity caused the increase in skin hydration. In addition, the hydration of the stratum corneum affects the rate of penetration of the substance into the skin.

Figure 2
Figure 2

Occlusivity of PMCA cream PMCA_SLN and PMCA_NLC.

Occlusivity data were analyzed using one-way Annova statistics. A calculated α value (0.00)

Penetration test on rat skin

In the penetration test, Nile red was used as a fluorescent marker due to its lipophilic nature23, otherwise known as a lipophilic dye. As can be seen in Figs. 3 and 4, the NLC base in the first 2 hours penetrated deep into the dermis layer. It proved that the NLC base penetrates deep into the skin layer, as well as PMCA in the cream, SLN and NLC. Indeed, Cream, SLN and NLC are lipid-based colloid carriers. The carrier system containing lipids is a good drug delivery system for the skin because it can facilitate penetration, act on the surface of the skin, repair adhesion and increase hydration of corneocytes in the stratum corneum9.

picture 3
picture 3

Penetration and distribution of Nile red in rat skin of PMCA cream, observed after 2 h (A) and 4.5 hours (B), PMCA_SLN observed after 2 h (VS) and 4.5 hours (D), NLC baseline observed after 2 h (E) and 4.5 hours (F), PMCA_NLC observed after 2 h (g) and 4.5 hours (H).

Figure 4
number 4

Fluorescence intensity of PMCA cream, PMCA_SLN, NLC base and PMCA_NLC after the 2nd and 4.5th hour of application.

The depth of penetration of the three formulations was compared over time (Fig. 4 and Table 3). After application for 2 h, PMCA SLN penetrated deeper than PMCA NLC and PMCA Cream. This was predicted due to the effect of differences in lipid crystal modification in SLN and NLC. The crystal modification causes less drug entrapment in the SLN than in the NLC, so the amount of drug in the outer phase of the SLN was greater than that of the NLC. This result also occurred in a search24 indicating that the crystal modification of the SLN matrix forces the drug to the outer phase and accelerates penetration. Meanwhile, after application for 4.5h, NLC PMCA penetrated deeper compared to PMCA SLN and PMCA Cream. The results were different with the 2 h result. These differences could be caused by various factors that affect drug penetration into the skin, such as occlusivity, particle size, drug concentration, and the effect of carrier materials.25. The difference between PMCA NLC and PMCA Cream was more influenced by the particle size. The small particle size and the spherical shape of the particles result in a tight inter-particle structure, leading to increased occlusivity (water retained in the stratum corneum caused hydration and swelling of corneocyte cells in the stratum corneum), so that drug substances could enter easily26. The difference between PMCA NLC and PMCA SLN was due to the addition of oleic acid as a liquid lipid, which also has other functions, namely as a penetration enhancer25 and PMCA solubilizing agent. The function of oleic acid as a penetration enhancer is to increase drug transport to the subcutaneous intercellular zone15. The increase in the solubility of PMCA increased the diffusion coefficient of PMCA to the skin membrane so that the drug penetrates better26. The fluorescence intensity measured qualitatively by observing the amount of drug delivered by the cream, SLN and NLC to the layers of the skin, namely stratum corneum, viable epidermis and dermis. PMCA NLC could carry more drugs than PMCA SLN and PMCA Cream (Fig. 4.). Up to 4.5 h, the PMCA in the NLC system still had quite light nile intensity red luminescence in the dermis layer.

Table 3 Depth of penetration into rat skin after application for 2 and 4.5 h.

Military Families in Rural California Lose Access to Local Pharmacy

Some military families are wondering where they will go to get prescriptions now that their local pharmacies are out of the network. The military community around Beale Air Force Base in Nevada County has been hit hard by the change with the Department of Defense Health Agency. Members living in Penn Valley depend on their local pharmacy for Tricare benefits. Pleasant Valley Pharmacy is one of 15,000 independent and community pharmacies affected by the change. Express Scripts Tricare program for decades. “A lot of these people are risking their lives for us,” Wells said. “They deserve good care.” But for the first time, Wells didn’t sign the contract saying he wouldn’t be able to break even with what Express Scripts was offering. “I would be willing to do Tricare prescriptions without profit,” he says. Retired Air Force Lt. Col. Byron Maynard, 89, wonders why the government made the change, affecting veterans like him. “I’m stunned. I don’t understand why they would do something like this,” Maynard said. Her senior community neighbor Marty Wright, 73, also received a letter from Express Scripts telling her she needed to find a new pharmacy. Wright lost her Air Force veteran husband in 2015. She is eligible for Tricare for life. down the block. They’ve been filling their prescriptions at Wells Pharmacy for 30 years. “They’re small but are such an important part of our community,” Wright said. But the elderly said it was difficult to drive far, especially in bad weather. “It’s very important that we don’t have barriers on how to get the things we need and need to have,” Maynard said. Because the Department of Defense Health Agency monitors Tricare, 100 members of Congress from both political parties are now involved and pressing for answers. Congressional District, a large rural area with veterans who need local help and live hundreds of miles from a VA hospital. LaMalfa is one of 100 lawmakers who sent a letter to the Defense Health Agency urging Tricare to return to the military network. “make it almost impossible for family pharmacies to be there and it’s just fewer options for veterans,” LaMalfa said. ‘re here because they fo Our country should stay what it is,” Wright said. “It may sound silly, but it’s what’s on my heart.” statement to KCRA 3 News: “Express Scripts is privileged to continue to serve the men and women of the United States Armed Forces, retired military personnel and their families. Our responsibility is to ensure that TRICARE recipients can access their prescription drugs in a way that is safe, affordable, and convenient and at the best value for the Department of Defense and taxpayers. Any savings we make are passed directly to TRICARE beneficiaries and the Department of Defense, and to generate added value, we recently offered new terms for pharmacies and their wholesalers to participate in the new TRICARE Pharmacy Network. Nearly 41,000 chains, grocery stores and independent pharmacies have agreed to participate in the network. In California, 99% of beneficiaries will have an in-network pharmacy within a 15-minute drive of their home, and we will help all affected beneficiaries find an in-network pharmacy to fill their prescriptions. Express Scripts also said it has a dedicated team ready to support the small percentage of grantees who may be impacted by these changes. Grantees with questions or concerns may contact via email at DoD.Customer.Relations @express-scripts.com or by phone: 1-877-363-1303.

Some military families are wondering where they will go to get prescriptions now that their local pharmacies are out of the network.

The military community around Beale Air Force Base in Nevada County has been hit hard by the change with the Department of Defense health agency. Members living in Penn Valley depend on their local pharmacy for Tricare benefits.

Pleasant Valley Pharmacy is one of 15,000 independent and community pharmacies affected by the change.

“Not a day goes by that we don’t fill multiple prescriptions for Tricare recipients,” said Doug Wells, owner and pharmacist.

Wells has signed government contracts with the Express Scripts Tricare program for decades.

“A lot of these people are risking their lives for us,” Wells said. “They deserve good care.”

But for the first time, Wells didn’t sign the contract saying he wouldn’t be able to break even with what Express Scripts was offering.

“I would be willing to do Tricare prescriptions without profit,” he said.

Retired Air Force Lt. Col. Byron Maynard, 89, wonders why the government made the change, affecting veterans like him.

“I’m stunned. I don’t understand why they would do something like this,” Maynard said.

Her senior community neighbor Marty Wright, 73, also received a letter from Express Scripts telling her she needed to find a new pharmacy. Wright lost her Air Force veteran husband in 2015. She is eligible for Tricare for life.

“It’s so vital because, economically speaking, it’s such a big part of our overall budget,” Wright said.

Wright and Maynard rely on their hometown drugstore just around the corner. They’ve been filling their prescriptions at Wells Pharmacy for 30 years.

“They’re small but such an important part of our community,” Wright said.

Express Scripts has offered other major drugstore chains in other cities. But seniors said it was difficult to drive far, especially in bad weather.

“It’s very important that we don’t have barriers to getting the things we need and need to have,” Maynard said.

Because the Department of Defense Health Agency monitors Tricare, 100 members of Congress from both political parties are now implicated and demanding answers.

“I’m sick of them having to deal with this because they were there for us,” rep Doug LaMalfa said.

The Republican congressman represents the 1st Congressional District, a large rural area with veterans who need local help and live hundreds of miles from a VA hospital.

LaMalfa is one of 100 lawmakers who sent a letter to the Defense Health Agency urging Tricare to return to the military network.

“They make it almost impossible for family pharmacies to be there and it’s just less options for veterans,” LaMalfa said.

Former servicemen said they just wanted to be healthy for the few years they had left.

“We are here because they fought to keep our country what it is,” Wright said. “It may sound silly, but that’s what’s in my heart.”

Express Scripts provided this statement to KCRA 3 News:

“Express Scripts is privileged to continue to serve the men and women of the United States Armed Forces, military retirees, and their families. Our responsibility is to ensure that TRICARE recipients can access their prescription drugs in a way that is safe, affordable, and convenient and at the best value for the Department of Defense and taxpayers. Any savings we make are passed directly to TRICARE beneficiaries and the Department of Defense, and to generate added value, we recently offered new terms for pharmacies and their wholesalers to participate in the new TRICARE Pharmacy Network. Nearly 41,000 chains, grocery stores and independent pharmacies have agreed to participate in the network. In California, 99% of beneficiaries will have an in-network pharmacy within a 15-minute drive of their home, and we will help all affected beneficiaries find an in-network pharmacy to fill their prescriptions. »

Express Scripts also said it has a dedicated team ready to support the small percentage of recipients who may be impacted by these changes. Recipients with questions or concerns may contact by email at [email protected] or by phone: 1-877-363-1303.

UW College of Health Sciences Honors Distinguished Alumni | New

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November 11, 2022

The UW College of Health Sciences honored its distinguished alumni for 2022 during UW’s recent homecoming. Left to right, Joan Anderson, School of Pharmacy; Mary Gitau, Division of Social Work; Holly Miller, Fay W. Whitney School of Nursing; Paul Johnson, Wyoming WWAMI Medical Education Program; Marisa Yagi, Communication Disorders Division; and Carl Maresh, Division of Kinesiology and Health. (Photo UW)

The University of Wyoming College of Health Sciences honored six of its alumni during UW’s recent homecoming.

Joan Anderson, Mary Gitau, Paul Johnson, Carl Maresh, Holly Miller and Marisa Yagi were honored for their accomplished careers in the fields of communication disorders, kinesiology and health, medical education, nursing, pharmacy and social work.

Distinguished alumni of the College of Health Sciences are recognized for their outstanding professional achievements and contributions to excellence in education related to their professions. They also demonstrate continued support for their social and professional communities.

This year’s winners are:

Joan Anderson – UW School of Pharmacy

Anderson, of Cheyenne, received her bachelor’s degree in pharmacy, with honors, from the UW College of Pharmacy (now the School of Pharmacy) in 1959. As the only woman to graduate from the college of pharmacy that year, she became a Fulbright . Researcher, student at the Institute of Pharmacology at the University of Oslo in Norway from 1959 to 1960. She also completed one of the first pharmacy practice residencies accredited by the American Society of Health-System Pharmacists at the Jefferson Medical College Hospital from 1963 to 1964.

She then earned her master’s degree in pharmacy from the Philadelphia College of Pharmacy and Science in 1964, and she earned a master’s degree in education from Temple University College of Education in 1978.

She practiced acute care pharmacy and held administrative positions at Laramie County Memorial Hospital (now Cheyenne Regional Medical Center) in Cheyenne; West Nebraska General Hospital (now Western Regional Medical Center) in Scottsbluff, Neb.; and Thomas Jefferson University Hospital in Philadelphia. She served on the faculty of the first school of pharmacy in the United States, the Philadelphia College of Pharmacy and Science, from 1981 to 2004, serving in leadership positions as Vice President, Acting President, and Assistant Dean of student affairs. After her retirement, she joined the faculty of the UW School of Pharmacy as the Continuing Education Coordinator.

Anderson has been active in state, regional, national, and international organizations, including the American Association of Higher Education, American Pharmacists Association, American Association of Colleges of Pharmacy, International Pharmaceutical Federation, and Fulbright Alumni Association. She has given numerous presentations and served as an educational advisor to pharmacy student organizations.

Mary Gitau — Division of Social Work

Gitau, an associate professor of social work at Clarke University in Dubuque, Iowa, holds three degrees from UW. She obtained her Masters in Communication in 2007; a master’s degree in social work in 2012; and a doctorate. in Adult Learning and Post-Secondary Education in 2011. She received her BA in Organizational Communication from Ithaca College in 2004.

Gitau integrates social work, communication and nursing into its teaching, scholarship and research. As an international scholar, she conducts research in the United States and Kenya on immigration, women, social justice and human rights. In 2018, Gitau was awarded the Carnegie African Diaspora Fellowship hosted at Kisii University in Kenya. There, she initiated the creation of the Center for Peace, Social Justice, Equality and Security.

Her community service includes founding the Iowa Gazelle nonprofit Impact on Women & Youth in Kenya Inc., whose mission is to empower women and youth in rural Kenya. Working to foster intercultural competence, she has led numerous trainings in Iowa for community organizations and the university.

Paul Johnson – Wyoming WWAMI Medical Education Program

Johnson grew up in Laramie and graduated from Laramie High School in 1995. He received his undergraduate degree in biology from Baylor University before entering third class at UW Wyoming WWAMI (Washington, Wyoming, Alaska, Montana, Idaho) Medical Education Program in association with the University of Washington School of Medicine (UWSOM). After graduating from UWSOM in 2003, he completed his residency in otolaryngology at Columbia University.

Johnson returned to the Cowboy State after completing his medical training. He lives in Cheyenne and practices there as well as in Laramie. An active member of the Wyoming Medical Society, he was the first Wyoming WWAMI graduate to serve as president. He regularly contributes to classroom and clinical teaching in Wyoming’s WWAMI medical education program, and is a member of the program’s advisory board. Additionally, Johnson served on the advisory board of the UW College of Health Sciences.

Carl Maresh — Division of Kinesiology and Health

Maresh earned his Ph.D. in zoology and physiology from UW in 1981. He received his bachelor’s degree in health and physical education in 1971 and his master’s degree in health and exercise science in 1973, both from California State University-Fullerton.

He is a professor of kinesiology in the Department of Humanities at The Ohio State University (OSU) in Columbus, where he is also director of the exercise science program and director of the exercise science research laboratories.

His first professional position was director of the Institute of Health at Saint Luke’s Hospital in Kansas City, Mo. He was then recruited to the Midwest Research Institute (now MRIGlobal) in Kansas City, where he served as a research scientist principal in the departments of Organic Bio-Chemistry and Bio-Behavioral Sciences. Prior to joining OSU in 2014, Maresh was Professor Emeritus of Kinesiology on the University of Connecticut (UConn) Board of Trustees, where he held joint appointments in the departments of Physiology and Neurobiology, nutrition, physiotherapy and school sciences. of Medicine.

As Director of the Human Performance Laboratory at UConn from 1984 to 2014 and Head of the Department of Kinesiology from 1998 to 2012, he was recognized for bringing together a group of renowned scientists. Through focused teamwork, its department has been ranked over a 10-year period (2005-2015) as the #1 kinesiology doctoral program and most research-productive kinesiology department in the United States.

Holly Miller – Fay W. Whitney School of Nursing

Miller grew up on a ranch in central South Dakota. She received her AA degree in nursing from the University of South Dakota (USD) in 1974. She went on to earn two degrees from UW: a BSN in 1980 and a master’s degree in nursing education in 1996.

Miller’s first nursing position was as staff nurse at Sioux Valley Hospital (now Sanford USD Medical Center) in Sioux Falls, SD from 1974 to 1978. She married her husband and moved to Laramie in 1978 so that he could complete his graduate studies. From 1978 to 1988, she worked at Ivinson Memorial Hospital in the intensive care unit.

In 1988, she started at the UW Fay W. Whitney School of Nursing as coordinator of the Learning Resource Center. When the school moved to the current renovated building in 2005, the Learning Resource Center was renamed the Clinical Simulation Center (CSC). Miller was responsible for designing the CSC and outfitting the various areas with high-fidelity equipment and simulators. In 2012, she became Basic BSN Program Director, followed by BRAND Program Director in 2017.

In addition, she has been a clinical instructor in a hospital setting and has been an American Heart Association CPR instructor for 33 years.

After practicing nursing for 44 years, including 30 years with the School of Nursing, she retired in 2018. She continues to live in Laramie.

Marisa Yagi — Communication Disorders Division

Yagi is a Japanese-American “third culture kid”. She grew up in Egypt, Kenya and Japan, and she didn’t speak English until she was in college. Her first experience of life in the United States was at UW, where she earned three degrees. She obtained her BA in Visual Arts in 2015; his BS in communication disorders in 2015; and his master’s degree in speech therapy in 2017.

After becoming a certified speech therapist, she started Yagi Speech LLC to provide accessible and affordable online and in-person speech therapy services focused on international, multicultural and multilingual communities. At age 27, Yagi established a business unit in Okinawa, Japan called ShisaCare, which for the first time allowed U.S. military service members and their families in Japan to receive speech-related services covered by TRICARE.

About the College of Health Sciences

The UW College of Health Sciences educates health and wellness professionals and researchers in a wide variety of disciplines, including medicine, nursing, pharmacy, communication disorders, social work, kinesiology, community and public health and disability studies.

The college also oversees residency and fellowship programs in Casper and Cheyenne, as well as the operation of primary care and speech/hearing clinics in Laramie, Casper and Cheyenne. With more than 1,600 undergraduate, graduate, and professional students, the college is dedicated to training Wyoming’s health and wellness workforce and to high-quality research and community engagement, with particular emphasis on rural and border populations.

Northeast Greenland’s ice loss is vastly underestimated

Ice is continuously flowing from melting Greenland glaciers at an accelerating rate, dramatically raising global sea levels. New results published in Nature indicate that existing models have underestimated the amount of ice that will be lost in the 21st century. Therefore, its contribution to sea level rise will be significantly higher.

By 2100, ice flow from northeast Greenland will contribute six times more to sea level rise than previous models suggested, adding between 13.5 and 15.5mm, according to the new study . This is equivalent to the total contribution of the Greenland ice sheet over the past 50 years. The research was conducted by researchers from Denmark, the United States, France and Germany

“Our previous projections of ice loss in Greenland until 2100 are grossly underestimated,” said first author Shfaqat Abbas Khan, a professor at DTU Space.

“The models are mostly tuned to observations at the front of the ice sheet, which is easily accessible and where obviously a lot is going on.”

Ice loss occurs more than 200 km inland

The study is partly based on data collected from a network of precise GPS stations reaching up to 200 km inland on the northeast Greenland Ice Stream, located behind the Nioghalvfjerdsfjord glaciers. Gletscher and Zachariae Isstrøm, one of the harshest and most remote terrains on Earth. GPS data was combined with surface elevation data from the CryoSat-2 satellite mission and high-resolution digital modeling.

“Our data shows us that what we see happening at the front goes way back to the core of the ice sheet,” Khan said.

“We can see that the whole basin is thinning and the surface velocity is accelerating. Each year, the glaciers we have studied have retreated further inland, and we expect this to continue. over the decades and centuries to come. Under the current climate forcing, it is difficult to conceive how this retreat could stop.”

Significant contribution to sea level rise

In 2012, after a decade of melting, the floating extensions of Zachariae Isstrøm collapsed and the glacier has since retreated inland at an accelerating rate. And if the winter of 2021 and the summer of 2022 were particularly cold, the glaciers continue to retreat. Since northeast Greenland is a so-called arctic desert – rainfall is as low as 25mm per year in places – the ice cap is not regenerating enough to mitigate the melting. However, it is not easy to estimate the amount of ice loss and how far the process is occurring in the ice sheet. The interior of the ice sheet, which is moving less than a meter per year, is difficult to monitor, limiting the ability to make accurate projections.

“It is truly amazing that we are able to detect a subtle change in velocity from high precision GPS data, which ultimately, when combined with an ice flow model, informs us of how the glacier slips on his bed,” the co-author said. Mathieu Morlighem, professor of earth sciences at Dartmouth College.

“It’s possible that what we find in northeast Greenland is happening in other areas of the ice sheet. Many glaciers have been accelerating and thinning near the margin in recent decades. The data GPS help us detect how far inland this acceleration propagates, potentially 200 -300 km from the coast If this is correct, the contribution of ice dynamics to Greenland’s overall mass loss will be greater larger than current models suggest.”

The Zachariae Isstrøm remained stable until 2004, followed by a steady retreat of the ice front until 2012, when a large part of the floating sections disconnected. As more accurate observations of ice speed change are included in the models, it is likely that IPCC estimates of global sea level rise of 22-98cm will need to be corrected upwards.

“We project profound changes in global sea level, more than currently predicted by existing models,” said co-author Eric Rignot, professor of Earth system science at the University of California, Irvine.

“Data collected from the vast interior of ice sheets, such as those described here, help us to better represent the physical processes included in numerical models and, in turn, provide more realistic projections of global sea level rise. the sea.”

– This press release was originally published on the Technical University of Denmark website

3D Cell Culture and 3D Bioprinting Market Report to 2032: Visiongain Reports Ltd

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/EIN News/ — Visiongain launched a new report 3D Cell Culture and 3D Bioprinting Market Report 2022-2032: Forecast by technology (scaffold-based, scaffold-free, microfluidics-based, magnetic levitation, 3D bioprinting, others), by application (cancer and stem cell research, drug discovery and toxicology testing, tissue engineering and regenerative medicine), by end user (pharmaceutical and biotechnology companies, academic institutes, research laboratories, others) AND analysis of major national and regional markets PLUS analysis of major companies AND COVID-19 Recovery Scenarios.

How Has COVID-19 Significantly Negatively Impacted the 3D Cell Culture and 3D Bioprinting Market?

The COVID-19 pandemic is having a significant negative impact on the Global market for 3D cell culture and 3D bioprinting. The COVID-19 outbreak in 2020 has resulted in international border controls, nationwide shutdowns, pharmaceutical manufacturing restrictions and limitations. This pandemic has hampered the production and distribution of 3D cell culture and 3D bioprinting technologies.

Download an exclusive sample report

https://www.visiongain.com/report/3d-cell-culture-market-2022/#download_sampe_div

COVID-19 would undoubtedly have an effect on patients with chronic and infectious diseases and their care in the near future. Creating support networks for physicians and patients will help break down walls and provide patients with appropriate access to potentially life-saving services. Businesses are concerned about the impact of the COVID-19 outbreak on supply and demand. All of these factors are negatively impacting the 3D cell culture and 3D bioprinting technology industry, pushing the pharmaceutical industry and regulators to re-examine pharmaceutical supply chains.

How will this report help you?

Visiongain’s 380+ page report provides 356 charts and 352 charts/graphs. Our new study is suitable for anyone who needs in-depth business analytics for the global 3D cell culture and 3D bioprinting market, along with a detailed analysis of market segments. Our new study will help you assess the overall global and regional market for 3D cell culture and 3D bioprinting technologies. Get the financial analysis of the overall market and different segments including technology, application, end user and capture higher market share. We believe there are still great opportunities in this growing 3D cell culture and 3D bioprinting market. Find out how to use the existing and upcoming opportunities in this market to generate revenue in the near future. Moreover, the report would help you improve your strategic decision-making, enabling you to define growth strategies, strengthen analysis of other market players and maximize business productivity.

What are the current market drivers?

Use of 3D cell culture model in cancer research

The rise of cancer research, stem cell research and chronic diseases is expected to propel the demand for advanced 3D cell culture and 3D bioprinting technologies. According to the WHO, the prevalence of chronic disease cases is expected to increase by 57%, with higher disease cases in low- and middle-income countries. Additionally, the outbreak of current and past pandemics such as COVID19, SARS, Ebola, MERS, and H1N1 have added to the upsurge in drug use and vaccination.

3D bioprinting for pharmaceutical drug discovery and development

The convenience of use and cost effectiveness of 3D bioprinting technology is further driving market adoption. Pharmaceutical companies such as Corning Inc., Thermo Fisher Scientific Inc., Merck Group and Lonza Group are constantly investing in the development of 3D cell culture and 3D bioprinting technology to improve the oral bioavailability of new drugs using various excipients. In addition, the increasing number of patients with chronic diseases along with growing awareness of healthcare is expected to drive the demand for 3D cell culture and 3D bioprinting technology.

Where are the market opportunities?

3D bioprinting for animal-free meat

The daily increase in demand in the medical field for bio-alternatives capable of carrying out the living activities of the body’s organs has aroused the interest of researchers in the design of new biomaterials. Thus, market leaders are drifting from conventional techniques to innovative and improved techniques, thereby developing biocompatible and printable biomaterials.

Download an exclusive sample report

https://www.visiongain.com/report/3d-cell-culture-market-2022/#download_sampe_div

Development of biocompatible and printable biomaterials

Organoids developed from pluripotent stem cells or adult stem cells are three-dimensional cell cultures possessing some key characteristics of their organic counterparts, and they can mimic some biological development processes of organs in vitro. Therefore, they have promising applications in drug screening, disease modeling, and regenerative repair of tissues and organs. The combination of bioprinting and organoids with a focus on structure and function can facilitate the further development of real organs.

Competitive landscape

Major players operating in the Inflammatory Bowel Disease Drugs market include Corning Inc., Thermi Fisher Scientific Inc., Merck Group, Lonza Group AG, Reprocell Inc., Organovo Inc., Cellink, Aspect Biosystems, EnvisionTEC and Cyfuse Biomedical KK.

These major players operating in this market have adopted various strategies including mergers and acquisitions, R&D investments, collaborations, partnerships, regional business expansion and new drug launches. For example, in October 2020, Merck collaborated with D1Med, a Shanghai-based biopharmaceutical start-up, to accelerate the production of D1Med’s 3D cell culture technology applications used in the drug discovery process.

Find quantitative and qualitative analyzes with independent predictions. Receive insights that only our report contains, staying informed with this valuable business intelligence.

Information found nowhere else
With our new report title, you’re less likely to fall behind in your knowledge or miss opportunities. See how our work could benefit your research, analysis and decisions. The Visiongain study is for anyone who needs business analytics for the 3D Cell Culture and 3D Bioprinting Market and Key Companies. You will find data, trends and forecasts.

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Do you have any custom requirements that we can help you with? Do you need specific information about a specific country, geographic region, market segment or company? contact us todaywe can discuss your needs and see how we can help you: [email protected]

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Visiongain is one of the fastest growing and most innovative and independent market information companies, the company publishes hundreds of market research reports which he adds every year to his extensive portfolio. These reports offer in-depth analysis of 18 industries worldwide. The reports cover a 10-year forecast, are hundreds of pages long, with in-depth market analysis and valuable competitive intelligence data. Visiongain works across a range of vertical markets, which may currently influence each other, these markets include automotive, aviation, chemical, cyber, defence, energy, food and beverage, materials, packaging, pharmaceuticals and utilities. Our customized and syndicated market research reports mean you can have tailored market intelligence tailored to your own business needs.

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Walgreens completed another multi-billion dollar health care expansion

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The second-largest pharmacy chain in the United States is working to expand its primary healthcare footprint.

Primary Care Provider Walgreens Boots Alliance (Hereinafter Walgreens) Owns Majority Stake in VillageMD, Agreed to Acquire Urgent Care Provider Health-CityMD Summit. According a press release from November 7.

The agreement, which is expected to close in the first quarter of 2023, will create one of the largest groups of independent physicians in the United States providing primary care, specialty care and emergency care.

Walgreens goes beyond pharmacy retail

In a call for results on October 13CEO Rosalind Brewer cited building “our next growth engine with consumer-centric healthcare solutions” as one of the company’s top priorities.

This merger is just the latest move that puts Walgreens’ words of reducing dependence on retail into practice by diversifying into healthcare.

The acquisition of Summit Health adds to a recent nearly $10 billion spending spree to pivot the brick-and-mortar retailer into some sort of end-to-end service provider. The company expects the healthcare division to turn a profit by 2024.

MD Village: In July 2020, Walgreens took a 30% stake in VillageMD to begin offering co-located full-service medical practices in its stores for $1 billion. He increased his stake to 63% by pumping in $5.3 billion in October 2021.

Solution Health Shields: In September 2021, Walgreens plowed 970 million dollars in the specialty pharmacy company for a 71% stake. On October 29, the pharmacy company completed its acquisition shields, adding $1.37 billion increase its stake from 71% to 100%.

Care Centrix: Walgreens spent $330 million on a 55% of capital in the home care provider, which offers services such as home nursing, durable medical equipment, home infusion and home palliative care. Weeks before the Summit Health deal, Walgreens plans announced for full ownership of CareCentrix for an additional $392 million.

Walgreens healthcare raffle, in the words of CEO Rosalind Brewer

“When we think about driving profitability, it goes way beyond prescription use. When I think of a customer coming into VillageMD and understanding their health care needs better, it will help understand the expenses and also what arises from operating a primary care medical practice within our entity.” —CEO Rosalind Brewer on the Oct. 13 earnings call

Walgreens’ retail losses and healthcare gains, by the numbers

$32 billion: Market capitalization of Walgreens Boots Alliance, a distant second drugstore chain in the United States behind CVS, which is worth $100 billion more

4: commercial and retail brands owned by the alliance – Walgreens, Duane Reade, Boots and Alliance Healthcare

7.2%: year-over-year decline in U.S. retail pharmacy segment sales – $26.7 billion for the three months ended September 30, 2022. Drug sales and prescriptions filled, including and at excluding vaccinations, all fell. Additionally, online competitors like Amazon nibble away at home and beauty sales, according to Bloomberg

$12 billion: increased sales target for its healthcare business unit in 2025 from $11 billion

$3.5 billion: combination of debt and equity Walgreens invests in Summit Health

53%: Walgreen’s stake in combined VillageMD-Summit Health after deal closes

342 and 152: VillageMD clinics and co-located clinics open by October 13, respectively

680: Combined VillageMD and Summit Health provider locations

500,000: Summit Health Outpatient Visits Per Year

People Interested in Walgreens Leadership Roles

👨‍💼Lee Cooper, CEO of Shields, will lead Walgreens’ pharmaceutical operations,

👨‍💼CareCentrix CEO John Driscoll is President of US Healthcare at Walgreens and Executive Vice President

Company of interest: CVS

Walgreen’s biggest rival and the largest pharmacy chain in the United States, CVS, is also a big health care specialist: it purchased health insurance Aetna in 2018, to improve access and quality of care. In September of this year, he decided to buy home care provider Signify Health for $8 billion. It reportedly eyed Signify rival Cano Health, but apparently remote. He plans to enter the primary care playground by the end of the year as well.

Retail companies dominate CVS acquisitions, accounting for 42% of them, but healthcare already accounts for a large share at 30%, according to the M&A and Private Equity Mergr database.

Two things bind three American pharmacies

💊 Opioid crisis: CVS, Walgreens and Walmart have agreed to pay over $13 billion to resolve thousands of state and local lawsuits accusing drugstore chains of mishandling opioid painkillers

🩺 Clinical tests: The three companies are trying to improve diversity in clinical trials leveraging patient and point-of-care data.

Related stories

🩸 How Safeway and Walgreens fell in love with Theranos’ dream

👶 Walmart offers doula benefits

👩🏻‍🔬 The neighborhood CVS you grew up with is dead. It is now part of Big Pharma

Study finds licorice has little effect on enzymes that could cause drug interaction issues

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The new research has been published in the journal Metabolism and disposition of drugs​. It was the work of a group of researchers that included Professor Guido F. Pauli, who is the Norman Farnsworth Professor of Pharmacognosy at the University of Illinois at Chicago. Other team members were associated with the Linus Pauling Institute at Oregon State University.

Licorice (or licorice) is the common name for the botanical plant Glycyrrhiza glabra L..Extracts from the root and rhizomes of the plant have been used as a medicinal herb and flavoring agent since ancient times. The plant is a member of the bean family and is common to western Asia, northern Africa, and southern Europe.

In supplement applications, it is most commonly marketed to women for relieving symptoms of menopause.

Potassium depletion, enzyme inhibition

The researchers noted that despite the plant having GRAS status in the United States, there have been concerns about its safety when large amounts of one of its constituents, glycyrrhizic acid, are involved. Consumption of even small amounts of this organic acid, at the level of 2 mg/day, has been associated with potassium depletion.

However, regardless of this well-known, albeit rare, effect, the researchers said the plant has been suggested to inhibit certain cytochrome P450 enzymes. If the levels of these enzymes are artificially suppressed, it could can lead to an overdose of certain medicationswhich are metabolized by these same enzymes. According to the researchers, members of the CYP enzyme “superfamily” are responsible for the metabolism of more than 80% of commonly prescribed drugs.

To focus on these issues and leave aside the issue of potassium depletion, the researchers chose to use a G.glabraextract depleted in glycyrrhizic acid.

For one study population, researchers recruited 19 healthy peri-menopausal and post-menopausal American women ages 47 to 66 representing a range of ethnic backgrounds. (Only 14 completed the trial due to complications from the pandemic lockdown.) Although this may seem like a small sample, the researchers noted that it is consistent with recent botanical/drug interaction studies for clover. red and goldenseal.

Participants were prohibited from ingesting foods containing licorice, citrus or caffeine during the study. Citrus fruits are known to affect one of the enzymes in question, and caffeine has been used as one of the enzyme substrates. Subjects were instructed to abstain from any non-study dietary supplements or medications two weeks prior to the start of the study until its conclusion.

As substrates for the relevant enzymes, the authors used a cocktail of 100 mg caffeine (CYP1A2 substrate), 250 mg tolbutamide (CYP2C9 substrate), 30 mg dextromethorphan (CYP2D6 substrate), and 2 mg alprazolam ( CYP3A4/5 substrate).

The subjects took the cocktail every day for a week. On the eighth day, they added two capsules containing 150 mg of a licorice extract. Each capsule contained 75 mg of a G.glabra extract standardized to 3.1 mg of glabridin, 0.55 mg of glycyrrhizic acid, 0.50 mg of liquiritin and 0.47 mg of isoliquiritin.

They took both the licorice capsules and the substrate cocktail for 14 days. Blood was drawn at baseline, at the end of the 7-day start-up period, and again at the end of the study.

No clinically relevant enzymatic effect observed

Concentrations of enzyme substrates were assessed with pharmacokinetic parameters such as concentration-time curve (AUC), maximum serum concentration (Cmax), time to reach maximum concentration (Tmax), elimination half-life (T1/2) and oral clearance. rate (CL/F).

The researchers concluded that for the amount of licorice extract they administered, there appeared to be little concern about drug interactions. They observed some effect in the case of caffeine/CYP1A2, but noted that this was likely due to poor dietary compliance, as caffeine is found in many foods.

“Despite preclinical data predicting pharmacokinetic interactions between G. glabra and cytochromes P450, this investigation indicates that there is no clinically relevant risk of drug interactions for this extract with respect to CYP1A2, CYP2C9, CYP2D6 and CYP3A4/5”,they said.

As for caveats, the researchers noted that there is a wide range of dosages for the more than 700 licorice-containing products on the market. They chose the 150mg dose to be within the dosage range of most products, but some are much stronger. Additionally, some products labeled as licorice actually contain extracts of two related species – G. uralensisWhere G.inflate– and the data of this test cannot be applied to them.

Source: Metabolism and disposition of drugs​​
DOI: https://doi.org/10.1124/dmd.122.001050
Pharmacokinetic interactions of a licorice dietary supplement with cytochrome P450 enzymes in female participants
Authors: Liu J, et al.

PAWing It FOREward Golf Event Raises $27,000 | News, Sports, Jobs


Courtesy photo The sixth annual PAWing IT FOREward Golf Tournament was held on July 20 at the Scotch Valley Country Club in Hollidaysburg. The money raised will help purchase service dogs for people with disabilities, some of which can cost up to $35,000.

An annual tournament raises funds for service dogs

Service Paws of Central PA (SPCP) held its sixth annual golf tournament on July 20 at Scotch Valley Country Club. A net profit of $27,000 was achieved thanks to the help of numerous sponsors.

It was a four-person race for all skill levels with prizes for each golfer (gift cards donated by nearly 300 area businesses), as well as skills competitions.

Third place team was from UPMC Altoona Foundation, second place was from Encompass Health Altoona and the winning team was from DeGol Carpet.

Dan Bradley won the Puppy Putt contest. Courtesy Motor offered a new Ford Edge as the first person to hole-in-one, but no one took on that challenge; a second prize was awarded to Wes Elder who found himself less than a meter from the flag.

$25 gift cards were awarded to the six skills competition winners: Tony Alvarano, Keith Drass, David DeGol Sr., Wes Elder, Rachelle Hopsicker and Matt Taddy.

The gift basket winners were Tom Smith, Cory Tubo, Randy Fabbri, Marla L. Moon, Steve Dalecki and Frank Wiley.

Tim Balconi won the draw 50-50.

Service Paws of Central PA is a local non-profit organization established to financially assist those in need of a service dog and/or those who may already have a service dog and need assistance for extraordinary veterinary expenses.

Golfers enjoyed a relaxing dinner in the ballroom, where prizes were handed out. There were short presentations by two service dog handlers, which were sponsored by the SPCP. Each of them told how the dogs had impacted their families.

PAWing IT FOREward VII will take place on July 19, 2023 at Scotch Valley Country Club with a noon kickoff.

A full list of sponsors is at altoonamirror.com.

Main Sponsors: Bruno & Lena DeGol Family Foundation (cheque presentation); Sheetz, Inc.; Primati Bros.; Bolger Brothers, Inc.; Stucky Ford; 4print; Les Prés (dessert); CCSalesPro; Dennis C. Dobbins, DMD; First Leaf Wines; Courtesy motors; Pepsi-Cola; Blair Candy Co., Inc.

Tee & Teams: AFSCME Local 3155, unionized Altoona Water Authority employees; ARC Federal Credit Union; ARROW Land Solutions; Include Altoona Health; Kooman & Associates; S&T Bank; Saleme Insurance; Sylvan Veterinary Hospital; Tom Smith; UPMC Altoona Foundation.

Other teams: Amy Bergstrom; Bill Engelbret; CNB Bank; Dave McGarvey; Don Straub; ENVISION Laser Centers; Marla L. Moon, DO, FAAO; Morris Houser; Trust Bank; Texas Hot Dogs 58th Street and 12th Avenue; The Underdogs; Valley Rural Electric Cooperative, Inc.; Young, Oakes, Brown, & Co, PC

Sponsors:

Ace fix-it Hardware

Allegheny Orthoses

Allstate/Rob Sullivan

Altoona Arthritis and Osteoporosis Center

Altoona Center for Oral/Maxillofacial Surgery

Altoona Curve

Beard Legal Group

Start with us Childcare and preschool

Belle Lucia

Bill Wertz and Sons

Blair Auto Service and Electrical Equipment

Blair Gastroenterology Associates

Economy drink

Burgmeier’s Hauling, Inc.

Cato Modes

Physiotherapy and Rehabilitation Cross Roads Inc.

Designs by David Albright

Delgrosso family of companies

Do better business

Jewelry from Dorman, Inc.

EADS Group

Improved eye care

Fiore Toyota

First Commonwealth Bank

Freedom Excursions

Excavation and demolition G&R

Green bean coffee

Health First Chiropractic

Hite Company

Holidaysburg Veterinary Clinic

Howard Hanna Johnston Real Estate

Integrity Building

Altoona Investment Bank

Irwin Financial

Keller Engineers

Ketrow Tourist attractions

Laurel Eye Clinic

lawn doctor

Link Computer Corporation

Lisa Fry

M&T Bank

Manpower Inc. of Altoona

Martin Oil Company

McCann Wealth Strategies

Workplace Solutions from McCartney, Inc.

McDonald’s, JPN Management, Inc.

McKissick Kasun Architects

McMullen Furniture

Mike’s Court

Mountainview Eye Associates

Myers-Somers Funeral Home

Neely’s train shop

Newborn Enterprises, Inc.

NEXT Financial Group

computer works

Penn Crest Bank

Residential Building Pheasants

Progressive Periodontal Therapy, Michael Cohen, DDS.

Reilly, Creppage & Co., Inc.

Rhodes Pools and Patios

The true value of roaring spring

Roofing works

Small tube products

Spheria

Stevens Mortuary, Inc.

Stifel Investment Services

Chevrolet Storer

Tel-Power Tool & Equipment Rental, Inc.

VCA Metzger Veterinary Clinic #1301

Ward Transport Corp.

Windy Hill Furniture

Price :

A&A insurance

Allegheny Creamery and Pancakes

Allegheny Street Cigar Co.

allegro

Altoona Community Theater

Altoona Gourmet Buffet

Altoona Small Engine Repair

Altoona Freshwater

Golden Amber

Amish smokehouse

Angel and William Watts

Running in Appalachia

Athenian coffee

Aunt Anne’s

Baby Shorts Creations

bark box

Barr’s Auto Electric, Inc.

Bath and body care

BCAF – Mishler Theater

Pizza Bella Italia

Ben Blow

Auto Bender Service

Best way to pizza #3

Best Way Pizza, Altoona

Bickel’s surplus too

Bickel Too Altoona Surplus

Blair County Drink

Blair Picture Elements

Blocher Meat Market

Brackney Leather

Restaurant of the bull enclosure

Cameron Silva

Chili’s Bar & Grill

city ​​drink

clay cup

Comfort Suites

Courtyard Marriott Altoona

SVC

dairy queen

Davison Snack Shop

Days Inn and Suites by Wyndham

Dean Patterson Automotive

De Gennaro serve

Denney Candle Co.

Diemond Queen

dinosaur pizza

Domino’s Pizza, 17th Street

Domino’s Pizza, Duncansville

donut connection

Country Club Du Bois

Duck fritters

Duncansville Pharmacy

Dutch Hill Chocolates

Eat’n Park

Erica’s creations

Erwin and Joyce Bassler

Escape Altoona

Fairfield Inn & Suites

cinema center

Finelli’s Italian villa

Five star Mitsubishi

Front Street Submarines

Unfinished furniture

Galactic Ice Rink

Gardner’s Candy

Giant Eagle, Roaring Spring

Giant Eagle, Altoona

Grandview Meats

Greenwood Steakhouse

Hampton Inn

Equipment and distribution of medicinal plants

Hippie Sniffs and Good Juju’s

holiday bowl

Holiday Inn Express & Suites

Holiday pools and spas

PA Hometown Bank

Holidaysburg Hometown Market

Huntingdon Country Club

Irvin’s On Main

JAM promotional productions

Jax’s soaps

Jersey Mike’s Subs

Jethro

just tinkering

Kae’s path

Kay’s creations

Kerr Creations

La Fiesta Mexican Bar & Grill

Lakemont Park

Lavish luxury botanicals

Leighty Farm Market

Leyo market

Caesar’s pizza

Lucky’s beer dispenser

Moon Main Restaurant

Restaurant Mamma Mia

Mane Effects

Marcia’s Chocolates

#6292 from Martin

Martin’s Duncansville

Martin’s Pinecroft

Mayfield Restaurant

McCampbell Enterprises Unlimited, Inc.

Photography of moments

Nancy Ellenberger

Napa Auto Parts Duncansville

New Look Uniform and Embroidery

Nicoletta’s Restaurant

OIP, Juniata

O’Reilly Auto Parts Altoona

O’Reilly Auto Parts Duncansville

Outback Steakhouse

Daddy Johns

pedal power

Penn State Golf Course

Peterman Florist

Phoenix physiotherapy

Pizza Hut, Altoona

Planet Fitness

Recreational pottery

Bodywork professionals

red lobster

Robert Sandowski

Ron and Cindy Pertu

Sweetheart Salty Essentials

say it with candy

Shear Power Show

shoe fly

Discreet action zone

Styles by Paul

Summit Country Club

Sunmaid Growers of California

floral sunrise

SweetFrog

TA ticket printing

Tammy Garlock

Texas Truck Stop

Thaler Family Dentistry

That guy from Pierogie

Building II Athletics Club

The Naked Egg Cafe

The Summit Tennis and Athletics Club

Thompson’s Pharmacy

Custom Ink from the Three Hearts Initiative, LLC

Tim’s American Coffee

At Tom and Joe’s

Tom Kunetz, Jeff Keenan and Keven McCarthy

Top Nails

Trade Secrets Skincare and Saltroom

Mount Tussey

Unkel Joe’s Pyre

Walgreens

Walmart Supercenter Altoona

Walmart Supercenter Duncansville

Craving Cookies? Pastry shop

Warren A. Gingrich Agency

Warren’s Wax

Weis Everett Market

Weis Park Hills Plaza Market 40

Weis Market Pleasant Valley Blvd 64

Wisp hair salon

Special thanks to Barb Cottrill, Scotch Valley Event Planner and

Steve Gerhart, professional golfer.

Please check us out on Facebook and “As” we; we try to

reach 1,500 likes by the end of the year. You can help.

There are several photos from the golf tournament to view on the Paws Service of

Central AP Facebook page.



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Pharmacists challenged with amoxicillin and Adderall shortages

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Pharmacists are struggling with shortages of amoxicillin and Adderall due to increased demand for antibiotics and manufacturing issues with Adderall.

The FDA listed amoxicillin oral powder for suspension on its drug shortages website in late October, while the American Society of Health-Systems Pharmacists (ASHP) drug shortages website began listing many amoxicillin formulations in short supply on October 20, 2022.

“This shortage is difficult because some of the commonly prescribed drug strengths and forms are not available. Patients and providers may find that they have to call multiple pharmacies to find available supply,” said Michael Ganio, PharmD, senior director of pharmacy practice and quality for ASHP.

Rather than being the result of manufacturing issues, the shortage appears to be caused by an increase in demand, Ganio noted, “likely related to the increase in cases of respiratory syncytial virus and other respiratory illnesses reported nationally. “.

Nearly 66% of pharmacies have difficulty obtaining amoxicillin, according to a new National Community Pharmacists Association (NCPA) survey of 8,000 pharmacy owners and managers,1 while 89% realize a shortage of Adderall. Overall, 98% of pharmacies are experiencing drug shortages.

Sandoz is one of the few manufacturers to report a shortage of amoxicillin.

“We are currently facing a considerable increase in demand for antibiotics, which is leading to a tight supply situation: at the moment we are able to meet the historical demand for our antibiotics, but we are facing challenges in meeting this sudden surge in demand now that flu season is in full swing,” said Leslie Pott, vice president of communications for Sandoz US.

Sandoz also realized some market momentum from competitors’ (short-term) stock-outs, “resulting in unanticipated high sales of our products, resulting in supply issues,” Pott added.

“The combination of the rapid succession of the impact of the pandemic and resulting fluctuations in demand, manufacturing capacity constraints, raw material scarcity and the current energy crisis mean that we are currently facing a particularly difficult situation,” Pott said.

Pharmacists are likely communicating with prescribers to determine the best amoxicillin product available for patients during the intermittent shortage, Ganio said.

The good news is that there are alternative therapies if amoxicillin isn’t available, Ganio said. “Depending on the diagnosis, pharmacists may recommend alternatives such as a cephalosporin or amoxicillin/clavulanic acid if therapeutically appropriate,” he noted.

According to the ASHP, most amoxicillin products in short supply are expected to return to normal levels by the end of this year, but the shortage could extend into early next year.

The shortage of Adderall, which pharmacies have been reporting since this summer, is also causing significant problems. The FDA officially issued a drug shortage notice for the drug, which treats both attention deficit/hyperactivity disorder and narcolepsy, on October 12, 2022.

“The FDA is in frequent communication with all manufacturers of mixed amphetamine salts, and one of these companies, Teva, is experiencing ongoing intermittent manufacturing delays,” the FDA said in the notice. “Other manufacturers continue to produce mixtures of amphetamine salts, but there is not enough supply to continue to meet US market demand through these producers.”

“Until the supply is restored, there are alternative therapies, including the extended-release version of mixed salts of amphetamines, available to healthcare professionals and their patients for the approved indications of mixed salts of amphetamines. ‘amphetamines,’ the FDA said. “Patients should work with their healthcare professionals to determine their best treatment option.”

Adderall is a “very significant shortage that affects both patients and clinicians,” Ganio noted. Finding an Adderall alternative therapy isn’t as simple as switching between drug classes, such as a blood pressure or cholesterol drug, he explained.

“Medications for this indication often require dose adjustment over time to find the right dose, so for patients who are stable on an amphetamine salt combination product, this shortage is very disruptive.”

Additionally, mixed salts of amphetamines are Schedule II controlled substances, so prescriptions cannot be transferred from one pharmacy to another. “If a patient finds a pharmacy with the drug in stock, their prescriber will need to send a new prescription to that pharmacy. So, in addition to disrupting patients, it can also take up time for pharmacists and clinicians helping manage the shortage,” Ganio said.

Ganio attributes the shortage to both an increase in demand for amphetamine salt combination products and a disruption in manufacturing.

Although Teva previously experienced a labor shortage, the manufacturer said it has now been resolved, Ganio noted.

NCPA and ASHP leaders are concerned about the multitude of drug shortages that continually cause headaches for pharmacies, healthcare providers and patients.

“We are heavily dependent on foreign countries, some of which may be conflicting, for many of our pharmaceuticals. And the supply chain issues resulting from the pandemic have not been fully resolved,” NCPA CEO B. Douglas Hoey said in a press release.2

“Community pharmacies are the last link in the supply chain and the only one that deals directly with patients. If there is a disruption between the manufacturer and the patient, it affects the entire health care system and community pharmacists are the ones helping patients determine their options,” Hoey added.

References

  1. November 2022 report on drug shortages. Report. NCPA. Accessed November 3, 2022. https://ncpa.org/sites/default/files/2022-11/NCPA-ExecSummary_DrugShortage_NOV22.pdf
  2. Survey: Almost all community pharmacies are experiencing drug shortages. Press release. NCPA. Published November 3, 2022. Accessed November 3, 2022. https://ncpa.org/newsroom/news-releases/2022/11/03/survey-nearly-all-community-pharmacies-experiencing-drug

Croyle Wins Best Paper Award at the 2022 Collaborative Research Excellence Awards

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Dr. Maria Croyle.

The Office of the Vice President for Research, Scholarships, and Creative Efforts and the University Cooperative Society announced the 2022 winners university scholarships for excellence in cooperative research. Maria A. Croyle, Ph.D.professor in the College of Pharmacy’s Division of Molecular Pharmacy and Drug Delivery, won this year’s best paper award.

His paper, “New technology for the storage and distribution of live vaccines and other biological drugs at room temperature“, presents a new thin-film platform that preserves live viruses, bacteria, antibodies and enzymes without refrigeration for an extended period. This work introduces the possibility of improving global access to a variety of vaccines and of medicines by offering technology capable of reducing the costs of production, distribution and maintenance of the supply chain.

Croyle’s work won him the 2021 award David Lehr Fellowship from the American Society for Pharmacology and Experimental Therapeutics (ASPET) and received wide coverage in Texas monthly. The startup Jurata thin film is working to commercialize thin film technology.

The Best Research Paper Award recognizes the extraordinary achievements of a faculty member or staff researcher who was the primary or sole author of a peer-reviewed scientific paper reporting original research and published from January 1, 2020 to December 31, 2021. The winners were announced at the Co-op Awards ceremony on November 3, 2022.

What is Quercetin? Here’s what to know about how the ingredient can help with immune support*

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Quercetin is known for its antioxidant properties, which can help neutralize free radicals in the body.*

Image credit:
Nature’s Way/GettyImages/LIVESTRONG.com Creative

When you hear the words “nutrients for immune support,” you probably automatically think vitamin C (or maybe vitamin D or zinc if you really know your immune support stuff).*

The first word that probably comes to mind ‌is not‌ “Quercetin,” but this lesser-known nutrient also has a lot to offer your immune system.*

“Along with vitamins D and C and zinc, quercetin is a versatile nutrient with antioxidant properties that can complement other key nutrients to support immune health,” says Vani Chopra, PhD, RDN, educational content manager at Nature’s Way. .®.*

Chopra says quercetin can be found in certain fruits and vegetables, as well as in Nature’s Way Quercetin Gummies with Zinc, which also provides 100% of the Daily Value of zinc per two-gummies serving. Keep reading for more reasons why she thinks quercetin should be part of everyone’s daily immune support habits.*

Quercetin is a yellow plant pigment that is one of the most abundant dietary flavonoids, according to a December 2016 study ‌Pharmacognosy journalsexam. * Flavonoids have antioxidant properties and are associated with a wide range of health benefits, including immune system support, according to a December 2016 study‌Journal of Nutritional Sciencesexam.*

“[Flavonoids] scavenge and neutralize particles in the body known as free radicals that damage cell membranes and have other effects,” says Chopra.*

How Quercetin Helps Support the Immune System*

In addition to its antioxidant properties, quercetin may help support the immune system through its special relationship to zinc, which is known for its immune-supporting properties.*

“Quercetin can act as a zinc ionophore, meaning it can transport zinc to cells where it’s needed,” Chopra says. to the body.”*

That’s why the two come together in Nature’s Way Quercetin Gummies – consider quercetin zinc’s best friend, helping it reach its full potential.*

How to fill up on quercetin

Because quercetin is not produced by the human body, you must turn to ingestible sources for your daily supply.

The nutrient can be found in foods such as onions, berries, grapes, cherries, citrus fruits and broccoli, according to Chopra. However, she notes that the amount of quercetin in foods is relatively low.

In fact, the National Institutes of Health notes that a nutritious diet provides up to 13 milligrams of quercetin daily, while quercetin gummies with zinc contain 125 milligrams per two-gummy serving. With the dual power of quercetin and zinc, your immune system will thank you for the extra dose of daily support.*

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

AI Uncovers Best-Ever Terms & Conditions for Cross-Couplings, Doubling Yields | To research

An artificial intelligence performing experiments using a synthesis robot discovered what could be the most generic conditions for cross-coupling reactions from a pool of thousands of possible combinations. The AI-created reaction more than doubled the average yield in 20 delicate cross-couplings compared to baseline conditions.

Reaction conditions that work for compounds of different shapes, sizes and functional groups are “essential for automating the synthesis of small molecules, which in turn is essential for democratizing molecular innovation”, says the head of the study Martin Burk from the University of Illinois Urbana-Champaign, USA. In 2009, Burke’s team created a version of the Suzuki-Miyaura cross coupling which combines chloroarenes and NOT-methyliminodiacetic acid boronates (Mida).

The team then turned to AI to adapt the reaction to work for the widest possible range of substrates. They asked him to scour the literature and find the most generic reaction conditions among an almost infinite number of catalyst, ligand, temperature, and base combinations. Yet, rather than finding new general terms, the algorithm would only “discover” terms that are already the most popular. One reason, Burke explains, is that “the literature is remarkably deficient in negative data. Nobody publishes what does not work. But algorithms need both good and bad examples to learn.

Reaction scheme

Now the teams of Bartosz Grzybowski at the Polish Academy of Sciences and Alan Aspuru-Guzik at the University of Toronto, Canada, with Burke and colleagues combined AI and robotic experimentation to solve the generality problem without biased data from the literature. First, clustering analysis selected 22 coupling partners that would represent the chemical space of 5400 commercial aryl halides and 54 boronates from Mida. Then the team let the AI ​​lose the data. “We didn’t make any decisions once we had it in place,” Burke says.

Over several months, the AI ​​went through five rounds of design experiments, running them on the synthesis robot and evaluating the results. “The algorithm wasn’t set up necessarily to try to find the best conditions, it was trying to minimize uncertainty,” says Burke. For this, the AI ​​ran a surprisingly high number of low-yielding reactions – around 100.

The conditions proposed by the algorithm do not seem very different from those of Burke’s 2009 article: 100°C instead of 60°C, sodium instead of potassium carbonate and a slightly different phosphine ligand for the catalyst palladium. However, in 20 cross-couplings of heteroarenes, the average yield more than doubled, from 21% to 46%. The speed and precision of the AI ​​”was very humble and inspiring, but also shocking and disturbing at the same time,” says Burke.

“It’s great for parallel medicinal chemistry, for example in high-throughput labs where they use automation to create compound libraries,” says Cayetana Zarate, who works in process development at Janssen Pharmaceuticals. However, she points out that the chemical space examined by the team lacked molecules with pharmaceutically relevant substituents such as halogens and aliphatic amines.

If similar AI could optimize conditions for a particular reaction, it could dramatically speed up the development of labor-intensive processes, Zárate says. After all, the Suzuki-Miyaura cross-coupling is “probably one of the reactions where we invest the most time in screening.”

Burke says he now wants their AI setup to search for molecules that have specific functions, such as materials in solar cells. “In chemistry, we tend to focus on structure. To me, what’s so exciting about this closed-loop engine, [is] it’s an opportunity for us to pivot to a function-driven approach.

US FDA grants orphan drug

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  • ODD for HI in the United States follows July 2022 granting of ODD for HI treatment in Europe
  • Currently only one drug approved in the US to treat IH while no drugs are currently approved in Europe for IH
  • High unmet medical need in this rare indication
  • ZURICH, SWITZERLAND/ACCESSWIRE/November 2, 2022/ NLS Pharmaceuticals Ltd. (Nasdaq: NLSP, NLSPW) (“NLS” or the “Company”), a Swiss clinical-stage biopharmaceutical company focused on the discovery and development of innovative therapies for patients with rare and complex central nervous system disorders, announces that it has received Orphan Drug Designation (“ODD”) from the US FDA for Mazindol, the active ingredient in its lead product candidate, Quilience® (Mazindol ER) for the treatment of idiopathic hypersomnia ( “HI”). ODD is granted by the United States Food and Drug Administration (“FDA”) to encourage the development of treatments for diseases or conditions that affect fewer than 200,000 patients in the United States. Drugs that receive this designation gain seven years of market exclusivity from the date of FDA marketing approval, as well as tax credits for clinical trial costs and filing fee waivers. marketing demand.

    “We are very pleased to receive ODD for Mazindol in the US for the IH indication, given the potential versatility of this active ingredient in the treatment of multiple sleep and wakefulness disorders,” said Alex Zwyer, CEO of NLS Pharmaceuticals. “In our recently published early Phase 2a results, Quilience® (Mazindol ER), our novel formulation and lead product candidate, demonstrated the ability to significantly promote wakefulness in narcoleptic patients with II, which has strong similarities with IH. We are excited to advance our pipeline of Mazindol-based solutions, and ODD status in addition to our formulation patents strengthens our ability to protect this franchise for the long term as we seek to create meaningful value for our shareholders. »

    About Idiopathic Hypersomnia (IH)

    Idiopathic hypersomnia is characterized by chronic excessive daytime sleepiness (EDS), which is the inability to stay awake and alert during the day, resulting in an uncontrollable need to sleep or unexpected interruptions in sleep or sleepiness. Main symptoms may include confusion, irritability, and severe sleep inertia or sleep drunkenness (prolonged difficulty waking up with frequent returns to sleep). The quality of life of people living with IH is negatively affected due to potential impacts on mental health, social relationships, memory loss and attention deficits. The socio-economic costs of HI are therefore substantial. According to the Hypersomnia Foundation, “People with idiopathic hypersomnia often live without a proper diagnosis for many years, blaming themselves and struggling to maintain their jobs, studies, and relationships.” An estimated 37,000 people in the United States have been diagnosed with idiopathic hypersomnia, a neurological sleep disorder characterized by chronic EDS.

    About NLS Pharmaceuticals Ltd.

    NLS Pharmaceuticals Ltd. is a clinical-stage Swiss biopharmaceutical company led by an experienced management team with a proven track record in the development and reuse of product candidates to treat rare and complex central nervous system disorders. The Company’s lead product candidate, Quilience®, is a proprietary extended-release formulation of Mazindol (Mazindol ER) and is being developed for the treatment of narcolepsy and potentially other sleep and wakefulness disorders such as as idiopathic hypersomnia (IH), for which NLS recently obtained Orphan Disease Designation (ODD) from the European Medicines Agency (EMA). Mazindol is a triple monoamine reuptake inhibitor and partial orexin-2 receptor agonist that has been used for many years to treat patients with narcolepsy in compassionate use programs. A US multicenter phase 2a clinical trial evaluating Quiilience® in adult subjects with narcolepsy met its primary endpoint with high statistical significance and demonstrated a favorable safety and tolerability profile. NLS has also successfully completed a Phase 2 study in the United States evaluating Nolazol® (Mazindol Controlled-Release) in adult subjects with ADHD. The study met all primary and secondary endpoints and Nolazol® was well tolerated. Quilience® has received orphan drug designation in the United States and Europe for the treatment of narcolepsy. Up to 1/3 of narcoleptic patients are also diagnosed with ADHD.

    Safe Harbor Statement

    This press release contains express or implied forward-looking statements pursuant to United States federal securities laws. For example, NLS uses forward-looking statements when discussing Mazindol’s ability to treat sleep disorders and the possibility of FDA marketing approval, NLS’s portfolio of Mazindol-based solutions and the ability of NLS to create shareholder value. statements and their implications are based on the current expectations of the management of NLS only and are subject to a number of factors and uncertainties that could cause actual results to differ materially from those described in the forward-looking statements. The following factors, among others, could cause actual results to differ materially from those described in the forward-looking statements: changes in technology and market requirements; NLS may encounter delays or obstacles in initiating and/or completing its clinical trials; NLS products may not be approved by regulatory agencies, NLS technology may not be validated as it advances, and its methods may not be accepted by the scientific community; NLS may not be able to retain or attract key employees whose knowledge is essential to the development of its products; unforeseen scientific difficulties may develop with the NLS process; NLS products may turn out to be more expensive than expected; laboratory results may not translate to as good results under real clinical conditions; results of preclinical studies may not correlate with results of human clinical trials; NLS patents may not be enough; NLS products may harm recipients; changes in legislation may have a negative impact on the NLS; failure to develop and introduce new technologies, products and applications on a timely basis; loss of market share and pricing pressure resulting from competition, which could cause NLS’s actual results or performance to differ materially from those contemplated in such forward-looking statements. Except as otherwise required by law, NLS undertakes no obligation to issue revisions to these forward-looking statements to reflect events or circumstances after the date hereof or to reflect the occurrence of unforeseen events. More detailed information about the risks and uncertainties affecting NLS can be found under the heading “Risk Factors” in NLS’s Annual Report on Form 20-F for the fiscal year ended December 31, 2021 filed with the Securities and Exchange Commission (SEC ), which is available on the SEC website, www.sec.govand in subsequent filings by NLS with the SEC.

    Corporate contact details

    Alex Zwyer, CEO: +41 44 512 21 50

    Investor Relations

    Cindy Rizzo
    [email protected]
    www.nlspharmaceutics.com

    THE SOURCE: NLS Pharmaceuticals AG

    See the source version on accesswire.com:
    https://www.accesswire.com/723437/US-FDA-Grants-Orphan-Drug-Designation-ODD-for-QuilienceR-Mazindol-ER-for-the-Treatment-of-Idiopathic-Hypersomnia-IH

Tesco and Diabetes UK will help 1 million people understand the risk of type 2 diabetes

Tesco has launched a campaign with Diabetes UK to help one million people understand the risk of type 2 diabetes and get help to prevent or delay the disease.

By offering a free online ‘Know Your Risk’ tool through Diabetes UK or visiting a Tesco pharmacy, those who complete the assessment will be directed to free advice and information on the help available to manage their risk.

This follows new research commissioned by the partnership which found that people under the age of 40 are generally unaware of many symptoms of type 2 diabetes or the complications the disease can cause and 68% did not know how to check if they were at risk.

It also found that due to the cost of living crisis, 57% of people have deprioritized their health and 23% have avoided or postponed medical checks.

In addition to the campaign leading up to World Diabetes Day on November 14, the retail leader has also launched a series of healthy and economical recipes.

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“Type 2 diabetes is one of the most common health problems we face in the UK, but the reality is that many cases could be prevented or delayed. And we know healthy eating is the key. ‘one of the ways to reduce your risk’, Jason Tarry, CEO of Tesco UK & ROI.

“With 373 Tesco pharmacies across the country, serving half a million people a week, our community pharmacists can also provide expert support and advice.

“The next time you’re in store, visit the pharmacy and have a quick chat with one of our pharmacists or try one of the healthy and economical recipes we’ve created. Reducing your risk of type 2 diabetes is doable and affordable, with the right support, and a few simple changes can make a big difference.

Diabetes UK chief executive Chris Askew OBE added: “This rapidly increasing trend in early type 2 diabetes is incredibly troubling. This marks a change from what we have seen historically and should be taken as a serious warning to policy makers and our NHS.

“If you are under 40, you are not immune to type 2 diabetes. It is essential that you check your risk now and that people, regardless of age or background, have the opportunity access support to reduce their risk of type 2 diabetes.”

Gerresheimer and Nelson Labs NV Announce Strategic Alliance for Laboratory Testing of Extractables and Leachables for the Pharmaceutical and Biotech Industries

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To accelerate and reduce the risks of drug development, Gerresheimer AG and Nelson Labs NV announce a formal strategic partnership on drug analysis and compatibility laboratory testing for the pharmaceutical and biotechnology industries.

Düsseldorf / Leuven, Belgium, October 31, 2022 – Gerresheimer AG, one of the world’s leading providers of healthcare, beauty and drug delivery systems for the pharmaceutical, biotech and cosmetics industries, and Nelson Labs, a global leader in microbiological and analytical chemistry testing and consulting services for the medical device and pharmaceutical industries, today announced a strategic partnership to support pharmaceutical and biotechnology companies in their development of primary packaging systems. Partnership between Gerrensheimer’s Gx Biological Solutions and Nelson Labs leverages the expertise and skills of two science and technology leaders to dramatically reduce risk and time to market for primary packaging solutions for injectables . Through this collaboration, Nelson Labs will perform extractables and leachables (E&L) testing, toxicological risk assessments, impurity identifications, and biocompatibility testing of injectable primary container closure systems or components.

Piet Christiaens, Scientific Director, Nelson Labs
“I am extremely pleased that Gerresheimer and Nelson Labs have taken this very important step by joining forces to provide customers with stellar testing and expert guidance in container/closure qualification. was clear that both companies share the same values ​​of service-oriented customer support. This partnership is designed to help the pharmaceutical industry take full advantage of our scientific leadership, our unique compounds, personalized support and other resources that will be offered through this alliance. This strategic partnership will enable Nelson Labs to further expand our position in the dynamic and growing Asia-Pacific region.”

Stefan Verheyden, Global Vice President, Gx Biological Solutions
“Through this partnership with Nelson Labs and its proven track record in the areas of container closure integrity (CCI) and E&L, we at Gerresheimer have become one of the leading global partners for industries Our extensive portfolio includes many pharmaceutical packaging products and safe drug delivery systems such as insulin pens, inhalers, pre-filled syringes, vials, cartridges, vials and containers for liquid and solid medications with systems closure and safety.We have been serving the biologics market with our solutions for many years and have recently observed an increasing diversification of the market, its industry leaders and their requirements.Therefore, we are extremely excited to the idea of ​​entering into this strategic partnership with Nelson Labs to further expand the support we offer to businesses. its biopharmaceuticals.

Jean-Edouard Rabier, Director, Business Development, Gx Biological Solutions
“With this agreement, Gx Biological Solutions will be able to offer an expanded set of services to our pharmaceutical and biotechnology customers for their new drug development and product lifecycle management. We are now able to provide our customers the best selection of primary packaging systems (vials, syringes and cartridges) in glass or cyclic olefin polymer (COP) without any concern for compatibility, stability or drug safety. , strong market recognition from Nelson Labs is definitely a must for Gx Biological Solutions to achieve our goals of being a science-based destination and premier primary packaging systems provider, with end-to-end support to our customers. .

Contact at Gerresheimer

Contact the press
Ueli Utzinger
Group Senior Director Communication & Marketing
Telephone +41 79 400 86 40
ueli.utzinger-remove@remove-www.gerresheimer.com

Contact the professional press
Marion Stolzenwald
Corporate Communication Manager
Phone +49 211 6181-246
marion.stolzenwald-remove@remove-www.gerresheimer.com

Contact Investor Relations
caroline nadilo
Senior Director of Investor Relations
Telephone +49 211 6181-220
carolin.nadilo-remove@remove-www.gerresheimer.com

Contact at Nelson Labs

Media Contact
Paul Huis
Senior Director of Global Marketing
+1 801-290-7500
push-remove@remove-nelsonlabs.com

About Gerresheimer

Gerresheimer is the global partner for pharma, biotech, healthcare and cosmetics with a very wide range of products for pharmaceutical and cosmetic packaging solutions and drug delivery systems. The company is a provider of innovative solutions, from concept to delivery of the final product. Gerresheimer achieves its ambitious goals through a high level of innovative strength, industrial competence and focus on quality and customer orientation. To develop innovative and sustainable solutions, Gerresheimer relies on a comprehensive international network with numerous innovation and production centers in Europe, America and Asia. Gerresheimer produces close to its customers worldwide with around 11,000 employees and generated annual revenues in 2021 of around 1.5 billion euros. With its products and solutions, Gerresheimer plays an essential role in people’s health and well-being.
www.gerresheimer.com

About Gx Biological Solutions

Gx Biological Solutions is an interdisciplinary team with global resources and cross-divisional product expertise to advise our customers. We support companies during drug development and throughout the product lifecycle by providing personalized applications and indications-based recommendations. We provide short-term platform solutions as well as product samples for early clinical studies. Gx Biological Solutions can also perform, evaluate and interpret functional or laboratory tests as well as develop custom solutions for our clients.

About Nelson Labs

Nelson Labs is a global leader in microbiological and analytical chemistry testing and consulting services for the medical device and pharmaceutical industries. Nelson Labs serves more than 3,800 customers at 15 facilities in the United States, Mexico, Asia and Europe. We have a comprehensive portfolio of over 800 laboratory tests to support our customers from initial product development and sterilization validation, through regulatory approval and ongoing product testing for sterility, safety and quality assurance. We are considered a premier partner with a strong track record of working with customers to solve complex problems.
Based in Leuven, Belgium, Nelson Labs Europe specializes in providing high-end extractables and leachables analysis services to the pharmaceutical and medical device industries. We also help pharmaceutical companies around the world develop global compliance testing strategies to qualify container/closure applications and pharmaceutical production equipment from an extractables and leachables perspective.
With decades of expertise, we guarantee the quality of our results and the strength of our partnerships with our clients. Along with our sister companies Sterigenics and Nordion, we are part of Sotera Health, the leading protector of global health.
Safeguarding Global Health® – with every test we perform.
www.nelsonlabs.com

Specimen Pages, Qiushi Footprints

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At the Zhejiang University College of Pharmaceutical Sciences, there is the Herbarium of Medicinal Plants which collects more than 5,000 plant specimens of great medical value and historical significance. As William Blake’s beautiful poem says, “to see a world in a grain of sand and a paradise in a wildflower”. Today, let’s trace Qiushi Spirit from these silent storytellers.

Specimen: A World in a Wildflower

Gathered in the mountain, forest and wetland regions of Zhejiang Province, the collections unfold the panorama of the spectacular landscapes of Zhejiang Province. There is Nothodoritis zhejiangensis Tsi., a rare and endangered national plant, picked from the corner of a remote wild forest in Ningbo city; there are Habenaria sagittifera Rchb.f collected from the grasslands on top of a mountain in Quzhou city; there is also Platanthera tipuloides Lindl. found in the wetland of a valley in Lishui city. From valley bottoms to mountain tops, plant specimens provide an abundant resource for researchers to study the ecological environment of Zhejiang Province.

Nothodoritis zhejiangensis Tsi.

Habenaria sagittifera Rchb.f

Platanthera tipuloides Lindl.

In the Orchidaceae family alone, the herbarium has collected 326 specimens, 50 of which are rare and threatened at the national level. These specimens accurately record the rich medical resources, sketch a fabulous world of natural vegetation, and meanwhile provide exhaustive references for relative cultural study.

Tags: notes for the Qiushi spirit

Recently, students from the school of pharmacy rearranged the specimens in the herbarium. Looking back at the time-worn specimens of half a century, they recovered the Qiushi spirit condensed in the specimen and note patch pages.

Students arranging the specimens under instruction

Few things can contain eternity in an instant, but these specimens did. Among the collections is a specimen of Dioscorea spongiosa patched with five notes. The confirmation of his name is a whole experience of twists and turns, where the tireless scholars of ZJU’s Qiushi spirit found precise expression.

Dioscorea spongiosa JQ Xi, M. Mizuno and WL Zhao

In the 1980s, Professor XI Jingqing and his student ZHAO Weiliang found that Dioscorea spongiosa in Zhejiang was different from the standard specimen. They stuck to this clue and assumed that Zhejiang Dioscorea spongiosa was a new species. In 1987 they published their findings and evidence, only to be disappointed that this new Dioscorea spongiosa was not recognized since the standard specimen did not exist in China. After positive communications with overseas scholars, they got access to the standard in Japan, then carried out a thorough analysis, finally verified the value of Zhejiang Dioscorea spongios and established its status in taxonomy. The renewed information not only added a sharp note to this specimen, but also demonstrated the very core of the Qiushi spirit: always seeking the truth with constant effort. It is their unwavering spirit of pursuing the truth regardless of all obstacles that underpins the progress of their study as well as every great stride of this university.

Commitment goes all the way

The history of the Herbarium of Medicinal Plants can be traced back to 1920, which was then the Zhejiang Provincial Medical School. Many specimens have been used for almost a century, in courses such as Medicinal Plants and Pharmacognosy and From Shennong Herbal Medicine to Modern Chinese Medicine. During this time, what has been passed down is much more than specimens, but also the enduring commitment to pharmaceutical sciences and the clarity of passion for research.

Students having a course in pharmaceutical botany in the 1950s

Students conducting field study in West Tianmu Mountain, Hangzhou

From classroom experiences to field studies, generations of scholars and students are consolidating their basic skills of memorizing plants, exploring medicinal value, and practicing learning in the thick forest and mountains, thus realizing their motto of traveling thousands of miles and reading thousands of books. Specimen paper may be discolored, but this commitment will extend into the future.

Screenwriters: XU Xiao, ZHOU Yichen, XU Juanhua, SHI Shuiyang

Translator: ZHANG Jinmei

Publisher: TIAN Minjie

/Public release. This material from the original organization/authors may be ad hoc in nature, edited for clarity, style and length. The views and opinions expressed are those of the author or authors. See in full here.

With the likely approval of over-the-counter birth control pills, pharmacies could play an increasingly important role in reproductive health care

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By Lucas Berenbrok and Marian Jarlenski from Pittsburgh University of Health Sciences

The U.S. Food and Drug Administration is expected to review a drugmaker’s application for the first over-the-counter birth control pill in November 2022, with a decision expected in the first half of 2023.

An approved over-the-counter hormonal contraceptive product would not require a prescription and would be considered self-care, defined as “the practice of individuals taking care of their own health using the knowledge and information at their disposal.”

Currently, in many US states, pharmacists can already prescribe hormonal birth control that requires a prescription. The process begins with a consultation with a pharmacist to screen patients for eligibility, collect medical histories and measure blood pressure. If the patient is eligible, the pharmacist can give them a prescription; otherwise, the pharmacist refers the patient to a doctor.

FDA approval of an over-the-counter birth control pill will further expand options for people seeking hormonal birth control in all 50 states. The first of these over-the-counter pills – an estrogen- and progestin-only contraceptive – could be available by mid-2023.

We are pharmacists and public health experts. We view the move toward over-the-counter birth control as an important step toward accessible and equitable reproductive health care for all Americans, and pharmacists will play an indispensable role in this effort.

Making birth control more accessible

With over 60,000 pharmacies nationwide, pharmacists are the most accessible members of the healthcare workforce. Nearly 90% of Americans live within 5 miles of a pharmacy. Throughout the COVID-19 pandemic, pharmacies have provided testing, vaccinations and treatment to millions of people in the United States, proving their value by supporting and sustaining important public health initiatives.

Traditionally, hormonal contraception – also known as birth control, or when taken orally, “the pill” – was only accessible after a full medical evaluation by a physician, medical assistant or a nurse practitioner.

But in 2016, California and Oregon became the first states to allow pharmacists to prescribe contraceptives. This quickly expanded to 20 states plus Washington, DC, which now allow pharmacists to prescribe some form of birth control, whether it’s the pill, patch, ring or shot.

However, the move to over-the-counter contraception without a prescription is important because it will significantly reduce some of the known barriers to contraception. These barriers include the inability to pay for doctor’s office visits needed to obtain a prescription, lack of insurance to cover the cost of prescription contraception, or lack of accessibility to pharmacist-prescribed contraception.

Over-the-counter contraceptives can also reduce barriers to access by eliminating the need to make an appointment with a primary care physician during working hours or to travel long distances to obtain such care.

But it’s important to note that over-the-counter access to hormonal contraceptives does not replace the importance of regular office visits or reproductive health discussions with doctors.

Overcome remaining obstacles

Even in states where pharmacists are currently allowed to prescribe contraceptives, patients may still face barriers.

For example, if state policies do not create payment pathways to reimburse pharmacists for their counseling and prescribing time, pharmacists may choose not to participate. In addition, the pharmacist’s availability and time may be limited and more restricted than the opening hours of a pharmacy.

Finally, there are notable cases of pharmacists denying patients access to emergency contraception, also known as the “morning after pill”, and prescriptions for medical abortion on the grounds of moral, ethical and nuns.

For example, in 2019, a pharmacist in Minnesota denied a patient emergency contraception, citing his personal beliefs. As a result, the patient traveled 50 miles to access the drug. Ultimately, a jury found that the pharmacist had not discriminated against the woman by refusing to fill her prescription.

This precedent suggests that pharmacists who object to the use of reproductive drugs may additionally choose not to participate in prescribing hormonal contraception even when permitted by state law. They can also choose not to sell over-the-counter contraceptives when they become available.

Pharmacist’s “conscience clauses”

Notably, many states give pharmacists autonomy when dispensing drugs. Currently, 13 states have laws or regulations known as “conscience clauses” that allow pharmacists to refuse to dispense a drug when it is contrary to their religious or moral beliefs.

The American Pharmacists Association also recognizes the right of an individual pharmacist to conscientiously refuse to dispense a drug; however, the organization supports a system to ensure patient access to medications without compromising the pharmacist’s right to refuse. In other words, pharmacists are encouraged to “step aside”, but must not “obstruct” the distribution or sale of drugs that conflict with their personal beliefs.

Some states with conscience clauses legally require pharmacists to refer patients elsewhere when they refuse to dispense a drug for ethical and/or moral reasons. In addition, company policies may require pharmacists with objections to arrange for another pharmacist – who has no objections – to provide medications and care requested by the patient. However, some states do not require a system to ensure this access for patients, as the American Pharmacists Association suggests.

Contraception Deserts

Ongoing legislation to reduce access to abortion in the post-Roe era in the United States only increases the importance of patient access to contraception. Geographic spatial analyzes revealed that people of lower socioeconomic class and of color disproportionately reside in contraceptive deserts, which are areas with low access to family planning resources. These contraceptive deserts could be reduced or completely eliminated in states that allow pharmacists to prescribe contraceptives, or in areas with access to community pharmacies that offer hormonal contraceptives when available.

In our view, pharmacists can positively contribute to the safe, effective and accessible use of contraception across the country.

Lucas Berenbrok is associate professor of pharmacy and therapeutics and Marian Jarlenski is associate professor of health policy and management, both at Pittsburgh University of Health Sciences This article is republished from The Conversation under a Creative Commons license. Read the original article.

EMPLOYMENT (29-10-2022) – Jammu Kashmir Latest News | Tourism

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MOB NO. 9419183679

AROMA FOUNDATION
PUBLIC SCHOOL
SEC 2, LOWER ROOP NAGAR, JAMMU
OBLIGATORY
HINDI TEACHER (F) – 1 NO – BA/B.ED.
KINDERGARTEN TEACHER (F) – 2 NO – BA / B.SC / B.ED
TOWEL – 1 NO
NEGOTIABLE SALARY
INTERVIEW: 10/29/22 & 10/31/22
TIME: 10:00 AM TO 12:00 PM
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EMPLOYMENT EMPLOYMENT EMPLOYMENT
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ELECTION 2022: Q&A with Locust Candidates – The Stanly News & Press

Editor’s note: For coverage of the primary election, The Stanly News & Press sent questions to each group of candidates. We limited their responses to 200 words per response. Responses appear as is, except for correction of grammatical/spelling or length errors. This allows potential voters to see the candidates through their own words and gives them an equal chance to respond.

city ​​of locusts

Mayor
Steve Huber*

Advice
Roger Hypes
barry sims
mandy watson

* did not respond

1. Tell me a bit about your background?

Roger Hypes

Hype: Locally, I’ve been in the Lions Club, church clerk, part-time customer service at Stanly Funeral Home. For eight years, wrote an article for Locust Patch every Saturday.

Served in the United States Air Force and National Security Agency for a total of five years, 46 years in retail[10yearsinStoreOperationsfromstoremanagerdistrictsupervisorandRegionalSalesDirectorof125stores[10ansdanslesopérationsdemagasinentantquedirecteurdemagasinsuperviseurdedistrictetdirecteurrégionaldesventesde125magasins[10yearsinStoreOperationsfromstoremanagerdistrictsupervisorandRegionalSalesDirectorof125stores

36 more years in real estate departments finding locations to buy land, finding locations in malls and malls. Map and tag all retail businesses and report to management committees, including site visits. Once the sites were approved, the negotiation of the specifics of the economy then began. This enabled analytical and negotiation skills as well as presentations. States I was responsible for: Alabama, Delaware, Florida, Georgia, Illinois, Indiana, Iowa, Kentucky, Maryland, Mississippi, North Carolina, Ohio, Pennsylvania, South Carolina, Tennessee, Virginia, and West Virginia.

barry sims

Sims: I have had several things in my life which I believe have given me a lot of life experience which adds to the knowledge of the meaningful things in life.

Watson: I grew up in Concord and my husband and I moved to Locust after we got married in 2005. We have been here 17 years raising our children here. We have a 14 year old daughter and an 11 year old son.
We own the medical pharmacy of Locust and Xpressit in

mandy watson

Locust and Albemarle. I have been a pharmacist since 2005 and I love the independent pharmacy.

Outside of work, we keep very busy with our children in different sports all year round. We like to travel and be at the beach when we have free time.

2. For Newcomers: What made you decide to get involved in your community and run for Locust City Council? For the incumbent: What has the council accomplished since you took office and why do you think voters should elect you back?

Hype: Repay sewer loans and repay City Hall in nine years of a 40-year loan; ORS at Locust Elementary School; canine to the anti-locust police department; equip the Public Security with lighter vests; incentives for the police department to continue their training and certifications; modification of residential requirements to include width of lot lines, materials; reassessment of conditional use, rezoning and land use; highway speeds changed after state engineers introduced; Public Works minimize excess drain on water/sewer capacity, install new pump station and repair existing pump stations; Parks & Recreation having staff and new restrooms and offices to ensure competitive facilities for recruiting sporting events; redevelopment of the town hall; no tax increase in 23 years; all street signs have been replaced; all signs indicating the direction of the city have been replaced; installation of a new “Welcome to Locust” sign; the addition of Retail Strategies to assist with further growth of Locust; the town of Locust receives national awards for fiscal responsibility and reporting; in recent years, the State of North Carolina has given credence and recognition to Locust’s finances; a coordinated plan to repave the streets; plantation of crepe myrtle trees as the entrance to Locust from the west.

Sims: I’ve always cared about the community I live in and think it’s important to participate in events that could have an effect.

Watson: One of the accomplishments I am most proud of as a board member was the establishment of the School Resource Officer position at Locust Elementary in 2018.
I feel like this has been crucial in protecting our children and educating them about law enforcement.

3. Why do you think you are the most qualified candidate for the job?

Hype: Integrity, compassion, concern and care for Locust; timeliness, transparency of City Council’s cooperative efforts for the welfare of Locust and surrounding communities to ensure the safety, security, sensitivity, maintenance, training and equipping of services; watchdog on budget items; flexibility in navigating through COVID and/or contentious issues; continue to favor quality over quantity in commercial and residential growth; monitor growth to ensure growth is within guidelines.

If an issue affects Locust and surrounding communities, people need to be heard and everything needs to be addressed. I live here and I don’t want to do anything that isn’t in Locust’s best interest. The city council works together to ensure this.

Sims: I still attend all city council meetings and currently sit on the planning and zoning committee and think I could serve the city on council as well.

Watson: I am qualified for the job because I want the best for our Locust community. I am actively involved in the community between schools, sports and community events and can relate to many Locust residents.

I am open-minded and will listen to our neighbors and work every day in the best interests of each of them.

4. In your opinion, what are the most important issues that affect the residents of your community the most?

Hype: Water and sewer capacity to accommodate growth. Roads and traffic problems to accommodate growth, whether signals, roundabouts, 4-way stop signs.

Sims: Quality of life for the city, ensuring it grows within its means.

Watson:I think the biggest issue affecting our residents would be to create smart, steady growth and development for Locust businesses.

5. What would you focus on if elected/re-elected?

Hype:Although the public has the opportunity to register to make comments or ask questions at each board meeting, I would encourage greater participation in any way to get the message out. Social media is not the channel for negative comments.

Attendance at board meetings would provide the necessary education in the decision-making process. As the Town Councilor of the Town of Locust (The Town with a Soul), we believe that as a living citizen, working in Locust, we need all residents to be part of the decisions that affect us all as we navigate through everything that affects our city.

If the audience is not present, I call it “the volume of silence”.

Sims:Cities have to grow somewhat or they will stand still, the important thing is to make sure they don’t outgrow their infrastructure, because that would be as bad as not growing at all. To help ensure that the quality of life and growth meet the expectations of citizens.

Watson:I think my goal would be to continue to support smart and steady business growth. Additionally, as an advocate for the parks, I will continue to focus on growing our youth with sporting and community events.

Use of an ex vivo tissue model to study skin regeneration following microneedle stimuli

0
  • Mobayed, N., Nguyen, JK & Jagdeo, J. Minimally invasive facial cosmetic procedures for the millennial aesthetic patient. J. Drugs Dermatol. 19100–103 (2020).

    PubMed

    Google Scholar

  • Ablon, G. Safety and efficacy of an automated micro-needling device for improving signs of skin aging. J. Clin. Esthete. Dermatol. 1129-34 (2018).

    PubMed
    PubMed Center

    Google Scholar

  • Gowda, A., Healey, B., Ezaldein, H. & Merati, M. A systematic review examining the potential adverse effects of microneedling. J. Clin. Esthete. Dermatol. 1445–54 (2021).

    PubMed
    PubMed Center

    Google Scholar

  • de Lima, EA Microneedling in recalcitrant facial melasma: report of a series of 22 cases. Anna. Arms. Dermatol. 90919-921 (2015).

    Google Scholar

  • Lima, EVA, Lima, MMDA, Paixão, MP & Miot, HA Evaluation of the effects of cutaneous microneedling as an adjuvant treatment for facial melasma: a pilot study. BMC Dermatol. 171–6 (2017).

    Google Scholar

  • Alster, TS & Graham, PM Microneedling: A review and practical guide. Dermatol. Surg. 44397–404 (2018).

    CASE
    PubMed

    Google Scholar

  • Zeitter, S. et al. Microneedling: Matching the results of medical needling and repetitive treatments to maximize the skin’s regenerative potential. Burns 40966–973 (2014).

    CASE
    PubMed

    Google Scholar

  • Sancho-García, I. & Piñero-Zapata, M. A systematic review examining the potential adverse effects of microneedling. Evidence 18e12814 (2021).

    Google Scholar

  • Fernandes, D. Minimally invasive percutaneous collagen induction. oral maxillofacial. Surg. Clin. N.Am. 1751–63 (2005).

    Google Scholar

  • Ogunjimi, AT, Carr, J., Lawson, C., Ferguson, N. & Brogden, NK Micropore closure time is longer after microneedle application on skin of color. Science. representing ten1–14 (2020).

    Google Scholar

  • McCrudden, MTC et al. Applications of micro-needles to improve the appearance of the skin. Exp. Dermatol. 24561–566 (2015).

    PubMed

    Google Scholar

  • Singh, A. & Yadav, S. Microneedling: Progress and Expanding Horizons. Indian Dermatol. J online. seven244 (2016).

    PubMed
    PubMed Center

    Google Scholar

  • Levy, MD & Gold, MH Acne scars – use of needling devices. Dermatol. Round. 1154-162 (2020).

    Google Scholar

  • Amer, M., Farag, F., Amer, A., ElKot, R. & Mahmoud, R. Dermapen in the treatment of wrinkles in cigarette smokers and effective skin aging. J.Cosmet. Dermatol. 2025 (2018).

    Google Scholar

  • Schmidt, L. et al. Complete molecular characterization of microneedling therapy in a three-dimensional human skin model. PLoS One 131–11 (2018).

    CASE

    Google Scholar

  • Vora, D., Garimella, HT, German, CL & Banga, AK Microneedling and iontophoresis enabled delivery of methotrexate into and through healthy and psoriatic skin. Int. J. Pharm. 618121693 (2022).

    CASE
    PubMed

    Google Scholar

  • Bhattaccharjee, S., Beck-broichsitter, M. & Banga, AK In situ gel formation in microporated skin for improved topical delivery of niacinamide. Pharmacy 129-11 (2020).

    Google Scholar

  • Wei, Z. et al. Two-dimensional and three-dimensional cellular bioprinted skin models to screen compounds for topical use for irritation potential. Front. Bioeng. Biotechnol. 8109 (2020).

    PubMed
    PubMed Center

    Google Scholar

  • Ritsu, M. et al. Critical role of tumor necrosis factor-α in the early skin healing process. J. Dermatol. Dermatol. Surg. 2114-19 (2017).

    Google Scholar

  • Zduńska, K., Kołodziejczak, A. & Rotsztejn, H. Is skin microneedling a good alternative method of removing various skin defects. Dermatol. The. 311–9 (2018).

    Google Scholar

  • El-Domyati, M. et al. Multiple microneedling sessions for minimally invasive facial rejuvenation: an objective assessment. Int. J. Dermatol. 2025 (2015).

    Google Scholar

  • Dogra, S., Yadav, S. & Sarangal, R. Microneedling for acne scarring in Asian skin: an effective low-cost treatment modality. J.Cosmet. Dermatol. 2025 (2014).

    Google Scholar

  • Al Qarqaz, F. & Al-Yousef, A. Dermal microneedling for pigmentation-associated acne scars in dark-skinned patients. J.Cosmet. Dermatol. 2025 (2018).

    Google Scholar

  • Fabbrocini, G., Fardella, N., Monfrecola, A., Proietti, I. & Innocenzi, D. Treatment of acne scars by dermal needling. Clin. Exp. Dermatol. 34874–879 (2009).

    CASE
    PubMed

    Google Scholar

  • Aust, MC, Fernandes, D., Kolokythas, P., Kaplan, HM & Vogt, PM Percutaneous collagen induction therapy: An alternative treatment for scars, wrinkles, and sagging skin. Plastic. Rebuild Surg. 1211421-1429 (2008).

    CASE
    PubMed

    Google Scholar

  • Garg, S. & Baveja, S. Combination therapy in the management of atrophic acne scars. J. Skin. Esthete. Surg. 2025 (2014).

    Google Scholar

  • Chandrashekar, B., Sriram, R., Mysore, R., Bhaskar, S. & Shetty, A. Evaluation of micro-needle fractional radiofrequency device for the treatment of acne scars. J. Skin. Esthete. Surg. 2025 (2014).

    Google Scholar

  • Alam, M. et al. Efficacy of a needling device for the treatment of acne scars: a randomized clinical trial. JAMA Dermatol. 150844–849 (2014).

    PubMed

    Google Scholar

  • August, MC et al. Percutaneous collagen induction. Scarless skin rejuvenation: fact or fiction?. Clin. Exp. Dermatol. 35437–439 ​​(2010).

    CASE
    PubMed

    Google Scholar

  • August, MC et al. Induction–percutaneous collagen regeneration instead of healing?. J.Plast. Rebuild Plastic surgery. 6497-107 (2011).

    CASE

    Google Scholar

  • Schwarz, M. & Laaff, H. A prospective controlled evaluation of microneedling with the dermaroller device. Plastic. Rebuild Surg. 127146th–148th (2011).

    CASE
    PubMed

    Google Scholar

  • Saferling, K. et al. Wound healing revised: a new re-epithelialization mechanism revealed by in vitro and in silico models. J. Cell Biol. 203691-709 (2013).

    CASE
    PubMed
    PubMed Center

    Google Scholar

  • Paquet-Fifield, S. et al. A role of pericytes as microenvironmental regulators of human skin tissue regeneration. J. Clin. Invest. 1192795–2806 (2009).

    CASE
    PubMed
    PubMed Center

    Google Scholar

  • Mathes, SH, Ruffner, H. & Graf-Hausner, U. The use of skin models in drug development. Adv. Deliver. Round. 69–7081–102 (2014).

    PubMed

    Google Scholar

  • Caserta, AV et al. 932 Development of an early wound model in an ex vivo human skin explant as a preclinical model of wound healing. J. Invest. Dermatol. 139S161 (2019).

    Google Scholar

  • vonMuller, C. et al. Active neutrophil responses thwart Candida albicans burn wound infection of ex vivo human skin explants. Science. representing ten1–15 (2020).

    Google Scholar

  • Greenwald, DP, Gottlieb, LJ, Mass, DP, Shumway, SM & Temaner, M. Full-thickness cutaneous wound explants in tissue culture: a mechanical assessment of wound healing. Plastic. Rebuild Surg. 90289–294 (1992).

    CASE
    PubMed

    Google Scholar

  • Cho, H., Won, CH, Chang, SE, Lee, MW, and Park, G. Usefulness and limitations of skin explants for evaluating laser treatment. Med. Laser 258–63 (2013).

    Google Scholar

  • Rakita, A., Nikolić, N., Mildner, M., Matiasek, J. & Elbe-Bürger, A. Re-epithelialization and behavior of immune cells in an ex vivo human skin model. Science. representing ten1–11 (2020).

    CASE
    PubMed
    PubMed Center

    Google Scholar

  • Lebonvallet, N. et al. Evolution and use of skin explants: potential and limits for dermatological research. EUR. J. Dermatol. 20671–684 (2010).

    PubMed

    Google Scholar

  • Lee, HJ et al. Efficacy of microneedling plus conditioned human stem cell medium for skin rejuvenation: a randomized, controlled, blinded split face study. Anna. Dermatol. 26584-591 (2014).

    PubMed
    PubMed Center

    Google Scholar

  • Ismail, ESA, Patsatsi, A., Abdel-Maged, WM & Nada, EEDA Efficacy of microneedling with topical vitamin C in the treatment of melasma. J.Cosmet. Dermatol. 2025 (2019).

    Google Scholar

  • Ibrahim, MK, Ibrahim, SM & Salem, AM Cutaneous microneedling plus platelet-rich plasma versus cutaneous microneedling alone in the treatment of post-acne atrophic scars: a comparative split-face study. J. Dermatol. Treat. 29281-286 (2018).

    Google Scholar

  • Chawla, S. Comparative split face study of microneedling with PRP versus microneedling with vitamin C in the treatment of post-acne atrophic scars. J. Skin. Esthete. Surg. seven209 (2014).

    PubMed
    PubMed Center

    Google Scholar

  • Hou, A., Cohen, B. & Haimovic, A. Microneedling: A Comprehensive Review. Dermatol. Surg. 20321–339 (2017).

    Google Scholar

  • Ramaut, L., Hoeksema, H., Pirayesh, A., Stillaert, F. & Monstrey, S. Microneedling: Where are we? A systematic review of the literature. J.Plast. Rebuild Plastic surgery. 711–14 (2018).

    Google Scholar

  • Saadawi, AN, Esawy, AM, Kandeel, AH & El-Sayed, W. Microneedling by dermapen and glycolic acid peeling for the treatment of acne scars: a comparative study. J.Cosmet. Dermatol. 2025 (2019).

    Google Scholar

  • BOE solves traffic at Trumbull school, insurance cover | Top stories

    WATERTOWN — As the school board meeting began Monday, Oct. 24, Superintendent Dr. Alison Villanueva addressed the traffic situation at John Trumbull Elementary School, thanking the community for working with the school district as new Traffic patterns are explored to alleviate increased traffic congestion as students congregate and leave school.

    This week, all traffic was directed to the front of the school, avoiding the use of the back door.

    Dr Villanueva said: ‘I always maintain that we need a secondary exit just for the number of vehicles entering and exiting our school building when arriving and departing. But, right now, with a little delay here and there, and with the police presence, we can get in and out with a little delay. »

    She looks forward to a traffic study that is scheduled and thanks everyone for their patience.

    Following his comments, she responded to the council saying that she had no timetable for the start of the traffic study. SLR Consulting, the company that will conduct the study, reviewed the site in person and developed a proposal for the city and school district.

    In other business, the superintendent reminded the board that a large portion of the budget is funded by insurance benefits for the six collective bargaining units, then introduced Alexandra Humble of the Office of the State Comptroller, Policy Health and Benefit Services.

    Ms. Humble described how the school district could access the Connecticut Partnership Plan, which is a point-of-care health insurance plan administered by Anthem Blue Cross/Blue Shield.

    Monthly premiums are based on the aggregate state claims experience of over 250,000 participants.

    There is a zero dollar co-payment for visits to providers and service sites on the approved list, which has been checked for quality of care.

    For other visits, there is a copayment of $15.

    There is a $250 co-payment for ER visits, waived if the need is a true emergency; the high cost is intended to deter use for conditions that would be better served by a visit to a doctor’s office.

    Provider of Distinction is a list that offers a cash incentive to patients who visit these providers for procedures such as colonoscopies and there are programs to support those with chronic conditions such as diabetes.

    Coverage is 100% after the annual maximum of $2,000 for individuals and $4,000 for families.

    The pharmacy is managed by CVS/Caremark with a four-tier payment system for acute and maintenance medications.

    Acute medications can be filled at any pharmacy, but maintenance medications must be filled at a participating pharmacy.

    There is no deductible for the pharmacy but a maximum amount after which coverage is 100%.

    Dental and vision are options offered by Cigna, with the latter focusing on hardware such as eyeglasses, as the medical plan covers one eye exam per year.

    The Health Enhancement Program supports wellness, which provides long-term savings and encourages a healthier population by encouraging preventative care such as wellness exams and preventative screenings.

    The HEP also has a chronic disease management component that targets diabetes, asthma or COPD, heart disease/heart failure, hyperlipidemia and hypertension.

    Applications can be made on the state website and are reviewed either as a Watertown BOE group or as a partial group; the latter would be if some unions elected against the insurance offer.

    Ms Humble said the presentation was high level and offered to provide more information if the council wanted to move forward.

    There is a three-year commitment that a group must make if they join the plan.

    Ms Humble said the plan is attractive because of the pooling and benefits. “Our rate increases are much more stable since we have a larger population.”

    As the board continued to discuss the idea, they learned that the premiums are listed as what the state would charge Watertown and the group itself would determine the percentages that would dictate what the school district and employees would pay. .

    Dr. Villanueva announced that the current supplier, Cigna, will share information at the next meeting to ensure that the board is as informed as possible.

    During the meeting, the board received an overview of the School Diversion Initiative from Jeana Bracey and Rebekah Behan, Project Coordinators of the Child Health and Development Institute.

    SBDI is a state-backed initiative focused on how schools view expulsion rates, among other factors.

    Dr. Villanueva said the school district is experiencing a higher number of expulsions and recommended a review of what could be done to reduce that number and avoid expulsions.

    A grant funds this work by CHDI over the next two years.

    The presentation noted that the initiative aims to better serve children through the behavioral health system rather than the juvenile justice system, noting that the highest rate of unmet health needs and school risk is among children. young people who are arrested or expelled.

    SBDI’s goals are to reduce the number of arrests, expulsions, and out-of-school suspensions, to develop the knowledge and skills of teachers and staff, and to connect at-risk youth with schools. and relevant communities. services and supports.

    The presentation included a reference to United Way’s 2-1-1 hotline, which provides free and confidential 24/7 access to many services, including mobile case of crisis.

    These services bring professional services to where a child is in crisis to assess the situation, offer brief treatment and connect to more care.

    The response rate is 45 minutes or less and free for all Connecticut children; there is no specific definition of a seizure and it can range from acting out or behavior that could indicate the child is considering self-harm or suicide.

    While children are held accountable in SBDI, the emphasis is on relationship building rather than punishment.

    The board asked how this work is impacted by students who do not have behavioral issues, recognized the importance of helping children build resilience in the face of adversity, and noted the importance of include the family to help the child.

    Before the meeting adjourned, the board accepted a $450 donation from Joshua McGrath to help pay for transportation and school trips for the students.

    Federal Grand Jury Returns Indictment Charging Local Physician and LPN with Illegally Obtaining and Distributing Controlled Substances | USAO-WDLA

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    SHREVEPORT, La. Dr. Jeffrey L. Evans, Jr.65, from Mansfield, Louisiana, and Debra E. Craig66, of Converse, Louisiana, was each indicted today by a federal grand jury in Shreveport for unlawfully obtaining and distributing controlled substances, the US announced Attorney Brandon B. Brown.

    Evans was a doctor licensed to practice medicine in the state of Louisiana with an office in Mansfield, and Craig was an LPN who worked in the medical clinic and was assigned to work with Evans. The indictment alleges that beginning on or about January 2, 2014 and ending on or about March 9, 2022, Evans and Craig conspired together and with others to obtain hydrocodone and Adderall, two Schedule II controlled substances, by fraud.

    It is alleged in the indictment that Evans would write prescriptions for Schedule II controlled substances to an anonymous person identified as “Individual 1” and his co-defendant and LPN, Craig. Controlled substances prescribed included hydrocodone-acetaminophen tablets, hydrocodone-homatropine syrup, and Adderrall. According to the indictment, Individual 1 would fill the prescriptions at a pharmacy in the Mansfield, Louisiana area and then provide the Adderrall to Evans, who would share the controlled substance containing hydrocodone with Individual 1. .

    The indictment further alleges that Craig would fill prescriptions at a Mansfield, Louisiana-area pharmacy under the name “Debbie Craig.” Evans would provide money to Craig to pay the pharmacy for Schedule II controlled substances and after filling the prescriptions, Craig would in turn provide them to Evans.

    It is alleged in nine counts in the indictment that Evans obtained controlled substances by fraud from December 2017 to August 2018. In addition, Evans and Craig are both charged with five counts of obtaining controlled substances by fraud between September 2020 and March 2022. Finally, the indictment alleges that Evans distributed controlled substances through prescriptions that were not dispensed for legitimate medical purposes between February 2018 and August 2018.

    An indictment is simply an accusation and an accused is presumed innocent unless and until proven guilty beyond a reasonable doubt.

    If convicted, Evans faces a sentence of up to 20 years in prison, 3 years of probation and a fine of up to $250,000. If convicted, Craig faces a sentence of up to 4 years in prison, 3 years of probation and a fine of up to $250,000.

    The case is being investigated by the United States Drug Enforcement Administration and is being prosecuted by Alexander C. Van Hook, Special Counsel to the United States Attorney.

    # # #

    New potential of “one-pot, one-step” polymer synthesis

    Research at Hokkaido University brings a new level of control to make long, geometrically linked polymer molecules from several different, alternating molecular units joined in a controlled sequence.

    The process could open up new avenues for producing a wide range of advanced materials, with applications in many fields including drug delivery, data storage, microelectronics and nanolithography.

    Synthetic polymers are among the most common materials in the modern world, formed when individual “monomer” molecules react together to create polymer chains. Polyesters in clothing, polypropylene in packaging, and polyamides in ropes and machinery components are just a few common examples.

    Greater versatility is possible by gaining precise control over the sequence in which different monomer molecules combine to form blocks, which then bind themselves further together. The fine control of the formation of these materials, known as block polymers, generally requires complex cycles of chemical reactions.

    “We were able to control the formation of block polymers in a one-pot, one-step process,” says Professor Toshifumi Satoh of Hokkaido University’s Applied Chemistry Division.

    The realization is an example of what is commonly described as a one-pot, one-step reaction, as it simply involves adding the required monomers to a single reaction vessel and using chemistry to control monomer assembly. into blocks, then into a block polymer.

    The monomers in this study are called cyclic anhydrides, epoxides and oxetanes. A crucial key to controlling their reaction is the use of an alkali metal carboxylate – which acts as a catalyst – to switch the polymer building processes between different reaction forms.

    “We can control the two- and three-dimensional topology and structure of our polymers, in addition to the base sequence in which the monomers combine,” adds Satoh.

    In one experiment, the team demonstrated the potential of their technique by controlling the combination of four different monomers to make diblock tetrapolymers. The temperatures at which these materials changed from a solid to more viscous and rubbery states, called glass transition temperatures, could be changed by varying the specific chemical structures of the bound blocks. This is just one example of the many design possibilities offered by the control of the synthesis reaction.

    The procedure can also create a variety of symmetrical polymer molecules, such as globular structures extending outward from a single core, similar to the branches of a tree. “We are excited to have developed such a controllable polymer production process that could be easily adopted for industrial-scale production, as well as being useful for laboratory explorations of polymer chemistry,” Satoh concludes.

    – This press release was originally published on the Hokkaido University website

    Sauvie Inc. Enters into Exclusive Worldwide License Agreement to Develop and Commercialize Nanobody-Based NK Cell Engager

    0

    SHORT HILLS, NJ, October 24, 2022 /PRNewswire/ — Sauvie Inc. (the “Company”), a mission-driven biopharmaceutical company focused on building a sustainable immuno-oncology company, today announced that Sauvie’s subsidiary, Sauvie BiKE LLC, has entered into an exclusive licensing agreement with Rutgers, The State University of New Jersey (“Rutgers”) for the development and worldwide commercialization rights to bispecific cell engagement technology natural killers (NK) in the field of oncology.

    The licensed technology is based on the discoveries and invention of Arash Hatefi, PhD, Professor in the Department of Pharmacy at Rutgers’ Ernest Mario School of Pharmacy, who has over 20 years of experience developing new treatments against cancer and over 50 original, peer-reviewed studies. publications in this field.

    “As an emerging biopharmaceutical organization focused on the development and commercialization of critical cancer therapies, Sauvie is truly honored and excited to have this opportunity to advance lead inventor, Dr. Hatefi’s discovery, to offer great hope to people with cancer and to position Sauvie as a key player in the field of NK cells,” said Ken Suh, CEO of Sauvie Inc.

    “We are excited about the vast potential the NK Cell Engagement Platform can offer to fight multiple tumors and help many people around the world,” said Dr. Brian E. Jahns, Chief Operating Officer of Sauvie Inc.

    “I am delighted with the agreement and collaboration between Rutgers and Sauvie to advance my research into novel nanobody formats such as bispecific natural killer cell engagers capable of stimulating NK cells, not only amplifying their direct role in the eradication of tumors, but also their function inducing multicellular immune responses ultimately leading to long-lasting tumor control,” said Dr. Arash Hatefi.

    The exclusive license granted to the Company relates to a camelid nanobody which has demonstrated high affinity and specificity for NK cells and which has the potential to target several solid and hematological tumor antigens. NK cell engagers are designed to harness the power of NK cells found in the innate immune system and bind NK cells to tumor-specific receptors. Several clinical research programs around the world have demonstrated the potential efficacy of safely harnessing NK cells to attack tumor cells.

    About Sauvie Inc.

    Sauvie Inc. is a Delaware company formed in 2022 by Unionville Capital LLC to focus on the development and commercialization of lifesaving immuno-oncology therapies for people with cancer. The company expects to generate substantial value by executing an expanding pipeline of critical cancer therapies through strategic acquisitions, partnerships, R&D and commercialization.

    About Sauvie BiKE LLC

    Sauvie BiKE LLC is a subsidiary of Sauvie Inc. and was formed to advance the NK cell engagement platform with the primary target of HER2+ tumors and expand potential indications for NK cell engagement.

    Contact

    Sauvie inc.

    Ken Suh

    [email protected]

    Visit us on social media:

    https://www.linkedin.com/company/sauvieinc

    Quote Show original content to download multimedia:https://www.prnewswire.com/news-releases/sauvie-inc-enters-into-an-exclusive-worldwide-license-agreement-to-develop-and-commercialize-a-nanobody-based-nk-cell- engage-301657739.html

    SOURCE Sauvie inc.

    NJ street is named after one of the all-black female postal groups of World War II

    It’s not often you hear of a 100-year veteran who is also from New Jersey.

    Not only are we hearing her story, but New Jerseyans can now visit what was once known as North Oraton Parkway and Davis Place to see the new and improved Gladys Eva Blount Way.

    via East Orange Town Hall on Facebook

    via East Orange Town Hall on Facebook

    The street is named after none other than Gladys Blount, who was sent to England to help in the Second World War over 77 years ago.

    She was one of 855 members of an all-black female postal battalion responsible for sorting letters and packages during the war.

    They were looking for family letters to cheer soldiers up and remind them of those back home.

    Blount sorted through thousands of letters a day, and the battalion’s work was a valuable part of the war effort.

    via East Orange Town Hall on Facebook

    via East Orange Town Hall on Facebook

    However, upon her return to the United States, she received little to no recognition for her efforts.

    This was partly due to the political climate at the time, as she was considered a minority in her community.

    However, she kept her head down and maintained her work ethic regardless of who was watching.

    via East Orange Town Hall on Facebook

    via East Orange Town Hall on Facebook

    She was proud of her actions and wanted to continue making a difference in people’s lives.

    His sensitivity and thoughtfulness are ultimately what earned him the honor of having his native street renamed in his honor.

    This recognition means his legacy can now live on in East Orange forever.

    via East Orange Town Hall on Facebook

    via East Orange Town Hall on Facebookv

    Not only did members of the Six-Triple-Eight Battalion receive the Congressional Gold Medal this year, but Blount was also honored by Hillsborough County leaders and awarded the key to the city to her hometown of East Orange.

    Blount has always been a valued and underappreciated member of her community and I’m grateful to see her being appreciated today.

    The views expressed in the above post are those of New Jersey 101.5 talk show host Judi Franco only.

    You can now listen to Dennis & Judi — On demand! Listen to New Jersey’s favorite Best Friends anytime, anywhere, and any day of the week. Download the Dennis & Judi show wherever you get podcasts, on our free app, or listen now.

    Click here to contact an editor about a comment or correction for this story.

    WATCH: These are the 50 largest retailers in America

    This is where legal NJ weed is sold

    The number of recreational cannabis dispensaries continues to grow, with nearly two dozen state approvals granted since the first adult recreational sales in the state in April. Here is where the open sites are.

    State Lawmakers Hear Testimony About Hospital, Pharmacy Consolidation | State News

    0

    Health economics researchers from the University of California, Berkeley shared their analysis of Indiana’s health care markets on Thursday – finding that the concentration of insurers and hospitals has contributed to rising costs during the last decade.

    Prices in non-merged hospitals, for example, remained relatively stable over the period analyzed, while prices in entities involved in a merger or acquisition increased by around 50%.

    The presentation came at a joint meeting between the interim finance and public health committees, and dozens of policymakers reviewed the state-commissioned studies.

    But the work on Indiana’s high health care costs is an ongoing discussion, said committee chair Rep. Brad Barrett, R-Richmond.

    The systems analyzed included health insurance, hospitals, healthcare professionals, retail pharmacies, pharmacy benefit managers, pharmacy wholesalers, and pharmacy service administration organizations.

    “We started these discussions with stakeholder groups … a year or two ago and maybe even a little further on,” Barrett said. “It’s just kind of a formal chapter in this ongoing process, so it’s the frustration…I think the main focus today was to get these reports and get these groups talking about it. “

    Testimony divided into two main categories: hospitals and insurers then pharmacies and services adjacent to the pharmacy. In both areas, vertical integration has driven up costs. A hospital may own an organization of physicians while a pharmacy may own a benefits manager, consolidating services into one company that could artificially raise prices.

    “I kind of have an optimistic view that we’re gaining ground in this area; I hope that’s not naïve,” Barrett said toward the end of the four-hour meeting. “We hear what consumers, what patients pay for health care…but we also see that there are unintended consequences. It hurts our pharmacies, it hurts our independent doctors.

    “…it kind of allows us to see that the impact of this is maybe bigger than I originally thought.”

    Hospital and Insurance Consolidation Study Results

    The new study found that between 2011 and 2020, Indiana’s healthcare spending grew by 48% per capita, while other Midwestern states – Illinois, Michigan, Ohio and Wisconsin – grew only by 35%. In particular, hospital mergers in Indiana were associated with a 13.2% increase in inpatient prices, while each additional insurer reduced its premiums by 3.3%. However, Indiana did not have an insurer in the market during this decade.

    The researchers said other states have established a merger review authority to analyze proposed future mergers. But, due to the already consolidated nature of Indiana’s healthcare market, advised lawmakers to seek instead to “ensure” that entities do not use “anti-competitive contract terms.”

    A slide from a presentation on Indiana’s high health care costs showing cost differences in metropolitan areas. (Slide from Dr. Brent Fulton’s October 20 presentation)

    In particular, health care monopolization was evident in Fort Wayne, which the report found had higher monthly premiums than the rest of the state. Parkview Health, the region’s largest healthcare player, has 14 general and specialty hospitals and more than 200 physician group locations.

    The hospitals pushed back, blaming Indiana’s high health care costs on the Hoosiers’ poor health, particularly for “the high prevalence of frequent mental distress, the high prevalence of obesity (and) the high smoking prevalence”.

    Lakshmi Aggarwal, a Fort Wayne oncologist, refuted claims that Indiana’s poor health was driving up prices, noting that other states had the same struggles or were even worse.

    “The whole Midwest is obese — look at Michigan, look at Ohio,” Aggarwal said. “How come they can keep their prices low?”

    Aggarwal was one of the few health care professionals in Fort Wayne to testify before the committee about how patients had been harmed by the consolidation of health services under Parkview Health.

    Aggarwal said she worked with doctors for years through referrals before they suddenly left the Fort Wayne oncology and hematology practice after it was purchased by Parkview.

    Instead, she said, the health system kept services at the center and limited outpatient referrals, even closing competing oncology clinics after buying them up.

    “It’s about power and we don’t have any power,” Aggarwal said. “I think you (in the legislature) can do more than me…that’s why I got (a partner) to cover my calls and came here. And when I come back, I’ll be back on duty.

    Hospitals dispute results

    Pushing back against the Petris Center’s findings, the Indiana Hospital Association (IHA) said the researchers could not be objective, noting that it had received funding from Arnold Ventures, a philanthropic health care organization that the report said ‘IHA, pushes for ‘government price fixing and other anti-free market solutions.

    In another submission to the committee, the IHA said state premiums are in line with the national average and neighboring states, using information from the Kaiser Family Foundation. Using Petris’ own analysis, the IHA said privately insured Hoosiers’ health care spending is comparable to or lower than the national average.

    Indiana Hospital Association President Brian Tabor (Photo by Indiana Hospital Association)

    Brian Tabor, IHA president, said Petris’ analysis for the Fort Wayne area didn’t capture the 2020 meeting between Anthem and Parkview to negotiate pricing and reduce health care costs.

    “The deal was hailed as a success…these pricing studies and others are quite behind the times, so you haven’t seen the fruits of those negotiations in the datasets,” Tabor said. “There’s an awful lot of change in this northeast Indiana market that developed later, after the data used in the study (from Petris).”

    Regarding vertical integration and buying physician organizations, Tabor said the study did not reflect the tough market for independent healthcare providers.

    “We’re … almost all the way down the country in how commercial insurers pay doctors,” Tabor said. “This makes it even harder for doctors in Indiana to stay independent, which is why they often come to a hospital for a job and why hospitals have to subsidize and incur significant losses in doctor’s offices.”

    Recently, the IHA released a study detailing rising costs for hospitals, in part due to the nationwide shortage of healthcare workers and the impact of inflation on supplies. One critic called it an attempt to dissuade lawmakers from adopting antimonopoly tactics in the upcoming legislative session.

    Employer rejection of IHA claims

    But even the Indiana Employers’ Forum identified high costs as the culprit for Indiana’s rising health care spending, noting that policies with high premiums typically had low deductibles, but that Indiana had high costs overall.

    For individual policies, Indiana’s premiums were the 15th highest in the nation, while deductibles were 10th highest and most expensive of all neighboring states. Indiana ranked highest in family premiums, with the 27th highest premiums and 13th highest deductibles in the nation.

    A slide from the Indiana Employers’ Forum presentation attributes high health care prices to hospital costs. (Screenshot from October 20 presentation)

    “The biggest slice of the pie (is) hospital expenses, followed by doctors,” said Gloria Sachdev, president and CEO of the forum. “What really drives up health care costs are prices.”

    Sachdev said hospitals accounted for almost a third of the costs, 31%, compared to doctors, who were responsible for 20%. According to an analysis by the American Enterprise Institute, while inflation had increased the cost of goods and services across the economy, hospital services were 200% more expensive in June 2022 than in January 2020.

    “Our hospital prices are the fourth highest in the country,” Sachdev said, referring to research by the RAND Corporation. “Our prices for outpatient (services) are more than twice Michigan’s…workforce shortages are impacting every hospital nationwide, as is inflation. Why, if other hospitals can keep their prices low, can’t ours? »

    Sen. Ed Charbonneau, R-Valparaiso, said he believes there’s enough money in the health care system, but lawmakers need to refocus on where it’s being spent — in part acknowledging the request for $250 million to fill gaps in public health funding.

    “We’re great at treating people after they get sick and we’re terrible – there’s no other way to put it – we’re terrible at preventing problems from developing,” he said. he declares. “We need to start paying attention to treatment and prevention.”

    Diabetes Solution Kit Review – Barton Diabetes Reversed Program

    The Diabetes Solution Kit is a digital guide from Joe Barton and Dr. Scott Saunders that helps consumers regulate their blood sugar. By following the instructions, consumers could see a significant change within four weeks.

    What is the Diabetes Solution Kit?

    Diabetes is stressful, especially for people learning to manage it. Even people who have lived with this condition for years can feel overwhelmed by the constant adjustments they have to make in their lives, and the continued supplementation and medication for the condition can be overwhelming. With a new program called the Diabetes Solution Kit, consumers may be able to manage this problem independently.

    The Diabetes Solution Kit explicitly helps consumers with type 2 diabetes, reduce their risk of complications that could impact their lives. Rather than offering another supplement, this program shows consumers multiple dietary changes and therapies that can be used in their favor. It works for men and women of all ages, even if they’ve had diabetes for a long time.[periodoftime[periodoftime

    The program benefits anyone who wishes to reverse the effects of diabetes and prediabetes on their body. The Diabetes Solution Kit uses recommended lifestyle changes to help regulate blood sugar management naturally, meaning consumers may be able to avoid medical support with the advice of their doctor.

    However, without additional materials, there would be no Diabetes Solution Kit. In this collection, users will get instructions, planners and other content that will help them in their fight against diabetes. By changing their routine, they will also begin to heal from some of the pain and suffering that comes with the disease. Users won’t have to design a plan independently and they should stay consistent with the instructions revealed in the kit.

    While other programs may take a while to make a difference, this blood glucose program works quickly. Rather than taking months to make a difference, consumers should notice a significant change in their blood sugar levels within four weeks.

    How the Diabetes Solution Kit Works

    This blood sugar support program includes lifestyle changes users should make to achieve the desired result starting with the user’s diet. The Diabetes Solution Kit will help users create a diet that improves their blood sugar and cholesterol levels. This diet will also support the necessary levels of carbohydrates, fiber and fat in their usual diet.

    Then there is weight loss. Consumers who change their diet will inherently improve their weight loss because they won’t eat more food than their body needs. Reducing excess weight without losing healthy nutrients can have impressive health benefits.

    Users will also start exercising to support their blood sugar management. Exercise is a great way to maintain defense against disease, although it also improves overall health, which is good for blood sugar levels.

    Ultimately, these changes aim to regulate the user’s blood sugar levels. While users will have to work to improve their blood sugar levels, the creators claim that this program could permanently solve their blood sugar management issues.

    Additional Diabetes Solution Kit Contents

    With the purchase of the Diabetes Solution Kit, consumers will receive four free bonuses as gifts for investing in the program.

    The first bonus is the Card Counting Cheat Sheet. With this cheat sheet, users can keep a diary of their daily carb intake to get an idea of ​​how much is entering their body.

    The next is the Diabetes Solution Kit Grocery List. Consumers worry enough to plan and prepare their diet, but offering a grocery list to the user makes it easier to determine the best items to buy at the grocery store. Plus, it helps them save tons of money.

    The Cookbook for low blood sugar is the third bonus to help users get the meal recipes they need to control their blood sugar.

    Finally, as a super bonus, consumers will get the Diabetes reversal plan. This guide provides users with everything they need to do to reverse their diabetes. It then pulls all the reports together into a simple, easy-to-follow guide.

    Buy Diabetes Solution Kit

    The main way of Order Diabetes Digital Solution Kit Via Official Website for $19.97, free of shipping as there is no physical copy. However, if customers want a physical copy, they can print one with their download.

    With purchase, consumers will receive:

    • The Diabetes Reversal Guide shows the three-step process users must follow to make a difference.
    • A personal meal and exercise planner to create a personalized plan.

    Purchases can be made with any credit card or PayPal. Dissatisfied customers have up to 365 days for a full refund by contacting weekdays from 8:00 a.m. to 7:00 p.m. EST. the company for order or program support to:

    • Hotline: 617-603-0085

    Other Options for Buying Diabetes Solution Kits

    Even though the best place to buy the Diabetes Solution Kit is from the official website, consumers can also order a physical copy from other retailers for $39.97.

    According to the description on the site, the Diabetes Solution Kit is a best selling guide for anyone who needs to manage their diabetes, helping to address the root cause of diabetes while lowering their A1C levels. The instructions are exactly what users get from the PDF version of the Diabetes Solution Kit, although they will have to pay a bit more to go through a third-party website.

    Diabetes Solution Kit Frequently Asked Questions

    Q: Can users stop using their insulin medication?

    A: The decision to stop taking medication should only be made under the supervision of a physician. Although this program is beneficial, one should never alter the chemistry of the body with drugs without informing a doctor.

    Q: Is the Diabetes Solution Kit legit?

    A: Yes. This program includes healthy changes consumers should make to safely regulate their blood sugar. So far, no side effects have been reported.

    Q: Is there a money back guarantee?

    A: Yes. If the user finds that this program is not helping them manage their blood sugar levels, they can get a refund within the first 365 days.

    Diabetes Solution Kit Summary

    The Diabetes Solution Kit allows consumers to overcome their diabetes without requiring another medication or injection. The program shouldn’t entirely replace current medications without a doctor to guide the transition, but it’s powerful enough to eliminate the need. Enjoying diabetes solution kit requires a little expense for different shopping for users, but the cost is not too much.

    Consumers can visit the official website to order their Diabetes Solution Kit today.

    Affiliate Disclosure:

    Links in this product review may result in a small commission if you choose to purchase the recommended product at no additional cost to you. This serves to support our research and writing team. Know that we only recommend high quality products.

    Disclaimer:

    Please understand that any advice or guidance revealed here does not even remotely replace sound medical or financial advice from a licensed healthcare provider or certified financial advisor. Be sure to consult a professional doctor or financial advisor before making any purchasing decisions if you are using any medications or have any concerns from the review details shared above. Individual results may vary and are not guaranteed as statements regarding these products have not been evaluated by the Food and Drug Administration or Health Canada. The effectiveness of these products has not been confirmed by the FDA or Health Canada approved research. These products are not intended to diagnose, treat, cure or prevent any disease and do not provide any type of enrichment program. Reviewer is not responsible for pricing inaccuracies. See the product sales page for final prices.

    The above is a sponsored article, the opinions expressed are those of the sponsor/author and do not represent the position and opinions of Outlook Editorial.

    Abbe Refractometers Market Size and Forecast

    0

    New Jersey, United States – Verified Market Reports recently published a research report titled “Abbe Refractometer Market Overview, Forecast 2028“. The Abbe Refractometers market is discussed at length in the report to help readers gain a sound understanding of the key trends, key strategies, and potential growth opportunities. The Abbe Refractometers report offers Porter’s Five Forces analysis, PESTEL analysis, and qualitative and quantitative analysis to paint a complete and accurate picture of the current and future market situation. Analysts have carefully forecasted market size, CAGR, market share, revenue, production, and other vital factors using industry-leading primary and secondary research tools and methodologies. Players can use the Abbe Refractometers report to develop effective strategies to focus on key segments and regions and boost their businesses in the Abbe Refractometers market.

    Our report includes current and latest market trends, company market shares, market forecasts, competition benchmarking, competition mapping and an in-depth analysis of key sustainability and development tactics. their impact on market growth and competition. In order to estimate the quantitative aspects and to segment the Abbe Refractometers market, we have used a recommended combination of top-down and bottom-up approaches. We have studied the Abbe refractometer market from three key angles through data triangulation. Our iterative and comprehensive research methodology helps us deliver the most accurate market forecasts and estimates with zero or minimal errors.

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    Key Players Mentioned in the Abbe Refractometers Market Research Report:

    In this section of the report, Abbe Refractometers market focuses on the major players operating in the market and their competitive landscape present in the market. The Abbe Refractometers report includes a list of initiatives taken by companies in recent years as well as those that are likely to occur in the years to come. The analysts also took note of their expansion plans in the near future, the financial analysis of these companies and their research and development activities. This research report includes a comprehensive dashboard view of the Abbe Refractometers Market which helps the readers to have in-depth knowledge of the report.

    A.KRISS Optronic, Bellingham & Stanley, a Xylem brand, JP Selecta, Reichert, Schmidt&Haensch GmbH & Co., Optika Srl, AFAB Enterprises, Anton Paar, Auxilab

    Abbe Refractometer Market Segmentation:

    Global Abbe Refractometers Market Segment By Type:

    • Automatique
    • Semi-automatic

    Global Abbe Refractometer Market by Applications:

    • Chemical
    • Petroleum gas
    • Pharmaceutical
    • Food and drinks
    • Others

    For better understanding of the market, analysts have segmented the Abbe refractometer market on the basis of application, type, and regions. Each segment provides a clear picture of which aspects are likely to drive it and which should hold it back. The segment-wise explanation links the reader to particular updates in the Abbe Refractometer market. Changing environmental concerns, changing political scenarios and different government approaches to regulatory reforms were also mentioned in the Abbe Refractometers research report.

    In this chapter of the Abbe Refractometers Market report, researchers have explored the various regions that are likely to witness fruitful developments and make serious contributions for the flourishing growth of the market. Apart from general statistical information, the Abbe Refractometers market report has provided data about every region regarding its revenue, productions and presence of major manufacturers. Major regions covered in the Abbe Refractometers market report include North America, Europe, Central & South America, Asia-Pacific, South Asia, Middle East & South America. Africa, GCC countries and others.

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    Pharmacists and technicians can work to mitigate pharmaceutical preparation risks

    0

    A more comprehensive set of regulations is needed to ensure consistency and patient safety.

    Due to less stringent oversight of pharmaceutical compounding compared to oversight of FDA-approved drugs, certain risks may be associated with drug compounding in the pharmacy environment. As a result, pharmacists and technicians can work to alleviate any potential issues.

    Pharmaceutical compounding involves the preparation of medications customized for the needs of each patient. This is usually done on a small scale for a single prescription, according to an opinion piece published in Drugs in R&D.

    While FDA-approved drugs are manufactured and tested under Good Manufacturing Practices (GMP) regulations, compounded drugs are exempt from this process, and testing to assess product quality is inconsistent. Compound products are not clinically evaluated for safety and efficacy, and do not have standard product labeling or patient prescribing information.

    Additionally, compounding pharmacies are not required to report adverse events to the FDA, unlike manufacturers of FDA-regulated drugs. Some pharmacies also do compounding on a larger scale without individual prescriptions for patients or drug compounds that have not been approved for use in the United States.

    Without GMP, compounded drugs are at greater risk of potential compounding errors, which can be particularly dangerous when compounding is done on a large scale. FDA reports and state agency investigations have consistently shown that compounded drugs fail to meet specifications at a higher rate than FDA-approved drugs.

    In addition, compounded sterile preparations pose a risk of microbial contamination without proper processes. According to the authors, non-sterile compounding is known to lead to large outbreaks of meningitis and other diseases, and has resulted in increased scrutiny of compounding procedures.

    Despite these concerns, traditional pharmaceutical compounding is an important means of providing access to medicines for people with unique medical needs that cannot be met with commercially available products. For example, pharmacists can prepare a liquid suspension for a pediatric or geriatric patient who has difficulty swallowing.

    Compounding sterile medications requires specific conditions and practices to prevent microbial contamination, bacterial endotoxins, chemical and physical contaminants, and substandard ingredients. USP classifies aseptic handling of sterile products or ingredients as low risk, but the level of sterility assurance for these products still tends to be significantly lower than for pharmaceutical products manufactured under GMP. USP is enforceable by the FDA, but the authors noted that the agency typically defers pharmacy regulation to the states.

    All of these concerns have important implications for clinical practice, according to the authors. The prescription of compound drugs must itself be carefully considered, and the reason why the FDA-approved version is not appropriate must be documented. In particular, however, the Principles of composition by the Pharmacy Compounding Accreditation Board asserts that price differences are not enough to justify compounding.

    Traditional pharmacy compounding offers an important option for many patients, the authors concluded, but it must be done carefully and safely. They added that a more comprehensive set of regulations governing all aspects of drug manufacturing and testing, and enforced through FDA inspections, is needed to ensure consistency and patient safety.

    REFERENCE

    Gudeman J, Jozwiakowski M, Chollet J, and Randell M. Potential risks of pharmaceutical preparation. Drugs in R&D 13(1-8) (2013). Accessed September 22, 2022. https://link.springer.com/article/10.1007/s40268-013-0005-9

    Two small molecules reverse pancreatic acinar duct metaplasia

    Pancreatic cancer often hides as a silent disease. In the absence of known symptoms, it can progress undetected and spread to other organs.

    According to the National Cancer Institute, more than 60,000 Americans will be diagnosed with pancreatic cancer this year, and only about 1 in 10 of those diagnosed will survive the next five years. The disease ranks as the third leading cause of cancer death in the United States because it is rarely detected in the early stages, when treatment options are most effective.

    The stealthy nature of pancreatic cancer is attracting the attention of scientists at the University of Florida, who have discovered a way to reverse a key cellular process involved in its progression.

    UF researchers have identified two small molecules that inhibit the progression of precancerous cells. The molecules also reversed a process known as acinar duct metaplasia, or ADM, which precedes pancreatic cancer.

    To our knowledge, this is the first time that researchers have been able to pharmacologically reverse ADM. With these compounds, we could potentially treat a patient with pancreatic cancer at an early stage of the disease and hopefully improve the treatment options available. »


    Tom Schmittgen, Ph.D., Study Lead Author and Chair, Department of Pharmacy, UF College of Pharmacy

    ADM often occurs when inflammation is present. It is a defense mechanism to prevent the pancreas from producing too many digestive enzymes and destroying itself. During ADM, stable, enzyme-producing acinar cells transform into protective duct cells that line the pancreatic duct. If certain genes mutate during the transition, the cells can become precancerous and eventually progress to cancer.

    To study ADM, UF scientists built a laboratory model using animal cells with pancreatic cancer and tissue from a healthy human. They introduced the two-compound cells -; one of which was developed by Chenglong Li, Ph.D., Nicholas Bodor Professor of Drug Discovery at UF College of Pharmacy. Duct cells responded by reverting to acinar cells. Pancreatic cancer can be prevented when acinar cells are maintained in their natural state.

    “The results are important because we have now demonstrated that ADM can be reversed with drugs,” said Schmittgen, who is also the V. Ravi Chandran Professor of Pharmaceutical Sciences at UF College of Pharmacy. “This research could lead to the development of treatments for patients at high risk of developing pancreatic cancer.”

    Schmittgen hopes this finding will encourage scientists to think about new ways to treat pancreatic cancer by manipulating ADM. Future research will involve testing other compounds in collaboration with Hendrik Luesch, Ph.D., study co-author and professor and holder of the Medicinal Chemistry Chair and the Debbie and Sylvia DeSantis Chair in Discovery and drug development for natural products in the UF College of Pharmacy. These compounds may prove more effective as scientists search for new treatments for a disease with very few treatment options.

    Source:

    Journal reference:

    da Silva, L. et al. (2022) Pharmacological inhibition and reversal of pancreatic acinar duct metaplasia. Discovery of cell death. doi.org/10.1038/s41420-022-01165-4.

    Benefits of Peppermint Tea for Stomach, Sore Throat and More

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    Peppermint is one of those classic, time-tested flavors found in a myriad of products and foods (looking at you, candy canes). Fresh leaves are also popular toppings for drinks, from mojitos to plain water. And tea drinkers can enjoy the herb in the form of peppermint tea, which is made with nothing but peppermint leaves and hot water and is essentially the beverage equivalent of a warm hug.


    Along with its refreshing and delicious flavor, the drink has a surprising list of health benefits that will have you whipping up a casserole. Ahead, find out everything you need to know about the benefits of peppermint tea, plus how to brew peppermint tea for maximum mint enjoyment (sorry, I had to).



    What is Peppermint Tea?

    Peppermint is an herb native to Europe and is a hybrid of two varieties of mint – spearmint and water mint – according to a newspaper article Food Science and Quality Management. According to the University of Illinois Urbana-Champaign, peppermint plants can grow up to three feet tall and have pointed green leaves, which can be steeped fresh or dried in hot water to make tea. with peppermint. The leaves (and by extension, the tea) contain peppermint essential oil, which can be extracted and used in foods or topical products, according to the National Center for Complementary and Integrative Health.



    Peppermint tea

    Peppermint leaves (which, again, are used to make tea) contain a small amount of minerals, including magnesium, potassium, iron, zinc and selenium, according to an article by the Journal of Pharmacognosy and Phytochemistry. The herb also offers antioxidants, such as flavonoids and phenolic compounds, says Maddie Pasquariello, MS, RD, registered dietitian and founder of Nutrition with Maddie. However, the real star of the show is menthol, the main active compound in peppermint leaves and tea, which is responsible for many of the health benefits of peppermint tea.


    Note, if you are sensitive to caffeine, peppermint tea is the perfect drink before bed. Like other herbal teas, the drink is naturally caffeine-free, according to the Harvard TH Chan School of Public Health. This means it won’t ruin your restful sleep, even if you drink it at night.





    What are the benefits of peppermint tea?

    Find out how the benefits of peppermint tea can impact your health, according to nutrition experts.


    May reduce the risk of chronic disease

    As mentioned, peppermint tea is a source of antioxidants. This includes phenolics, flavones and vitamin C, according to Pasquariello. “Antioxidants are part of our cellular defense mechanism; they neutralize free radicals, responsible for cellular distress in the body,” she explains. According to an article in Frontiers of Physiology. But by drinking peppermint tea — and eating plenty of antioxidant-rich foods, of course — you can increase your antioxidant intake, which can potentially prevent chronic disease.


    Improves digestive problems

    If you’ve researched natural remedies for digestive issues, you’ve probably heard of the benefits of peppermint tea and oil. “Peppermint calms stomach muscles and improves the flow of bile, which the body uses to digest fat,” says Kylie Ivanir, MS, RD, registered dietitian and founder of Within Nutrition. This can help food and gas pass faster, improving stomach upset, according to Ivanir. The calming and anti-inflammatory effects of the menthol in peppermint can also help relieve nausea, which is often rooted in gut inflammation, she adds.


    Relieves pain

    If you’re on your period, you might want to add peppermint tea to your monthly personal care line. In addition to calming the gastrointestinal tract (which can be helpful for those dreaded period poops), the menthol in peppermint relaxes muscle spasms, “which can help reduce uterine contractions and cramps,” explains Ivanir. But wait, there’s more: when ingested, peppermint can also provide analgesic (pain-relieving) properties, according to Pasquariello. « Analgesics [work] by blocking signals from the nervous system to the brain and how the brain makes sense of those signals,” she explains. This can further soothe menstrual pain, as well as headaches and other types of discomfort.


    Reduces congestion

    Another benefit of peppermint tea is its ability to relieve congestion. “Menthol is a decongestant and has a thinning effect on mucus,” according to Ivanir. “It breaks down phlegm [and] mucus, thereby relieving your stuffy nose and sore throat. Even just inhaling the steam from a hot peppermint tea will also have a decongestant effect, she adds.



    Potential Risks of Peppermint Tea

    For the average person, peppermint tea is safe, according to Pasquariello. The exception is if you have a peppermint allergy, which is rare but possible, according to an article by Allergy, asthma and clinical immunology. An allergic reaction to peppermint can cause symptoms such as throat tightness, coughing, itchy mouth, swollen lips, wheezing, difficulty swallowing and shortness of breath, according to Pasquariello.


    Additionally, despite the soothing benefits of peppermint tea, the drink may do more harm than good if you suffer from gastroesophageal reflux disease (GERD). “Peppermint can relax the sphincter between the stomach and esophagus, allowing stomach acids to flow back up into the esophagus, making heartburn worse,” according to Ivanir. If you have a history of GERD or heartburn, be careful with peppermint tea and ask your doctor if it’s safe for you.



    How to Reap the Benefits of Peppermint Tea

    If you want to reap the benefits of peppermint tea, there are several options available to you. It is available in tea bags or loose leaf, both of which consist of dried peppermint leaves. To brew peppermint tea (or any tea, for that matter), start by warming up your teapot by adding hot water, swirling it around, and then pouring it out, says Jee Choe, sommelier at the tea and founder of Oh, How Civilized, a tea and food blog. Tea professionals always take this step to prevent the water from cooling significantly during steeping, she notes. Next, add your peppermint tea and hot water (208 to 212 degrees Fahrenheit), steep for at least five minutes, then pop out the tea bag or strain the loose tea, Choe says. And just like that, your peppermint tea is ready to enjoy.


    Another option is to use fresh peppermint leaves to make tea – and no, you don’t need to dry them first. Simply rinse the leaves under running water, then add them to a hot teapot with hot water and steep for five minutes, says Choe. The exact number of leaves depends on their size and your preference, but try to use seven to ten leaves per cup to start.




    Peppermint tea, whether made with dried or fresh leaves, can be enjoyed as is. But if you’re looking for a tasty twist, consider the following ideas for serving peppermint tea:


    Drink it cold. There’s nothing like a peppermint iced tea to quench your thirst. To make it cold, prepare the peppermint tea as usual, let it cool and add ice cubes. If you’re worried about the tea getting diluted, you can steep the leaves longer for a stronger flavor.


    Add it to green tea. When making cold brew green tea, Choe likes to add fresh peppermint leaves to make the drink even more refreshing. Check out her recipe for how to make iced green tea from scratch.


    Mix the sweetener. For a sweeter kick, add a little maple syrup, honey, or coconut sugar to your next cup of peppermint tea.

    Auburn University Celebrates Opening of Health Care Clinic at Boykin Community Center

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    Body of the article

    With a mission to provide access to health care for the uninsured and underinsured in the Auburn community, the Auburn University Health Care and Education Clinic officially opens its doors in the northwest Auburn. The clinic is located at the north end of the Boykin Community Center at 400 Boykin Street, Suite 700.

    The opening was commemorated with a ribbon cutting and open house on Tuesday. Representatives from Harrison College of Pharmacy and Auburn University’s College of Nursing, Edward Via College of Osteopathic Medicine, and Auburn city officials attended the dedication.

    The clinic is the product of an agreement between Harrison College of Pharmacy and the City of Auburn. As part of the renovation and reinvention of the Boykin Community Center, space has been allocated for a clinic. Although operated by the Harrison College of Pharmacy, or HCOP, the clinic is interprofessional with support from students and faculty in a variety of health care disciplines from the colleges of nursing, liberal arts, humanities, and colleges. education from Auburn, as well as the Edward Via College of Osteopathic Medicine.

    “We are very excited about the opening of the clinic at the Boykin Community Center and what it means for the residents of Northwest Auburn and the greater Auburn community,” said Auburn Mayor Ron Anders. “Having access to health care is vital and having a facility like this that is accessible to so many is a great addition to the community.”

    Located in the Boykin Community Center in Northwest Auburn, the clinic provides health care services to Auburn residents who are uninsured, underinsured, or insured patients who prefer to access health care in Northwest Auburn. Services include general health and wellness screenings, acute/urgent care services, chronic disease status management, psychosocial assessment, vaccinations and a wellness program for children.

    For many, the ability to access health care can be life-changing, and interprofessional clinic outreach efforts can have a significant impact.

    “This clinic is a perfect example of how we fit into Auburn’s land grant mission to serve and care for the people of Alabama,” said Kimberly Braxton Lloyd, HCOP Associate Dean for clinical affairs and outreach. “In addition to providing health care services to those who may not otherwise have access to them, we also offer students the opportunity to learn in an interprofessional setting with a variety of other health care practitioners and students. health.”

    Continuing the interprofessional nature of the clinic, the site is also officially approved for one of the first collaborative pharmacy practice agreements for the state of Alabama. Pharmacists Dave Brackett and Fallon Hartsell, along with physician Dennis Scott, are operating under a new agreement granting pharmacists the formal ability to modify, discontinue and initiate medications for specific medical conditions. Scott was recently hired as a physician who will practice at the UA Health Care and Education Clinic and State Wellness Center in Montgomery.

    “Having Dr. Scott on board and being one of the first recipients of the Collaborative Practice Agreement in Alabama means a lot to the services and care we can provide,” said Braxton Lloyd.

    In addition to services provided to the community, the clinic serves as an education and training center, providing a site for Auburn University students from multiple disciplines to engage with each other and learn to treat patients from various walks of life in real life. setting.

    “Interprofessional and experiential education experiences are essential for healthcare students, and we are excited to bring these experiences to Boykin,” said HCOP Acting Dean Timothy Moore. “This collaboration with the City of Auburn reinforces our students’ recognition that they are making an impact in improving health outcomes within the communities where they learn and serve.”

    The clinic has received support from Blue Cross and Blue Shield of Alabama. Through donations to the HCOP and the College of Nursing, Blue Cross continues its commitment to promoting interprofessional education.

    “On behalf of Auburn University, I would like to thank the Blue Cross Blue Shield Caring Foundation for their support of this clinic,” Moore said. “This clinic would not have been possible without their commitment and partnership with Harrison College of Pharmacy and the College of Nursing. Thanks to their support, the clinic is now a reality that will continue to support the surrounding community.

    The Auburn University Health Care and Education Clinic is currently open Monday and Wednesday from 8 a.m. to 12 p.m. and 1 p.m. to 5 p.m.; and Friday from 8 a.m. to 12 p.m. For more information, patients can call 334-844-8911, email [email protected] or visit pharmacy.auburn.edu/boykin.

    31 scientists from IICT-Hyderabad are on Stanford University’s elite list

    The updated Stanford University Global Database Standardized Citation Indicators Scientific-Scale Author Databases published by Elsevier features 31 CSIR-Indian Institute of Chemical Technology (IICT) scientists, Hyderabad, among the 2% most cited scientists in the world. The report was prepared by a team of experts led by John Ioannidis of Stanford University.

    The study created a publicly accessible database of highly cited scientists that provides standardized information on citations, h-index, co-author-adjusted hm-index, article citations in different d author and a composite indicator (c-score). Career-wide data is updated to the end of 2021 and data for a single recent year refers to citations received in calendar year 2021

    S. Venkata Mohan and V. Ramalingam were in the biotechnology category; SV Manorama in materials; JV Rao, Ashok Kumar Tiwari, C. Ganesh Kumar, Kantevari Srinivas, Manika Pal Bhadra and Sistla Ramakrishna were on the list of medicinal and biomolecular chemistry. Chitta Ranjan Patra was on the list of nanosciences and nanotechnologies. Srivari Chandrasekhar, BV Subba Reddy, Harshadas Mitaram Meshram, Sabitha Gowravaram, Venkata Narsaiah, Sridhar Bojja, L. Giribabu and John Mondal were listed under organic chemistry.

    The list includes Sridhar Sundergopal in chemical engineering, M. Benjaram Reddy in physical chemistry, Srinivasan Palaniappan in polymers, Rajkumar Banerjee in pharmacology and pharmacy, R. Nageshwar Rao in analytical chemistry, Kandimalla Ramesh in neurology and Mohammed Fazlur Rahman in toxicology.

    Mannepalli Lakshmi Kantam, Jhillu Singh Yadav, Ahmed Kamal, Boyapati Manoranjan Choudary, Tushar Kanti Chakraborty and Biswanath Das who were previously associated with CSIR-IICT are also listed as other institutes/universities, a press release said.

    “I tend to value my time much more than money” – The Irish Times

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    Laura Dowling is the Founder, CEO and Chief Scientist of fabÜ and a top health activist on Instagram under the tag, @fabulouspharmacist. She is a qualified pharmacist and scientist, specializing in pharmacognosy (the study of plants, herbs and fungi) and was recently named 2022 Pharmacist of the Year.

    Are you a saver or a spender?

    I would most definitely consider myself a saver, but that tends to suggest that I have a lot of money accumulating at the end of each month. My young family and my big boxer dog seem to suck up all my disposable income, no matter how much I try to save.

    Do you shop around for better value?

    Traditionally, no. I’m terrible at looking for value or discounts. Whether I’m shopping for groceries, food, or clothes, I’ll usually go with the easier and less painful option. I tend to juggle a thousand things at once, and so I tend to value my time much more than money. When it comes to my business, I don’t make purchasing decisions lightly. I want value and more importantly, top notch service, thank you so much!

    What was your most extravagant purchase and how much did it cost?

    Extravagant purchases are not really in my nature. I think I got that from my parents. They were both hard workers when I was growing up. We never lacked for anything but the word “extravagance” was definitely not part of our vocabulary. That said, I let myself go a bit this year by buying a custom tuxedo. It was a bit of a crazy idea, but I justified it with the fact that I was nominated for an award at a black-tie dinner.

    What purchase have you made that you consider to be the best value?

    My iPhone. I’m definitely not a techie, but it’s probably thanks to this amazing little gadget that I created my Instagram account, @fabulouspharmacist, a few years ago. At first it was just a hobby for me. I was looking for a fun and lighthearted way to engage with my pharmacy patients during these very dark times of Covid, to give them health, medication and wellness information. It quickly came to life and I now have over 56,000 subscribers. I think it helped me get up and go to give up the pharmacy career, take the leap and become a full-time entrepreneur.

    How did you prefer to shop during the Covid-19 restrictions – online or local?

    I worked on the front line in a pharmacy throughout the Covid-19 restrictions so my buying habits haven’t changed I kept most of it local. My social media business and work is all heavily online now, so to compensate, I love eating out with friends and loved ones. And shopping in the physical world can be fun too!

    Do you negotiate prices?

    Private life? No. Professional life ? All day, every day.

    How has the Covid-19 crisis changed your consumption habits?

    I stopped doing my nails and let my gray hair show naturally without trying to hide it. This means fewer visits to salons and hairdressers. This may seem trivial to some, but when I posted about it on my Instagram, many women reached out to tell me they were doing the same. Killing the gray is what we call it.

    Do you invest in stocks?

    No never. But my kids are telling me that cryptocurrencies are crashing – again – and they’re adamant I should start looking into bitcoin. Uh, no thank you.

    Cash or card?

    Card or Apple Pay for me, please. Even my kids are largely cashless because I gave them all a Revolut junior account to simplify my hectic lifestyle.

    What’s the last thing you bought and was it good value?

    The very last thing I bought was my big weekly online grocery store. I have three boys growing up and they are bottomless pits.

    Have you ever managed to save for a relatively large purchase?

    A house deposit. I know how boring it is.

    Have you ever lost money?

    No, but I bought my family home in 2004. Does negative equity qualify?

    Are you a gambler and if so, have you ever won a jackpot?

    I only bet on myself.

    Is money important to you?

    It’s important insofar as I can provide for my family, but it’s not what motivates me.

    How much money do you have on you now?

    Only maps and my phone.

    In conversation with Tony Clayton-Lea

    Outstanding QLD Pharmacists Recognized | Mirage News

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    The Queensland branch of the Pharmaceutical Society of Australia (PSA) celebrated outstanding pharmacists yesterday through its annual awards, presented at Queensland’s Annual Therapeutic Update (ATU).

    PSA Queensland Vice President Karla Wright presented the awards on Saturday evening and thanked them for their continued dedication to the profession.

    The 2022 PSA Queensland Pharmacist of the Year has been awarded to Lakis ‘Lucky’ Zeniou.

    Professor James Dare Queensland Pharmacy Graduate of the Year 2022 has been awarded to Renee Buckland from James Cook University.

    Queensland’s 2022 Early Career Pharmacist of the Year has been awarded to Elisha Noone.

    The Queensland Lifetime Achievement Award 2022 has been awarded to Carmel Delahunty.

    Ms Wright congratulated all the winners on their achievements and thanked all Queensland pharmacists for their hard work over the past year.

    “Congratulations to all the winners and nominees,” she said.

    “These pharmacists have gone above and beyond to demonstrate their leadership and commitment to the health and well-being of their communities. PSA is proud to celebrate all that makes Queensland pharmacists great.

    “ATU QLD 2022 demonstrated the commitment and dedication of our profession, bringing together pharmacists from across Queensland to collaborate and celebrate our many successes.”

    Media notes on the winners

    2022 PSA Queensland Pharmacist of the Year – Lakis ‘Lucky’ Zeniou.

    Lucky is passionate about the health and well-being of Aboriginal and Torres Strait Islander peoples and communities and is a role model and advocate for the integration of pharmacists into primary health care teams in government-controlled health services. the Aboriginal community (ACCHO).

    Lucky has worked with the Indigenous Community Controlled Health Organizations (ACCHO) sector for over 12 years, including his current role of 7 years as a Senior Pharmacist at the Institute for Urban Indigenous Health (IUIH). Together with his team, they oversee the implementation of quality medicine use initiatives at the 19 Aboriginal Community Controlled Health Services clinics located in South East Queensland. Prior to working at IUIH, he was Queensland’s QuMAX Support Pharmacist, which involved implementing QuM measures within ACCHOs across Queensland and liaising with community and hospital pharmacies to encourage QuM initiatives through collaboration and improved cultural safety.

    2022 Professor James Dare Queensland Pharmacy Graduate of the Year – Renee Buckland.

    Professor James Dare Queensland Pharmacy Graduate of the Year recognizes achievement in pharmacy beyond mere academic achievement. Renee was nominated for this award for her outstanding commitment to pharmacy and her promising career in the industry.

    QLD 2022 Early Career Pharmacist – Elisha Noone.

    Elisha has a particular interest in palliative care and is currently completing her Masters in Palliative Care at Flinders University. She is a pharmacist advocate with a passion for the integration of pharmacists into the palliative care sector.

    Elisha is the project pharmacist – Brisbane South Palliative Care Collaborative (BSPCC) on the palliPHARM initiative, works on PallConsult, a 24/7 palliative care advice helpline for doctors, nurse practitioners, paramedics and pharmacists and supports the palliative care project specializing in the care of the elderly, which accompanies people at the end of life housed in nursing homes. More recently, Elisha has supported statewide Voluntary Medical Assistance in Dying (VAD) services in Queensland.

    QLD Lifetime Achievement Award 2022 – Carmel Delahunty.

    Carmel Delahunty has been a pharmacist for 46 years since her internship in 1976 at McSweeny’s at Oriel Rd & Toombul Pharmacies.

    During her career, she has owned and operated several pharmacies, health food stores, perfumeries and photo development stores.

    Additionally, Carmel has been an active member of the pharmaceutical industry, serving as secretary of the QLD Pharmacy Ball Committee in the 1990s which, at its height, brought together approximately 1,000 pharmacists. Carmel was also an inaugural member of the QUT Pharmacy School Advisory Board, mentoring many pharmacy students and pharmacists during her career.

    Carmel was an early adopter and champion of expanding pharmacy practice throughout her career. She earned an advanced degree in nutritional pharmacy in 1996, is certified as a counselor for the preventive medicine movement, served on the advisory board of Endeavor College of Natural Medicine, and is registered as an immunization pharmacist. She has continued to contribute to the pharmaceutical industry, most recently working for QLD Health manufacturing Covid vaccines during peak demand for vaccines.

    Carmel is also a Fellow of the Australian College of Pharmacy and a Fellow of the Australia Institute of Company Directors.

    On top of all that, she managed to raise 4 children and volunteer with several community groups.

    /Public release. This material from the original organization/authors may be ad hoc in nature, edited for clarity, style and length. The views and opinions expressed are those of the authors.

    Brain drain won’t stop due to global shortfall of 15 million health resources -Prof Fatusi – New Telegraph

    The Vice Chancellor of the University of Medical Sciences (UNIMED), Prof. Adesegun Fatusi spoke with ADEWALE MOMOH on the healthcare sector, the confrontation between the Academic Staff Union of Universities (ASUU) and the federal government and the progress of its institution. done over the years. Excerpts…

    As a stakeholder, what do you think will be the implications of the ongoing eight-month strike by ASUU on the education system?

    For a broader image of the country, it’s rather a shame. And I think the answer to that question or those problems lies on both sides, changing each a little bit. ASUU has a strong point. There are things that ASUU demands as an association that are very important in developing the Nigerian education system.

    Government is also a constraint, especially in the economic situation in which we find ourselves. Both sides need to talk more, give more room for negotiation and discussion and finally come to an agreement because it is not good for our nation. Because it’s not just individuals, it affects young people, their parents and all of society. Every great society depends on the intellectual power of the citizens. When you put millions of young people at home doing nothing, that’s not the best thing. We hope the government and ASUU will resolve this issue.

    But many Nigerians blame the government for not being forthright and doing enough to end the stalemate, do you think this is so?

    I don’t see any sane government that would want schools closed for months on end unless the matter goes beyond them. I am not a spokesperson for the government, but sometimes you have to understand that the government has constraints. I think the economy we find ourselves in, the government seems more challenged than ever and that is why we must all continue to pray and work hard, that Nigeria as a country and the whole of the Nigerian development are improving. Let me remind you that Nigerians forget that universities were not originally free. People forget that Nigerian universities started with people paying tuition. Nigerian universities did not give free food to students.

    Would you say that sufficiently justifies the current underfunding of universities?

    What I am saying is that we must not forget that it was the government itself that brought this thing about because the government had more money. While money has become a challenge, the government is also turning things around because it’s getting into a corner where it’s harder to cope. This is the situation. I’m not speaking on behalf of the government but that’s the trajectory, it’s just a simple reflection. As things get harder, the government will say I can’t do this. However, there is a basic minimum that the government must do. Some of what ASUU asks for is a base minimum and some of them are slightly above the base minimum, so I think that’s where a trade-off has to come in so that our schools can come back. There is no way our Nigerian university system can continue and provide zero kobo quality education, there is no way. I don’t know of any country that does that, maybe a communist country. I was educated in three continents of the world, what is done in the country that I know is that there are tuition fees to pay for those who can afford it, there are scholarships for those who can obtain it, there is a work-study scheme.

    Some time ago you started a program with these students who came from Ukraine. How far has the university gone in this regard?

    For Ukrainian students, we have published a notice that if you have been to Ukraine, we are ready to support you because we know the problems are beyond you. Our Senate at the university has graciously relaxed some of the terms to allow us to admit them. For example, you cannot transfer to our university without us seeing your transcript, not from you but from your university. But what university in Ukraine now has the leeway to issue a certificate when it was even running around looking for a way to survive. So we said we were going to relax it. So we said if you have your own proof of your student result, bring it and we will grant you provisional admission and we will give you up to one year, that is until the end of the academic session to produce the result. But we cannot go beyond the pre-clinical year. We can take you to the start of the clinic, but we cannot ask you to go start in the middle of the clinic, as we want to be sure of the clinical skills you have. If you come and want to go to the clinic, you will come and take the exam that our students take. And you don’t take it separately so they don’t say we ask harder questions. They will sit together when our students take the exam, and their result will tell us either that you are suitable for that class or that we should recommend you for a lower class. This is how we try to help Ukrainian students and a number of them have tried. More than 20 of them applied.

    How has UNIMED’s journey been since its creation?

    At the University of Medical Sciences, we are proud of our track record as Nigeria’s premier specialist medical university. Many people often ask us, you are a medical university, does that mean you are just leading medicine? I said no, we handle medicine, nursing and physiotherapy. We run all courses in UNIMED except Pharmacy which we are about to start and we have the largest collection of healthcare professional courses across the country. Among the 26 courses, people said, why do science, why do physics, biology, chemistry, mathematics? You are not a specialized university? And I always explain to them that we need to better understand how the health profession has developed. And the truth is that the greatest development you find in healthcare does not come from what we call healthcare professionals; does not come from doctors, nurses or physiotherapists, it comes from scientists. And one of the biggest examples is what we’re seeing in COVID-19. We arrived with COVID-19, doctors were running around trying to help but they were helpless. What was the best thing doctors could do? Put a patient on the ward and try this or that drug, you don’t know which one would work. You put people on ventilators and the ventilators weren’t made by doctors but by scientists.

    Are you talking about science in relation to medicine or just pure and allied science?

    I’m talking about chemical, biological and physical sciences because if you look around, everyone wants to be a doctor. But without these sciences, we cannot advance the field of health. That is why, for example, when others produce vaccines, we cannot produce vaccines, we have to wait for other people to produce and we will buy. That’s why we don’t produce drugs. For us at the University of Medical Sciences, we believe that our responsibility is to help expand the field of health and related health fields. So if you don’t develop science, you can’t develop health professions. In Nigeria, according to the National University Commission, if you do not have a program at the undergraduate level, you cannot have it at the postgraduate level. Thus, at UNIMED, we do chemistry, physics, biology, animal environmental biology, plant biotechnology. Our goal is to eventually produce people in the medicinal chemistry we need to produce drugs. Our goal is to train people in the medical physics we need to develop the scopes and equipment that doctors use. When you think of things like plant biology and biotechnology, we can also discover drugs from our own plants, but if you don’t have physics, chemistry, biology, you can’t do medicinal chemistry at Masters level.

    So what is this NextGenS about?

    We strongly believe that Nigeria is not putting enough emphasis on science that can help us produce health scientists who will help us drive health and health development in the future. So we go back to the background and that’s nothing new. When you want to fill in a field, you offer an incentive to draw them to that field. That’s what we do in NextGenS, to provide the incentive that will inspire young people to understand the role of science and help them become more than just undergraduates. And if they pass, we will go on to graduate school. In fact, our postgraduate incentive is even higher than the undergraduate. We do this for two groups of people; our nation because our nation needs growing capacity in science; for our young people, most of them walk the streets because they have no vision of where life is going. Today the brightest guys in America and other countries don’t read medicine, they read something like computational biology because that’s what the world needs more than ever.

    Do you consider the brain drain factor, that after training them, they leave the country in search of better opportunities?

    The brain drain is a big problem. But the way to tackle the brain drain is not magic, it is simple. If you are experiencing a brain drain, what do you want to do? You’ll produce more so that if the ones that were gone, you’ll still have enough to use. The brain drain is a problem you cannot stop, especially in the medical field.

    According to the World Health Organization (WHO), we have more than 15 million health resource gaps across the world. So, as long as this market exists, people will go, but what do we do?

    We need to produce more. In fact, we can turn brain drain into brain gain if we know what we are doing as a country. One of the things we can do is to produce more and satisfy exports as well as domestic demand. And this is part of what we do in UNIMED.

    TRY TONIGHT!!! —

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    Service Spotlight: UConn Health Pharmacy

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    This is another group of medical professionals who may not physically appear on the front lines of patient care, but they are there in the trenches with those who do.

    UConn Health’s pharmacy staff includes more than 85 employees in nearly 20 roles, many in areas that never close.

    “Our pharmacy staff are yet another example of unsung heroes who, although not always recognized, have continued to show up and excel at their jobs to help provide our exceptional patient care at the height of a crisis. pandemic and beyond,” says Dr. Bruce T. Liang. , interim CEO of UConn Health.

    This year’s National Pharmacy Week, established in 1925 as National Pharmacy Week by what was then called the American Pharmaceutical Association, runs from October 16-22.

    UConn Health Central Pharmacist Paul Armstrong (right), pictured with his family, says his interest in the pharmacy profession dates back to his childhood. “Most pharmacies back then had the best social media platform around…it was called the ‘soda fountain’.” (Photo courtesy of Paul Armstrong.

    “Working during the pandemic was a challenge,” says Paul Armstrong, central pharmacist on weekends. “I felt exposed, not to disease, but rather to the fear that my night staff would not be able to provide the level of care required in an ever-changing environment. However, we were able to do so thanks to the foresight of management, pharmacists working from home and dedicated technicians. »

    Armstrong, who describes himself as “a utility hitter on a unique team of pharmacists, who put all patient care and safety at the forefront of their practice,” says his favorite part of his job is energy. and student and resident pharmacy contributions. He joined UConn Health in 2006.

    Asma Shahid-Khan joined UConn Health Pharmacy as a technician in 2016.

    “Working during the pandemic has tested our systems and our personal strengths in various ways, but I like to believe that we have come out of it stronger with quicker and more user-friendly solutions and better informed of our abilities as department and UConn Health as a whole. says Shahid-Khan, who moved into the IT side of the pharmacy last year as the administrative and clinical systems coordinator.

    Molly Kennedy, who joined UConn Health as a pharmacy technician in 2009, followed a similar path, transitioning into pharmaceutical informatics earlier this year.

    “I love this role because it keeps me on my toes and learning new things every day,” Kennedy says. “During my short time in the department, I was able to support the pharmacy in the maintenance and improvements related to the pharmaceutical systems. Some tasks include clinical system maintenance, troubleshooting, deployment of pharmacy-specific technologies, and capability analysis for technology improvements.

    Aneta Grauer has the perspective of a pharmaceutical operations manager, a role she held until becoming an IT pharmacist last month.

    “While working during the pandemic has been challenging, in many ways it has also been inspiring to see various departments and disciplines come together to care for our patients,” Grauer said. “In my role, I supported patient care by facilitating the set-up of overflow units and ensuring they were properly equipped and stocked. It pushed everyone to think outside the box and work as a team.

    four headshots
    Clockwise from top left: Aneta Grauer, Daniel Vo, Molly Kennedy and Asma Shahid-Khan are part of the UConn Health Pharmaceutical Informatics team. (Photos provided by Kevin Chamberlin)

    Now, she focuses on troubleshooting software critical to pharmacy operations and optimizing technology to improve workflows.

    Although they may not always wear the lab coats traditionally associated with pharmacy work, those who work in pharmaceutical informatics have crucial responsibilities that are largely unseen and unadvertised. Daniel Vo’s time as an IT pharmacist dates back to just before the pandemic.

    “My main responsibilities are to ensure that pharmacotherapeutic therapies are configured in a safe and interoperable manner in our electronic health record and pharmacy systems, and to improve and optimize processes through the implementation and technology systems support,” says Vo. “To get through the pandemic, we have all had to adapt to an ever-changing landscape. The more we learned about COVID-19 and as it spread through our communities, it was imperative that we could shift priorities. From biocontainment modifications to the deployment of vaccine and monoclonal antibody therapies, our team was one of many cogs here at UConn Health working to care for members of our community.

    Purchasing and inventory pharmacist Iwona Zalweska says the pandemic has caused supply and shipping disruptions that are still having an impact.

    “The pharmaceutical industry is facing drug supply chain issues, increasing pharmaceutical spending and high drug costs,” Zalweska says. “Our daily efforts are focused on providing the drugs needed to care for our patients, evaluating our inventory, providing purchase reports to evaluate our formulary, and assisting with decision making at pharmaceutical and therapeutics meetings.”

    Kevin Chamberlin, acting assistant vice president and chief pharmacy officer, says there’s a lot going on behind the scenes to secure medications safely and get them to patients.

    “Some drugs have to be made from scratch or compounds, others reconstituted or mixed under sterile conditions,” says Chamberlin. “We are mailing test packages to the United States and various shipping procedures to test the integrity of our pharmaceutical products that are shipped to the East Coast from our specialty pharmacy. We monitor temperature sensors and their alerts 24/7 on refrigerators wherever medication is stored so that we can ensure the integrity of our products while they wait to be administered to our patients. . We ensure a secure and sealed process whereby controlled substances enter our facilities throughout the process when they reach the patient to prevent drug diversion at any stage. We review every medication safety event and every reported adverse event.

    And you can count Vo, one of the computer pharmacists, among those who say they’re in the right place to do the job.

    “I am privileged to be part of the team working at the UConn Health Pharmacy,” Vo says. “We support each other and have and continue to work collaboratively at a higher level.”

    Learn more about the UConn Health Department of Pharmacy.

    HRSA ADR Panel Dismisses NACHC 340B Complaint Against Two Drugmakers

    Key points to remember:

    • In late September, an Administrative Dispute Resolution (ADR) panel for the Health Resources and Services Administration (HRSA), within the Department of Health and Human Services (HHS), issued its first decision.

    • The panel dismissed a complaint by the National Association of Community Health Centers (NACHC) against two pharmaceutical manufacturers, Sanofi-Aventis and AstraZeneca, regarding the manufacturers’ decision to restrict sales of 340B drugs to contract pharmacies.

    • Although the ADR Panel denied NACHC’s request, the ADR Panel’s decision is notable, in part, due to a number of ongoing legal challenges to the Panel’s authority, as well as the development of anticipated rules that may change the ADR process in the future.

    • Given the number of ongoing disputes between manufacturers and covered entities, we may see similar ADR proceedings in the future.

    Background

    The 340B program requires drug manufacturers to offer outpatient pharmaceutical products to covered entities defined by law (including certain hospitals and certain federal recipients, such as federally qualified health centers) at the greatly reduced 340B ceiling price. While drug manufacturers were initially required to offer 340B rebates only to Covered Entities’ in-house pharmacies, HRSA has since allowed Covered Entities to contract with retail pharmacies to fill prescriptions for acquired 340B drugs at their name. The use of contract pharmacies was initially limited, 61 Fed. Reg. to 43,549, but in 2010 the HRSA issued guidelines allowing covered entities to work with an unlimited number of contracted pharmacies. 75 Fed. Reg. 10.272-79.

    The use of contract pharmacies has been a major driver of growth for the 340B program. As a result, throughout 2020, several drugmakers have announced policies to limit the distribution of acquired 340B drugs to contract pharmacies.1 A number of disputes ensued, some of which are still ongoing.

    ADR regulations

    Section 7102 of the Patient Protection and Affordable Care Act (ACA) required HHS to implement an ADR process to resolve certain disputes arising from the 340B drug rebate program. While the HRSA issued a Notice of Proposed Rulemaking (NPRM) on this topic on August 12, 2016, 81 Fed. Reg. 53381-88, in 2020 this rule had not been finalized.2 On October 21, 2020, NACHC filed suit against HHS to compel the agency to promulgate rules to implement the ADR program (NACHC v. Azarno. 1:20-cv-03032 (DDC filed October 21, 2020) (stayed)). In the complaint, the NACHC alleged that HHS has violated this legal requirement since 2010, when the ADR process was first added to Act 340B. More than four years after the proposed rule, on December 14, 2020, HHS issued a final rule to establish an ADR panel empowered to resolve disputes between manufacturers and covered entities and to make final agency decisions, as required by (85 Fed. Reg. 80632-46) (effective January 13, 2021).

    On November 18, 2021, HHS submitted a proposed rule titled
    340B Drug Pricing Program; Settlement of administrative disputes at the Office of Management and Budget (OMB). As of October 2022, this proposed rule is still pending review by the OMB.

    Builder dispute

    In 2021, six pharmaceutical manufacturers filed separate lawsuits in federal court challenging HRSA’s policy requiring manufacturers to supply drugs at the $340 billion ceiling price to contracted pharmacies. In their claims, the manufacturers asserted that the HRSA exceeded its authority by allowing unlimited use of contracted pharmacies under the 340B program and, further, that the HRSA’s ADR rule was unconstitutional and inconsistent with the Administrative Procedure Act (APA). Some of the manufacturers who have challenged the ADR Final Rule have won favorable legal results: for example, in the Southern District of Indiana, Eli Lilly obtained a preliminary injunction against HHS, preventing the agency from enforcing the ADR Rule against the manufacturer. But, overall, the legal results have been mixed, as some district courts have allowed HRSA’s contract pharmacy policy to continue. In addition, several of the manufacturers’ victories were based on procedural grounds, i.e. that HRSA had improperly enacted rules relating to contract pharmacies, rather than claiming that HRSA was prohibited from doing so.

    Additionally, AstraZeneca sued HHS in response to a Dec. 30, 2020 advisory opinion, AO 20-06, in which HHS said manufacturers were legally required to provide discounted drugs “at a ceiling price of $340 billion.” to the maximum” to pharmacies under contract.3 The District Court for the District of Delaware found that the HHS advisory opinion was “legally flawed” and noted that the wording of Statute 340B “says nothing about the role that contract pharmacies can play in connection with 340B drug purchases by covered entities.” AstraZeneca Pharm. LP vs. Becerra, 543 F. Supp. 3d 47, 59 (D.Del. 2021).4 Importantly, the court noted that HHS and AstraZeneca’s interpretations of 340B “add requirements to it… [u]under
    [HHS’] interpretation, pharmaceutical manufacturers are required to deliver 340B drugs to an unlimited number of contracted pharmacies. Under AstraZeneca’s interpretation, Covered Entities are required to purchase their 340B drugs through in-house pharmacies. No requirement is contained in the law, nor (therefore) imposed by it. Thus … the Court is not authorized to read either of these requirements into the statute.”
    Astra Zeneca, 543 F. Supp. 3d, at 61. The court recognized the statute’s ambiguity and noted that HHS “could reasonably choose to rule” on certain interpretations, such as whether (or not) manufacturers must supply drugs unlimited discounts to contract pharmacies, but added that the statutory language “does not compel” this interpretation, and “Congress simply hasn’t pronounced on the matter.” ID.

    HHS retracted AO 20-06 on June 18, 2021. In its Notice of withdrawalHHS said his removal “does not impact ongoing efforts to…[HRSA] to enforce the obligations that 42 USC § 256b imposes on drug manufacturers, including the May 17, 2021 HRSA violation letters regarding restrictions on contract pharmacy agreements. »5

    ADR decision

    On January 13, 2021, the day the ADR Final Rule came into effect, the NACHC filed its complaint with the ADR Panel against Sanofi-Aventis and AstraZeneca. At the end of September 2022 – twenty months after the NACHC presented its dispute – the panel dismissed the NACHC complaint against the manufacturers.6 According to the panel, the court of AstraZeneca vs. Becerra 543 F. Sup. 3d 47, 62 (D. Del. 2021) determined that Congress failed to state clearly and unambiguously that manufacturers must supply discounted drugs to an unlimited number of contracted pharmacies. Therefore, the court has already addressed the issue of the NACHC before the panel.seven

    It is possible that there will be future ADR filings related to the contract pharmacy issue, although the development of pending ADR rules may create additional delays. Additionally, the manufacturers’ legal challenges (mentioned above) are currently on appeal; if the federal appeals courts unite around a particular position regarding the legality of the policy, that could solve the problem. Alternatively, if there is a circuit split, the case could go to the Supreme Court. Ultimately, in the absence of a Supreme Court ruling or legislative change regarding the role of contract pharmacies in the 340B program, legal challenges in this area are likely to continue.

    Footnotes

    1. Identifier. According to the NACHC
    Statement“…restrictions imposed on contract pharmacies by drug manufacturers have steadily increased since September 2020… [and] [e]Large manufacturers are now refusing to ship drugs priced at B340 to contracted pharmacies of covered entities. »

    2. See Final Rules 2020, 340B Drug Pricing Program; Administrative Dispute Settlement Regulations (85 Fed. Reg. 80632-46). Note that on September 20, 2010, HHS issued a Notice of Proposed Rulemaking (ANPRM) seeking comments on the development of an ADR process (75 Fed. Reg. 57233-35). On August 12, 2016, HRSA issued a Notice of Proposed Rulemaking (NPRM) seeking comments on establishing an ADR process (81 Fed. Reg. 53381-88). The 2016 NPRM was removed from the HHS regulatory program with the January 20, 2017 memorandum
    Regulatory freeze pending review; however, the 2016 NPRM was never officially retired. HHS considered comments submitted in response to the 2016 NPRM in developing the 2020 Final Rule, which was ultimately released on December 14, 2020.

    3. HHS, Advisory Opinion (AO 20-06), On pharmacies under contract under the 340B program (December 30, 2020) available at: https://www.hhs.gov/guidance/sites/default/files/hhs-guidance-documents/340B-AO-FINAL-12-30-2020_0.pdf.

    4. In a February 16, 2022 opinion granting summary judgment to AstraZeneca regarding a May 17, 2021 “violation letter” from the HRSA, the District Court for the District of Delaware wrote that the HHS advisory opinion “was based on an “unwarranted assumption” about [340B] law,
    [therefore] AstraZeneca was entitled to compensation.”
    AstraZeneca Pharm. LP vs. Becerra, no. 21-27-LPS, 2022 US Dist. LEXIS 27842, at *5 (D. Del. February 16, 2022).

    5.HHS, Notice of Withdrawal (June 18, 2021) Withdrawal of Advisory Opinion 20-06 on Contract Pharmacies under the 340B Program (issued December 30, 2020)available at: https://www.hhs.gov/sites/default/files/notice-of-withdrawal-of-ao-20-06-6-18-21.pdf.

    6. NACHC, Statement Regarding HHS Rejection of ADR Resolution 340B (September 28, 2022) available at: https://www.nachc.org/nachc-statement-regarding-hhs-dismissal-of-adr-resolution-on-340b/.

    7. NACHC, Statement Regarding HHS Rejection of ADR Resolution 340B (September 28, 2022) available at: https://www.nachc.org/nachc-statement-regarding-hhs-dismissal-of-adr-resolution-on-340b/; John Wilkerson, HHS panel dismisses 340B dispute, dashes health center hopesInsideHealthPolicy (September 29, 2022) available at: https://insidehealthpolicy.com/daily-news/hhs-panel-dismisses-340b-dispute-dashes-health-centers%E2%80%99-hopes;
    AstraZeneca Pharm. LP vs. Becerra, 543 F. Supp. 3d 47, 62 (D.Del. 2021); see also AstraZeneca Pharm. LP vs. Becerra, no. 21-27-LPS, 2022 US Dist. LEXIS 27842 (D. Del. February 16, 2022).

    The content of this article is intended to provide a general guide on the subject. Specialist advice should be sought regarding your particular situation.

    Queensland government pursues watered-down pharmacy pilot, but doctors say patients are still at risk

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    The Queensland Government will still press ahead with its controversial plan to dramatically increase pharmacists’ responsibilities, but it has softened its approach in the face of widespread criticism from doctors.

    Health Minister Yvette D’Ath announced the North Queensland Pharmacy Scope Pilot on Wednesday evening at a parliamentary reception for the Pharmacy Guild of Australia (PGA).

    The pilot project is the brainchild of the PGA, a powerful lobby group that represents chemical company owners across the country.

    “This will see pharmacists administering more types of vaccines and prescribing drugs for a range of common conditions,” Ms D’Ath said.

    After months of development, the final scope of the pilot project would allow pharmacists in North Queensland to prescribe medication for common conditions such as nausea and vomiting, reflux and mild skin conditions without the supervision of a GP .

    It will also allow pharmacists to prescribe programs for chronic conditions such as cardiovascular disease and asthma and provide “health and wellness services” for hormonal contraception, oral health screening, weight management and help with quitting smoking.

    Healthcare ‘more than just prescriptions’

    The Royal Australian College of General Practitioners (RACGP) said it was a softer approach compared to an earlier version of the plan, which proposed letting pharmacists diagnose and prescribe drugs for a list of 23 conditions .

    “They agreed it was too bold, but even the current list of proposals is just a scriptwriting service,” said RACGP Rural President Michael Clements.

    Michael Clements fears the pilot scheme poses a risk to patients in North Queensland.(ABC North Queensland: Chloe Chomicki )

    “General medicine is a specialty of the whole person, and that involves their history, blood, investigations, examinations and follow-up, and we know that pharmacists will not have access … to get that full picture,” said said Dr. Clements.

    Drafts of materials intended for the pilot to launch in June 2022, but the Department of Health said it was now on track to start mid-next year after pharmacists completed 12 training month.

    Doctors remain indifferent

    The pilot has already received fierce opposition from medical groups including the RACGP, the Queensland branch of the Australian Medical Association (AMA), the College of Rural and Remote Medicine and the National Aboriginal Community Controlled Health Organization ( NAACHO).

    A pair of hands holding a stethoscope.
    Queensland doctors have criticized the pilot program.(ABC Riverina: Romy Stephens)

    They all withdrew from the pilot’s steering committee earlier this year, arguing that it compromised patient care.

    “The fact that they have now limited the pilot does nothing to reduce the risk to patients in these catchment areas,” Dr Clements said.

    “It’s asking pharmacists to do half the work, and it’s a real risk to the people of North Queensland.”

    Pharmacy Guild Australia Queensland chairman Chris Owen said there was international evidence that pharmacists had “the qualifications, skills and expertise to carry out the necessary treatment or vaccinations”.

    A potential solution to the doctor shortage, pharmacists say

    He said the pilot came in response to “constant blocking by doctors” in recent years.

    “More than a third of emergency room presentations are the result of conditions that could be treated by a pharmacist or GP,” Mr Owen said.

    “This pilot project will help alleviate those pressures.”

    But physician groups have challenged the pilot’s user-pay model, which charges patients up to $55 for consultations and does not provide reimbursement under the Pharmaceutical Benefit Scheme.

    “The only people getting into the service are those with deep pockets,” Dr Clements said.

    “Our most vulnerable patients are those who have the most difficult access to GPs, so this does not solve access to GPs in any way.”

    The Pharmacy Guild said the pilot was intended to “provide choice” for patients.

    Muna Therapeutics receives $4.9 million grant from the Michael J. Fox Foundation for Parkinson’s disease research

    Supports the development of a modifying therapy for Parkinson’s disease

    Copenhagen, Denmark and BOSTON, October 11, 2022 /PRNewswire/ — Muna Therapeutics (Muna), a biopharmaceutical company that discovers and develops novel therapies for the treatment of Parkinson’s disease and other neurodegenerative disorders, today announced that it has been awarded a $4.9 million grant from the Michael J. Fox Foundation for Parkinson’s Disease Research (MJFF).

    The grant will be used to support ongoing preclinical research and development of novel brain-exposed small-molecule type 1.3 (Kv1.3) potassium channel blockers to abrogate disease-associated microglia-mediated neuroinflammation and enhance neuroprotection as a disease-modifying treatment for patients with Parkinson’s disease.

    Parkinson’s disease is a neurodegenerative disease associated with motor symptoms (slow movements, tremors, rigidity, gait and imbalance) and a wide variety of non-motor complications (cognitive disorders, mental health disorders, sleep disorders, pain and others sensory disturbances). Motor impairments, such as dyskinesias (involuntary movements) and dystonias (painful involuntary muscle contractions) contribute to limitations in speech, mobility and restrictions in many areas of life. It is estimated that more than 10 million people worldwide are living with Parkinson’s disease without current treatment.

    Muna is focused on addressing the staggering unmet medical needs faced by Parkinson’s disease patients worldwide through its all-human, transformative therapeutic target discovery and validation platform that aims to preserve brain function and improve resilience to neurodegenerative diseases.

    “We are very pleased to receive this significant funding from the Michael J. Fox Foundation to fund this promising research that has the potential to dramatically improve the lives of people with Parkinson’s disease. Kv1.3 plays an important role in the creation and maintenance of neuroinflammation in Parkinson’s disease and other neurodegenerative diseases. Reducing neuroinflammation by blocking Kv1.3 has enormous potential to slow or prevent neurodegeneration and disease progression.” said Rita Balice-GordonCEO of Muna Therapeutics.

    “The studies will support ongoing efforts in medicinal chemistry and structural biology and will deepen the understanding of the mechanism of Kv1.3 in microglial activation and the role of Kv1.3 blockade, in vitro in human cells and in vivo in humanized mouse models, to achieve normalization of disease-associated microglial phenotypes, which will enhance neuroprotection,” said Niels Plathscientific director of Muna Therapeutics.

    “Fostering a strong and healthy pipeline of therapies to improve the lives of people with Parkinson’s disease is central to MJFF’s mission. We are proud to support the work of Muna Therapeutics researchers investigating a potential disease-modifying therapy for people with Parkinson’s disease,” said Brian FiskePhD, Scientific Co-Director, MJFF.

    The MJFF grant will support the work of Muna Therapeutics and in collaboration with Prof. Bart DeStrooper at VIB/KU Leuven, scientific co-founder of Muna, for two years.

    About Muna Therapeutics

    Muna Therapeutics is a private biopharmaceutical company founded in 2020 and based in Copenhagen, Denmark and Leuven, Belgium and United States. Muna discovers and develops therapies that slow or stop devastating neurodegenerative diseases, including Parkinson’s disease, Alzheimer’s disease, frontotemporal dementia and multiple sclerosis. These disorders impact memory, movement, language, behavior and personality, leading to disability and death in millions of patients worldwide. Muna’s groundbreaking science focuses on identifying new drugs to preserve cognition and other brain functions and improve resilience to neurodegenerative diseases. Our name reflects this goal: Muna means “to remember” in Old Norse. For more information, visit www.munatherapeutics.com

    SOURCEMuna Therapeutics

    Bioresorbable Polymers Market is Expected to Demand Drivers

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    Bioresorbable Polymers Market

    Coherent Market Insights has announced a new analysis on the state of the Bioresorbable Polymers Market 2022-2028 which has been prepared based on an in-depth market analysis with inputs from industry experts and key industry vendors . The report covers the market landscape and its development prospects over the next few years. The report also contains a discussion of the major vendors operating in this market.

    Market analysis report speaks about the growth rate of Bioresorbable Polymers market till 2028, key factors driving this market with sales, revenue, and price analysis of major market manufacturers, distributors, traders and resellers of the bioabsorbable polymers market.

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    The Bioresorbable Polymers market study includes the market space, opportunities and threats faced by the vendors in the Bioresorbable Polymers industry, opportunities, industry risks and market overview. The process is studied in depth in three areas: raw material and equipment suppliers, the various expenses related to production (material costs, labor costs, etc.) and the process itself. .

    The Bioresorbable Polymers Market research provides an in-depth and modest picture of the market position and company profiles of key competitors operating in the global market. It also provides a summary of product specification, production, technology, and product type analysis, while considering such essential factors as gross, gross margin, revenue, and cost structure. . By providing a detailed picture of this market, the study helps the user to strengthen their decision-making ability to plan the strategic steps to start or expand their business.

    This study will provide you with a comprehensive perspective if you are or intend to be active in the Bioresorbable Polymers market. It is essential that you keep your industry information up to date and categorized by major companies. We can customize reports to suit your needs if you have a distinct set of players/manufacturers based on geography or need data broken down by region or country.

    The main players are: Corbion NV, DSM, Degradable Solutions, Evonik Industries AG, Foster Corporation, Galatea Surgical, KLS Martin, LACTEL Absorbable Polymers, MAST Biosurgery, Poly-Med Inc. and Sigma-Aldrich.

    Bioresorbable Polymers Market Dynamics

    Bioresorbable polymers find applications in the medical field, as they are completely biodegradable inside the human body, which in turn avoids the need for a second surgery and reduces post-operative risks. Drug delivery is one of the most commonly used applications of bioabsorbable polymers. Poly(D,L-lactic-co-glycolic acid) (PLGA) is the most frequently used bioabsorbable polymer for controlled release of drugs. Various pharmaceutical ingredients such as anticancer drugs and antibiotics can be delivered with controlled and consistent release using timely biodegradation of the drug carrier. PLGA is primarily being studied for localized drug delivery for the treatment of cancer, glaucoma and periodontal disease, and for coating biodegradable and metal stents. For example, drug-eluting stents (DES) have shown significant advantages over their bare metal stent predecessors by reducing the risk of recurrent blockage (restenosis). The bioresorbable polymers market is expected to gain popularity over the forecast period due to their extensive use in surgery and pharmacy such as artificial skin, biodegradable sutures, and implantable supports for drug delivery. In recent years, PLAs have been extensively researched due to their biodegradability and biocompatibility, which has led to applications in medical science. Additionally, ongoing research on 3D printing is expected to drive the growth of the bioresorbable polymers market.

    Key points covered in this Bioresorbable Polymers Market report are:-

    Who are the opportunities, risks and driving force of bioabsorbable polymer? Knows upstream raw material sourcing and downstream buyers
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    What will be the Market Growth Rate, Overview and Analysis by Type of Bioresorbable Polymer in 2028?
    What are the key factors driving the Analytics industry by applications and countries?
    What is Dynamics? This overview includes scope analysis and price analysis of key manufacturers profiles ?

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    The next part also sheds light on the gap between supply and consumption. Apart from the mentioned information, growth rate of Bioresorbable Polymers market in 2028 is also explained. Additionally, type-wise and application-wise consumption tables and figures of Bioresorbable Polymers market are also provided.

    Detailed segmentation:

    On the basis of polymer type, the bioresorbable polymers market is segmented into:

    Agro-polymers
    Polysaccharides
    Proteins
    Biopolyesters
    polylactic acid
    Polyglycolic acid
    Polycaprolactone
    Others

    On the basis of Application, the bioresorbable polymers market is segmented into:

    Medication administration
    Orthopedics
    Others

    Points covered in the Bioresorbable Polymers market research report:

    Chapter 1: Bioresorbable Polymers Market Overview (2022-2028)

    • Definition
    • Features
    • Classification
    • Apps
    • Regions

    Chapter 2: Market Competition by Players/Suppliers 2022 and 2028

    • Manufacturing cost structure
    • Raw material and suppliers
    • Manufacturing process
    • Industry chain structure

    Chapter 3: Sales (Volume) and Revenue (Value) by Region (2022-2028)

    • Sales
    • Turnover and market share

    Chapter 4, 5 and 6: Global Bioresorbable Polymers Market by Type, Application and Profiles of Players/Suppliers (2022-2028)

    • Market share by type and application
    • Growth rate by type and application
    • Drivers and opportunities
    • Basic company information

    Chapter 7, 8 and 9: Manufacturing Cost, Supply and Marketing Strategy Analysis of Bioresorbable Polymers

    • Analysis of key raw materials
    • Supply of raw materials upstream
    • Marketing channel

    Chapter 10 and 11: Bioresorbable Polymers Market Effect Factor Analysis and Market Size (Value & Volume) Forecast (2022-2028)

    • Technological progress/risk
    • Sales Volume, Revenue Forecast (by Type, Application and Region)

    Chapter 12, 13, 14 and 15: Bioresorbable Polymers Market Research Findings and Conclusion, Appendix and data source

    • Methodology/Research Approach
    • Source of data (secondary sources and primary sources)
    • Estimation of market size

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    Health Benefits of Bush Mango Seeds

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    This week, I will talk about the seed of Irvingia gabonensis in the family Irvingiaceae. It is known by common names such as wild mango, African mango, dika nut, and bush mango. It is a tree native to West Africa. After eating the fleshy pulp of the ripe fruit, you are left with a hard, pebbly nut enclosing a sweet, oil-rich kernel wrapped inside a brown seed coat. The core/seed is the popular Ogbono (Igbo) and Apon (Yoruba).

    Allow me to make a few quick clarifications before continuing. Do not confuse Irvingia gabonensis with common mango (Mangifera indica). The reason I said that is because on Google it is the pictures of the common mango that are used in some places where they talk about bush mangoes. The fruit of the Irvingia gabonensis plant is the fruit called Oro (Yoruba), Upupa/Ujiri (Igbo). It is not the ordinary mango that we eat as a fruit. There is one more thing that bothers me. Modern medicine rejects the doctrine of signatures (the doctrine of signatures states that herbs resembling various parts of the body can be used by herbalists to treat ailments in those parts of the body). However, scientific research continues to validate them without wanting to! In this situation, the seed of Irvingia gabonensis is slimy just like semen when cooked and there are studies that support the claims of the use of the seed by traditional medicine practitioners as a fertility agent. How to balance this?

    Phytochemicals found in Irvingia gabonensis seeds are flavonoids, tannins, saponins, alkaloids, terpenoids, volatile oils, steroids, and cardiac glycosides. The flavonoids present in this plant have been shown to possess numerous pharmacological properties such as antioxidant, anti-inflammatory, anti-cancer, anti-ulcer and anti-microbial activities. The seed is a good source of fiber, so it promotes weight loss. It is a good pain reliever, good for cardiovascular health, prevents constipation, controls blood sugar levels, improves energy and boosts the immune system. It increases levels of high density lipoprotein (good) cholesterol and reduces inflammation. They are also good sources of antioxidants, including polyphenols, carotenoids and flavonols. Dietary supplements of Irvingia gabonensis, under the name “African mango”, are marketed for the management of body weight. Several researches and studies have shown that the seed or kernels contain amino acids and are full of vitamins and minerals such as calcium, magnesium, potassium, ascorbic acid, zinc, sodium, amino acids, dietary fiber, vitamin C, phosphorus and iron. It contains fatty acids such as stearic acid, oleic acid, palmitic acid, myristic acid and lauric acid.

    I spoke with the Head of Herbarium, Department of Pharmacognosy, Obafemi Awolowo University, Ile-Ife, Osun State, Mr. Ife Ogunlowo, about this plant and he said that the mesocarp of the fruit contains vitamin C and that it is rich in fiber. Thus, when consumed, it minimizes the urge to eat, which can be helpful in managing excessive weight gain. He also confirmed that the seeds can be used to manage male infertility. He added that he uses the fruit as a natural perfume for his car by putting 2/3 of unripe fruit in a box and leaving it in the trunk of the car. The fruit’s fragrance is released as it ripens. He however expressed his displeasure that the tree is now an endangered species due (the wood of Irvingia gabonensis is hard and it is useful for heavy construction work) to the logging of the products foresters. He advised on the need to start thinking about ways to preserve the common heritage.

    The kernel is an important source of vegetable oil which is considered a suitable source of industrial and edible oils. Raw dika paste yields, on heating or boiling, 70-80% of a pale yellow or almost white solid fat, dika butter, which has qualities comparable to cocoa butter and is in fact an adulterant or a possible substitute for the latter in the manufacture of chocolate. Stripped of its slight odor, it can also be considered suitable for making margarine. The fat is extracted from the seeds to make soap, cosmetics and candles. Since the plant is native to West Africa, I’m tempted to talk about some of its other parts so that if you suddenly come across them, you can explore their uses. The fruits are eaten, the sweet pulp can be squeezed or used to make smoothie, jelly, jam, wine and it is used to prepare a black dye for fabric. The bark has a bitter taste and has the usual uses for bitter barks in Africa. It is used as a purgative to treat gastrointestinal and liver ailments, infertility, hernias and urethral discharge. It is considered by some to be a powerful aphrodisiac and beneficial in case of senility. It is used in an enema or added to a cooked banana to relieve diarrhea and dysentery. It can be ground with water and applied externally to the body to relieve pain. It is used in mouthwashes to relieve toothache, made into a poultice and applied to wounds and wounds.

    Scientific studies

    In a study titled. “Effects of the aqueous extract of the seeds of Irvingia gabonensis on the hormonal parameters of male guinea pigs”, by Wolfe et al, the study supports the claim on the folk use of the seeds of this plant to improve the libido and the reproductive function in men.

    Also in the study, “Terminalin from African mango (Irvingia gabonensis) stimulates glucose uptake through inhibition of protein tyrosine phosphatases”, by Yoon et al, the results suggest that terminalin derived from African mango may be used as a functional food ingredient or pharmaceutical supplement for the prevention of type 2 diabetes.

    In a study titled “IGOB131, a novel extract from the seeds of the West African plant Irvingia gabonensis, significantly reduced body weight and improved metabolic parameters in overweight humans in a randomized, double-blind, placebo-controlled study,” by Ngondi et al, the conclusion is that Irvingia gabonensis extract may prove to be a useful tool in addressing the emerging global epidemics of obesity, hyperlipidemia, insulin resistance and their comorbidities.

    In another study, “Extraction and physicochemical composition of almond oil from Irvingia gabonensis: a potential healthy source of lauric-myristic oil”, by Ibinga et al, the oil of I. gabonensis can thus be used for the manufacture of margarine and cooking butter because of its thermal stability but also because of the non-degradation of fatty acids due to the absence of unsaturated and polyunsaturated fatty acids.

    In a study entitled “Anti-diarrheal and anti-ulcer properties of Irvingia gabonensis in rats”, by Y. Raji et al, the results show that Irvingia gabonensis has anti-diarrheal and anti-ulcer properties.

    In a study titled “Irvingia Gabonensis leaf extracts increase urine output and electrolytes in rats”, by Nosiri et al, from this investigation, the different doses of the extract showed that Irvingia gabonensis has a diuretic effect.

    In a study titled “Analgesic effect of Irvingia gabonensis stem bark extract”, by Okolo et al, these findings provide for the first time the pharmacological basis for the folk use of Irvingia gabonensis in the relief of pain. It’s time to start seeing ogbono soup as medicine in your pot!

    Davenport refuses to let knee injuries derail his UCA career

    Darin Davenport has done a lot to impress his teammates and coaches. And it’s not just because he’s a valuable member of the University of Central Arkansas Bears defense.

    For Davenport, a junior linebacker, it’s about always being ready.

    “In high school, I had two knee surgeries and then another in my freshman year (college),” Davenport said. “So far this year, rehabilitation has helped me a lot. I’m very lucky to be on the pitch.”

    Davenport had a season-high six tackles in ASUN’s 49-20 breakout of Austin Peay last week.

    To stay on the court, let alone keep the dream alive, Davenport spends as much time lifting weights and following a tight regiment his coaches have him on. Then there’s the day-to-day life of college athletics.

    “Playing college sports takes a huge commitment, not just to playing football, but to school as well,” Davenport said. “You get up at 7 a.m. to lift weights, then it’s off to 8 a.m. to noon classes, then to practice. Then when you get home, you have to study.

    “And then it all starts again the next day.”

    Davenport appeared in 11 games as a rookie, racking up a career-high 49 tackles and three TFLs (plate for loss). He has appeared in just 20 games since, including three this season.

    But, thanks to COVID (2020), Davenport still has this season and another.

    “It’s (football) a blessing,” he said. “I’m very lucky to be on the pitch.

    “It shows how committed I am.”

    The Bears coaching staff noticed it too.

    “Coaches love the mental side and the strength of the game,” Davenport said. “Being here in the training room is just part of it. If you’re going to play, you have to work on it.”

    His parents, Carin and Jimmy rarely miss a game, Davenport said. “They even went to Hawaii my freshman year,” he said. “They’ve only missed one game this year.”

    Castillow leads OBU to 3-1 win

    Lexi Castillow (Greenwood) and the Ouachita Baptist Lady Tigers snapped a mini two-game losing streak on Thursday with a hard-fought 24-26, 25-19, 25-14, 25-17 win over East Central.

    Castillow had another strong performance with 16 digs, two aces and two assists.

    The Lady Rods (11-9 overall and 4-4 in the Great American Conference) were scheduled to face Southeast Oklahoma State on Friday and Austin College on Saturday.

    For Castillow, the 16 digs gives him 1,808 for his career OBU and 2,020 for his college career.

    Gleason fires 4 TD assists in win

    Braden Gleason (Muldrow, Okla.) threw four touchdown passes and the Emporia State Hornets rebounded from their tough loss to Pitt State with a 42-35 over Washburn.

    The Hornets (3-2 in the Mid-America Intercollegiate Athletics Association) led 42-14 with 10 minutes remaining before they held on. Gleason certainly did his part.

    The Muldrow junior completed 27 of 39 passes for 300 yards.

    He had at least one touchdown pass in the last 19 games (November 9, 2019) and now has 48 career touchdown passes.

    Gleason also added 22 rushing yards, including a 19-yard quarterback.

    Freeman continues to shine for CBC

    Former Hackett star Madeline Freeman managed a team record 17 decisive wins in the five-set loss to Central Baptist College (26-24, 20-25, 25-22, 24-26, 15 -13) against Cottey College (Mo.) in America. Midwest Conference play last week, the Lady Mustangs’ sixth straight loss.

    Freeman is certainly doing his part. The standout freshman also had two blocks and three aces.

    The Lady Mustangs (2-1) were scheduled to face St. Louis University of Health Sciences and Pharmacy on Friday. The team will continue a four-game swing Saturday against Hannibal-LaGrange.

    CBC have dropped all three of their five-setters this season.

    Ennis gets kicked at Harding

    Grant Ennis (Greenwood) threw a 23-yard field goal and Harding University earned a 38-23 victory over Oklahoma Baptist in last week’s GAC game.

    Ennis also connected on his five extra kicks in the team win. Harding (4-1) travels to Bethany, Okla. today to play the Southern Nazarene.

    Ennis, who played on undefeated 2017 state title team Greenwood with, among others, Connor Noland, now has 22 career field goals and 130 PAT kicks to give him 196 career points – 14 points behind Alan Dixon (1970-73) for seventh place on the all-time scoring list.

    He is one placement behind Stu Varner (1984-87) for ninth place all-time.

    Holland gets 8 kills

    Junior Hannah Holland (FS Southside) had eight kills and a pair of blocks in the Lady Lions’ 25-16, 25-20, 25-13 sweep of non-conference foe Drury University this week.

    UAFS (10-8) travels to Russellville on Monday to take on Arkansas Tech before resuming Lone Star Conference play Oct. 14 against West Texas A&M. The Lions will face Cameron University and Dallas Baptist in all three home games.

    Holland’s two blocks give him 48 for the season and his 131 kills are good enough for third-best on the team.

    Luke plays well in defeat

    Larkin Luke (Greenwood) had three kills, two blocks and three digs in Henderson State’s tough five-set loss to Southeastern Oklahoma State on Thursday in the GAC game.

    The Lady Reddies, who have lost six matches in a row, were due to play East Central on Friday. The Lady Reddies are 7-13 overall and 1-7 in the league.

    Luke is fifth on the team in kills (62) with 1.09 per set and third in blocks (44).

    The Lady Reddies travel to Alva, Okla. Next week they will play in Northwestern Oklahoma State.

    Third and long

    Mckenzi Stidman (Waldron) of the University of Arkansas-Rich Mountain ran a 23:27.5 (223rd overall) at the Chili Pepper Festival last week in Fayetteville. Teammates Dariana Mendez-Hernandez (Southside), Faith Rainwater (Mansfield) and Hope Rainwater (Mansfield) also participated in the event. … Tyreek Gilkey (Northside) paced the Bucks with a time of 29:48.7 at the Chile Pepper event. … Emma Morton (Van Buren) of John Brown University ran a 22:31.6 at the Chili Pepper Festival in Fayetteville last week. … Jett Frazier (Northside) pitched two scoreless innings last week for the Carl Albert State College Vikings in a fall game with UA-Rich Mountain. Teammate Reed Carroll also homered for the Vikings. … Bryant Burns (Ozark) had a reception for 15 yards in Southwest Baptist University’s 44-17 loss to Indianapolis University. … Taye Gatewood (Southside) went for eight yards on three carries in Arkansas Tech’s 48-35 win over Southern Nazarene last week. Isaac Davis (Van Buren) made a tackle in the Wonder Boys win.

    Sofa
    Photo Castillow
    Photo Free man
    Photo Ennis
    Photo Holland
    Photo Gilkey
    Photo burns

    Albany Medicaid Pharmacy Exclusion Harms Rural Health Care | News, Sports, Jobs


    America is facing a major doctor shortage, and nowhere is this more evident than in upstate New York.

    According to the Association of American Medical Colleges, the United States is expected to miss up to 124,000 physicians by 2034, as practitioners age or choose to leave due to stress from the COVID-19 crisis. Upstate — and western New York, in particular — has struggled for years to attract enough doctors to meet demand and ensure residents have access to high-quality, affordable care.

    Rural residents also have to travel greater distances to seek care, living on average at least five miles further from the nearest hospital than their suburban and urban counterparts.

    Extreme weather conditions, lack of public transport and high gas prices make such travel prohibitive for many patients, especially those with low incomes.

    That’s why the Chautauqua Center has prioritized meeting patients where they are and bringing services directly to them whenever possible. Our home medicine delivery service delivers life-saving prescriptions to the doorsteps of more than 760 people each month. And we regularly provide transportation to appointments for the more than 12,000 patients we serve.

    These essential services are made possible through our participation in 340B – a 30-year-old federal program that requires drugmakers to offer deep discounts so safety-net providers can use the savings to provide care to New Uninsured and underserved Yorkers. This funding stream allows safety net facilities to provide services not covered by Medicaid.

    In addition to medication delivery and transportation, the Chautauqua Center is using $340 billion in funds to provide free blood pressure monitors, in-house translation services, chronic pain management assistance, and nutritional counseling, all at no cost. extra for taxpayers.

    This critical funding stream is now under threat due to a change first proposed by former Governor Andrew Cuomo before the Covid-19 crisis and which is expected to be implemented next spring. In short, the state health department wants to divert $340 billion in savings from safety net providers to its own coffers, resulting in more than $250 million in annual losses for community health facilities each year. .

    According to the DOH, withdrawing Medicaid drug benefits will result in at least $125 million in savings in the first year of implementation. But a 2020 Weakley Consulting Group report found the state would actually incur $154 million in additional costs, and that would rise to $1.5 billion over five years.

    These funds support lifesaving care and are also flexible and predictable, allowing providers to respond faster and more effectively to unexpected public health crises like COVID-19. Without this revenue, services will be cut, jobs will be lost, and some clinics in medically underserved communities will close completely. Nearly two-thirds of the Chautauqua Center’s annual budget is made up of 340B funds.

    The $340 billion loss will disproportionately affect low-income members of communities of color, who have long experienced disparities in access to quality health care. Forty percent of Chautauqua Center patients are members of racial or ethnic minority groups, and just over 80 percent are at or below 200 percent of the federal poverty level.

    The pandemic has forced providers to rethink how they provide care to vulnerable patients and keep them safe. Telehealth, which allowed individuals to speak virtually with healthcare professionals, was an important tool – particularly in the case of underserved rural areas – which remains a key aspect of our services. But access to drugs and treatment in person is still necessary to ensure high-quality care.

    The Chautauqua Center is experiencing a growing demand for services for hard-to-reach people, including members of the Amish community, migrant farm workers and the urban homeless, all of whom face transportation challenges. We are committed to continuing to provide high-level care to these emerging populations as well as our existing patients, but we will not be able to do so if Albany insists on moving forward with exclusion.

    We call on the governor to repeal this outdated and harmful plan, and hope that our local elected officials will support us in this effort.

    Mike Pease is CEO of the Chautauqua Center, a federally licensed health center that has been providing high quality, patient-centered health and support services in the Chautauqua area since 2013.



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    Hemp Production Potential Sustainable Economic Future for Indigenous Communities

    At 6 a.m. on August 24, 2000, Alex White Plume was awakened by a call from his brother. All he said was, “They’ve arrived. White Plume knew exactly who his brother was talking about. Walking outside, White Plume was ambushed by Drug Enforcement Administration agents holding machine guns.

    “[An agent] pointed his gun at me and said ‘Halt’ three times,” White Plume recalled in the 2006 PBS documentary “Standing Silent Nation”. something inside me got angry, like an accusation. I just looked at him and I’m not going to say what I said, but I said, ‘You’re going to have to shoot me in the back’ and I just started walking.”

    The DEA raided White Plume’s property on the Pine Ridge Reservation in South Dakota over its decision to grow hemp, a class of cannabis used for medicinal and industrial purposes but lacking the high amounts of Psychotropic THC found in marijuana. What could have been a cash crop for White Plume and her family was decimated by DEA agents in the raid.

    The story of White Plume illustrates how hemp has been regulated in the United States for decades – as a Class 1 drug – but it also represents how Indigenous peoples have been blocked from trying to use hemp. as an economic driver for themselves and their communities. .

    Between farm legislation and the marijuana legalization movement, hemp has become a more viable commodity for farmers, including indigenous farmers, in recent years. For Indigenous communities, hemp production could be an opportunity to build powerful, self-sufficient economies.

    “Long before the Europeans arrived, we were farming, and we were doing it well,” says Tim Houseberg, co-founder and executive director of the indigenous nonprofit Cherokee Nation. Indigenous health issues. “Now we are mostly landless, so even when you have highly skilled farmers like me, we don’t have thousands of acres. We are not part of this agricultural network. It overtook us. I watched [hemp] as an opportunity, in many cases, where people of indigenous backgrounds, of diverse backgrounds, could all of a sudden be involved in something to provide a living wage.

    The potential of hemp

    Unlike marijuana, hemp has low levels of THC – less than 0.5% compared to an average of 15% in marijuana – high levels of CBD and thousands of potential uses. Hemp is used in clothing, animal and human food, rope, and some exciting new uses.

    “I think there is a significant opportunity to capitalize on and innovate,” says Jared Auclair, an associate professor of chemistry and chemical biology at Northeastern University. “There are some pretty interesting things where we could leverage hemp and cannabis in general in other areas like biofuels.”

    For Houseberg, the potential of hemp production for tribal communities is more than just additional income: it is part of a path to a sustainable “circular” economy for indigenous peoples.

    “You have people who could go out and learn about emerging crops and make a career out of it or rent land,” Houseberg says. “They could also be involved in growing hemp and producing hemp not for the fiber but for the seed and for the nutritional value, to eat and stay alive.”

    However, there are regulatory, economic, and educational hurdles that still present challenges for Indigenous farmers looking to enter the hemp industry.

    The complicated history of hemp

    Part of this has to do with the curious history of hemp as a crop in the United States. Hemp has been grown by farmers for thousands of years all over the world, including in the United States. In 1937, Congress passed the Marijuana Tax Act, legally separating hemp from marijuana. as culture. Hemp production was encouraged by the government in the 1940s as part of agricultural efforts during World War II. However, hemp fell victim to the war on drugs, starting in 1970 under the Controlled Substances Act, which criminalized hemp and classified it alongside heroin and marijuana as a abused drug.

    For tribal communities, the question of sovereignty still hangs over all of this, especially since recent efforts to get rid of it. The Oglala Lakota of Pine Ridge, like all tribes in the United States, were granted sovereignty over their lands, and in 1998 the tribe passed an ordinance legalizing the cultivation of hemp on the Pine Ridge reservation.

    “I said [the DEA agents], “You’re breaking tribal law,” White Plume said on “Standing Silent Nation.” “’This is our family’s land. … You are raping us and you are taking something that we have planted and we are going to sell it.’ »

    With the 2014 Farm Bill, states could set up pilot programs regulating the production of hemp for research purposes, which meant that educational institutions and their partners could get into the industry. The 2018 Farm Bill went further by allowing large-scale production of hemp, provided it was made legal by states or tribes, and removing it from the DEA’s list of controlled substances.

    However, these recent changes haven’t made things much easier for Indigenous farmers, Houseberg says.

    Obstacles to success

    Native Health Matters, his Oklahoma-based nonprofit, has been ahead of the curve in the world of hemp production in general. In 2018, the nonprofit partnered with the University of Arkansas for the first university-supported hemp agronomic study in the United States. It has an extensive genetic library of hemp varieties from around the world. But even with all of these benefits, Native Health Matters has faced challenges in the world of hemp production.

    Most tribal communities simply don’t know where or how to grow and harvest hemp or who to talk to, which can leave them vulnerable to “unscrupulous promoters,” says Houseberg. For people already facing significant economic challenges, the difference between a successful or failed deal with a developer is significant.

    “As with any emerging business, there are good and bad. There are people there just to take advantage of it, so in a tribal community, where you have young and new businesses, they can’t accept “I just spent $10,000 to buy the wrong seed,” says Houseberg . “They can be done, period. They could not survive contracts that are more unilateral than bilateral. There’s just a lot of lack of knowledge about who to do business with.

    Equipment and land are also expensive, and because of the federal government’s history of deletion indigenous to their land, tribal communities have very little acreage to work with in the first place. Then there are droughts, pests, and fertilizer shortages that present additional hurdles. Houseberg started growing hemp under the 2014 Farm Bill, but he saw farmers who weren’t so lucky. Some lost their farms, went to jail or even committed suicide.

    “If you see a Native American farmer period, take a picture because it’s rare,” Houseberg says. “It’s tough for the farmer back in the days of the United States, let alone a Native American farmer, let alone the one who decided to try growing hemp.”

    There are also regulatory hurdles, which can vary from state to state, says Paul Peiteaching assistant professor of mechanical and industrial engineering at Northeastern.

    “Fifteen days before harvest, if the THC content of the plant exceeds a certain level, you have to destroy the land completely,” says Pei. “All the money is gone.”

    To look forward

    But there are some signs of hope. After 20 years of a court order preventing it from growing hemp, White Plume recently partnered with Minnesota-based hemp company Evo Hemp in 2017 to create a line of hemp-based food products. Even if it takes time, Houseberg remains optimistic that this type of agricultural development can be a boon for tribal communities.

    “There are opportunities for Indigenous communities that aren’t in cities just because we were, we are, a plant-based society, although we’ve moved away from that,” Houseberg says. “Getting back to those things, starting with the little ones, is an opportunity to create a workforce in emerging areas, but that’s what we’ve forgotten. It’s a chance for us to get back to those things and join this new economy.

    To help provide pathways to success, Native Health Matters created the Indigenous Production Trade Alliance, a group of farmers, universities, seed breeders and entrepreneurs who aim to educate and strengthen the workforce. work in the hemp industry and the world of sustainable agriculture. Native Health Matters also works with other tribal communities and organizations on remediation efforts, improving soil to help grow hemp and other crops. All of these efforts must start at the community level, Houseberg says, or the benefits of hemp production won’t stick or work for the community.

    But that doesn’t mean indigenous farmers have to figure it out for themselves. Houseberg says a group like the Indigenous Production Trade Alliance is proof that collaboration is key to success in the hemp industry.

    “Like cannabinoids, companies [and] individuals should start working together to create unique links in the global supply chain to have incalculable impacts on the environment,” says Houseberg. “A Healthy Energy Conservation Ecosystem [and] well-being is a collaboration, much like the symbiotic effects of the cannabis plant, which was coined the entourage effect. With such a diversity of useful innovations, hemp companies, like cannabis compounds, and synergistic corporate alliances [can] create a Hempire like the world has never seen.

    Although Houseberg has spent a decade exploring the potential of hemp in tribal communities, he is adamant that hemp alone is no panacea. But it’s a way to embrace a sustainable future that could prove fruitful for Indigenous peoples across the United States.

    “Everyone thinks hemp will save the world. Well, he’s not – he can only do his part,” says Houseberg. “It’s us who are working to create more of a plant-based ecological environment that will change things.”

    For media inquiriesplease contact [email protected].

    UAMS will hold the fifth annual giving day on October 12

    Enlarge image

    Donation day will be October 12.

    Launched in 2017, the event is UAMS’ largest one-day philanthropic effort, helping to energize patient care, education and research programs across the institution, while celebrating the resilience of the entire UAMS community. As a statewide institution, UAMS has set itself the goal of receiving a donation from all 75 counties of Arkansas.

    “The Day of Giving is a time not only to celebrate the philanthropic spirit within UAMS, but also to recognize the generosity of donors in Arkansas and beyond,” said Cam Patterson, MD, MBA, Chancellor of UAMS and CEO of UAMS Health. “Regardless of the size of the donation, we are truly honored by the continued support for our mission.”

    The UAMS Donation Day will last for 24 hours, beginning at 6 a.m. on October 12 and ending at 6 a.m. on October 13. Patterson will kick off the day’s events by making the first donation. Any donation, no matter the amount, will have a positive impact on patients, staff, faculty and students.

    All funds raised will support the various programs, funds, colleges or institutes chosen by the donor. Gifts are tax deductible and can be made online at dayofgiving.UAMS.edu or by phone during regular business hours at 501-686-8200.

    UAMS is looking for Giving Day Ambassadors from within the community to help make this year’s event a success. Email [email protected] to register.

    Throughout the day, supporters of the initiative can share stories on social media about how UAMS has made a difference for them using the hashtag #UAMSDayofGiving. The institution will be active on social media, encouraging donations, sharing testimonials and encouraging others to support the causes that matter most to them.

    UAMS providers oversee more than one million patient appointments each year at its main campus, regional campuses, Central Arkansas Veterans Healthcare System, and Arkansas Children’s. UAMS graduates nearly 1,000 doctors, nurses, pharmacists, and allied health professionals each year, the majority of whom remain in Arkansas to practice.

    State funding is only a small percentage of UAMS’ $1.5 billion annual budget. Revenue from patient care takes the lion’s share, at 75%. UAMS relies on the philanthropic support of generous donors in Arkansas and beyond to provide much-needed funds for clinical excellence, groundbreaking research, and innovative training for the next generation of healthcare professionals. . To learn more, visit giving.UAMS.edu.

    UAMS is the only health sciences university in the state, with colleges of medicine, nursing, pharmacy, health professions, and public health; a doctoral school; a hospital; a main campus in Little Rock; a Northwestern Arkansas Regional Campus in Fayetteville; a statewide network of regional campuses; and seven institutes: Winthrop P. Rockefeller Cancer Institute, Jackson T. Stephens Spine & Neurosciences Institute, Harvey & Bernice Jones Eye Institute, Psychiatric Research Institute, Donald W. Reynolds Institute on Aging, Translational Research Institute, and Institute for Digital Health & Innovation. UAMS includes UAMS Health, a statewide health system that encompasses the entire clinical enterprise of UAMS. UAMS is the only Level 1 adult trauma center in the state. UAMS has 3,047 students, 873 medical residents and fellows, and six resident dentists. It is the largest public employer in the state with more than 11,000 employees, including 1,200 physicians who provide patient care at UAMS, its regional campuses, Arkansas Children’s, VA Medical Center and Baptist Health. Visit www.uams.edu or uamshealth.com. Find us on Facebook, TwitterYouTube or Instagram.

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    How AI and ML are revolutionizing the logistics segment

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    Logistics and supply chain networks are difficult to manage. The COVID-19 pandemic and other recent global geopolitical events have drawn public attention to the complexities and weaknesses inherent in logistics systems. Almost daily, the media tells us about the adverse effects of supply shortages, logistical bottlenecks, industry disruptions and rising commodity costs.

    Logistics problems have serious effects on national and global economies, disrupting fundamental and critical areas that depend on well-functioning logistics, including healthcare, food, trade, manufacturing, energy and farming.

    The extent of logistical inefficiencies is well known and well documented. An example of a study estimated that the extent of wastage of heat-sensitive pharmaceuticals (vaccines) due to logistical issues $35 billion in direct hardware loss and indirect disruption of service costs each year.

    The dawn of logistics AI

    Many of the fundamental ills of the logistics industry can be solved or at least greatly mitigated with advanced data-centric algorithmic technologies such as augmented intelligence, artificial intelligence (AI), and machine learning (ML).

    Still adopted only by early adopters, these technologies are already proving their worth, enabling logistics managers in small and large organizations to become more resilient, work more efficiently, improve service levels, minimize waste, reduce costs and increase profitability.

    Think of solving a super huge sudoku puzzle: we as humans are limited in our ability to consider and analyze many interrelated variables, constraints and contingencies. Therefore, the considerable time and resources required to solve such a large and complex puzzle is unreasonable, unachievable and, often unavailable, making the human-driven solution unattainable. The logistics are much more complicated than Sudoku, with many more variables, uncertainties and constraints. The upshot is that, to deal with sudoku-like complexities, managers traditionally simplify assumptions about their reality and simply accept the inherent uncertainty and risky aspects of their jobs as a “fact of life.” This often leads to sub-optimal operations. For years, many problems and inefficiencies have been deemed “unsolvable,” and their suboptimal consequences have traditionally been accepted as unavoidable costs of doing business.

    But AI agents and ML algorithms can change this inherited way of thinking!

    With these new technologies, human logistics managers can cost-effectively augment our (limited) capabilities and efficiently solve large, complex, multivariate operational logistics problems without giving up unachievable costs or compromising service levels.

    Machine learning technology can help mitigate risk and uncertainty. Over time, ML can deliver substantial improvements in performance, quality, and cost efficiency, as early adopters of these powerful technology tools are already demonstrating. For example, early AI implementations for local “last mile” deliveries show efficiency improvements of up to 30%!

    One of the many examples of the revolutionary benefits of using machine learning algorithms in the logistics industry is route planning and optimization. With artificial intelligence algorithms processing thousands of parameters simultaneously, in real time, many multiple route plans can be dynamically accelerated at the press of a button, not only ensuring the timely arrival of all of the fleet, but also the costs of organization within strict budgetary limits. .

    With such technology, the combined requirements and constraints of all different stakeholders – shippers, carriers and consignees – can finally be taken into account without compromise, to provide optimal operational information and decision support for all parties throughout the supply chain. . Route optimization not only considers destinations, distance and time constraints, but also forecast traffic patterns, forecast weather conditions and service levels (SLAs) and service provider cost structures. third-party or 4th-party services and their respective customers.

    And there are many other examples. Dynamic AI-powered platforms can support and even predict QoS anomalies or failures, autonomously generating predictive and preemptive solutions to issues on the fly, as they happen. they occur, or even before they happen. This powerful predictive AI capability helps logistics companies maintain the high service levels they are committed to, improve their reputation and increase customer satisfaction, thereby increasing their competitiveness.

    AI for critical time-temperature logistics

    Specialized logistics such as time and/or condition sensitive logistics (e.g. temperature controlled) are on the rise, especially in specific categories such as fresh food (think strawberries) and healthcare (e.g. COVID and other critical vaccines). When a given delivery window or specific temperature is required, being able to provide real-time responsiveness and pre-emptively avoid issues becomes even more crucial, as a pre-emptive response to unforeseen variations in conditions throughout of the supply chain becomes essential. for the success of the logistics mission.

    Real-time monitoring, combined with predictive analytics algorithms, can ensure safe and timely transportation that meets both customer expectations and stringent regulatory requirements, every step of the way.

    In the future, in the next 5 years

    Recent global events and supply issues have triggered the start of acceptance and is accelerating the adoption of AI in the logistics segment. In other segments such as healthcare, banking, and retail, AI is already becoming a core technology for operational improvement. I think AI will eventually become mainstream in the logistics segment as well. The benefits of this powerful breakthrough technology become apparent to those who understand the massive global logistics challenges and how AI can be applied to solve them. To stay competitive and profitable, logistics players big and small will widely adopt AI tools for both their planning and day-to-day logistics management.

    Written by Raviv Yatom, co-founder and CTO of Amphorica

    1 credit

    Center for Transdisciplinary Research (Cftr)

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    Chennai, 6th October 2022: CFTR researchers are involved in various interdisciplinary researches at the Gold Laboratory of Saveetha Institute of Medical and Technical Sciences, Chennai. Researchers are specialists in computational biology, cell culture, animal studies, nanotechnology, oncology, pharmacognosy, toxicology, and microbial studies including antimicrobial resistance.

    We have scientists who are also involved in studies of biocompatibility, wound healing and surgical bone defects in small animals. Researchers are also specialized in carrying out pharmacological and toxicological studies using cell cultures and animal models.

    CFTR researchers are also experts in the synthesis of nanoparticles, nanocomposites and nanoformulations using plant and bioactive compounds. They study the biomedical applications of nanomedicines and develop dental nanoproducts such as mouthwashes, toothpastes, dental varnishes, paints and nanoformulation gels.

    We also have a zebrafish model to perform studies related to tissue regeneration and toxicology. We have a stem cell bank and a facility to do research on stem cells isolated from periodontal ligament, dental pulp, etc.

    Researchers are also involved in evaluating the therapeutic efficacy of phytocompounds and small molecule animal models. We also have advanced Zeiss Microscope, qPCR, ELISA, Western Blot, Automated Analyzer and other facilities to carry out molecular studies.

    PSI researchers optimize a method for diagnosing tumors using radionuclides

    Researchers from the Paul Scherrer Institute PSI, in collaboration with ETH Zurich, have optimized a method for diagnosing tumors using radionuclides. Potential side effects can now be significantly reduced with a molecular trick. The researchers report their findings in the current issue of the scientific journal Bioorganic and medicinal chemistry.

    With the development of a new class of so-called radiopharmaceuticals, researchers have been able to solve the problem of radioactive substances remaining in the kidneys for a long time. Their approach relies on an additional protein that can be broken down in the kidneys. This cleavage detaches the radioactive substance from the drug, allowing it to go directly into the urinary tract so that it can be excreted.

    Radiopharmaceuticals are drugs, given by injection, that can be used to detect and attack tumors in the body. In principle, these substances consist of a radionuclide and a biomolecule. The biomolecule, for example an antibody or a peptide, binds specifically to certain surface structures of the tissues. The radionuclide emits radiation that can be used to detect a tumor or to destroy it.

    The principle seems simple, but there are many obstacles to overcome on the way to a ready-to-use drug. Besides the purely practical difficulty of coupling a radionuclide to a biomolecule, it is essential and difficult to find the right molecule in the first place. Martin Béhé, head of the pharmacology group at the Center for Radiopharmaceutical Sciences at PSI, explains the problem: “If the molecule is too specific, there is a risk that all the tumors will not be detected. On the other hand, if it is too general, it could possibly bind to healthy tissues, leading to false positive diagnoses.”

    Target the extracellular matrix

    For suitable molecules, however, there are other possible targets besides tumor surfaces, for example the so-called extracellular matrix. Instead of directly targeting the tumour, the research group led by Martin Béhé attacked this extracellular matrix. It is the part of the tissue located between the cells. You can imagine this space as a three-dimensional framework in which the cell is embedded – a very complex and flexible framework, since the extracellular matrix is ​​in constant exchange with the cell and regulates, for example, cell growth and intracellular chemical balance. . Also in pathological processes, such as the growth of cancer cells, the extracellular matrix plays a crucial role. Numerous studies indicate that certain proteins present in it promote the viability of cancer cells. Indeed, it has been shown that tumor growth is accompanied by remodeling of the extracellular matrix.

    The researchers, led by Martin Béhé from PSI and Viola Vogel, head of the Applied Mechanobiology Laboratory at ETH Zurich, want to exploit this remodeling to bring the radionuclide into the tumor tissue. Specifically, they focus on a particular matrix protein known as fibronectin. In healthy tissue, fibronectin exhibits an extended and tense structure, which begins to relax as the disease progresses. Martin Béhé offers an analogy: “You can think of it as a mechanical spring. When the spring is stretched, there are large spaces between the individual coils where the drug cannot bind. If instead the spring relaxes, the gaps are closed and binding affinity increases.” Thus, fibronectin undergoes structural change while retaining its chemical composition. However, this change is sufficient to significantly increase the binding affinity with certain peptides.

    In a previous study, Martin Béhé and his team were able to show that so-called fibronectin-binding peptides (FnBPs) can be used as vectors to transport radionuclides in a targeted manner into the extracellular matrix of a tumor. To do this, the researchers combined the fibronectin-binding peptide FnBP5 with the radioactive isotope indium-111. Thanks to this radiopharmaceutical, prostate cancer can be successfully detected at a preclinical stage. However, the radionuclide accumulates not only in the tumor, but also in the kidneys.

    The problem with the kidneys

    High levels of radioactive deposits in the kidneys not only interfere with imaging, but can also damage the kidneys. The problem arises because many proteins and peptides are filtered by the kidneys before being excreted in the urine. This complicated process can lead to peptide-bound radionuclides persisting in the kidney for a long time before eventually breaking down completely or being processed in some other way.

    To solve this problem, the researchers modified the FnBP5 peptide with a special protein that can be broken down in the kidneys. This protein acts as a bridge between the original peptide and the radionuclide. Thus, FnBP5 can still bind to fibronectin and, through the radionuclide, make the tumor visible. But as soon as the modified drug enters the kidneys, the additional added protein is cut off and the radionuclide enters directly into the urinary tract, from where it can be excreted.

    Using this molecular trick, the researchers were able to maintain the effectiveness of the original drug while effectively reducing radioactive deposits in the kidneys.

    Béhé: “We hope that our findings can also be used for other radiopharmaceuticals associated with similar side effects.”

    Source:

    Journal reference:

    Valpreda, G., et al. (2022) Dual MVK cleavable linkers effectively reduce renal retention of 111In-fibronectin binding peptides. Bioorganic and medicinal chemistry. doi.org/10.1016/j.bmc.2022.117040.

    Miracle Plant Consumed By Ancient Greeks Rediscovered 2,000 Years Later

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    One of the most sought-after products in the Mediterranean world is said to have been rediscovered in Asia Minor after disappearing 2000 years ago. The silphion, a plant with golden flowers, was considered a treasure for doctors in ancient Greece, who used it to cure illnesses.

    For Roman chefs, this botanical survivor was a gourmet staple, needed to spice up an everyday meal, adding a saltier feel.

    During the reign of Julius Caesar, over a thousand pounds of the plant were amassed alongside gold in the treasuries of Rome, as silphions were valued by weight at the same price as silver.

    The silphion disappeared from the ancient Mediterranean world seven centuries after the plant was originally documented growing along the coast of Cyrenaica, what we know today as modern Libya.

    According to National Geographic, Roman chronicler Pliny the Elder said “only one rod was found”, adding “and it was given to Emperor Nero”. This was Silphion’s last documented report.

    A coin from Magas of Cyrene c. 300–282/75 BC. The reverse represents a silphion. Photo: Wikimedia Commons

    Professor Mahmut Miski, a specialist in pharmacognosy, discovered the plant 40 years ago, and after decades of consistent research, he suspects he has rediscovered the last vestiges of the ancient plant two thousand years after disappearing from the history books. , and nearly a thousand miles from where it once grew. He thinks the Ferula Drudeana that grows on Mount Hasan is the elusive ancient plant.

    “For me, the smell is uplifting and relaxing,” Miski explained. “You can see why everyone who comes across this plant becomes attached to it,” he added.

    According to a National Geographic report, the researcher found it to have similarities to the silphion plant, which aligns with ancient botanical texts and images of the plant on ancient Greek coins.

    According to a 2021 study published in the journal ‘Plants’ by Miski and his team, Ferula drudeana had similarities to the silphion as described in ancient text and depicted on Cyrenaic coins, from thick branching roots to leaves resembling celery.

    Miski noticed that both plants had the same thick branching root, yellow flowers, and powerful medicinal properties. Ferula Drudeana has anticancer compounds and anti-inflammatory properties similar to those found in silphium. The researcher received a grant to collect samples of Ferula, which belongs to the same family as carrots, fennel and parsley, and has a reputation for producing many new disease-fighting compounds.

    During Miski’s study on Mount Hassan, he thought the plant had thirty secondary metabolites for medical purposes, including anticancer, anti-inflammatory, and contraceptive properties, for which it was also famous in the ancient world.

    The plant, called silphion by the ancient Greeks, was once the most sought after product in the Mediterranean. Photo by alice.zoo/Instagram

    He believes there are still many compounds to be discovered that will benefit the medical industry.

    The similarities in appearance were not the only connection, however. According to Miski’s research, the first silphion appeared after a “heavy spring shower”, which at the time was called “black rain”.

    According to Miski and his team, “we find that it is said by the most reliable among Greek writers that this plant made its appearance near the gardens of the Hesperides and Great Sirte immediately after the earth had been soaked by a downpour as black as the ground.” This event took place seven years before the founding of the city of Cyrene.

    Erica Rowan, associate professor of archaeobotany at Royal Holloway University in London, found Miski’s speculations credible. “The ancients were very good at carrying things,” Rowan noted. “There’s no reason why the people of Cyrenaica couldn’t bring the seeds to Cappadocia and plant them. They are quite similar with a Mediterranean climate. And this species of Ferula looks like what is shown on the coins.

    The hidden faces of hunger in America


    Heather Thomas walks the aisles of the Western Fairfax Christian Ministries pantry in Chantilly, Va., last month. (Keren Carrion/NPR)

    Heather Thomas can count the tragedies that have plunged her family of eight into poverty. She and her husband lost their jobs and their home, their small business folded, several relatives died, and health crises pushed them into medical debt.

    “It went very quickly from a drip to a flood. And we lost everything,” Thomas recalls.

    “The food was really, really, really tight. My husband’s health, because of his conditions, there were times when we just couldn’t eat well. And one of his health problems ended up getting worse. We were rationing diapers… It was really bad.

    They are among more than 1.2 million people who struggled to put food on the table at some point last year in the Washington, DC area. That’s a third of the population living in and around the capital of one of the wealthiest nations on earth.

    Nationwide, more than 33 million people, including five million children, are food insecure, according to the USDA. No community is spared, with rural areas, families with children and communities of color being disproportionately affected.

    This week, the White House hosted its first hunger conference in a generation, unveiling a national strategy that included reducing obesity and diet-related diseases – like diabetes – through healthier eating, good nutrition and physical activity. The private sector and charities committed eight billion dollars. But a divided Congress could roll back some of the Biden administration’s broader proposals that could help lift people like Heather out of poverty.

    Living in poverty can be traumatic

    Thomas, 47, hasn’t always been on this side of the poverty line. A social worker by training, she used to give bags of food and other gifts to children in need. In the not-too-distant past, the family lived in a three-story townhouse they shared with Thomas’ grandmother.

    “My husband and I are college educated. My husband is an honorably discharged combat vet. And we’ve always worked since we were teenagers. I’ve worked in social services, in human services for over 30. And my husband served in the military. And then when he got out, he did different jobs,” she said. “It could happen to anyone.”

    She spoke after picking up free groceries from the food pantry run by Western Fairfax Christian Ministries in Chantilly, Virginia. cans of soup per person. And she’s only allowed one visit to the pantry a month.

    “Living in poverty makes you sicker or makes you sicker if you’re not and it’s hard to get out of it,” Thomas said. “No matter how long you live there, it causes trauma,” she added, noting that the stress caused her and her husband to develop PTSD, bringing out his lupus and rheumatoid arthritis. of remission. The trauma in turn affected the children, whose health also “deteriorated”.

    "take what you need" written on blue tape
    The Western Fairfax Christian Ministries Food Pantry offers fresh produce to those in need. (Keren Carrion/NPR)
    large industrial refrigerators filled with milk, eggs and other foods
    Pantry customers are only allowed a limited number of visits, and there are limits on certain grocery items. (Keren Carrion/NPR)

    A common scenario

    As crude as it is, their story is not unique.

    “Coming out of the peak of the pandemic with inflation as sustained and high as it is, it’s a tough time for many families,” said Capital Area Food Bank CEO Radha Muthiah. “As we reflect on how our nation rebuilds in a more equitable and inclusive way, food and nutrition programs have a truly critical role to play.”

    His group distributed more than 64 million meals last year, more than any previous year and double 2019 levels. Meeting the growing needs of those most in need required a healthy dose of innovation. The food bank’s Curbside Groceries is a store on wheels that has at least 12 stops in food desert areas. This includes Washington’s Ward Eight, a predominantly black area with higher poverty whose approximately 80,000 residents have very limited access to full-service grocery stores.

    “When they have multiple jobs, like most of our customers, and have to drop off or pick up their kids from school, daycare, an hour or two to get to the grocery store, it’s really far enough,” Muthiah said.

    “Systemic racism, lack of access to education, lack of mentorship, lack of access to banks, financial instruments, wealth creation tools, lack of access to affordable housing – all these things are the basis of food insecurity. And so it’s important to not only address the surface things and some of the symptoms, but also address those root causes.

    At the National Children’s Hospital, the Capital Region Food Bank has set up a food pharmacy so doctors can prescribe healthy foods to complement medical and clinical care.

    Good nutrition is especially essential for children, whose minds and bodies are still growing.

    “When they have that, they can focus and they can learn and they can absorb and they can dream and they can aspire,” Muthiah explained.

    Communities of color are hit hard

    Through good times and bad, Carla Claure peels, cuts and slices the freshest produce and meat she can find for her husband and teenage daughters Alejandra and Daniela in the dim light of her prefab home. “It’s beans, tortillas, maseca – I make my own tortillas – tomatoes and cheese. It’s good food. It’s healthy food. It’s good for families too,” said Claure as she made tostadas.

    But fresh fruits, vegetables and meat are also among the most expensive items in the store. And with rent costing nearly a thousand dollars a month, the food budget is stretched.

    Claure, 45, is Bolivian and her husband is Mexican. They live in an almost entirely Hispanic trailer community in Alexandria, Virginia.

    They both lost their jobs at the start of the pandemic – she could no longer clean houses due to her clients’ COVID fears, and work stopped on her husband’s construction sites. So they had to rely on food stamps and product donations.

    Now Carla is helping facilitate distributions of donated food that she and her neighbors can use. “Normally I have a food distribution here on Wednesdays, fresh fruit. I have a few days. And the rest I buy from Aldi. It’s not expensive. Or sometimes it’s at the Latino supermarket; it’s also a good price,” Claure said.

    Some of their neighbors are undocumented migrants who cannot access many benefits – or fear reprisals if they try. “For Spanish [Hispanic] undocumented people, whether your children are citizens or not, you can’t get anything else… You can’t apply for food stamps either,” Claure said. “It’s really difficult for the children, especially for the children, because the children don’t understand why we don’t have food.”

    Muthiah, the head of the regional food bank, says households of color with children are struggling the most to put food on the table, with two-thirds of those families being food insecure.

    “Although the numbers overall are unacceptable, they are ridiculously high for those who belong to a minority,” she added.

    This grim statistic includes Heather’s family. Her husband is African American.

    sour cream is drizzled over a tostada
    Carla Claure cooks simple meals for her family, like a tostada with refried beans, lettuce, avocado and tomato on a tortilla. She does her shopping through donations, food stamps and a food pantry. (Keren Carrion/NPR)
    Carla Claure’s daughters would rather eat home-cooked meals than the “bad” food served at school. (Keren Carrion/NPR)

    Food insecurity can come with stigma

    Back at the pantry, Thomas said being poor requires sacrifice. She had to make tough choices to decide what to buy with her limited budget.

    “You become very protective of food because you can’t just go out there and get exactly what you want. And sometimes parents don’t eat, or they eat very little, so their children can eat,” she said. “Junk and processed foods are so much cheaper than healthy foods. What’s wrong with this photo? »

    Thomas called for more people like her – with lived experience of poverty – to have a say in shaping hunger policies. She’s already active in that space herself — she and other advocates met with Housing and Urban Development Secretary Marcia Fudge last month.

    “I would challenge anyone who has what is considered a living wage to live on less than life wages. They wouldn’t get very far,” Thomas said. “You get creative and then you learn to live without things, like Q-tips and other things that we take for granted become, like, prizes, don’t you – Oh, cool, we got Q-tip money this month!”

    a woman in a polka dot shirt stands indoors
    Heather Thomas has been on both sides of the poverty line, enjoying the kind of gifts she used to pack. (Keren Carrion/NPR)

    For a family of three with two working parents in Fairfax County, the living wage is $36.88 per hour per adult, according to an MIT database. That’s nearly five times the poverty wage and more than three times the minimum wage.

    Even now, six years after falling into poverty, Thomas is still reluctant to tell people that she depends on handouts for food and shelter. It took a full-fledged effort that lasted two years to find the right programs for her family and complete the associated paperwork before she finally received those benefits.

    “You feel a lot of shame with it and people judge you,” she said. “When you go to the store, it becomes like this secret.”

    The audio version of this story was produced by Chad Campbell and edited by Reena Advani.

    Copyright 2022 NPR. To learn more, visit https://www.npr.org.

    Health Benefits of African Nutmeg

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    I want to say a big thank you to all of you for all the feedback on the cesarean article. You are deeply appreciated. I was asked the local names of flaxseeds. It is a non-native plant. I don’t know any local names for it. However, you can have them purchased. It’s the brown flaxseed I’ve ever bought. I have never seen one in golden color before. Let me give a weight loss tip before I continue. Avoid weight loss teas. Not all of them are safe for you. You must protect your internal organs. However, I don’t want to sound too critical.

    If it’s from a reliable source, you can go for it.

    For example, last year I had the opportunity to see a slimming capsule produced by the pharmacognosy department of a university in this country. Although I haven’t used it, I have no fear of it. Overall, portion control is the best bet for getting results because even if you’re on slimming teas/capsules and still overeating, you won’t get results.

    This week I will discuss the seed of a plant botanically known as Monodora myristica. It is commonly known as African nutmeg and calabash nutmeg. It is a tropical tree in the Annonaceae family and an alternative to its better known cousin, nutmeg. The tree grows naturally in the evergreen forests of countries like Liberia, Nigeria, Cameroon, Angola, Uganda, and western Kenya. It is variously known as Ikposa (Benin), Ehuru (Igbo), Ariwo/Ariyo in (Yoruba), and Kposa (Ilaje).

    For medicinal purposes, they are used as stimulants, diuretics, stomachics, for headaches, wounds and also as insect repellent. When ground into a powder, the kernel is used to prepare soup as a stimulant to relieve constipation and control uterine bleeding in women immediately after childbirth. After roasting and grinding, the seeds are rubbed on the skin for skin diseases, thus suggesting that the seeds of the M. myristica plant could be germicidal or antiseptic. Different parts of this plant such as the bark and flowers contain important minerals and are a good source of protein, vitamins, β-carotene, amino acids and various phenolic compounds. The stem bark is used in the treatment of haemorrhoids, stomach-ache, feverish pains and eye diseases. The herb has been shown to have anti-sickle cell properties, relieves constipation, has anti-inflammatory properties, serves as an insect repellent, is used to treat coughs, improves brain function, is a good laxative, helps to burn fat, relieves colds and flu. . It is an excellent sexual enhancer and can greatly improve libido in both men and women.

    Phytochemical screening performed on M. myristica extract revealed the presence of tannin, saponin, flavonoid, steroid, terpenoids, cardiac glycoside, alkaloid and phenol. They contain bioactive substances that exhibit health benefits including stimulation of the cardiac and circulatory system, anti-inflammatory, antispasmodic, diuretic, antihypertensive, cholesterol-lowering, antioxidant, antidiabetic, hepatoprotective, antibacterial and antifungal activities. African nutmeg is rich in potassium, calcium, manganese, iron, zinc, copper, phosphorus, magnesium and essential B-complex vitamins including vitamin C, folic acid, riboflavin, niacin, vitamin A and many flavonoid antioxidants that are essential for optimal health. . Studies have shown that the seeds have a high oil and protein content. The essential oil that can be obtained from the leaves contains β-caryophyllene, α-humulene and α-pinene. The main compounds present in the essential oil of the seeds are α-phellandrene, α-pinene, myrcene, limonene and pinene. The essential oil has antidepressant effects, can be used as linolenic-rich salad oil, edible shortening or margarine, and is used in pharmaceutical and dental preparations. The effects of the essential oil on the cardiovascular system have been studied and the result shows that the essential oil induces a hypotensive effect.

    Roasting is considered to cause the seed coat to break easily (Ehuru comes in a hard shell which contains the seed), it also gives it a stronger aroma. You can roast in a pan or put yourself directly inside a fire. Break the husks and remove the seeds. You can mix the seeds with your pepper to give a nice aroma to your stew. You can also brush it on a grater like you do for nutmeg to put it into a powder form. It is an aromatic cooking spice that complements a variety of dishes such as pepper soup, abacha, nkwobi, peanut soup, black soup, ofe Akwu, ugba/ukpaka, ose-oji, egusi, ogbono, banga soup, garden egg sauce, goat meat stew, isi ewu and so on. If you don’t want to roast, just crack open the shell and remove the seed.

    Scientific studies

    In a study titled “African nutmeg (Monodora myristica) lowers cholesterol and modulates lipid peroxidation in experimentally induced hypercholesterolemic male Wistar rats,” by Onyenibe et al, the results show that aqueous extracts of Monodora myristica could reverse the liver toxicity induced by high cholesterol. diets and have a cholesterol-lowering effect.

    In a study titled “Antimicrobial Evaluation of Crude Extracts, Fractions, and Seed Oil of Monodora myristica (Gaertn.) dunal,” by Obonga et al, the result compared favorably to the standard antibiotic, ciprofloxacin. In conclusion, the present results support the ethnomedicinal uses of M. myristica seed as an antimicrobial agent.

    In a study titled “Assessment of Nutritive Potential and Antioxidant Properties of African Nutmeg (Monodora myristica)” by Ukachukwu et al, the result of analysis of Monodora myristica showed that it possesses powerful antioxidant effects. and as such can be used as a food preservative.

    In a study titled “Sperm profile and testicular weight assessment of albino rats given African nutmeg (Monodora myristica) and African basil (Ocimum gratissimum)” by Okonko et al, the results of this study show that M. myristica promotes male fertility, while O. gratissimum and the combination of the two herbs might have anti-fertility effects.

    In a study titled “In vitro anti-inflammatory evaluation of African nutmeg (Monodora myristica) seeds”, by Akinwunmi et al, the result obtained in the present investigation indicates that the flavonoid-rich fraction of M. myristica may be a potential source of anti-inflammatory agent. This confirms the role of M. myristica seeds as a natural source of anti-inflammatory agent.

    In a study titled “Behavioral and biochemical indications of the antidepressant activities of essential oils from Monodora myristica seed (Gaertn) and Xylopia aethiopica fruit (Dunal) in rats”. by Ekeanyanwu et al, the study found that essential oils from both seeds relieved depression-like states in the rats used in the study.

    In a study titled “Chemical Composition and Hypotensive Effects of Monodora myristica Gaertn Essential Oil”, by Koudou et al, the result shows that the oil has anti-hypertensive activity.

    In a review titled “Some Common West African Spices with Antidiabetic Potential: A Review”, by Okaiyeto et al, Monodora myristica listed some of these spices.

    Who would believe that our very own Calabash Nutmeg has all these benefits? What are you waiting for? You can buy it from people who sell pepper soup spices in the market. Try to get it and start adding it to your meals.

    New Research Shows Cannabis Trichomes Trigger Positive Results on Rapid Plaque Yeast and Mold

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    Kevin McKernan, Chief Scientific Officer and Founder of Medicinal Genomics, shares insight from his recently published paper on cannabis trichomes and positive results in yeast and mold rapid plates.

    In a recent preprint article by Kevin McKernan and Yvonne Helbert of Medicinal Genomics (1), they present the latest findings from their labs demonstrating that certain trichome-rich strains can be confused with pathogen-rich samples.

    Kevin McKernan, chief scientific officer and founder of Medicinal Genomics, recently explained to Cannabis science and technology (TSC) that his team is frequently asked to have more modern techniques such as quantitative polymerase chain reaction (qPCR) to mimic legacy plating technologies. “Many regulators write laws that relate to colony forming units (CFU)/g, but what is a colony forming unit? It varies depending on the temperature you use. It varies depending on the sources of carbon you have on your plates. It’s now known to also vary if you have trichomes in your sample. But those metrics are poor correlates for patient risk,” McKernan said.

    In the abstract of their paper, McKernan and Helbert explained their process for carrying out the study (1): “We plated cannabis trichomes on several different plating media and observed a high number of colonies on 3M plates. Rapid Yeast and Mold Petrifilm. Further investigation revealed that cannabis trichomes induce a blue color change with the phosphatase-based indicator dye used on 3M RYM Petrifilms. We confirmed these events by microscopy and noted that the color change does not expand in diameter as quickly as yeasts and molds.

    McKernan also shared with TSC that in this study they simply took kief from a kief collector and plated them on various plating technologies and noticed that the plating system which used phosphatase reactions as its readout chemistry also designated trichomes as UFCs.

    “These data imply that 3M Petrifilms may generate false positives compared to more traditional plating methods, if used for less than 48 hours with trichome-rich cannabis flowers. Longer incubation times may be required to differentiate false positives derived from trichomes from true yeasts and molds,” they explained (1).

    “If you are growing plants rich in trichomes, contact your test lab to ask if they use these plates. This may explain a high TYM [total yeast and mold] account and the product failed due to false positives related to the non-specific phosphatase reaction on which these plates are based,” McKernan said. “Few foods are selected for high trichome density, but some spices from the food industry would create similar false positives. Cannabis rich in trichomes will be falsely penalized in testing labs that use these plates.

    The article concludes that microbial testing methods that falsely elevate yeast and mold counts will inappropriately select for trichome-rich cultivars. The authors stress that care must be taken to understand what triggers each microbial test and what percentage of yeasts and molds can grow on these media (1). McKernan also added that people should “use plates that don’t rely on this indicator reaction of phosphatase or use qPCR where trichomes are purified before TYM DNA quantification.”

    Reference

    1. https://osf.io/2jvm3/

    Arunachal APPSC Drug Inspector Recruitment 2022 Application Ends Today, Eligible Pharmacy Graduates

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    The Arunachal Pradesh Public Service Commission (APPSC) today closed the online application window for the recruitment for the position of Drug Inspector. Interested candidates can apply for vacancies on the official website appsc.gov.in.

    The APPSC recruitment campaign aims to fill a total of 8 vacancies for Medicines Inspector in the Ministry of Health and Family Welfare, Government. of Arunachal Pradesh. The salary is Tier 7 (Rs 44,900-1,42,400) Group-B.

    Here is the APPSC Drug Inspector recruitment notification 2022.

    Eligibility criteria

    Age limit: 18-32 years old on September 30, 2022. Relaxation of 5 years in the upper age limit for reserved categories.

    Education Qualification: Degree in Pharmacy or Pharmaceutical Chemistry with Pharmacy as a special subject OR Degree in Medicine or Science from a recognized university.

    Selection process

    The selection process is in two stages: a written exam followed by an interview/viva-voice.

    Registration fees

    APST candidates: Rs 100
    Other candidates: Rs 150

    Steps to Apply for APPSC Recruitment 2022:

    1. Visit the official website appsc.gov.in
    2. On the home page, click on “One-time registration”
    3. Register and login to your profile and apply for the job
    4. Fill in the details and upload the required documents
    5. Pay the application fee
    6. Take a printout for future reference

    Emergency Preparedness | VA Fayetteville Coastal Health Care

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    Forest fires affect everyone. They can spread quickly and harm us. Forest fires are becoming larger and more dangerous. More and more people live in areas at risk of wildfires, but we can take steps to prepare for them. Learn how to prepare your home and your community.

    Protect yourself from smoke.

    When wildfires create smoky conditions, it is important for everyone to reduce their exposure to smoke. Wildfire smoke irritates the eyes, nose, throat and lungs. This can make it difficult to breathe and cause you to cough or wheeze. Children, pregnant women, and people with asthma, chronic obstructive pulmonary disease (COPD), or heart disease should be especially careful when breathing in smoke from a wildfire.

    Keep the smoke out.

    • Choose a room that you can isolate from outside air.
    • Install a portable air purifier or indoor air filtration to keep the air in that room clean even when there is smoke in the rest of the building and outside. If you are using a DIY box fan filtration unit, never leave it unattended.

    Reduce your exposure to smoke while wearing a respirator.

    • A respirator is a mask that fits tightly to your face to filter smoke before you breathe it in.
    • You need to wear the right respirator and wear it correctly. Respirators are not designed for children.
    • If you have heart or lung disease, ask your doctor if it’s safe for you to wear a respirator.
    • Avoid using candles, gas, propane, wood stoves, fireplaces or aerosols and do not fry or grill meat, smoke tobacco products or vacuum.
    • If you have a central air conditioning system, use high-efficiency filters to capture fine smoke particles. If your system has a fresh air intake, set the system to recirculation mode or close the outside air intake damper.

    Pets and other animals can also be affected by wildfire smoke.

    Follow the fires near you to be ready.

    • AirNow’s “Fires: Current Conditions” page contains a map of the fires in North America.
    • NOAA’s “Fire weather outlook” page maps fire watches and warnings.
    • Listen to the National Oceanic and Atmospheric Administration (NOAA) Emergency Alert System (EAS) and Weather Radio for emergency alerts.

    Pay attention to any health symptoms if you suffer from asthma, COPD, heart disease or if you are pregnant. Get medical help if you need it.

    Learn more about wildfire smoke protection.

    Evacuate safely.

    Public authorities may ask you to evacuate or you may decide to evacuate. Learn how to evacuate safely and how to make a family disaster plan, including:

    • Find out what could happen to you
    • Development of an emergency plan
    • Complete the checklist
    • Practice your plan

    Stay healthy during power outages.

    Large fires can cause long-term power outages. Read what to do in the event of a power outage, including:

    • Prevent carbon monoxide poisoning
    • Food safety
    • Safe drinking water
    • Power Line Hazards

    Fight endometriosis pain with $100,000

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    Dr Thomas Tapmeier received a combined sum of $100,000 to develop novel antagonists against the Neuropeptide S 1 receptor

    Congratulation to Dr Thomas Tapmeier from the Uterine Biology and Gynecological Diseases Group of the Department of Obstetrics and Gynecology, which received a combined $100,000 from Therapeutic Innovation Australia (TIA) and the Monash Research Impact Fund (MRIF) to develop novel antagonists against the receptor Neuropeptide S1 (NPSR1).

    “I am thrilled! This is a wonderful opportunity to advance the search for new and better treatments for endometriosis – and other indications –. We are fortunate to have initiatives here such as TIA and MRIF, that allow rapid progress towards translation,” said Dr. Tapmeier.

    After identifying NPSR1 as a novel non-hormonal target in endometriosis in collaboration with Bayer AG while at the University of Oxford’s Nuffield Department of Women’s & Reproductive Health, Dr. Tapmeier formed a collaboration with Prof. Jonathan Baell of the Monash Institute of Pharmacological Sciences (MIPS) to raise funds for medicinal chemistry on antagonists and a screening campaign.

    It is hoped that this will lead to new therapies for pain and inflammation related to endometriosis.


    About Monash University

    Monash University is Australia’s largest university with over 80,000 students. In the 60 years since its founding, it has established a reputation as a world leader in high-impact research, quality teaching and inspiring innovation.

    With four campuses in Australia and a presence in Malaysia, China, India, Indonesia and Italy, it is one of Australia’s most internationalized universities.

    As a leading international medical research university with Australia’s largest medical school and integrated with Australia’s leading teaching hospitals, we consistently rank among the world’s top 50 universities for clinical, preclinical and health.

    For more information, visit Medicine, Nursing, and Health Sciences or Monash University.

    MEDIA INQUIRIES

    Email: [email protected]

    Why You Might Want To Add Grapeseed Oil To Your Skincare Routine

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    Full of omega fatty acids and vitamin E, grapeseed oil has also been proven to have impressive anti-inflammatory, antimicrobial and antioxidant properties – a winning combination for any skincare product (per Healthline ). Many people have started using grapeseed oil to treat skin rashes. Although research has not yet confirmed the reason for its success, it can be inferred that (thanks to its antimicrobial properties) it penetrates deep into the pores to kill acne-causing bacteria.

    A 2010 study published in Pharmacognosy Magazine also found that grapeseed oil has the ability to improve skin hydration, smoothness, and elasticity, and a 2004 study published in Phytotherapy Research suggests that when taken orally on a regular basis, grapeseed oil can even tone the skin and improve symptoms of hyperpigmentation. As if that weren’t enough to send us straight to the store for a bottle, a 2011 review published in Pharmacognosy Review credits grapeseed oil with protecting skin from UV rays.

    Healthline notes that unless you’re allergic to grapeseed oil, it’s considered safe for almost everyone to try. You can buy the oil and apply it directly to your skin like a serum, add a few drops to your favorite moisturizer, or mix it with frankincense, juniper, and lavender oils for a super hydrating mask. It is also available in capsules if you prefer to take it orally. In this case, however, be prepared to wait a few weeks to see your dazzling results.

    KU awards degrees in various disciplines

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    The Council for Advanced Studies and Research of the University of Karachi awarded one DSc, 38 PhD, 75 MPhil, one MD, four MS and 18 MS Course Work (30 Cr. Hr.) degrees in various disciplines.

    According to the KU Registrar, Prof. Dr. Abdul Waheed here on Wednesday, the ASRB at the meeting under the chairmanship of the KU Vice Chancellor, Prof. Dr. Khalid Mahmood of Iraq, awarded the degrees.

    He said the PhD degree in Chemistry was awarded to Professor Khalid M. Khan, while the PhD degrees were awarded to Nabeela Afzal (Agriculture and Agribusiness Management), Muhammad Noman, Humera Sultana , Hamna Nasir, Lubna Naz (applied economics [AERC]), Nazish Waris, Shahla Perveen, Uzma Imran, Hira Rafi, Shoaib Ahmad, Maria Azam (Biochemistry), Rabeeya Iftikhar (Biotechnology [KIBGE]), Tahir (Chemistry), Syeda Danish Ahmad, Rabia Jaffar (Clinical Psychology), Humera (IT), Abdul Jabbar Dahri (Education), Muhammad Moonis Azad (English [Literature]), Asia Neelam (environmental studies), Atif Uddin, Hatim Aziz Solangi (law), Mehwish Shafi Khan, Sumayyah Saadi (mathematics), Aneela Mehboob, Dr Muhammad Farooque Baig (microbiology), Rabia Mehtab (pharmaceutical chemistry), Sehreen Far Bukhari (Philosophy), Shabir Ijaz (Plant Conservation), Malik Safdar, Farhana Mukhtar (Political Science), Abdul Lateef Kalwar, Usman Ali, Sofia Bano, Hassaan Ahmed (Public Administration), Wajiha Shahid (Social Work), Frah Syed, Irum Nayyar (Urdu) and Hafiz Muhammad Yunus (Usool-Ud-din).

    Meanwhile, he mentioned that MPhil degrees were awarded to Sibtain Barkat, Shagufta Siddique (Agriculture and Agribusiness Management), Syeda Tabeer Zehra (Applied Chemistry and Chemical Technology), Sumaiya Zaheer, Fatima Zehra ( Applied Economy [AERC]), Hafsa (Arabic), Sadia Munawer, Noureen (botany), Bibi Zainab, Wajiha Wahid (biochemistry), Hafiza Farhat ul Ain (biotechnology [KIBGE]), Muhammad Asif (chemistry), Mazhar Iqbal, Seerat Iqbal, Mohsin Raza, Mahroza Kanwal Khan, Humaira Karim, Iqra Ghaffar, Perveen Bano, Memoona Bibi, Muhammad Awais (chemistry [HEJ]), Ammarah Javaria, Shania Zafar, Ayla Faisal, Neelam Naz, Reshma Iqbal (clinical psychology), Muhammad Farrukh Aslam (commerce), Akhtar Nawaz, Tariq Javed Bhatti (criminology), Carissa Prima Simplicia D’Souza (economics), Humaira Saeed (European studies [ASCE]), Javeria Naz, Bushra Naseem (food science and technology), Saira Sana Khan (genetics), Nida Shafaat (general history), Muhammad Hassan, Aurang Zeb (Islamic learning), Mehdi Hassan (library and information science), Umm-e -Aimen (marine biology), Ania Qadri (mass communication), Daniyal Ur Rehman, Muhammad Fahad (mathematics), Mustansir Abbas, Usama Hafeez, Urooba Jamal (microbiology), Faiza Ramzan, Amber Mirza, Hina Ansar, Saria Tariq, Saleha Tabassum, Dur E Shahwar, Sidrah Asghar (molecular medicine), Muhammad Nasir Singhar (Pakistani studies), Syeda Sara Fatima (pharmacy), Warda Ainuddin, Anosh Tahir (pharmacology), Rubab Kiran (pharmacognosy), Sabah Farhat (physiology ), Rabia Akhlaq (Plant Conservation),

    Aurangzeb (Political Science), Muhammad Asif, Kahkashan Mamal (Psychology), M. Mustaneer Noor, Anum Shah, Aashi Noor Muhammad (Public Administration), Siraj Ahmed (Quran and Sunnah), Farid Bin Masood (Sociology), Fouzia Shaukat (Space and planetary astrophysics [ISPA]), Iqra Khalid, Saba Naz (statistics), Saira Batool, Muhammad Tariq Khan, Urooj Zehra (Urdu), Muhammad Ayaz (zoology) and Sumbul (zoology [MRCRC]).

    LACMA-Blog | Partner Connect: prescription delivery of capsules and AMB

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    The Los Angeles County Medical Association works with the Association Member Benefits & Insurance Agency (AMBA), formerly Mercer Health & Benefits Insurance Services LLC, as the broker and plan administrator for LACMA-sponsored insurance programs . AMBA offers best-in-class insurance to protect you, your practice and your family!

    LACMA works with AMBA and insurance companies to design and implement insurance plans that meet the coverage needs of member physicians. Help support the practice of medicine by purchasing your insurance through the sponsored program.

    Plans available for your practice include: Workers Compensation, Cyber ​​Liability, Business Owner Package and Small Group Health. Plans for you and your family include group term life insurance, group long term disability insurance, long term care, dental, travel assistance and more!

    If you are already insured through the sponsored program, we want to assure you that you will continue to receive the same high quality products, benefits and service standards that you have come to expect. All your current payments and billings will remain unchanged under the new AMBA name. The team you know and trust will continue to serve you, and your benefits and services will continue uninterrupted.

    Contact AMBA for more information regarding your specific situation and needs, and to find out how you can increase coverage, reduce premiums or both today!

    Visit CountyCMAMemberInsurance.com

    Email [email protected] or

    Call a customer advisor at (800) 842-3761

    Association Member Benefit Advisors, LLC.

    In CA d/b/a Association Member Benefits & Insurance Agency

    CA Insurance License #0I96562

    97346 (9/22) Copyright 2022 AMBA. All rights reserved.

    280 Chana Drive, Auburn, CA 95603 • 800-842-3761

    [email protected]

    www.CountyCMAMemberInsurance.com

    Visit here

    Race Oncology Ltd contracts with Monash University fragment-based screening program to help discover new drugs FTO and ALKBH5

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    Race Oncology Ltd (ASX: RAC) is moving forward with its Pillar 3 “Beyond Zantrene” strategy aiming to add new drugs for use in cancer and other indications to its pipeline.

    To aid the precision oncology company in its pursuit, the Monash Fragment Platform (MFP) at Monash University Melbourne has been contracted to carry out a fragment-based screening program to discover new drugs that inhibit m6A FTO and ALKBH5 RNA demethylases.

    Led by eminent medicinal chemist and Director of MFP, Professor Martin Scanlon, the project will begin immediately using the latest techniques in nuclear magnetic resonance (NMR) spectroscopy. Results will be reported over the next 12 months.

    Race will own all intellectual property developed through the project, which is expected to cost $286,786.

    “Adding new FTO inhibitors to Race’s drug pipeline creates major value as it expands Race ‘Beyond Zantrene’ and positions us as one of the leading RNA epitranscriptomics pharmaceutical companies,” said said Phil Lynch, Managing Director of Race.

    Arrest the big culprits

    Important scientific discoveries made over the past decade have identified dysregulation (loss of control) of RNA epigenetics (epitranscriptomics) as a key driver of cancer and other complex diseases.

    They are caused by the proteins Fatso/FaT and Obesity Associated (FTO) and ALKBH5, two of the only m6A RNA demethylases found in humans. Changes in the expression of FTO or ALKBH5 have a profound impact on the growth, spread and resistance to treatment of cancer.

    Inhibition of FTO or ALKBH5 activity is capable of killing or slowing the growth of a wide range of cancers including leukemia, breast, lung, ovary, stomach, brain, melanoma , pancreas, kidney and many more.

    Race’s most advanced asset Zantrene® is a potent FTO inhibitor and is the only m6A RNA demethylase inhibitor and RNA epitranscriptomic drug in the clinic.

    Expanding portfolio

    Race’s lead scientist, Professor Mike Kelso, said: “Race is extremely pleased to be working with Professor Scanlon and his experienced team on this important project. The discovery and patenting of new FTO and ALKBH5 inhibitors will significantly strengthen Race’s drug development pipeline and add valuable assets to our growing intellectual property portfolio.

    “Building on my career in medicinal chemistry, I relish the downstream challenge of evolving the molecules discovered in this campaign into ready-to-use FTO and ALKBH5 inhibitors as innovative new cancer treatments and to ‘other diseases.’

    Professor Scanlon said: “Developing next-generation drugs requires exceptional scientific discovery. The Monash Fragment platform was created to help researchers accelerate this long and complex journey. We are excited to work with Race to use our fragment-based screening technology to identify novel FTO and ALKBH5 inhibitors. »

    Professor of Medicinal Chemistry at the Monash Institute of Pharmaceutical Sciences, Scanlon has published over 100 articles in top international journals and has led over 30 successful fragment-based discovery campaigns at MFP for academic and industrial clients since its creation in 2015. .

    10 tips to reduce the appearance of stretch marks

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    If you haven’t developed stretch marks yet, don’t think you’re off the hook. The above risk factors can be applied to many years of a lifetime, so if you think you’re going to have them soon, prevention is always the best offense, according to Stretchmarks.org. This way you are already ahead of the stretch mark curve.

    If possible, everyone likes to save a dollar or two, especially when dealing with long-term issues. So, let’s start with what you can do at home. One of the best things you can do is invest in good moisturizers that will keep your skin supple and soft through all stages of life. The softer and hydrated your skin is, the less likely it is to tear if, or when, it’s stretched.

    There are of course hundreds, if not thousands of moisturizers on the market. It doesn’t have to be complicated, though. Simple cocoa butter or even coconut oil will work well to keep the skin on your body hydrated, soft and supple. As long as you religiously apply moisturizer to all parts of your skin, your skin should be able to handle any kind of stretch. Be sure to pay particular attention to your abdomen, thighs, arms, buttocks, and breasts, as these areas are most likely to develop stretch marks.

    Optus Breach Triggers Banks Data Sharing Plan; Voice in parliament supported by voters; federal ICAC legislation to be introduced; RBA Interest Rate Hikes Cause $120 Billion Fiscal Hole; Jacqui Lambie supports medical cannabis for veterans

    Independent MP for Indi, Helen Haines, says she is confident that Labor legislation to create a national integrity commission will cover third parties after further discussions with the government.

    “What I want to see … is that anyone who seeks to negatively influence the impartial exercise of government be brought under the jurisdiction of this commission,” she told ABC TV moments ago.

    Independent MP Helen Haines wants the proposed Federal Anti-Corruption Commission to have broad investigative powers.Credit:Simon Dallinger

    “It is important that this commission can look for corruption in dark places. And if we just limit it to government officials or contractors, we miss those other organizations or people who seek to harm our governments.

    However, the crossbench MP will continue to push the government to act on new protections for whistleblowers.

    “I cannot rest as a parliamentarian until I know that whistleblowers will be protected. We have seen many examples where they fail. The Attorney General has publicly stated that whistleblower protection will not be included in this bill, but it is very clear that he will undertake the necessary reforms to the Public Interest Disclosure Act.

    “I don’t want to see a powerful corruption commission set up without whistleblower protection.”

    In a later interview on ABC TV, Labor MP Ged Kearney said protecting whistleblowers was something she “feels very strongly” as a nurse and trade unionist.

    “I think there should be strong protections for whistleblowers,” she said.

    How Women Can Handle ADHD When Anxiety Soars at Work

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    New guidelines from the US Task Force on Preventive Services warned this week that there is a critical need to reduce stress and anxiety in Americans, which wreaks head-to-toe havoc on our bodies. The government’s draft recommendation is that adults should be screened annually for anxiety to safeguard our sanity. They offered no immediate solution.

    This news made my head spin. In particular, I worry about women in the workplace, especially women with ADHD and women like me. There are more of us than you think. I’ve started wondering what level of anxiety is manageable and what isn’t normal over the past few years. If you have them too, this definition might help you. Medical experts call it cognitive distortion. “Anxiety is the anticipation of a future threat. This threat may be real or imagined, but it is not immediate,” writes Tracey Marks, MD, an Atlanta psychiatrist and author of Why am I so anxious? Cognitive distortion is what derails so many of us, especially women who often jostle between jobs and are primary caregivers.

    The issue of stress is not new, of course. In 2013, a study showed that 80% of visits to the doctor were stress-related. The amount of advice provided by primary care providers was found to be suboptimal (this is the researchers’ word, not mine). What’s new is that more women are being diagnosed (or self-diagnosed) with ADHD/ADD, and they are becoming more aware of their unique stressors and propensity for anxiety and depression. They also seek help, but there is a shortage of therapists and psychiatrists to diagnose them. What has proven to be helpful is peer counseling. Peer groups are a great alternative for people who cannot afford the time or price of therapy or who can, but cannot find an available practitioner with a specialty in ADHD and women.

    My job is to help employees gain buy-in from supervisors and colleagues who may not understand how and why we work differently. I’m the human antidote to “because we’ve always done it this way”. I help people see that they are not strangers or weirdos, but insiders with specific strengths who know how to do their job best. This reduces anxiety exponentially.

    Here, suggestions on how to restore your balance and do your best in an unstable work environment. You can start using these career tips immediately, even if there is no working group or official guidelines.

    Describe how you work best. Instead of saying I have ADHD and having a blank stare like I’ve seen so often, discuss what you’re going to do, why you’re going to do it this way, and how others can help you. Be specific. For example, say out loud: I color-code each department on the whiteboard in my office so you can each see where your projects are and when they will be completed. Or I’ll write memoirs in the morning and make phone calls in the afternoon. Please schedule meetings with me every two weeks to catch up. If you email me, please note in the subject line which project you are talking about as I work on seven to 12 projects a month. These are habits that shouldn’t be offensive to anyone, but if they are, talk to the person offline. It is not necessary to go into details during the meetings.

    The goal: to tie your habit to your strength. This way you don’t have to connect a label (ADHD, dyslexia) to your person. Explain your process if necessary, but be sure to note your progress at each meeting. This allows people to guide you in achieving your goals. In other words, it puts a cork in office anxiety.

    Don’t be a martyr or keep secrets. There’s a brilliant new book on the subject, The Secret Life of Secrets by Michael Slepyan. He explains there what everyone intuitively knows but does not talk about. That keeping secrets is stressful and unhealthy.

    Getting rid of stress is like composting. You must learn to take care of your waste. There is a learning curve. It’s helpful to keep a diary of your ADHD-related weaknesses, tell jokes about how ADHD is upsetting your life, but don’t keep secrets. And then move on. I repeat: Admit the mistake and move on.

    This summer, I was stopped at a construction site by a worker who asked me: Why are you driving too fast here? I told her that I rushed to the airport and apologized several times. She made several faces at me. Before letting me go, she said, “If you’re late, you’re late. I started the car and continued as my daughter said the words, mom, if you’re late, you’re late. So basic. We laughed.

    You can also. I promise. If you get called to rush into a project at work because you procrastinated or made a math mistake or didn’t catch a typo or send an email to the wrong place, this is what you did. . Admit it. If you’re late, you’re late. Pass. So basic. Not a situation—at all.

    Show your work. It sounds obvious, but you can’t imagine how many people I talk to who hide their quirky way of working. Being overprotective of your process breeds mistrust. This causes anxiety. It can even lead to harassment and bullying.

    Be open about the process you use, no matter how odd. For example, first I write, then I print, then I highlight, then on some occasions, like 70-page white papers, I cut out the pieces and rearrange the sections with a scissor. No shame here. That might be too much for the average person (who knows how to ‘cut and paste’ to be a minor keystroke or two.) who cares. Do what works.

    Once you pitch your amazing project and the board approves it or you get the contract, no one will care how much scrap paper you used. And if your process is spiraling out of control, it allows nice co-workers to offer their help before things get really crazy or your brain explodes.

    Be real and don’t skip the self-care. There are things you need to do to keep your life running smoothly that others don’t. ADHD is a constant in your life, so you will constantly have to make doctor’s appointments to check medications and how you are feeling. You will likely need to meet with a medication manager every month who can prescribe medication for you. Also, you can see a therapist or counselor who can help you learn coping skills. Or you could be part of a peer group that meets at 7 p.m. on Thursdays when the rest of your team goes out for drinks or date nights. That’s life. Know that you are doing yourself a lot of good by not drinking with your co-workers and instead talking to other people like you. Having a community of ADHD peeps is crucial. Find them in Facebook groups, through national associations, or by asking a community health center if they get peer counseling or group therapy.

    Avoiding the giant ups and downs that leave you paralyzed and unable to work takes practice. While helpful, group or peer therapy and self-care can be exhausting. Persevere. If you devote time to it, you are very likely to emerge on the other side a stronger, more flexible and self-aware human being. You will also be better able to respond to managers and colleagues who are unaware of your need to take care of yourself and set boundaries.

    If we stick to the theme of being real, that’s it. There is no way around this. You will make your managers anxious with all these appointments. What is she doing now? Why does she take so long to go to the pharmacy? Why does she go to the pharmacy again (medicines are rarely ready on time and often contain errors, which forces you to contact your doctor or play phone games with your pharmacy). What kind of therapy does she attend so often, and why does she also have to leave about to take an exercise class? Therapy and exercise are two brilliant anti-anxiety drugs. Make time for them even if it takes you away from your job. If you don’t spend time with them, you will be more anxious. If you do, you’ll make your manager anxious because you’re not in the office or available.

    I’m so glad we had this somewhat circular, possibly anxiety-provoking conversation. Please join me here for more ideas next week when ADHD Awareness Month begins.

    Partnership with National Council on Aging Brings UB’s Dangers of Overmedication Program to National Audiences

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    UB’s Alice team gives students, providers and the public the tools they need to prevent life-threatening medical errors in older adults

    BUFFALO, NY The nation’s oldest charitable organization dedicated to improving the lives of older Americans has chosen the University at Buffalo as its partner in an effort to better protect older adults from preventable medical errors.

    The National Council on Aging (NCOA) works with UB faculty to deliver to the organization’s national audiences the message of Team Alice, an interprofessional research, education, and advocacy program that is part from the UB Center for Successful Aging. The goal of the collaboration is to educate seniors about the dangers of overmedication and empower them to actively participate with their health care providers in making decisions about medications.

    “The NCOA is thrilled to partner with Team Alice at the University at Buffalo to shed light on the all-too-common issues of medication errors and inappropriate prescribing for older adults,” said Kathleen Cameron, Director principal of the NCOA, Center for Healthy Aging.

    “We are happy to contribute to efforts to educate older adults and their caregivers on how to reduce these issues,” she said. “This important work aligns with the NCOA’s belief that every person deserves to age well. The appropriate, effective and safe use of medications is essential to help older people maintain their well-being and independence.

    Alice’s Story: A Cautionary Tale

    Last month, the organization released “Medication Safety: How Alice’s Story Can Protect Older Adults”, the first in a series of stories and resources the Alice team is providing to the NCOA to enable seniors to make decisions about the medications they take. Yesterday, the organization released its second Team Alice resource: “Tips when starting new prescriptions and why building a list is important.”

    Alice’s story grew out of the tragedy that struck in 2009 when Mary Brennan Taylor lost her mother, Alice, a feisty, otherwise healthy, independent 88-year-old, to preventable medical errors in just six weeks. Stunned and distressed by the rapid decline and death of her mother, Taylor wanted to raise awareness of the issue and try to bring about a change in healthcare culture and politics.

    She began sharing Alice’s story in 2011 with UB students at the Jacobs School of Medicine and Biomedical Sciences and the School of Nursing. Soon she was also sharing the story with other UB students in the School of Pharmacy and Pharmaceutical Sciences and the School of Public Health and Health Professions. To date, she has shared the story with literally thousands of health science students at UB and other colleges so that early in their careers they are well aware of the problem of medical errors. and how to prevent them.

    “Since 2011, when UB health science students first heard Alice’s story, they embraced her message about preventing drug-related harm, especially in the elderly,” said Allison Brashear, MD, vice president of health sciences and dean of the Jacobs School. “We are proud that our faculty across the health sciences strive to advance the mission of the Alice team through interdisciplinary research, interprofessional education, and advocacy for change in policy and our health care system. Health care. »

    Taylor noted that Team Alice “literally never would have happened if UB medical school hadn’t embraced the message of Alice’s story and made it a required part of clerkship. third year”.

    In more than a decade of working with every health science school at UB, Taylor has seen Alice’s story open the eyes of tomorrow’s healthcare workers. She has been invited to speak at national meetings of the Centers for Medicare and Medicaid Services, the United States Department of Health and Human Services, and the Centers for Disease Control and Prevention, as well as national media.

    “Alice’s story is a story that strikes a chord,” said Taylor, adjunct assistant professor in the Department of Family Medicine at the Jacobs School. “Time after time, people who hear it say, ‘OMG, it happened to my mom or my dad. “”

    This recognition only strengthens Taylor’s resolve to keep sharing it, which the Alice team is doing through events at local senior centers and through short videos that the UB team has developed with funding. of the RRF Foundation for Aging.

    Ranjit Singh, MD, vice chair of research, Department of Family Medicine and physician at UBMD Family Medicine, co-leads the Alice team with Robert G. Wahler, PharmD, clinical associate professor of pharmacy practice. “It’s important to have academic rigor behind our research,” Singh said, “but we also need the message to reach the very people who need it, and the NCOA does that.”

    Taylor agreed that the partnership with the NCOA, which works with thousands of organizations nationwide, expands the reach of Team Alice’s message exponentially.

    “It’s like a dream come true for us to be able to partner with such an incredible organization that reaches the exact audience that needs to hear this message,” Taylor said.

    Always inspiring students

    UB health science students continue to benefit from Team Alice, an interdisciplinary effort focused on research, education, and advocacy. “We’re taking a unique holistic approach to preventing medication errors,” said Singh, who added that the project includes faculty from the Jacobs School, School of Pharmacy and Pharmaceutical Sciences, School of Nursing, School of Public Health and Health Professions and even the School of Engineering and Applied Science.

    Taylor still gives her talk a dozen times a year to different groups of UB medical students and nursing students, many of whom continue to be inspired by Alice’s story.

    Natalie Tjota, MD, a Jacobs School graduate now in her second year of internal medicine residency at UB, is one of them. She remembered the impact Alice’s story had on her when she heard it as a student.

    “In medicine, you intend to do no harm, but in Alice’s case, you might see the negative effects of polypharmacy (the simultaneous use of many drugs),” she said. “It made me want to be part of the team trying to make sure that doesn’t happen.”

    Focusing on geriatrics now, Tjota recalls the lessons of Alice’s story and says it stuck with her. “During my rotations in medical school and in residency, we see a lot of side effects from antipsychotics and anticholinergics, and they can be pretty scary,” she said. “It’s gratifying to be able to take medicine and see the patient get better. Medicine has come so far and we can do so much, but to see a patient get better while we are doing less is pretty amazing.

    Andrew Baumgartner, another Jacobs School alumnus who is currently doing a family medicine residency at UB, began doing research with Team Alice during his very first year at Jacobs School. He recalled how this experience helped shape his approach to health care and his own specialty.

    “At the start of medical training, I think most learners assume that health care is infallible,” said Baumgartner, who will join the Jacobs School faculty next year. “Over time, however, it feels like providing high-quality healthcare in the modern system is akin to swimming upstream, even for the best professionals. The Alice team gives voice to this sentiment and reminds learners to always look for ways to make positive system-wide changes for the benefit of their patients. The impact of a generation of physicians concerned with patient safety is incalculable.

    Taylor can’t think of a better way to honor her mother.

    “If you think about the number of students who have been involved in this from the beginning and hopefully benefited, taking Alice’s story with them to think differently about aging and prescription, those things will resonate,” Taylor said. “It’s Alice’s legacy.”

    New On-Campus Counseling and Psychological Resources – The Santa Clara

    With the start of a new school year, the Counseling and Psychological Services (CAPS) department has made significant changes to better support student mental health. A campus-wide email sent Sept. 15 to the Santa Clara student body announced a revamped Cowell Center.

    To better assist students, the administration has announced several changes. With new funding, CAPS has increased the number of psychologists available, removed service fees, added a limited in-house pharmacy, and implemented new programs and services that have expanded the accessibility of on-campus support.

    Thanks to these efforts, Hadley Johanson, administrative assistant at the Cowell Center, is optimistic about the development of the center. “[The services] will be more accessible to all students, regardless of schedule,” Johanson said. Removing service fees and session limits “will ensure that more students receive support.”

    These changes were administered due to student and alumni concerns about the lack of mental health resources on campus. After several crises last year, demonstrations took place on campus to accessibility of mental health resources for students.

    The protests and a Change.org petition have received campus-wide support. The outcry led to increased funding for mental health staff from the Santa Clara budget.

    An article published by the Mayo Clinic in July 2022 quoted that “44% of students reported experiencing symptoms of depression and anxiety.” Due to the transient nature of college and the ongoing coronavirus pandemic, college students are exposed to many factors that impact their mental health.

    Despite the prevalence of anxiety and depression among students, “ 75% of students are reluctant to ask for help.” The Mayo Clinic says exposure to risk factors and resistance to seeking support can increase the likelihood of worsening mental health.

    To address these issues, CAPS has developed new resources to support students. For example, the CAPS 24/7 helpline was introduced this year. This line is accessible to all full-time students and offers mental health support”24 hours a day, 7 days a week.”

    “CAPS 24/7 will be a vital resource for any student who needs a little extra support in their darkest times,” said Andres Garza, a junior community animator. “Change and [unforeseen challenges] are difficult for everyone and CAPS 24/7 will be the bridge for all students to receive help in a professional and confidential manner. It is a tool that every university needs.

    CAPS will also continue to offer individual and group counseling appointments and workshops. These resources will be more readily available due to an increase in therapist staffing and, according to the email sent to the community, “service fees and session limits being eliminated.”

    Support is also more accessible with the addition of Residence Counsellors. Residence counselors live on campus and conduct one-on-one therapy, conduct sessions to meet resident needs, and support residence life staff.

    Some programs include Question, Persuasion, and Refer (QPR) and Mental Health First Aid (MHFA). These programs train students to recognize the warning signs of mental health issues and respond appropriately. Through these programs, students at Santa Clara University will be able to help each other deal with mental health issues by recommending CAPS-appropriate resources.

    Magis Residential Learning Community Deputy Resident Director Petra Glenn believes the addition of Residence Counselors will have a noticeable impact. “A home mental health resource [will make] get more accessible but also more personal help,” said Glenn. ” [I am] incredibly excited about the addition of [Counselors in Residence] position and hope to see continued growth in CAPS resources for students in residence and for the student body in general.

    If you or someone you know has mental health issues, help is available on and off campus.

    Suicide and 24 hour crisis line: (988)

    The Santa Clara University Mental Health Counseling Line is available 24/7 for all students: (408) 554-5220

    Raman Spectroscopy Market Will Continue to Boom Globally

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    ✤ Horiba Jobin Yvon
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    ✤ Thermo
    ✤ B&W Teak
    ✤ Brucker
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    ✤ Ocean Optics
    ✤ Detection of blacksmiths
    ✤ JASCO
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    ✤ ITS
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    ✤ Zolix
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    Quotient Sciences Expands UK Facilities to Support Delivery of Translational Pharmaceutics® Programs

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    Company Expands Laboratory and Clinical Capabilities to Meet Demand for Fully Integrated Drug Development Capabilities

    NOTTINGHAM, England, September 22, 2022 /PRNewswire/ — Quotient sciencea drug development and manufacturing accelerator, has made significant investments and expansions at its Nottingham, United Kingdom and Reading, UKfacilities to support the delivery of fully integrated drug development programs through the company’s flagship platform, Translational Pharmaceutics®.

    The new clinical pharmacology space and expanded development labs increase the company’s ability to conduct integrated translational pharmacology programs for global pharmaceutical and biotechnology customers.

    Translational Pharmaceutics integrates drug substance, drug product, and clinical trial activities under a single outsourcing vendor to accelerate development times and reduce costs.

    Developed in consultation with the UK’s Medicines and Healthcare Products Regulatory Agency (MHRA) and the US Food and Drug Administration (FDA), the platform uses rapid ‘manufacture-to-test’ cycles, where drug products are manufactured, released and dosed in a clinical setting. study in days rather than months.

    In Nottingham, United Kingdom, Quotient Sciences has opened a 17,000 square foot, MHRA-inspected clinical pharmacology facility that includes 40 beds with ancillary volunteer lounges, processing labs, a dispensary and controlled storage. The new facility is located adjacent to their existing formulation development, manufacturing and clinical operations facilities at the Company’s plant. Nottingham Campus.

    Their Reading, UK site, the company completed a £1.5 million expansion of its early development and manufacturing facilities, which doubled its formulation development and analytical footprint on the facility, increasing the office space also part of the expansion.

    “Quotient Sciences’ mission is to help bring new medicines to patients faster by breaking down traditional industry silos,” said Marc EgertonPh.D., CEO of Quotient Sciences.

    “Our unique Translational Pharmaceutics platform was launched over 15 years ago and has accelerated the development of nearly 1,000 molecules for our clients. These expansions are consistent with our overall growth strategy and in direct response to customer feedback and growing demand for our services.”

    About Quotient Science

    Quotient science is a drug development and manufacturing accelerator that offers integrated programs and tailored services throughout the development journey. By breaking down silos across a range of drug development capabilities, we save valuable time and money getting drugs to patients. Everything we do for our customers is driven by the unwavering belief that ideas must become solutions and molecules must become cures, fast. Because humanity needs solutions, fast.

    SOURCE Science Quotient Global News